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Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/bbrc.1995.2110openalex-snapshot
Molecular-Cloning of the Human Gene Encoding Lanosterol Synthase from a Liver cDNA Library
inferredcites →https://doi.org/10.1006/bbrc.1996.0232openalex-snapshot
Molecular Cloning of aSchizosaccharomyces pombecDNA Encoding Lanosterol Synthase and Investigation of Conserved Tryptophan Residues
inferredcites →https://doi.org/10.1007/s00425-002-0871-9openalex-snapshot
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway
inferredcites →https://doi.org/10.1016/0031-9422(80)80206-8openalex-snapshot
The identification of cholesterol and other steroids in Euphorbia pulcherimma
inferredcites →https://doi.org/10.1016/0031-9422(92)80019-bopenalex-snapshot
Carbon-13 nmr studies on sitosterol biosynthesized from [13C]mevalonates
inferredcites →https://doi.org/10.1016/0031-9422(95)00075-iopenalex-snapshot
A reinvestigation of the biosynthesis of lanosterol in Euphorbia lathyris
inferredcites →https://doi.org/10.1016/j.abb.2005.12.010openalex-snapshot
Lanosterol biosynthesis in plants
inferredcites →https://doi.org/10.1016/s0021-9258(18)62128-3openalex-snapshot
Concerning the Role of Lanosterol and Cycloartenol in Steroid Biosynthesis
inferredcites →https://doi.org/10.1016/s0021-9258(19)50249-6openalex-snapshot
Plant sterol biosynthesis. Identification and characterization of two distinct microsomal oxidative enzymatic systems involved in sterol C4-demethylation
inferredcites →https://doi.org/10.1016/s0031-9422(00)84828-1openalex-snapshot
Aspects particuliers de la biosynthèse des triterpènes dans le latex d'Euphorbia
inferredcites →https://doi.org/10.1016/s0031-9422(00)88211-4openalex-snapshot
Études chimiotaxonomiques dans la famille des euphorbiacées—III Répartition des triterpènes dans les latex d'Euphorbia
inferredcites →https://doi.org/10.1021/cr00022a009openalex-snapshot
Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
inferredcites →https://doi.org/10.1021/ja974387qopenalex-snapshot
Multigram Synthesis of Mevalonolactone-d9 and Its Application to Stereochemical Analysis by 1H NMR of the Saturation Reaction in the Biosynthesis of the 2,3-Di-O-phytanyl-sn-glycerol Core of the Archaeal Membrane Lipid
inferredcites →https://doi.org/10.1021/ja992589bopenalex-snapshot
Directed Evolution To Investigate Steric Control of Enzymatic Oxidosqualene Cyclization. An Isoleucine-to-Valine Mutation in Cycloartenol Synthase Allows Lanosterol and Parkeol Biosynthesis
inferredcites →https://doi.org/10.1021/np990081gopenalex-snapshot
Nonpolar Components of the Latex of Euphorbia peplus
inferredcites →https://doi.org/10.1039/b002685iopenalex-snapshot
The biosynthesis of C5–C25 terpenoid compounds
inferredcites →https://doi.org/10.1039/c39870001876openalex-snapshot
Stereospecificity in the side-chain formation of 24β-ethylsterols in tissue cultures of Trichosanthes kirilowii
inferredcites →https://doi.org/10.1039/cs9871600123openalex-snapshot
Applications of multinuclear NMR to structural and biosynthetic studies of polyketide microbial metabolites
inferredcites →https://doi.org/10.1039/np9971400591openalex-snapshot
Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function
inferredcites →https://doi.org/10.1039/p19880002407openalex-snapshot
Biosynthesis of sitosterol, cycloartenol, and 24-methylenecycloartanol in tissue cultures of higher plants and of ergosterol in yeast from [1,2-13C2]- and [2-13C2H3]-acetate and [5-13C2H2]MVA
inferredcites →https://doi.org/10.1039/p19910002065openalex-snapshot
Biosynthesis of cholesterol and lanosterol in isolated dog hepatocytes: incorporation of [1,2-13C2]- and [2-13C2H3]-acetate, and [1-13C]acetate and [1-2H2]ethanol
inferredcites →https://doi.org/10.1073/pnas.0407360102openalex-snapshot
The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers
inferredcites →https://doi.org/10.1073/pnas.0712190105openalex-snapshot
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis
inferredcites →https://doi.org/10.1073/pnas.90.24.11628openalex-snapshot
Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen.
inferredcites →https://doi.org/10.1074/jbc.m208659200openalex-snapshot
Contribution of the Mevalonate and Methylerythritol Phosphate Pathways to the Biosynthesis of Gibberellins inArabidopsis
inferredcites →https://doi.org/10.1074/jbc.m302526200openalex-snapshot
Cross-talk between the Cytosolic Mevalonate and the Plastidial Methylerythritol Phosphate Pathways in Tobacco Bright Yellow-2 Cells
inferredcites →https://doi.org/10.1093/pcp/pcj031openalex-snapshot
Lanosterol Synthase in Dicotyledonous Plants
inferredcites →https://doi.org/10.1093/pcp/pcj032openalex-snapshot
Plant Lanosterol Synthase: Divergence of the Sterol and Triterpene Biosynthetic Pathways in Eukaryotes
inferredcites →https://doi.org/10.1104/pp.104.046367openalex-snapshot
GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox
inferredcites →https://doi.org/10.1111/j.1365-313x.2004.02003.xopenalex-snapshot
Loss of function of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels
inferredcites →https://doi.org/10.1111/j.1432-1033.1969.tb00513.xopenalex-snapshot
The Conversion of [14C]Cycloartenol and [14C]Lanosterol into Phytosterols by Cultures of Nicotiana tabacum
inferredcites →https://doi.org/10.1111/j.1432-1033.1970.tb00288.xopenalex-snapshot
The Conversion of Parkeol into its 24,25-Epoxide by Tissue Cultures of Nicotiana tabacum
inferredcites →https://doi.org/10.1146/annurev.arplant.55.031903.141616openalex-snapshot
BIOSYNTHESIS AND ACCUMULATION OF STEROLS
inferredcites →https://doi.org/10.1146/annurev.pp.26.060175.001233openalex-snapshot
Plant Sterols
inferredcites →https://doi.org/10.1146/annurev.pp.30.060179.002101openalex-snapshot
Biosynthesis of Terpenoids
inferredcites →https://doi.org/10.1248/bpb.23.231openalex-snapshot
Molecular Cloning and Characterization of a cDNA for Glycyrrhiza glabra Cycloartenol Synthase.
inferredcites →https://doi.org/10.1248/bpb.26.642openalex-snapshot
Oxidosqualene Cyclases from Cell Suspension Cultures of Betula platyphylla var. japonica: Molecular Evolution of Oxidosqualene Cyclases in Higher Plants

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Lipid Metabolism in Plants
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Sterol and Steroid Biosynthesis and Metabolism in Plants and Microorganisms
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Oxidative Cyclization in Natural Product Biosynthesis
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Biosynthesis of Cholesterol and Other Sterols
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Distinct triterpene synthases in the laticifers of Euphorbia lathyris
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Diverse triterpene skeletons are derived from the expansion and divergent evolution of 2,3-oxidosqualene cyclases in plants
inferred← citeshttps://doi.org/10.1080/87559129.2021.1936006openalex-snapshot
A Review of Vitamin D and Its Precursors in Plants and Their Translation to Active Metabolites in Meat
inferred← citeshttps://doi.org/10.1093/aesa/saw059openalex-snapshot
Complex Lipids and Sterols in the Leaves ofEucalyptus macrorhyncha(Myrtaceae) in the Context of Feeding by an Unnamed Gall-Inducing Species ofGlycaspis(Synglycaspis) (Hemiptera: Psylloidea: Aphalaridae)
inferred← citeshttps://doi.org/10.1093/hr/uhad032openalex-snapshot
Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei
inferred← citeshttps://doi.org/10.1093/jxb/eraa429openalex-snapshot
Dissecting cholesterol and phytosterol biosynthesis via mutants and inhibitors
inferred← citeshttps://doi.org/10.1093/mp/sss015openalex-snapshot
Structure and Dynamics of the Isoprenoid Pathway Network
inferred← citeshttps://doi.org/10.1093/mp/sst096openalex-snapshot
From Squalene to Brassinolide: The Steroid Metabolic and Signaling Pathways across the Plant Kingdom
inferred← citeshttps://doi.org/10.1093/pcp/pcaf166openalex-snapshot
Rab geranylgeranyl transferase activity is required for proper sterol biosynthesis in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1101/2022.09.28.509966openalex-snapshot
Pathway elucidation of pharmaceutical cucurbitacin IIa in Hemsleya chinensis and high-level production of precursor cucurbitadienol in engineered Saccharomyces cerevisiae and Nicotiana benthamiana
inferred← citeshttps://doi.org/10.1101/2023.04.05.535548openalex-snapshot
Functional characterization of five triterpene synthases through De-novo assembly and transcriptome analysis of Euphorbia grantii and Euphorbia tirucalli
inferred← citeshttps://doi.org/10.1101/cshperspect.a004762openalex-snapshot
Distribution and Functions of Sterols and Sphingolipids
inferred← citeshttps://doi.org/10.1104/pp.109.152587openalex-snapshot
The Sterol Methyltransferases SMT1, SMT2, and SMT3 Influence Arabidopsis Development through Nonbrassinosteroid Products
inferred← citeshttps://doi.org/10.1104/pp.111.183533openalex-snapshot
A New Insight into Application for Barley Chromosome Addition Lines of Common Wheat: Achievement of Stigmasterol Accumulation
inferred← citeshttps://doi.org/10.1104/pp.15.00287openalex-snapshot
Comprehensive Tissue-Specific Transcriptome Analysis Reveals Distinct Regulatory Programs during Early Tomato Fruit Development
inferred← citeshttps://doi.org/10.1105/tpc.109.072124openalex-snapshot
Cell Type–Specific Chromatin Decondensation of a Metabolic Gene Cluster in Oats
inferred← citeshttps://doi.org/10.1111/1462-2920.12326openalex-snapshot
Functions of the nicotinamide adenine dinucleotide phosphate oxidase family in G anoderma lucidum : an essential role in ganoderic acid biosynthesis regulation, hyphal branching, fruiting body development, and oxidative‐stress resistance
inferred← citeshttps://doi.org/10.1111/j.1365-313x.2010.04235.xopenalex-snapshot
A role for β‐sitosterol to stigmasterol conversion in plant–pathogen interactions
inferred← citeshttps://doi.org/10.1111/j.1365-313x.2012.05120.xopenalex-snapshot
Identification of marneral synthase, which is critical for growth and development in Arabidopsis
inferred← citeshttps://doi.org/10.1111/j.1469-8137.2011.03997.xopenalex-snapshot
Divergent evolution of oxidosqualene cyclases in plants
inferred← citeshttps://doi.org/10.1111/j.1550-7408.2012.00611.xopenalex-snapshot
Sterol Composition and Biosynthetic Genes of the Recently Discovered Photosynthetic Alveolate, Chromera velia (Chromerida), a Close Relative of Apicomplexans
inferred← citeshttps://doi.org/10.1111/jipb.70135openalex-snapshot
Phytosterols: Structural variations, biosynthetic pathways, and their biological roles
inferred← citeshttps://doi.org/10.1111/nph.12414openalex-snapshot
A metabolic gene cluster in L otus japonicus discloses novel enzyme functions and products in triterpene biosynthesis
inferred← citeshttps://doi.org/10.1111/nph.12917openalex-snapshot
Tracking the sterol biosynthesis pathway of the diatom P haeodactylum tricornutum
inferred← citeshttps://doi.org/10.1111/nph.13513openalex-snapshot
Rice microRNA osa‐miR1848 targets the obtusifoliol 14α‐demethylase gene Os CYP 51G3 and mediates the biosynthesis of phytosterols and brassinosteroids during development and in response to stress
inferred← citeshttps://doi.org/10.1111/nph.15080openalex-snapshot
Identification of key amino acid residues determining product specificity of 2,3‐oxidosqualene cyclase in Oryza species
inferred← citeshttps://doi.org/10.1111/nph.70642openalex-snapshot
Atomic basis for functional evolution of plant lanosterol synthase
inferred← citeshttps://doi.org/10.1111/plb.13426openalex-snapshot
Transcriptome dissection of candidate genes associated with lentil seed quality traits
inferred← citeshttps://doi.org/10.1111/ppl.12213openalex-snapshot
Sterol partitioning by HMGR and DXR for routing intermediates toward withanolide biosynthesis
inferred← citeshttps://doi.org/10.1111/ppl.12413openalex-snapshot
Spatial and temporal regulation of sterol biosynthesis in Nicotiana benthamiana
inferred← citeshttps://doi.org/10.1111/ppl.13764openalex-snapshot
The putative obtusifoliol 14α‐demethylase OsCYP51H3 affects multiple aspects of rice growth and development
inferred← citeshttps://doi.org/10.1111/tpj.12190openalex-snapshot
Sterols are required for cell‐fate commitment and maintenance of the stomatal lineage in A rabidopsis
inferred← citeshttps://doi.org/10.1111/tpj.14132openalex-snapshot
Multi‐omics data‐driven investigations of metabolic diversity of plant triterpenoids
inferred← citeshttps://doi.org/10.1111/tpj.17237openalex-snapshot
Haplotype‐resolved genome and population genomics provide insights into dioscin biosynthesis and evolutionary history of the medicinal species Dioscorea nipponica
inferred← citeshttps://doi.org/10.1128/mbio.01002-26openalex-snapshot
Lanosterol synthase inhibition as a potential approach for re-sensitizing triazole-resistant Aspergillus fumigatus
inferred← citeshttps://doi.org/10.1128/msystems.00765-20openalex-snapshot
Clade-Specific Sterol Metabolites in Dinoflagellate Endosymbionts Are Associated with Coral Bleaching in Response to Environmental Cues
inferred← citeshttps://doi.org/10.1134/s0006297916080046openalex-snapshot
Plant sterols: Diversity, biosynthesis, and physiological functions
inferred← citeshttps://doi.org/10.1146/annurev-arplant-050312-120229openalex-snapshot
Triterpene Biosynthesis in Plants
inferred← citeshttps://doi.org/10.1155/2014/850347openalex-snapshot
Identification of the AntiListerial Constituents in Partially Purified Column Chromatography Fractions of Garcinia kola Seeds and Their Interactions with Standard Antibiotics
inferred← citeshttps://doi.org/10.1177/1082013220983961openalex-snapshot
Formulation of goat’s milk yogurt with fig powder: Aromatic profile, physicochemical and microbiological characteristics
inferred← citeshttps://doi.org/10.1177/1934578x1000500736openalex-snapshot
Key Enzymes of Triterpenoid Saponin Biosynthesis and the Induction of Their Activities and Gene Expressions in Plants
inferred← citeshttps://doi.org/10.1177/1934578x1501000508openalex-snapshot
Momilactone Sensitive Proteins in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1186/1471-2164-11-262openalex-snapshot
De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis
inferred← citeshttps://doi.org/10.1186/s12864-016-3019-1openalex-snapshot
Gene expression and metabolism preceding soft scald, a chilling injury of ‘Honeycrisp’ apple fruit
inferred← citeshttps://doi.org/10.1194/jlr.m027482openalex-snapshot
Evolutionarily conserved Δ25(27)-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii
inferred← citeshttps://doi.org/10.1201/b12894-3openalex-snapshot
Simple Lipids with Only One Component
inferred← citeshttps://doi.org/10.1201/b12894-7openalex-snapshot
- Simple Lipids with Only One Component
inferred← citeshttps://doi.org/10.1270/jsbbs.19009openalex-snapshot
Effect of salt tolerance on biomass production in a large population of sorghum accessions
inferred← citeshttps://doi.org/10.1371/journal.pone.0083336openalex-snapshot
De Novo Transcriptome Sequencing Reveals Important Molecular Networks and Metabolic Pathways of the Plant, Chlorophytum borivilianum
inferred← citeshttps://doi.org/10.1371/journal.pone.0109156openalex-snapshot
Plant Oxidosqualene Metabolism: Cycloartenol Synthase–Dependent Sterol Biosynthesis in Nicotiana benthamiana
inferred← citeshttps://doi.org/10.1371/journal.pone.0181784openalex-snapshot
RNA-sequencing-based transcriptome and biochemical analyses of steroidal saponin pathway in a complete set of Allium fistulosum—A. cepa monosomic addition lines
inferred← citeshttps://doi.org/10.1371/journal.pone.0235221openalex-snapshot
Antidiabetes constituents, cycloartenol and 24-methylenecycloartanol, from Ficus krishnae
inferred← citeshttps://doi.org/10.14258/jcprm.2020047320openalex-snapshot
DETERMINATION OF THE STEROL STATE OF GENERATIVE PLANTS OF HEATH SPOTTED-ORCHID (DACTY-LORHIZA MACULATA (L.) SOÓ) (ORCHIDACEAE) BY GC-MS
inferred← citeshttps://doi.org/10.1515/chem-2022-0252openalex-snapshot
A comprehensive review of non-alkaloidal metabolites from the subfamily Amaryllidoideae (Amaryllidaceae)
inferred← citeshttps://doi.org/10.21273/hortsci.45.11.1634openalex-snapshot
Variation in Phytoecdysteroid Accumulation in Seeds and Shoots of Spinacia oleracea L. Accessions
inferred← citeshttps://doi.org/10.3389/fmicb.2016.01802openalex-snapshot
The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product
inferred← citeshttps://doi.org/10.3389/fnut.2016.00029openalex-snapshot
Plant Oils as Potential Sources of Vitamin D
inferred← citeshttps://doi.org/10.3389/fpls.2011.00025openalex-snapshot
Triterpenoid Biosynthesis and Engineering in Plants
inferred← citeshttps://doi.org/10.3389/fpls.2013.00136openalex-snapshot
Vitamin D in plants: a review of occurrence, analysis, and biosynthesis
inferred← citeshttps://doi.org/10.3389/fpls.2017.00594openalex-snapshot
De novo Sequencing and Transcriptome Analysis Reveal Key Genes Regulating Steroid Metabolism in Leaves, Roots, Adventitious Roots and Calli of Periploca sepium Bunge
inferred← citeshttps://doi.org/10.3389/fpls.2017.01048openalex-snapshot
Integrated Transcriptomic and Metabolomic Analysis of Five Panax ginseng Cultivars Reveals the Dynamics of Ginsenoside Biosynthesis
inferred← citeshttps://doi.org/10.3389/fpls.2021.665206openalex-snapshot
Phytosterol Profiles, Genomes and Enzymes – An Overview
inferred← citeshttps://doi.org/10.3389/fpls.2022.984100openalex-snapshot
Effects of impaired steryl ester biosynthesis on tomato growth and developmental processes
inferred← citeshttps://doi.org/10.3390/genes9010038openalex-snapshot
Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli
inferred← citeshttps://doi.org/10.3390/ijms22010437openalex-snapshot
Membrane Sterol Composition in Arabidopsis thaliana Affects Root Elongation via Auxin Biosynthesis
inferred← citeshttps://doi.org/10.3390/ijms222312691openalex-snapshot
Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications
inferred← citeshttps://doi.org/10.3390/ijms23042332openalex-snapshot
Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses
inferred← citeshttps://doi.org/10.3390/ijms23126393openalex-snapshot
Whole-Genome Identification and Analysis of Multiple Gene Families Reveal Candidate Genes for Theasaponin Biosynthesis in Camellia oleifera
inferred← citeshttps://doi.org/10.3390/ijms24098430openalex-snapshot
The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis
inferred← citeshttps://doi.org/10.3390/md20120743openalex-snapshot
Responses of the Macroalga Ulva prolifera Müller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches
inferred← citeshttps://doi.org/10.3390/metabo16010074openalex-snapshot
From Sunlight to Signaling: Evolutionary Integration of Vitamin D and Sterol Metabolism
inferred← citeshttps://doi.org/10.3390/metabo2041031openalex-snapshot
Medicinal Plants: A Public Resource for Metabolomics and Hypothesis Development
inferred← citeshttps://doi.org/10.3390/mi11090830openalex-snapshot
Deuterated Glutamate-Mediated Neuronal Activity on Micro-Electrode Arrays
inferred← citeshttps://doi.org/10.3390/molecules25051111openalex-snapshot
Inhibition of Phytosterol Biosynthesis by Azasterols
inferred← citeshttps://doi.org/10.3390/molecules26226806openalex-snapshot
The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity
inferred← citeshttps://doi.org/10.3390/molecules28186526openalex-snapshot
Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production
inferred← citeshttps://doi.org/10.3390/plants8090352openalex-snapshot
Strigolactone Signaling Genes Showing Differential Expression Patterns in Arabidopsis max Mutants
inferred← citeshttps://doi.org/10.3390/toxins15040241openalex-snapshot
Defensive Molecules Momilactones A and B: Function, Biosynthesis, Induction and Occurrence
inferred← citeshttps://doi.org/10.3769/radioisotopes.59.637openalex-snapshot
Technology Development of NMR for Metabolic Analysis and Its Future Perspective
inferred← citeshttps://doi.org/10.4319/lo.2010.55.1.0091openalex-snapshot
A comprehensive study of sterols in marine diatoms (Bacillariophyta): Implications for their use as tracers for diatom productivity
inferred← citeshttps://doi.org/10.53846/goediss-4896openalex-snapshot
Genetic variation and inheritance of phytosterol and oil content in winter oilseed rape (Brassica napus L.)
inferred← citeshttps://doi.org/10.5511/plantbiotechnology.24.0312copenalex-snapshot
Triterpene RDF: Developing a database of plant enzymes and transcription factors involved in triterpene biosynthesis using the Resource Description Framework
inferred← citeshttps://doi.org/10.5511/plantbiotechnology.27.105openalex-snapshot
Triterpenoid levels are reduced during Euphorbia tirucalli L. callus formation
inferred← citeshttps://doi.org/10.5564/pib.v39i1.3147openalex-snapshot
Plant secondary metabolite and glycosyltransferases
inferred← citeshttps://doi.org/10.7717/peerj.16702openalex-snapshot
Diosgenin biosynthesis pathway and its regulation in Dioscorea cirrhosa L.
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