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Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dvdy.20551openalex-snapshot

Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit

inferredcites →https://doi.org/10.1007/s11060-006-9132-2openalex-snapshot

Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice

inferredcites →https://doi.org/10.1016/0012-1606(88)90211-4openalex-snapshot

In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor

inferredcites →https://doi.org/10.1016/0168-9525(90)90114-lopenalex-snapshot

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

inferredcites →https://doi.org/10.1016/j.ccr.2008.07.003openalex-snapshot

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

inferredcites →https://doi.org/10.1016/j.ccr.2008.07.005openalex-snapshot

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

inferredcites →https://doi.org/10.1016/j.cell.2005.10.042openalex-snapshot

Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity

inferredcites →https://doi.org/10.1016/j.gene.2004.01.010openalex-snapshot

Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

inferredcites →https://doi.org/10.1016/s0070-2153(08)00809-0openalex-snapshot

Chapter 9 The Primary Cilium

inferredcites →https://doi.org/10.1016/s0092-8674(00)81268-4openalex-snapshot

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

inferredcites →https://doi.org/10.1016/s0896-6273(00)80344-xopenalex-snapshot

Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1

inferredcites →https://doi.org/10.1016/s0896-6273(00)80682-0openalex-snapshot

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

inferredcites →https://doi.org/10.1016/s0960-9822(99)80195-xopenalex-snapshot

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

inferredcites →https://doi.org/10.1016/s1534-5807(03)00394-0openalex-snapshot

All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3

inferredcites →https://doi.org/10.1038/287795a0openalex-snapshot

Mutations affecting segment number and polarity in Drosophila

inferredcites →https://doi.org/10.1038/415436aopenalex-snapshot

Prediction of central nervous system embryonal tumour outcome based on gene expression

inferredcites →https://doi.org/10.1038/nature06270openalex-snapshot

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

inferredcites →https://doi.org/10.1038/nrc2404openalex-snapshot

The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

inferredcites →https://doi.org/10.1038/sj.onc.1208567openalex-snapshot

Gli1 is important for medulloblastoma formation in Ptc1+/− mice

inferredcites →https://doi.org/10.1073/pnas.050467397openalex-snapshot

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

inferredcites →https://doi.org/10.1073/pnas.0832317100openalex-snapshot

Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors

inferredcites →https://doi.org/10.1073/pnas.091062498openalex-snapshot

Significance analysis of microarrays applied to the ionizing radiation response

inferredcites →https://doi.org/10.1073/pnas.112212199openalex-snapshot

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

inferredcites →https://doi.org/10.1074/jbc.274.12.8143openalex-snapshot

Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3

inferredcites →https://doi.org/10.1093/bioinformatics/bti593openalex-snapshot

TileMap: create chromosomal map of tiling array hybridizations

inferredcites →https://doi.org/10.1093/nar/30.1.207openalex-snapshot

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

inferredcites →https://doi.org/10.1101/gad.1693008openalex-snapshot

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

inferredcites →https://doi.org/10.1126/science.1073733openalex-snapshot

Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

inferredcites →https://doi.org/10.1126/science.272.5268.1668openalex-snapshot

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

inferredcites →https://doi.org/10.1126/science.277.5329.1109openalex-snapshot

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

inferredcites →https://doi.org/10.1128/mcb.10.2.634openalex-snapshot

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

inferredcites →https://doi.org/10.1128/mcb.10.2.634-642.1990openalex-snapshot

The GLI Gene Encodes a Nuclear Protein Which Binds Specific Sequences in the Human Genome

inferredcites →https://doi.org/10.1158/0008-5472.can-04-1813openalex-snapshot

The SmoA1 Mouse Model Reveals That Notch Signaling Is Critical for the Growth and Survival of Sonic Hedgehog-Induced Medulloblastomas

inferredcites →https://doi.org/10.1158/0008-5472.can-06-0505openalex-snapshot

Patched2 Modulates Tumorigenesis in Patched1 Heterozygous Mice

inferredcites →https://doi.org/10.1158/0008-5472.can-06-1621openalex-snapshot

N- myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth

inferredcites →https://doi.org/10.1186/1756-0500-7-157openalex-snapshot

In silico prediction of protein-protein interactions in human macrophages

inferredcites →https://doi.org/10.1186/gb-2003-4-5-p3openalex-snapshot

DAVID: Database for Annotation, Visualization, and Integrated Discovery

inferredcites →https://doi.org/10.1186/gb-2004-5-6-226openalex-snapshot

An overview of the basic helix-loop-helix proteins.

inferredcites →https://doi.org/10.1186/gb-2007-8-5-r82openalex-snapshot

Exon arrays provide accurate assessments of gene expression

inferredcites →https://doi.org/10.1242/dev.00182openalex-snapshot

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

inferredcites →https://doi.org/10.1242/dev.001966openalex-snapshot

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

inferredcites →https://doi.org/10.1242/dev.01438openalex-snapshot

Spatial pattern of sonic hedgehog signaling throughGligenes during cerebellum development

inferredcites →https://doi.org/10.1242/dev.02351openalex-snapshot

The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation

inferredcites →https://doi.org/10.1242/dev.02522openalex-snapshot

An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation

inferredcites →https://doi.org/10.1242/dev.127.8.1593openalex-snapshot

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

inferredcites →https://doi.org/10.1242/dev.128.24.5161openalex-snapshot

Gli1can rescue the in vivo function ofGli2

inferredcites →https://doi.org/10.1242/dev.129.20.4753openalex-snapshot

Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

inferredcites →https://doi.org/10.1371/journal.pbio.0060027openalex-snapshot

Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Hedgehog Pathway and its Inhibitors in Chronic Obstructive Pulmonary Disease (COPD)

inferred← citeshttps://doi.org/10.1002/dvdy.24394openalex-snapshot

LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease

inferred← citeshttps://doi.org/10.1002/ijc.28330openalex-snapshot

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

inferred← citeshttps://doi.org/10.1002/pros.21500openalex-snapshot

Paracrine hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli‐dependent manner

inferred← citeshttps://doi.org/10.1002/wsbm.1193openalex-snapshot

Toward a systems‐level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile

inferred← citeshttps://doi.org/10.1002/wsbm.139openalex-snapshot

Functional genomics of the brain: uncovering networks in the CNS using a systems approach

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JAMIE: A Software Tool for Jointly Analyzing Multiple ChIP-chip Experiments

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Detection of mRNA Encoding Receptors by In Situ and Northern Hybridization

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Future Prospective

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A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma

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Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1

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Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality

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GANT61/BI-847325 combination: a new hope in lung cancer treatment

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Can Clues from Evolution Unlock the Molecular Development of the Cerebellum?

inferred← citeshttps://doi.org/10.1007/s12035-017-0612-5openalex-snapshot

Neonatal Hyperoxia Perturbs Neuronal Development in the Cerebellum

inferred← citeshttps://doi.org/10.1007/s12311-014-0596-xopenalex-snapshot

Exogenous Sonic Hedgehog Modulates the Pool of GABAergic Interneurons During Cerebellar Development

inferred← citeshttps://doi.org/10.1007/s12311-017-0895-0openalex-snapshot

Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury

inferred← citeshttps://doi.org/10.1007/s12311-019-1009-yopenalex-snapshot

Differential Expression of Genes for Ubiquitin Ligases in Medulloblastoma Subtypes

inferred← citeshttps://doi.org/10.1016/b978-0-12-382026-6.00008-7openalex-snapshot

Growth Factors in the Gastrointestinal Tract

inferred← citeshttps://doi.org/10.1016/b978-0-12-394622-5.00009-2openalex-snapshot

Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay

inferred← citeshttps://doi.org/10.1016/j.biocel.2012.01.019openalex-snapshot

Cdon and Boc: Two transmembrane proteins implicated in cell–cell communication

inferred← citeshttps://doi.org/10.1016/j.ccell.2018.05.006openalex-snapshot

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111530openalex-snapshot

METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115673openalex-snapshot

Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression

inferred← citeshttps://doi.org/10.1016/j.cub.2021.04.075openalex-snapshot

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

inferred← citeshttps://doi.org/10.1016/j.devcel.2014.08.010openalex-snapshot

The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors

inferred← citeshttps://doi.org/10.1016/j.devcel.2018.11.015openalex-snapshot

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

inferred← citeshttps://doi.org/10.1016/j.gendis.2015.12.003openalex-snapshot

Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells

inferred← citeshttps://doi.org/10.1016/j.gene.2014.09.042openalex-snapshot

The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas

inferred← citeshttps://doi.org/10.1016/j.mcn.2011.12.008openalex-snapshot

Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2022.108295openalex-snapshot

Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD)

inferred← citeshttps://doi.org/10.1016/j.semcdb.2014.05.003openalex-snapshot

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

inferred← citeshttps://doi.org/10.1016/j.semcdb.2014.05.008openalex-snapshot

Sonic hedgehog signaling in the postnatal brain

inferred← citeshttps://doi.org/10.1016/j.ydbio.2015.03.015openalex-snapshot

Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling

inferred← citeshttps://doi.org/10.1016/j.ydbio.2022.07.009openalex-snapshot

Myogenic regulatory factors Myod and Myf5 are required for dorsal aorta formation and angiogenic sprouting

inferred← citeshttps://doi.org/10.1038/emboj.2010.137openalex-snapshot

NANOG regulates glioma stem cells and is essential in vivo acting in a cross‐functional network with GLI1 and p53

inferred← citeshttps://doi.org/10.1038/nature11889openalex-snapshot

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

inferred← citeshttps://doi.org/10.1038/ncomms6425openalex-snapshot

An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth

inferred← citeshttps://doi.org/10.1038/nm.3328openalex-snapshot

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

inferred← citeshttps://doi.org/10.1038/nm.3613openalex-snapshot

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

inferred← citeshttps://doi.org/10.1038/nm.4476openalex-snapshot

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

inferred← citeshttps://doi.org/10.1038/nrm3598openalex-snapshot

The mechanisms of Hedgehog signalling and its roles in development and disease

inferred← citeshttps://doi.org/10.1038/onc.2011.232openalex-snapshot

Sonic hedgehog regulates Bmi1 in human medulloblastoma brain tumor-initiating cells

inferred← citeshttps://doi.org/10.1038/onc.2016.108openalex-snapshot

SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development

inferred← citeshttps://doi.org/10.1038/onc.2017.208openalex-snapshot

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

inferred← citeshttps://doi.org/10.1038/oncsis.2015.38openalex-snapshot

A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma

inferred← citeshttps://doi.org/10.1038/pr.2011.62openalex-snapshot

Medulloblastoma stem cells: where development and cancer cross pathways

inferred← citeshttps://doi.org/10.1038/s41418-024-01325-2openalex-snapshot

Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth

inferred← citeshttps://doi.org/10.1038/s41467-020-18762-5openalex-snapshot

AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

inferred← citeshttps://doi.org/10.1038/s41467-020-19063-7openalex-snapshot

Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy

inferred← citeshttps://doi.org/10.1038/s41598-018-36912-0openalex-snapshot

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

inferred← citeshttps://doi.org/10.1038/s41598-019-50088-1openalex-snapshot

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma

inferred← citeshttps://doi.org/10.1038/s42255-021-00488-3openalex-snapshot

Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2

inferred← citeshttps://doi.org/10.1038/s42255-025-01269-yopenalex-snapshot

Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states

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Prion protein localizes at the ciliary base during neural and cardiovascular development and its depletion affects α-tubulin post-translational modifications

inferred← citeshttps://doi.org/10.1039/d1ra00732gopenalex-snapshot

Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition

inferred← citeshttps://doi.org/10.1063/1.5037882openalex-snapshot

Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype

inferred← citeshttps://doi.org/10.1073/pnas.1018510108openalex-snapshot

Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development

inferred← citeshttps://doi.org/10.1073/pnas.1114168109openalex-snapshot

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

inferred← citeshttps://doi.org/10.1073/pnas.2202821119openalex-snapshot

O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling

inferred← citeshttps://doi.org/10.1073/pnas.2409380121openalex-snapshot

Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI

inferred← citeshttps://doi.org/10.1074/jbc.m116.714857openalex-snapshot

The Pluripotency Factor NANOG Binds to GLI Proteins and Represses Hedgehog-mediated Transcription

inferred← citeshttps://doi.org/10.1074/jbc.m117.783845openalex-snapshot

Neuropilin-1 promotes Hedgehog signaling through a novel cytoplasmic motif

inferred← citeshttps://doi.org/10.1080/17460441.2021.1832078openalex-snapshot

Targeting the GLI family of transcription factors for the development of anti-cancer drugs

inferred← citeshttps://doi.org/10.1093/bioinformatics/btq314openalex-snapshot

JAMIE: joint analysis of multiple ChIP-chip experiments

inferred← citeshttps://doi.org/10.1093/hmg/dds505openalex-snapshot

Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal

inferred← citeshttps://doi.org/10.1093/hmg/ddt504openalex-snapshot

Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome

inferred← citeshttps://doi.org/10.1093/jmcb/mjr006openalex-snapshot

Disease and animal research: a meeting review

inferred← citeshttps://doi.org/10.1096/fj.202400019rropenalex-snapshot

The molecular biology of NF2 /Merlin on tumorigenesis and development

inferred← citeshttps://doi.org/10.1101/2023.09.20.558654openalex-snapshot

Loss of cilia after neurulation impacts brain development and neuronal activity in larval zebrafish

inferred← citeshttps://doi.org/10.1101/gad.173054.111openalex-snapshot

Neuropilins are positive regulators of Hedgehog signal transduction

inferred← citeshttps://doi.org/10.1101/gad.337584.120openalex-snapshot

Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation

inferred← citeshttps://doi.org/10.1111/j.1742-4658.2011.08388.xopenalex-snapshot

The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus

inferred← citeshttps://doi.org/10.1126/scitranslmed.aaa5731openalex-snapshot

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia

inferred← citeshttps://doi.org/10.1146/annurev-cellbio-092910-154048openalex-snapshot

Gli Proteins in Development and Disease

inferred← citeshttps://doi.org/10.1146/annurev-genom-090711-163723openalex-snapshot

Characterization of Enhancer Function from Genome-Wide Analyses

inferred← citeshttps://doi.org/10.1158/0008-5472.c.6513424.v1openalex-snapshot

Data from Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists

inferred← citeshttps://doi.org/10.1158/0008-5472.can-13-1299openalex-snapshot

Comparative Expression Analysis Reveals Lineage Relationships between Human and Murine Gliomas and a Dominance of Glial Signatures during Tumor Propagation In Vitro

inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-3186openalex-snapshot

Inhibition of the FACT Complex Targets Aberrant Hedgehog Signaling and Overcomes Resistance to Smoothened Antagonists

inferred← citeshttps://doi.org/10.1158/1535-7163.c.6541920openalex-snapshot

Data from A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis

inferred← citeshttps://doi.org/10.1158/1535-7163.c.6541920.v1openalex-snapshot

Data from A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-11-0341openalex-snapshot

A Polymeric Nanoparticle Encapsulated Small-Molecule Inhibitor of Hedgehog Signaling (NanoHHI) Bypasses Secondary Mutational Resistance to Smoothened Antagonists

inferred← citeshttps://doi.org/10.1158/1535-7163.mct-20-0037openalex-snapshot

A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis

inferred← citeshttps://doi.org/10.1158/1541-7786.c.6545124.v1openalex-snapshot

Data from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-21-0117openalex-snapshot

SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation

inferred← citeshttps://doi.org/10.1186/1471-2164-13-2openalex-snapshot

Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development

inferred← citeshttps://doi.org/10.1186/1471-2164-14-587openalex-snapshot

Comprehensive characterization of erythroid-specific enhancers in the genomic regions of human Krüppel-like factors

inferred← citeshttps://doi.org/10.1186/s12861-016-0106-0openalex-snapshot

Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway

inferred← citeshttps://doi.org/10.1186/s12863-018-0697-5openalex-snapshot

p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation

inferred← citeshttps://doi.org/10.1186/s12885-016-2200-xopenalex-snapshot

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

inferred← citeshttps://doi.org/10.1186/s12964-020-00544-7openalex-snapshot

Merlin regulates signaling events at the nexus of development and cancer

inferred← citeshttps://doi.org/10.1186/s12964-026-02993-yopenalex-snapshot

The SHH/GLI target Netrin-1 supports self-renewal in medulloblastoma tumor cells

inferred← citeshttps://doi.org/10.1242/bio.20136262openalex-snapshot

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish

inferred← citeshttps://doi.org/10.1242/jcs.220384openalex-snapshot

The Plk1 kinase negatively regulates the Hedgehog signaling pathway by phosphorylating Gli1

inferred← citeshttps://doi.org/10.1371/journal.pgen.1002572openalex-snapshot

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

inferred← citeshttps://doi.org/10.1371/journal.pgen.1007058openalex-snapshot

Gli3 is a negative regulator of Tas1r3-expressing taste cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0124870openalex-snapshot

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma

inferred← citeshttps://doi.org/10.1371/journal.pone.0145225openalex-snapshot

Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density

inferred← citeshttps://doi.org/10.1523/jneurosci.0688-18.2018openalex-snapshot

The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain

inferred← citeshttps://doi.org/10.18632/oncotarget.17769openalex-snapshot

Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation

inferred← citeshttps://doi.org/10.20381/ruor-2921openalex-snapshot

Identification of Sox8 and Ndp as Novel Targets of the Hedgehog Signaling Pathway in the Retina

inferred← citeshttps://doi.org/10.21236/ada599190openalex-snapshot

Function of Brg1 Chromatin Remodeling Factor in Sonic Hedgehog-Dependent Medulloblastoma Initiation and Maintenance

inferred← citeshttps://doi.org/10.2217/fon.13.185openalex-snapshot

The Biologic Era of Childhood Medulloblastoma and Clues to Novel Therapies

inferred← citeshttps://doi.org/10.3389/fncel.2015.00291openalex-snapshot

Osteogenesis and neurogenesis: a robust link also for language evolution

inferred← citeshttps://doi.org/10.3389/fncel.2019.00539openalex-snapshot

Rack1 Controls Parallel Fiber–Purkinje Cell Synaptogenesis and Synaptic Transmission

inferred← citeshttps://doi.org/10.3389/fonc.2014.00176openalex-snapshot

Pediatric Medulloblastoma – Update on Molecular Classification Driving Targeted Therapies

inferred← citeshttps://doi.org/10.3389/fphys.2016.00468openalex-snapshot

Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2

inferred← citeshttps://doi.org/10.3390/cancers7040894openalex-snapshot

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

inferred← citeshttps://doi.org/10.3390/cells8030216openalex-snapshot

Differential Expression of Mitochondrial Biogenesis Markers in Mouse and Human SHH-Subtype Medulloblastoma

inferred← citeshttps://doi.org/10.33915/etd.6863openalex-snapshot

Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4

inferred← citeshttps://doi.org/10.3410/f.717988280.793472634openalex-snapshot

Faculty Opinions recommendation of GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

inferred← citeshttps://doi.org/10.3410/f.732604703.793545061openalex-snapshot

Faculty Opinions recommendation of Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.

inferred← citeshttps://doi.org/10.3892/etm.2017.4282openalex-snapshot

Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines

inferred← citeshttps://doi.org/10.3892/ijo.2017.3946openalex-snapshot

Inhibition of the Hedgehog signaling pathway suppresses cell proliferation by regulating the Gli2/miR-124/AURKA axis in human glioma cells

inferred← citeshttps://doi.org/10.4199/c00096ed1v01y201310dbr011openalex-snapshot

Pattern Formation in the Cerebellum

inferred← citeshttps://doi.org/10.53846/goediss-5067openalex-snapshot

Interaction of the Hedgehog and vitamin D receptor signaling pathways in Patched associated cancers

inferred← citeshttps://doi.org/10.70675/bc221d41z5934z4e2fzb4fezdfbff39bda19openalex-snapshot

Genomic Profiling of Pediatric Low-Grade Gliomas

inferred← citeshttps://doi.org/10.70675/f9c5e21cz2cf8z424dz8a35z45035aaef298openalex-snapshot

Les effets des lipides exosomaux sur les cellules tumorales pancréatiques humaines : entre apoptose et survie

inferred← citeshttps://doi.org/10.7150/thno.75421openalex-snapshot

The PROTAC selectively degrading Bcl-xL represents a novel Hedgehog pathway inhibitor with capacity of combating resistance to Smoothened inhibitors while sparing bone growth

inferred← citeshttps://doi.org/10.7554/elife.56450openalex-snapshot

Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

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