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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.bbrc.2008.01.077openalex-snapshot

Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation

inferredcites →https://doi.org/10.1016/j.ceb.2005.01.006openalex-snapshot

New roles for the LKB1→AMPK pathway

inferredcites →https://doi.org/10.1016/j.cell.2006.01.016openalex-snapshot

TOR Signaling in Growth and Metabolism

inferredcites →https://doi.org/10.1016/j.cell.2008.06.028openalex-snapshot

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

inferredcites →https://doi.org/10.1016/j.cmet.2006.10.002openalex-snapshot

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

inferredcites →https://doi.org/10.1016/j.molcel.2004.08.025openalex-snapshot

Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death

inferredcites →https://doi.org/10.1016/j.molcel.2007.03.016openalex-snapshot

Hydrogen Peroxide Sensing and Signaling

inferredcites →https://doi.org/10.1016/j.molcel.2007.12.023openalex-snapshot

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

inferredcites →https://doi.org/10.1016/j.molcel.2008.03.003openalex-snapshot

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

inferredcites →https://doi.org/10.1016/j.tibs.2005.11.009openalex-snapshot

Chutes and Ladders: the search for protein kinases that act on AMPK

inferredcites →https://doi.org/10.1016/s0092-8674(00)80086-0openalex-snapshot

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

inferredcites →https://doi.org/10.1016/s0092-8674(03)00929-2openalex-snapshot

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

inferredcites →https://doi.org/10.1016/s1568-7864(01)00007-6openalex-snapshot

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

inferredcites →https://doi.org/10.1038/35043058openalex-snapshot

The many substrates and functions of ATM

inferredcites →https://doi.org/10.1038/nature03097openalex-snapshot

Cell-cycle checkpoints and cancer

inferredcites →https://doi.org/10.1038/ng1494openalex-snapshot

Dysregulation of the TSC-mTOR pathway in human disease

inferredcites →https://doi.org/10.1038/nrn2038openalex-snapshot

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

inferredcites →https://doi.org/10.1038/sj.onc.1203622openalex-snapshot

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

inferredcites →https://doi.org/10.1042/0264-6021:3620481openalex-snapshot

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz‒Jeghers cancer syndrome

inferredcites →https://doi.org/10.1042/bj20021284openalex-snapshot

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

inferredcites →https://doi.org/10.1056/nejmra055323openalex-snapshot

The Tuberous Sclerosis Complex

inferredcites →https://doi.org/10.1073/pnas.0502857102openalex-snapshot

The coordinate regulation of the p53 and mTOR pathways in cells

inferredcites →https://doi.org/10.1074/jbc.m511178200openalex-snapshot

Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells

inferredcites →https://doi.org/10.1083/jcb.200507119openalex-snapshot

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

inferredcites →https://doi.org/10.1093/embo-reports/kvf094openalex-snapshot

ROS, stress‐activated kinases and stress signaling in cancer

inferredcites →https://doi.org/10.1093/emboj/19.21.5720openalex-snapshot

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

inferredcites →https://doi.org/10.1093/jn/137.1.229sopenalex-snapshot

Antioxidants Suppress Lymphoma and Increase Longevity in Atm-Deficient Mice ,3

inferredcites →https://doi.org/10.1126/science.1099993openalex-snapshot

Autophagy in Health and Disease: A Double-Edged Sword

inferredcites →https://doi.org/10.1126/science.1140321openalex-snapshot

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

inferredcites →https://doi.org/10.1126/science.274.5293.1664openalex-snapshot

Cell Cycle Checkpoints: Preventing an Identity Crisis

inferredcites →https://doi.org/10.1126/science.7997877openalex-snapshot

Cell Cycle Control and Cancer

inferredcites →https://doi.org/10.1126/stke.4042007pe51openalex-snapshot

Dialogue Between LKB1 and AMPK: A Hot Topic at the Cellular Pole

inferredcites →https://doi.org/10.1146/annurev.biochem.75.103004.142702openalex-snapshot

LKB1-Dependent Signaling Pathways

inferredcites →https://doi.org/10.1158/0008-5472.can-04-0442openalex-snapshot

Effect of N -Acetyl Cysteine on Oxidative DNA Damage and the Frequency of DNA Deletions in Atm -Deficient Mice

inferredcites →https://doi.org/10.1158/0008-5472.can-05-1394openalex-snapshot

Platelet-Derived Growth Factor–Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of TSC2/Tuberin

inferredcites →https://doi.org/10.1158/0008-5472.can-06-4149openalex-snapshot

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

inferredcites →https://doi.org/10.1158/0008-5472.can-07-5756openalex-snapshot

AMP-Activated Protein Kinase Signaling Results in Cytoplasmic Sequestration of p27

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-0170openalex-snapshot

Cytoplasmic Sequestration of p27 via AKT Phosphorylation in Renal Cell Carcinoma

inferredcites →https://doi.org/10.1159/000373980openalex-snapshot

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

inferredcites →https://doi.org/10.1159/000479571openalex-snapshot

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

inferredcites →https://doi.org/10.1172/jci13505openalex-snapshot

Role of AMP-activated protein kinase in mechanism of metformin action

inferredcites →https://doi.org/10.1172/jci17222openalex-snapshot

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

inferredcites →https://doi.org/10.1242/jcs.01540openalex-snapshot

The AMP-activated protein kinase pathway – new players upstream and downstream

inferredcites →https://doi.org/10.1371/journal.pone.0002009openalex-snapshot

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Nerolidol inhibits proliferation of leiomyoma cells via reactive oxygen species-induced DNA damage and downregulation of the ATM/Akt pathway

inferred← citeshttps://doi.org/10.1002/adbi.201800259openalex-snapshot

Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination

inferred← citeshttps://doi.org/10.1002/advs.202413990openalex-snapshot

Targeting TTK Inhibits Tumorigenesis of T‐Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway

inferred← citeshttps://doi.org/10.1002/bies.201600268openalex-snapshot

mTORC1 senses stresses: Coupling stress to proteostasis

inferred← citeshttps://doi.org/10.1002/cbf.3385openalex-snapshot

Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy

inferred← citeshttps://doi.org/10.1002/cbic.202100641openalex-snapshot

Oxidative Stress in Cancer Therapy: Friend or Enemy?

inferred← citeshttps://doi.org/10.1002/dvdy.24522openalex-snapshot

Neurodegeneration in ataxia‐telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

inferred← citeshttps://doi.org/10.1002/emmm.201000097openalex-snapshot

Stressin' Sestrins take an aging fight

inferred← citeshttps://doi.org/10.1002/ijc.29113openalex-snapshot

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

inferred← citeshttps://doi.org/10.1002/ijc.29990openalex-snapshot

Stress management by autophagy: Implications for chemoresistance

inferred← citeshttps://doi.org/10.1002/jat.1787openalex-snapshot

Autophagy in toxicology: self‐consumption in times of stress and plenty

inferred← citeshttps://doi.org/10.1002/jcb.26217openalex-snapshot

Multiple Functions of Long Non‐Coding RNAs in Oxidative Stress, DNA Damage Response and Cancer Progression

inferred← citeshttps://doi.org/10.1002/jcb.26699openalex-snapshot

ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: A clinicopathologic study

inferred← citeshttps://doi.org/10.1002/jcb.27617openalex-snapshot

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

inferred← citeshttps://doi.org/10.1002/jcp.27979openalex-snapshot

Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation

inferred← citeshttps://doi.org/10.1002/jcp.30468openalex-snapshot

Oxidative stress in oocyte aging and female reproduction

inferred← citeshttps://doi.org/10.1002/jsfa.13171openalex-snapshot

Maternal folic acid and vitamin B12 supplementation during medium to late gestation promotes fetal development via improving placental antioxidant capacity, angiogenesis and amino acid transport

inferred← citeshttps://doi.org/10.1002/mabi.201600306openalex-snapshot

Exploring the Biocompatibility of Zwitterionic Copolymers for Controlling Macrophage Phagocytosis of Bacteria

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Integrating the DNA damage and protein stress responses during cancer development and treatment

inferred← citeshttps://doi.org/10.1002/wrna.1212openalex-snapshot

Translational reprogramming in cellular stress response

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_10openalex-snapshot

Other Major Types of Signaling Mediators

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_11openalex-snapshot

Signaling Pathways

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_12openalex-snapshot

Conclusion

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_2openalex-snapshot

Signaling Lipids

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_3openalex-snapshot

Preamble to Cytoplasmic Protein Kinases

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_4openalex-snapshot

Cytoplasmic Protein Tyrosine Kinases

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_5openalex-snapshot

Cytoplasmic Protein Serine/Threonine Kinases

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_6openalex-snapshot

Mitogen-Activated Protein Kinase Module

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_7openalex-snapshot

Dual-Specificity Protein Kinases

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_8openalex-snapshot

Cytosolic Protein Phosphatases

inferred← citeshttps://doi.org/10.1007/978-1-4614-4370-4_9openalex-snapshot

Guanosine Triphosphatases and Their Regulators

inferred← citeshttps://doi.org/10.1007/978-1-4614-8220-8_13openalex-snapshot

Autophagy in Necrosis: A Force for Survival

inferred← citeshttps://doi.org/10.1007/978-1-4614-8220-8_9openalex-snapshot

PARP Activation and Necrotic Cell Death

inferred← citeshttps://doi.org/10.1007/978-3-030-58532-7_16openalex-snapshot

Cell Proliferation, Survival, Necrosis and Apoptosis

inferred← citeshttps://doi.org/10.1007/978-3-030-74180-8_4openalex-snapshot

Amino Acids in Autophagy: Regulation and Function

inferred← citeshttps://doi.org/10.1007/978-3-031-55163-5_3openalex-snapshot

Mechanisms of DNA Damage Response in Mammalian Oocytes

inferred← citeshttps://doi.org/10.1007/978-3-319-06062-0_8openalex-snapshot

How to Personalize Chemotherapy in Stage IV NSCLC?

inferred← citeshttps://doi.org/10.1007/978-3-319-30079-5_3openalex-snapshot

The Complex Crosstalk Between Autophagy and ROS Signalling Pathways

inferred← citeshttps://doi.org/10.1007/978-3-319-56017-5_4openalex-snapshot

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation

inferred← citeshttps://doi.org/10.1007/978-94-007-6214-5_16openalex-snapshot

Rapamycin: Current and Future Uses

inferred← citeshttps://doi.org/10.1007/978-981-15-6930-2_3openalex-snapshot

Cross-Talk Between DNA Damage and Autophagy and Its Implication in Cancer Therapy

inferred← citeshttps://doi.org/10.1007/978-981-99-7342-2_2openalex-snapshot

ROS and Redox Regulation/Signaling and Metabolism in Cancer Stem Cells

inferred← citeshttps://doi.org/10.1007/978-981-99-7342-2_4openalex-snapshot

ROS/Redox Signaling and Apoptosis/Necroptosis/Autophagy in Cancer

inferred← citeshttps://doi.org/10.1007/s00018-011-0683-9openalex-snapshot

ATM protein kinase: the linchpin of cellular defenses to stress

inferred← citeshttps://doi.org/10.1007/s00018-014-1666-4openalex-snapshot

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

inferred← citeshttps://doi.org/10.1007/s00018-020-03667-9openalex-snapshot

Selective autophagy as a therapeutic target for neurological diseases

inferred← citeshttps://doi.org/10.1007/s00018-022-04625-3openalex-snapshot

New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease

inferred← citeshttps://doi.org/10.1007/s00204-018-2304-yopenalex-snapshot

Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood–brain barrier’s tight junction proteins

inferred← citeshttps://doi.org/10.1007/s00418-018-1724-3openalex-snapshot

Pexophagy in yeast and mammals: an update on mysteries

inferred← citeshttps://doi.org/10.1007/s00432-012-1308-xopenalex-snapshot

Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy

inferred← citeshttps://doi.org/10.1007/s00441-017-2599-7openalex-snapshot

Role of primary cilia in non-dividing and post-mitotic cells

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Deciphering the host-pathogen protein interface in chikungunya virus-mediated sickness

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Reduced risk of apoptosis: mechanisms of stress responses

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Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells

inferred← citeshttps://doi.org/10.1007/s10495-017-1424-9openalex-snapshot

Induction of reactive oxygen species: an emerging approach for cancer therapy

inferred← citeshttps://doi.org/10.1007/s10555-018-9727-zopenalex-snapshot

Pro-survival autophagy and cancer cell resistance to therapy

inferred← citeshttps://doi.org/10.1007/s10557-015-6571-zopenalex-snapshot

ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease

inferred← citeshttps://doi.org/10.1007/s11010-013-1568-zopenalex-snapshot

TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70

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AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells

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Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance

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In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagy

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Cd-Induced Autophagy Responses in Pakchoi as Revealed by Transcriptome Analysis

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Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

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Suppression of low-dose hyper-radiosensitivity in human lung cancer cell line A549 by radiation-induced autophagy

inferred← citeshttps://doi.org/10.1007/s12017-012-8173-2openalex-snapshot

Roles of AMP-activated Protein Kinase in Alzheimer’s Disease

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Implications of reactive oxygen species in lung cancer and exploiting it for therapeutic interventions

inferred← citeshttps://doi.org/10.1007/s12035-017-0503-9openalex-snapshot

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

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Radiobiological Characterization of Tuberous Sclerosis: a Delay in the Nucleo-Shuttling of ATM May Be Responsible for Radiosensitivity

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Mitochondrial Quality and Quantity Control: Mitophagy Is a Potential Therapeutic Target for Ischemic Stroke

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Protein Phosphatase 1 Regulatory Subunit 17 (PPP1R17) Regulates Cerebral Ischemia and Ischemia–Reperfusion Brain Injury by Suppressing YAP1-Mediated Mitophagy

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Cellular polarity in aging: role of redox regulation and nutrition

inferred← citeshttps://doi.org/10.1007/s12275-019-8475-2openalex-snapshot

Synthetic lethal interaction between oxidative stress response and DNA damage repair in the budding yeast and its application to targeted anticancer therapy

inferred← citeshttps://doi.org/10.1007/s12275-020-9520-xopenalex-snapshot

Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms

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Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment

inferred← citeshttps://doi.org/10.1007/s13238-011-1021-6openalex-snapshot

LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor

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Autophagy and its function in radiosensitivity

inferred← citeshttps://doi.org/10.1007/s13365-013-0189-3openalex-snapshot

Immunological control of herpes simplex virus infections

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Crosstalk between signaling pathways and DNA damage response

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The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease

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Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy

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Molecular Mechanisms Underlying the Activation of Autophagy Pathways by Reactive Oxygen Species and their Relevance in Cancer Progression and Therapy

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Cisplatin Exposure of Squamous Cell Carcinoma Cells Leads to Modulation of the Autophagic Pathway

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Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass Regulation

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Pro-oxidative Phytoagents Induce Autophagy in Tumors

inferred← citeshttps://doi.org/10.1016/b978-0-12-805253-2.00020-1openalex-snapshot

Autophagy, Oxidative Stress, and Redox Regulation

inferred← citeshttps://doi.org/10.1016/b978-0-12-805420-8.00010-xopenalex-snapshot

Regulation of the DNA Damage Response by Autophagy

inferred← citeshttps://doi.org/10.1016/b978-0-12-805421-5.00003-3openalex-snapshot

Role of Poly(ADP-Ribose) in Catalyzing Starvation-Induced Autophagy

inferred← citeshttps://doi.org/10.1016/b978-0-12-814253-0.00013-9openalex-snapshot

DNA-Damage-Induced Hormetic Responses

inferred← citeshttps://doi.org/10.1016/b978-0-444-63749-9.00003-7openalex-snapshot

Plant-Derived Prooxidants as Potential Anticancer Therapeutics

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RETRACTED: Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling

inferred← citeshttps://doi.org/10.1016/j.ajpath.2016.05.001openalex-snapshot

Huntington Disease

inferred← citeshttps://doi.org/10.1016/j.apsb.2019.06.005openalex-snapshot

Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

inferred← citeshttps://doi.org/10.1016/j.arr.2016.05.002openalex-snapshot

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

inferred← citeshttps://doi.org/10.1016/j.arr.2017.03.006openalex-snapshot

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells—Implications for age-related macular degeneration (AMD)

inferred← citeshttps://doi.org/10.1016/j.arr.2020.101237openalex-snapshot

Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent

inferred← citeshttps://doi.org/10.1016/j.arr.2022.101653openalex-snapshot

The hallmarks of aging in Ataxia-Telangiectasia

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102428openalex-snapshot

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

inferred← citeshttps://doi.org/10.1016/j.bbabio.2014.05.353openalex-snapshot

Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.bbabio.2014.12.002openalex-snapshot

Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis

inferred← citeshttps://doi.org/10.1016/j.bbadis.2014.04.003openalex-snapshot

Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells

inferred← citeshttps://doi.org/10.1016/j.bbadis.2014.06.012openalex-snapshot

AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease

inferred← citeshttps://doi.org/10.1016/j.bbadis.2015.11.010openalex-snapshot

Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bbagrm.2014.11.002openalex-snapshot

Stress-mediated translational control in cancer cells

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2013.06.001openalex-snapshot

Crosstalk between apoptosis, necrosis and autophagy

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.09.015openalex-snapshot

Inhibition of autophagy sensitises cells to hydrogen peroxide-induced apoptosis: Protective effect of mild thermotolerance acquired at 40 °C

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.06.011openalex-snapshot

mTORC1 pathway in DNA damage response

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119041openalex-snapshot

Interactions between reactive oxygen species and autophagy

inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.05.090openalex-snapshot

Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis

inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.01.117openalex-snapshot

Diversity of amino acid signaling pathways on autophagy regulation: A novel pathway for arginine

inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.11.016openalex-snapshot

Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6

inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.12.141openalex-snapshot

Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217

inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.08.125openalex-snapshot

TMP21 regulates autophagy by modulating ROS production and mTOR activation

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149243openalex-snapshot

Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch

inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150422openalex-snapshot

ATM facilitates autophagy and protects against oxidative stress and apoptosis in response to ER stress in vitro

inferred← citeshttps://doi.org/10.1016/j.bcp.2010.12.011openalex-snapshot

Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

inferred← citeshttps://doi.org/10.1016/j.bcp.2011.12.029openalex-snapshot

Role of autophagy in chemoresistance: Regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA–PKcs and PARP-1

inferred← citeshttps://doi.org/10.1016/j.bcp.2012.07.022openalex-snapshot

Redox modulation of the DNA damage response

inferred← citeshttps://doi.org/10.1016/j.bcp.2013.05.007openalex-snapshot

Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease

inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116729openalex-snapshot

The complex interplay between redox dysregulation and mTOR signaling pathway in cancer: A rationale for cancer treatment

inferred← citeshttps://doi.org/10.1016/j.biochi.2016.01.002openalex-snapshot

Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway

inferred← citeshttps://doi.org/10.1016/j.bj.2015.10.002openalex-snapshot

Metabolic, autophagic, and mitophagic activities in cancer initiation and progression

inferred← citeshttps://doi.org/10.1016/j.canlet.2011.12.004openalex-snapshot

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

inferred← citeshttps://doi.org/10.1016/j.canlet.2011.12.043openalex-snapshot

Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling

inferred← citeshttps://doi.org/10.1016/j.canlet.2012.08.034openalex-snapshot

ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis

inferred← citeshttps://doi.org/10.1016/j.canlet.2014.07.028openalex-snapshot

The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs

inferred← citeshttps://doi.org/10.1016/j.canlet.2018.01.061openalex-snapshot

Non-apoptotic cell death in malignant tumor cells and natural compounds

inferred← citeshttps://doi.org/10.1016/j.canlet.2018.04.034openalex-snapshot

Autophagy in glioma cells: An identity crisis with a clinical perspective

inferred← citeshttps://doi.org/10.1016/j.cbi.2014.04.017openalex-snapshot

Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1016/j.cclet.2023.109149openalex-snapshot

Advanced nano drug delivery systems for neuroprotection against ischemic stroke

inferred← citeshttps://doi.org/10.1016/j.ccr.2013.02.024openalex-snapshot

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

inferred← citeshttps://doi.org/10.1016/j.ceb.2016.02.017openalex-snapshot

The peroxisome as a cell signaling organelle

inferred← citeshttps://doi.org/10.1016/j.cell.2013.07.031openalex-snapshot

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

inferred← citeshttps://doi.org/10.1016/j.cellsig.2012.01.008openalex-snapshot

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

inferred← citeshttps://doi.org/10.1016/j.cellsig.2012.09.020openalex-snapshot

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

inferred← citeshttps://doi.org/10.1016/j.cellsig.2013.08.010openalex-snapshot

ATM pathway is essential for ionizing radiation-induced autophagy

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110354openalex-snapshot

K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113402openalex-snapshot

ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress

inferred← citeshttps://doi.org/10.1016/j.clim.2011.03.007openalex-snapshot

Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia

inferred← citeshttps://doi.org/10.1016/j.clim.2016.11.015openalex-snapshot

Abnormal cell-clearance and accumulation of autophagic vesicles in lymphocytes from patients affected with Ataxia-Teleangiectasia

inferred← citeshttps://doi.org/10.1016/j.clim.2019.07.003openalex-snapshot

Metabolic reprogramming in memory CD4 T cell responses of old adults

inferred← citeshttps://doi.org/10.1016/j.cmet.2012.06.003openalex-snapshot

Wip1-Dependent Regulation of Autophagy, Obesity, and Atherosclerosis

inferred← citeshttps://doi.org/10.1016/j.cotox.2017.10.006openalex-snapshot

Reciprocity in ROS and autophagic signaling

inferred← citeshttps://doi.org/10.1016/j.dci.2023.105128openalex-snapshot

PyLKB1 regulates glucose transport via activating PyAMPKα in Yesso Scallop Patinopecten yessoensis under high temperature stress

inferred← citeshttps://doi.org/10.1016/j.dld.2022.01.131openalex-snapshot

Possible role of nuclear factor erythroid 2–related factor 2 in the progression of human colon precancerous lesions

inferred← citeshttps://doi.org/10.1016/j.dnarep.2011.05.004openalex-snapshot

ATM protects against oxidative stress induced by oxidized low-density lipoprotein

inferred← citeshttps://doi.org/10.1016/j.dnarep.2013.04.014openalex-snapshot

The appropriateness of the mouse model for ataxia-telangiectasia: Neurological defects but no neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.dnarep.2013.11.002openalex-snapshot

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia

inferred← citeshttps://doi.org/10.1016/j.dnarep.2015.12.009openalex-snapshot

ATM kinase: Much more than a DNA damage responsive protein

inferred← citeshttps://doi.org/10.1016/j.dnarep.2020.102950openalex-snapshot

The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability

inferred← citeshttps://doi.org/10.1016/j.dnarep.2021.103155openalex-snapshot

DNA damage and regulation of protein homeostasis

inferred← citeshttps://doi.org/10.1016/j.ejcb.2016.10.005openalex-snapshot

Autophagy and the invisible line between life and death

inferred← citeshttps://doi.org/10.1016/j.ejcb.2018.09.004openalex-snapshot

Redox cell signaling and hepatic progenitor cells

inferred← citeshttps://doi.org/10.1016/j.ejcb.2026.151540openalex-snapshot

MDC1 promotes nuclear localization of Beclin-1 and supports its role in ATM pathway in response to oxidative stress

inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174562openalex-snapshot

PPAR-gamma agonists: Potential modulators of autophagy in obesity

inferred← citeshttps://doi.org/10.1016/j.envpol.2022.120574openalex-snapshot

The activated ATM/AMPK/mTOR axis promotes autophagy in response to oxidative stress-mediated DNA damage co-induced by molybdenum and cadmium in duck testes

inferred← citeshttps://doi.org/10.1016/j.etp.2014.01.004openalex-snapshot

Autophagy in arsenic carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.exphem.2011.08.009openalex-snapshot

The aging effect of chemotherapy on cultured human mesenchymal stem cells

inferred← citeshttps://doi.org/10.1016/j.fct.2014.05.006openalex-snapshot

Sodium arsenite induces ROS-dependent autophagic cell death in pancreatic β-cells

inferred← citeshttps://doi.org/10.1016/j.febslet.2011.02.001openalex-snapshot

TSC1/TSC2 signaling in the CNS

inferred← citeshttps://doi.org/10.1016/j.febslet.2011.03.010openalex-snapshot

The role of LKB1 and AMPK in cellular responses to stress and damage

inferred← citeshttps://doi.org/10.1016/j.febslet.2011.05.013openalex-snapshot

Beyond ATM: The protein kinase landscape of the DNA damage response

inferred← citeshttps://doi.org/10.1016/j.fmre.2023.04.016openalex-snapshot

Peroxisome and pexophagy in neurological diseases

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.09.006openalex-snapshot

Oxidative stress, inflammation, and cancer: How are they linked?

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.07.011openalex-snapshot

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2013.07.013openalex-snapshot

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2014.03.025openalex-snapshot

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.01.004openalex-snapshot

Reactive oxygen species and cancer paradox: To promote or to suppress?

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.09.008openalex-snapshot

Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.02.047openalex-snapshot

AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.01.024openalex-snapshot

Both selenium deficiency and excess impair male reproductive system via inducing oxidative stress-activated PI3K/AKT-mediated apoptosis and cell proliferation signaling in testis of mice

inferred← citeshttps://doi.org/10.1016/j.gendis.2014.06.002openalex-snapshot

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated

inferred← citeshttps://doi.org/10.1016/j.heliyon.2016.e00083openalex-snapshot

Chloroquine increases phosphorylation of AMPK and Akt in myotubes

inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e09957openalex-snapshot

What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e38959openalex-snapshot

The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.09.096openalex-snapshot

Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era

inferred← citeshttps://doi.org/10.1016/j.ijrobp.2012.01.026openalex-snapshot

Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation

inferred← citeshttps://doi.org/10.1016/j.ijrobp.2019.10.045openalex-snapshot

Human CCR6+ Th17 Lymphocytes Are Highly Sensitive to Radiation-Induced Senescence and Are a Potential Target for Prevention of Radiation-Induced Toxicity

inferred← citeshttps://doi.org/10.1016/j.immuni.2013.08.039openalex-snapshot

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110053openalex-snapshot

Forsythoside A regulates autophagy and apoptosis through the AMPK/mTOR/ULK1 pathway and alleviates inflammatory damage in MAC-T cells

inferred← citeshttps://doi.org/10.1016/j.isci.2022.105115openalex-snapshot

RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11

inferred← citeshttps://doi.org/10.1016/j.isci.2024.110265openalex-snapshot

Circulating biomarkers of kidney angiomyolipoma and cysts in tuberous sclerosis complex patients

inferred← citeshttps://doi.org/10.1016/j.isci.2025.112118openalex-snapshot

A bacterial genotoxin reveals a p53-proteasome-LC3 regulatory axis that drives the suppression of autophagy in cells experiencing sublethal DNA damage

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104570openalex-snapshot

Posttranslational regulation of liver kinase B1 in human cancer

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104906openalex-snapshot

Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response

inferred← citeshttps://doi.org/10.1016/j.jchromb.2020.122250openalex-snapshot

An improved pseudotargeted GC–MS/MS-based metabolomics method and its application in radiation-induced hepatic injury in a rat model

inferred← citeshttps://doi.org/10.1016/j.jff.2015.12.031openalex-snapshot

Inhibitory effect of Erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21

inferred← citeshttps://doi.org/10.1016/j.jhazmat.2020.122227openalex-snapshot

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2018.02.010openalex-snapshot

Low power lasers on genomic stability

inferred← citeshttps://doi.org/10.1016/j.jprot.2012.03.040openalex-snapshot

A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate

inferred← citeshttps://doi.org/10.1016/j.lfs.2017.12.001openalex-snapshot

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120787openalex-snapshot

Transcriptional profiling reveals ataxia telangiectasia mutated pathways regulate joint copper and arsenic toxicity for hepatic metalloplasia and anti-cancer therapies

inferred← citeshttps://doi.org/10.1016/j.mad.2019.111194openalex-snapshot

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

inferred← citeshttps://doi.org/10.1016/j.mad.2020.111207openalex-snapshot

Mitophagy and DNA damage signaling in human aging

inferred← citeshttps://doi.org/10.1016/j.mad.2020.111296openalex-snapshot

ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy

inferred← citeshttps://doi.org/10.1016/j.mam.2018.02.003openalex-snapshot

Redox control in cancer development and progression

inferred← citeshttps://doi.org/10.1016/j.matbio.2021.02.004openalex-snapshot

Causes and consequences of DNA damage-induced autophagy

inferred← citeshttps://doi.org/10.1016/j.mce.2012.04.009openalex-snapshot

Role of melatonin in the regulation of autophagy and mitophagy: A review

inferred← citeshttps://doi.org/10.1016/j.mcpro.2025.101035openalex-snapshot

mTORC2 Regulates Non-homologous End Joining Through Modulating the Temporal Dynamics of 53BP1

inferred← citeshttps://doi.org/10.1016/j.molcel.2010.09.023openalex-snapshot

Autophagy and the Integrated Stress Response

inferred← citeshttps://doi.org/10.1016/j.molcel.2010.09.028openalex-snapshot

Translational Regulation of Gene Expression during Conditions of Cell Stress

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