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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

https://doi.org/10.1073/pnas.0909586107
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneur.58.12.1985openalex-snapshot
Current Concepts in Mild Cognitive Impairment
inferredcites →https://doi.org/10.1001/archneur.60.3.337openalex-snapshot
Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases
inferredcites →https://doi.org/10.1002/1531-8249(199901)45:1<82::aid-art14>3.0.co;2-topenalex-snapshot
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
inferredcites →https://doi.org/10.1002/cne.903210309openalex-snapshot
Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: Compensatory response to neurotoxin‐induced cell death in the adult rat brain
inferredcites →https://doi.org/10.1016/0197-0186(94)90147-3openalex-snapshot
Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4
inferredcites →https://doi.org/10.1016/0304-3940(83)90171-4openalex-snapshot
Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type
inferredcites →https://doi.org/10.1016/0304-3940(92)90071-eopenalex-snapshot
Tumor necrosis factor alters synaptic transmission in rat hippocampal slices
inferredcites →https://doi.org/10.1016/j.brainresrev.2004.02.002openalex-snapshot
Noradrenergic mechanisms in neurodegenerative diseases: a theory
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2006.02.007openalex-snapshot
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease
inferredcites →https://doi.org/10.1016/s0006-3223(01)01235-5openalex-snapshot
Noradrenergic changes, aggressive behavior, and cognition in patients with dementia
inferredcites →https://doi.org/10.1016/s0006-3223(99)00008-6openalex-snapshot
Patterns of cerebrospinal fluid catechols support increased central noradrenergic responsiveness in aging and Alzheimer’s disease
inferredcites →https://doi.org/10.1016/s0028-3908(02)00211-3openalex-snapshot
Effects of norepinephrine on rat cultured microglial cells that express α1, α2, β1 and β2 adrenergic receptors
inferredcites →https://doi.org/10.1016/s0079-6123(08)63815-7openalex-snapshot
Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system?
inferredcites →https://doi.org/10.1016/s0092-8674(04)00259-4openalex-snapshot
A Distinct Role for Norepinephrine in Memory Retrieval
inferredcites →https://doi.org/10.1016/s0197-0186(02)00049-9openalex-snapshot
Noradrenergic regulation of inflammatory gene expression in brain
inferredcites →https://doi.org/10.1016/s0306-4522(99)00448-0openalex-snapshot
Impaired recovery of noradrenaline levels in apolipoprotein E-deficient mice after N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine lesion
inferredcites →https://doi.org/10.1016/s1389-0344(01)00067-3openalex-snapshot
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
inferredcites →https://doi.org/10.1038/nn1997openalex-snapshot
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
inferredcites →https://doi.org/10.1046/j.1471-4159.1998.70062468.xopenalex-snapshot
Restoration of Norepinephrine and Reversal of Phenotypes in Mice Lacking Dopamine β‐Hydroxylase
inferredcites →https://doi.org/10.1046/j.1471-4159.2000.0750634.xopenalex-snapshot
The Inhibitory Effects of Interleukin‐6 on Synaptic Plasticity in the Rat Hippocampus Are Associated with an Inhibition of Mitogen‐Activated Protein Kinase ERK
inferredcites →https://doi.org/10.1055/s-2007-1014267openalex-snapshot
Disproportionate Loss of Noradrenergic and Cholinergic Neurons as Cause of Depression in Alzheimer's Disease - A Hypothesis
inferredcites →https://doi.org/10.1074/jbc.274.10.6483openalex-snapshot
Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain
inferredcites →https://doi.org/10.1074/jbc.m408318200openalex-snapshot
The Microglia-activating Potential of Thrombin
inferredcites →https://doi.org/10.1096/fasebj.13.1.63openalex-snapshot
TNFα plus IFNγ induce the production of Alzheimer β‐amyloid peptides and decrease the secretion of APPs
inferredcites →https://doi.org/10.1097/00002093-198701040-00005openalex-snapshot
NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE
inferredcites →https://doi.org/10.1111/j.1471-4159.2007.04888.xopenalex-snapshot
Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta
inferredcites →https://doi.org/10.1128/mcb.20.11.4106-4114.2000openalex-snapshot
Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion
inferredcites →https://doi.org/10.1159/000337115openalex-snapshot
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
inferredcites →https://doi.org/10.1186/1475-925x-2-13openalex-snapshot
ScanImage: Flexible software for operating laser scanning microscopes
inferredcites →https://doi.org/10.1192/bjp.135.3.216openalex-snapshot
Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type
inferredcites →https://doi.org/10.1192/bjp.136.6.533openalex-snapshot
Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia
inferredcites →https://doi.org/10.1523/jneurosci.1982-06.2006openalex-snapshot
GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
inferredcites →https://doi.org/10.1523/jneurosci.22-07-02434.2002openalex-snapshot
Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease
inferredcites →https://doi.org/10.1523/jneurosci.4236-05.2006openalex-snapshot
Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice
inferredcites →https://doi.org/10.1523/jneurosci.4265-05.2006openalex-snapshot
Compensatory Changes in the Noradrenergic Nervous System in the Locus Ceruleus and Hippocampus of Postmortem Subjects with Alzheimer's Disease and Dementia with Lewy Bodies
inferredcites →https://doi.org/10.1523/jneurosci.4814-07.2008openalex-snapshot
Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance
inferredcites →https://doi.org/10.1523/jneurosci.4926-08.2009openalex-snapshot
Astrocyte-Derived MCP-1 Mediates Neuroprotective Effects of Noradrenaline

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Arousal Optimizes Neural Evidence Representation for Human Decision-Making
inferred← citeshttps://doi.org/10.2139/ssrn.4565839openalex-extracted
Ambient Air Pollution Exposure is Associated with Lower Mri-Assessed Locus Coeruleus Integrity
inferred← citeshttps://doi.org/10.1002/2211-5463.13735openalex-snapshot
Microglia heterogeneity in health and disease
inferred← citeshttps://doi.org/10.1002/acn3.50818openalex-snapshot
Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1002/adom.202502709openalex-snapshot
In Situ Activatable NIR‐II Polymer Dot Emitted at 1100 nm for Fluorescence Imaging of Norepinephrine Fluctuations in Live Neural Cell and Brain with Alzheimer's Disease
inferred← citeshttps://doi.org/10.1002/alz.12261openalex-snapshot
MRI‐assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction
inferred← citeshttps://doi.org/10.1002/alz.12937openalex-snapshot
Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
inferred← citeshttps://doi.org/10.1002/alz.14605openalex-snapshot
Mechanisms of comorbidity between Alzheimer's disease and pain
inferred← citeshttps://doi.org/10.1002/alz.70434openalex-snapshot
Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients
inferred← citeshttps://doi.org/10.1002/alz.70749openalex-snapshot
Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression
inferred← citeshttps://doi.org/10.1002/alz.70915openalex-snapshot
Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein
inferred← citeshttps://doi.org/10.1002/alz.71168openalex-snapshot
Female‐biased astrocytic priming shapes early locus coeruleus vulnerability in an Aβ oligomer milieu
inferred← citeshttps://doi.org/10.1002/alz.71249openalex-snapshot
The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis
inferred← citeshttps://doi.org/10.1002/alz.71334openalex-snapshot
Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model
inferred← citeshttps://doi.org/10.1002/alz.71542openalex-snapshot
Stress, stress systems, and Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/alz.71587openalex-snapshot
Vulnerability of the locus coeruleus–entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/alz.71703openalex-snapshot
Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition
inferred← citeshttps://doi.org/10.1002/alz.71737openalex-snapshot
Vulnerability of locus coeruleus connections to aging and Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/cne.24508openalex-snapshot
Features of the structure, development, and activity of the zebrafish noradrenergic system explored in new CRISPR transgenic lines
inferred← citeshttps://doi.org/10.1002/ctm2.397openalex-snapshot
Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies
inferred← citeshttps://doi.org/10.1002/dad2.12059openalex-snapshot
Reduced cortical thickness in World Trade Center responders with cognitive impairment
inferred← citeshttps://doi.org/10.1002/dad2.12513openalex-snapshot
Microstructural alterations in the locus coeruleus‐entorhinal cortex pathway in Alzheimer's disease and frontotemporal dementia
inferred← citeshttps://doi.org/10.1002/glia.22350openalex-snapshot
Microglia and neurodegeneration: The role of systemic inflammation
inferred← citeshttps://doi.org/10.1002/glia.22358openalex-snapshot
Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors
inferred← citeshttps://doi.org/10.1002/glia.22801openalex-snapshot
A novel role of microglial NADPH oxidase in mediating extra‐synaptic function of norepinephrine in regulating brain immune homeostasis
inferred← citeshttps://doi.org/10.1002/glia.23698openalex-snapshot
Phagocytic elimination of synapses by microglia during sleep
inferred← citeshttps://doi.org/10.1002/glia.23885openalex-snapshot
Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
inferred← citeshttps://doi.org/10.1002/glia.24323openalex-snapshot
Movers and shakers: Microglial dynamics and modulation of neural networks
inferred← citeshttps://doi.org/10.1002/glia.70054openalex-snapshot
Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia
inferred← citeshttps://doi.org/10.1002/jbt.70460openalex-snapshot
The Crosstalk Between Protective and Detrimental Interleukin (IL)‐1 Family of Cytokines in Alzheimer's Disease
inferred← citeshttps://doi.org/10.1002/jms.3536openalex-snapshot
Determination of catecholamines and their metabolites in rat urine by ultra‐performance liquid chromatography–tandem mass spectrometry for the study of identifying potential markers for Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/jnr.24718openalex-snapshot
Locus Coeruleus and neurovascular unit: From its role in physiology to its potential role in Alzheimer’s disease pathogenesis
inferred← citeshttps://doi.org/10.1002/mco2.70556openalex-snapshot
Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.1002/mds.27785openalex-snapshot
The locus coeruleus: Another vulnerability target in Parkinson's disease
inferred← citeshttps://doi.org/10.1002/mma.2710openalex-snapshot
Aggregation of microglia in 2D with string gradient weighted moving finite elements
inferred← citeshttps://doi.org/10.1002/pmic.201300337openalex-snapshot
Distortion of homeostatic signaling proteins by simulated microgravity in rat hypothalamus: A 16 O / 18 O ‐labeled comparative integrated proteomic approach
inferred← citeshttps://doi.org/10.1002/smi.3018openalex-snapshot
Association between symptoms of psychological distress and cognitive functioning among adults with coronary artery disease
inferred← citeshttps://doi.org/10.1007/164_2023_677openalex-snapshot
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease
inferred← citeshttps://doi.org/10.1007/7854_2018_83openalex-snapshot
Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry
inferred← citeshttps://doi.org/10.1007/978-1-4939-0974-2_13openalex-snapshot
Possible Therapeutic Targets in Microglia
inferred← citeshttps://doi.org/10.1007/978-1-4939-1429-6_3openalex-snapshot
Microglial Physiology
inferred← citeshttps://doi.org/10.1007/978-3-031-55529-9_16openalex-snapshot
Microglia and Systemic Immunity
inferred← citeshttps://doi.org/10.1007/978-3-031-89525-8_2openalex-snapshot
Noradrenaline Regulation of Brain-Body Communication
inferred← citeshttps://doi.org/10.1007/978-981-13-3585-3_6openalex-snapshot
Association Between Ageing and REM Sleep Loss: Noradrenaline Acting as a Mediator
inferred← citeshttps://doi.org/10.1007/978-981-13-9636-6_13openalex-snapshot
Neurobiological Mechanisms Involved in the Pathogenesis of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/978-981-95-4502-5_2openalex-snapshot
Prediction of Patients with Alzheimer’s Disease Using Extracted Waveform Features of the Pupil Light Reflex in Response to Chromatic Stimuli
inferred← citeshttps://doi.org/10.1007/s00115-019-0778-3openalex-snapshot
Neuroinflammation als Motor der Alzheimer-Erkrankung
inferred← citeshttps://doi.org/10.1007/s00401-011-0871-6openalex-snapshot
Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response
inferred← citeshttps://doi.org/10.1007/s00401-013-1182-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00401-015-1394-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00401-020-02248-1openalex-snapshot
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00702-010-0438-zopenalex-snapshot
Neuroinflammatory processes in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00702-017-1792-xopenalex-snapshot
Let’s make microglia great again in neurodegenerative disorders
inferred← citeshttps://doi.org/10.1007/s00702-021-02338-8openalex-snapshot
The connections of Locus Coeruleus with hypothalamus: potential involvement in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00726-023-03241-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10067-019-04769-xopenalex-snapshot
Rheumatoid arthritis and neurodegenerative dementia: a nested case-control study and a follow-up study using a national sample cohort
inferred← citeshttps://doi.org/10.1007/s10571-011-9788-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10571-017-0491-3openalex-snapshot
Stress-Induced Alterations of Immune Profile in Animals Suffering by Tau Protein-Driven Neurodegeneration
inferred← citeshttps://doi.org/10.1007/s10661-013-3213-4openalex-snapshot
Changes in urinary catecholamines in response to noise exposure in workers at Sarcheshmeh Copper Complex, Kerman, Iran
inferred← citeshttps://doi.org/10.1007/s11011-019-00407-2openalex-snapshot
Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways
inferred← citeshttps://doi.org/10.1007/s11011-025-01538-5openalex-snapshot
Brain interleukins and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s11033-022-07951-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11033-023-08438-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11064-012-0818-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11357-024-01359-xopenalex-snapshot
Monoamine alterations in Alzheimer’s disease and their implications in comorbid neuropsychiatric symptoms
inferred← citeshttps://doi.org/10.1007/s11357-026-02351-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11427-020-1810-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11481-013-9490-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11684-026-1242-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11910-020-01087-7openalex-snapshot
Locus Coeruleus Magnetic Resonance Imaging in Neurological Diseases
inferred← citeshttps://doi.org/10.1007/s11910-023-01324-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12017-012-8180-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12028-015-0203-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12035-014-8720-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12035-014-8994-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12035-016-9809-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12035-018-0918-yopenalex-snapshot
Visualization of Altered Hippocampal Connectivity in an Animal Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12035-018-1235-1openalex-snapshot
Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration
inferred← citeshttps://doi.org/10.1007/s12035-019-01695-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12035-024-04333-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12264-019-00457-7openalex-snapshot
Norepinephrine from the Locus Coeruleus Regulates Microglia Dynamics During Wakefulness
inferred← citeshttps://doi.org/10.1007/s12640-016-9643-3openalex-snapshot
Dysfunctional Sensory Modalities, Locus Coeruleus, and Basal Forebrain: Early Determinants that Promote Neuropathogenesis of Cognitive and Memory Decline and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12640-026-00794-2openalex-snapshot
Decreased Length of Locus Coeruleus Norepinephrine Axons and Increased Amyloid Beta Pathology in Male APP/PS1 Mice During Protracted Abstinence From Alcohol
inferred← citeshttps://doi.org/10.1007/s13670-011-0004-zopenalex-snapshot
Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
inferred← citeshttps://doi.org/10.1007/s13670-012-0008-3openalex-snapshot
Erratum to: Animal Models of Alzheimer’s Disease: Utilization of Transgenic Alzheimer’s Disease Models in Studies of Amyloid Beta Clearance
inferred← citeshttps://doi.org/10.1007/s40263-017-0483-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-380858-5.00005-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-386986-9.00011-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-800228-5.00013-3openalex-snapshot
Parkinson’s Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-800228-5.00018-2openalex-snapshot
Neuroinflammation in Neurological Dysfunction and Degeneration
inferred← citeshttps://doi.org/10.1016/b978-0-12-805088-0.00016-5openalex-snapshot
Potentiation of β -Amyloid-Induced Cortical Inflammation by Noradrenaline and Noradrenergic Depletion
inferred← citeshttps://doi.org/10.1016/b978-0-12-824010-6.00049-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-443-15736-3.00009-3openalex-snapshot
Functional and molecular brainstem imaging
inferred← citeshttps://doi.org/10.1016/b978-0-444-54299-1.00010-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-444-63327-9.00009-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-444-63772-7.00022-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/bs.pbr.2020.07.016openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/bs.pmbts.2019.06.013openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/bs.pmch.2016.11.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.alcohol.2025.05.004openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.apsb.2025.07.005openalex-snapshot
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.arr.2010.08.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.arr.2021.101317openalex-snapshot
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101784openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.arr.2026.103216openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.autneu.2021.102858openalex-snapshot
Transcutaneous vagus nerve stimulation (tVNS) as a potential therapeutic application for neurodegenerative disorders – A focus on dysautonomia in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.bbi.2016.07.155openalex-snapshot
Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment
inferred← citeshttps://doi.org/10.1016/j.bbi.2020.12.002openalex-snapshot
Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice
inferred← citeshttps://doi.org/10.1016/j.bbi.2025.04.022openalex-snapshot
Noradrenergic signaling controls Alzheimer’s disease pathology via activation of microglial β2 adrenergic receptors
inferred← citeshttps://doi.org/10.1016/j.bbii.2024.100048openalex-snapshot
Natural products as potential modulators of pro-inflammatory cytokines signalling in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.bbr.2012.03.020openalex-snapshot
Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116602openalex-snapshot
Pharmacological characterization of prostaglandin E2 EP2 and EP4 receptors in male rat locus coeruleus neurons ex vivo
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2016.05.005openalex-snapshot
Ceria/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-β peptide
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113179openalex-snapshot
The Locus Coeruleus – Noradrenaline system: Looking into Alzheimer’s therapeutics with rose coloured glasses
inferred← citeshttps://doi.org/10.1016/j.biopsych.2011.08.016openalex-snapshot
Neurobiological Elements of Cognitive Dysfunction in Down Syndrome: Exploring the Role of APP
inferred← citeshttps://doi.org/10.1016/j.biopsych.2013.05.024openalex-snapshot
Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome
inferred← citeshttps://doi.org/10.1016/j.bj.2018.01.003openalex-snapshot
Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
inferred← citeshttps://doi.org/10.1016/j.brainres.2011.06.050openalex-snapshot
Beta-adrenergic stimulation suppresses phagocytosis via Epac activation in murine microglial cells
inferred← citeshttps://doi.org/10.1016/j.brainres.2015.08.032openalex-snapshot
Lesion of the locus coeruleus aggravates dopaminergic neuron degeneration by modulating microglial function in mouse models of Parkinson׳s disease
inferred← citeshttps://doi.org/10.1016/j.brainres.2017.09.035openalex-snapshot
Assessing disease-modifying effects of norepinephrine in Down syndrome and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.brainres.2017.12.027openalex-snapshot
Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer’s disease pathogenesis: Potential strategies to protect the LC against aging
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.04.030openalex-snapshot
The role of catecholamines in HIV neuropathogenesis
inferred← citeshttps://doi.org/10.1016/j.brainres.2018.11.035openalex-snapshot
Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through β2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2019.08.007openalex-snapshot
The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2020.04.009openalex-snapshot
Epilepsy and Alzheimer’s Disease: Potential mechanisms for an association
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2024.110907openalex-snapshot
The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.06.001openalex-snapshot
Large-Scale Proteomics Highlights Glial Role in Neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.cortex.2017.09.025openalex-snapshot
Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction
inferred← citeshttps://doi.org/10.1016/j.drudis.2020.12.004openalex-snapshot
Role of reactive oxygen species in the progression of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.ejphar.2017.10.004openalex-snapshot
Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome
inferred← citeshttps://doi.org/10.1016/j.euroneuro.2020.12.013openalex-snapshot
A case-control study of the locus coeruleus degeneration in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.exger.2021.111452openalex-snapshot
New frontiers in Alzheimer's disease diagnostic: Monoamines and their derivatives in biological fluids
inferred← citeshttps://doi.org/10.1016/j.expneurol.2012.05.008openalex-snapshot
Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages
inferred← citeshttps://doi.org/10.1016/j.expneurol.2020.113250openalex-snapshot
Decreased excitability of locus coeruleus neurons during hypercapnia is exaggerated in the streptozotocin-model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.01.025openalex-snapshot
Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2010.11.004openalex-snapshot
Effect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain
inferred← citeshttps://doi.org/10.1016/j.jagp.2013.01.006openalex-snapshot
The Association of Neuropsychiatric Symptoms in MCI with Incident Dementia and Alzheimer Disease
inferred← citeshttps://doi.org/10.1016/j.jalz.2013.01.017openalex-snapshot
Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.jalz.2016.06.2362openalex-snapshot
Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early‐stage biomarker discovery
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.01.039openalex-snapshot
A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118775openalex-snapshot
Banisteriopsis caapi extract: Implications for neuroinflammatory pathways in Locus coeruleus lesion rodent model
inferred← citeshttps://doi.org/10.1016/j.jnrt.2026.100301openalex-snapshot
Imaging the locus coeruleus–glymphatic axis in Alzheimer’s disease: From neuromelanin MRI to DTI-ALPS
inferred← citeshttps://doi.org/10.1016/j.kint.2023.04.023openalex-snapshot
Self-maintaining macrophages within the kidney contribute to salt and water balance by modulating kidney sympathetic nerve activity
inferred← citeshttps://doi.org/10.1016/j.mcn.2016.11.002openalex-snapshot
Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility
inferred← citeshttps://doi.org/10.1016/j.mcn.2019.103414openalex-snapshot
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.mehy.2013.11.016openalex-snapshot
Uptake of environmental toxicants by the locus ceruleus: A potential trigger for neurodegenerative, demyelinating and psychiatric disorders
inferred← citeshttps://doi.org/10.1016/j.nbd.2020.105089openalex-snapshot
Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease
inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106048openalex-snapshot
Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107457openalex-snapshot
Impact of DSP4-induced locus coeruleus dysfunction on sleep: Systematic review and methodology
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2013.05.008openalex-snapshot
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2014.05.005openalex-snapshot
Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2016.12.020openalex-snapshot
Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2017.01.046openalex-snapshot
Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2018.03.007openalex-snapshot
Curiosity in old age: A possible key to achieving adaptive aging
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.06.039openalex-snapshot
Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease?
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2023.105167openalex-snapshot
Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2023.105311openalex-snapshot
Noradrenergic neuromodulation in ageing and disease
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2024.105647openalex-snapshot
Neuromodulatory systems in aging and disease
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2025.106442openalex-snapshot
Noradrenergic dysregulation in the locus coeruleus: Implications for neuropsychiatric disease pathophysiology- A systematic review
inferred← citeshttps://doi.org/10.1016/j.neuint.2015.07.010openalex-snapshot
Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation
inferred← citeshttps://doi.org/10.1016/j.neuint.2019.104469openalex-snapshot
Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neuint.2019.104531openalex-snapshot
Alzheimer's disease-like pathology-triggered oxidative stress, alterations in monoamines levels, and structural damage of locus coeruleus neurons are partially recovered by a mix of proteoglycans of embryonic genesis
inferred← citeshttps://doi.org/10.1016/j.neuint.2019.104551openalex-snapshot
Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance
inferred← citeshttps://doi.org/10.1016/j.neuint.2021.104987openalex-snapshot
Neuroendocrine, neuroinflammatory and pathological outcomes of chronic stress: A story of microglial remodeling
inferred← citeshttps://doi.org/10.1016/j.neuint.2023.105479openalex-snapshot
Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model
inferred← citeshttps://doi.org/10.1016/j.neulet.2020.135000openalex-snapshot
Regulation of microglia by neuromodulators: Modulations in major and minor modes
inferred← citeshttps://doi.org/10.1016/j.neulet.2025.138151openalex-snapshot
Alterations in iron levels in the locus coeruleus of a transgenic Alzheimer’s disease rat model
inferred← citeshttps://doi.org/10.1016/j.neulet.2026.138618openalex-snapshot
Prolonged β-adrenergic stimulation reduces β2-adrenergic receptor levels and limits astrocytic responsiveness during early amyloid pathology
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2010.10.009openalex-snapshot
Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2011.04.012openalex-snapshot
The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2012.05.019openalex-snapshot
A noradrenergic theory of cognitive reserve: implications for Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2012.09.010openalex-snapshot
Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2013.11.028openalex-snapshot
A right hemisphere role in cognitive reserve
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2014.05.020openalex-snapshot
Norepinephrine provides short-term neuroprotection against Aβ1–42 by reducing oxidative stress independent of Nrf2 activation
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2018.02.025openalex-snapshot
Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2020.12.019openalex-snapshot
Locus coeruleus MRI contrast is associated with cortical thickness in older adults
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2021.03.010openalex-snapshot
Implications for microglial sex differences in tau-related neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2021.11.006openalex-snapshot
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.neuroimage.2020.117409openalex-snapshot
Uncovering the locus coeruleus: Comparison of localization methods for functional analysis
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2012.01.028openalex-snapshot
Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2016.12.001openalex-snapshot
Noradrenaline induces CX3CL1 production and release by neurons
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2017.01.010openalex-snapshot
Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2010.11.052openalex-snapshot
Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2012.10.070openalex-snapshot
Deleterious effects of soluble beta amyloid on cognition, antagonism by saline and noradrenaline, a role for microglia
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2017.12.046openalex-snapshot
Celecoxib Prevents Cognitive Impairment and Neuroinflammation in Soluble Amyloid β-treated Rats
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2018.01.059openalex-snapshot
The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2016.04.001openalex-snapshot
Monoaminergic neuropathology in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2013.02.002openalex-snapshot
Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2017.05.004openalex-snapshot
Antidepressant drugs for beta amyloid-induced depression: A new standpoint?
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2018.05.010openalex-snapshot
Targeting central β2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice
inferred← citeshttps://doi.org/10.1016/j.saa.2018.05.040openalex-snapshot
Structural confirmation and spectroscopic study of a biomolecule: Norepinephrine
inferred← citeshttps://doi.org/10.1016/j.semcdb.2021.05.013openalex-snapshot
Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?
inferred← citeshttps://doi.org/10.1016/j.tics.2016.01.001openalex-snapshot
The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain
inferred← citeshttps://doi.org/10.1016/j.tins.2018.12.005openalex-snapshot
Microbes and Monoamines: Potential Neuropsychiatric Consequences of Dysbiosis
inferred← citeshttps://doi.org/10.1016/j.tins.2026.09.005openalex-snapshot
Sleep-dependent microglial functions in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1017/9781108539623.010openalex-snapshot
The Effect of Systemic Inflammation on Cognitive Function and Neurodegenerative Disease
inferred← citeshttps://doi.org/10.1017/9781108554350.010openalex-snapshot
Aging and Attention
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b09011openalex-snapshot
Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline
inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00360openalex-snapshot
Mechanistic Approach to Immunity and Immunotherapy of Alzheimer’s Disease: A Review
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