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Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/smim.1995.0026openalex-snapshot

The Src and Csk families of tyrosine protein kinases in hemopoietic cells

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Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173

inferredcites →https://doi.org/10.1016/j.bbapap.2004.10.005openalex-snapshot

The SH2 domain: versatile signaling module and pharmaceutical target

inferredcites →https://doi.org/10.1016/j.bbapap.2007.08.012openalex-snapshot

Src family kinases: Regulation of their activities, levels and identification of new pathways

inferredcites →https://doi.org/10.1016/j.bbrc.2004.09.171openalex-snapshot

Src protein–tyrosine kinase structure and regulation

inferredcites →https://doi.org/10.1016/j.chom.2009.03.004openalex-snapshot

Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins

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Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein

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SagA of CagA in Helicobacter pylori pathogenesis

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Emerging roles of pseudokinases

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Tyrosine-phosphorylated bacterial effector proteins: the enemies within

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Activation of a Src-dependent Raf–MEK1/2–ERK signaling pathway is required for IL-1α-induced upregulation of β-defensin 2 in human middle ear epithelial cells

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An African origin for the intimate association between humans and Helicobacter pylori

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma

inferredcites →https://doi.org/10.1046/j.1365-2958.2002.02817.xopenalex-snapshot

A tyrosine‐phosphorylated 12‐amino‐acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals

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Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice

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A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin

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A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells

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Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa -induced mucin overproduction in epithelial cells

inferredcites →https://doi.org/10.1074/jbc.m208155200openalex-snapshot

Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase

inferredcites →https://doi.org/10.1074/jbc.m511314200openalex-snapshot

Pragmin, a Novel Effector of Rnd2 GTPase, Stimulates RhoA Activity

inferredcites →https://doi.org/10.1074/mcp.m500089-mcp200openalex-snapshot

Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules

inferredcites →https://doi.org/10.1080/08977190500368031openalex-snapshot

Cross-regulation of JAK and Src kinases

inferredcites →https://doi.org/10.1084/jem.20100602openalex-snapshot

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

inferredcites →https://doi.org/10.1111/j.1462-5822.2006.00871.xopenalex-snapshot

Anaplasma phagocytophilum AnkA is tyrosine-phosphorylated at EPIYA motifs and recruits SHP-1 during early infection

inferredcites →https://doi.org/10.1111/j.1462-5822.2007.00985.xopenalex-snapshot

Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection

inferredcites →https://doi.org/10.1126/science.1067147openalex-snapshot

SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein

inferredcites →https://doi.org/10.1126/stke.2772005pe14openalex-snapshot

Orchestration of Aberrant Epithelial Signaling by Helicobacter pylori CagA

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Haemophilus ducreyi LspA Proteins Are Tyrosine Phosphorylated by Macrophage-Encoded Protein Tyrosine Kinases

inferredcites →https://doi.org/10.1128/iai.73.12.7808-7816.2005openalex-snapshot

Haemophilus ducreyi Targets Src Family Protein Tyrosine Kinases To Inhibit Phagocytic Signaling

inferredcites →https://doi.org/10.1158/0008-5472.can-08-2354openalex-snapshot

Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-09-4690openalex-snapshot

Translocation of Helicobacter pylori CagA into Human B Lymphocytes, the Origin of Mucosa-Associated Lymphoid Tissue Lymphoma

inferredcites →https://doi.org/10.4049/jimmunol.165.1.473openalex-snapshot

Differential Involvement of Src Family Kinases in Fcγ Receptor-Mediated Phagocytosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation

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Disease-Related Signaling Through Rnd2 is Associated with Inhibition of Differentiation in Oligodendroglial Fbd-102b Cells, Which is Recovered by the Citrus Flavonoid Hesperetin

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Structural Insights into Helicobacter pylori Cag Protein Interactions with Host Cell Factors

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CagA

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A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses

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siRNA high throughput screening identifies regulators of chloropicrin and hydrogen fluoride injury in human corneal epithelial cell models

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Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111365openalex-snapshot

A tandem recruitment site in the pseudokinase scaffold PEAK3 is subject to phosphorylation-dependent regulation and cancer-associated mutations

inferred← citeshttps://doi.org/10.1016/j.jksus.2014.05.001openalex-snapshot

EPIYA (or -like) motifs in mammalian proteins

inferred← citeshttps://doi.org/10.1016/j.nmni.2021.100865openalex-snapshot

EPIYA motifs of Helicobacter pylori cagA genotypes and gastrointestinal diseases in the Iranian population: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1016/j.sbi.2015.03.004openalex-snapshot

Convergent evolution and mimicry of protein linear motifs in host–pathogen interactions

inferred← citeshttps://doi.org/10.1016/j.sbi.2024.102932openalex-snapshot

View from the PEAKs: Insights from structural studies on the PEAK family of pseudokinases

inferred← citeshttps://doi.org/10.1016/j.str.2018.01.017openalex-snapshot

Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation

inferred← citeshttps://doi.org/10.1016/j.tcb.2014.03.008openalex-snapshot

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

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Evaluating the in vitro therapeutic effects of human amniotic mesenchymal stromal cells on MiaPaca2 pancreatic cancer cells using 2D and 3D cell culture model

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SLiMAn: An Integrative Web Server for Exploring Short Linear Motif-Mediated Interactions in Interactomes

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Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

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Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3

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Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling

inferred← citeshttps://doi.org/10.1038/s41467-025-62107-zopenalex-snapshot

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation

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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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Microarray Analysis of 8p23.1 Deletion in New Patients with Atypical Phenotypical Traits

inferred← citeshttps://doi.org/10.1073/pnas.1906360116openalex-snapshot

PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization

inferred← citeshttps://doi.org/10.1074/jbc.m116.748897openalex-snapshot

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases

inferred← citeshttps://doi.org/10.1080/19336918.2017.1394570openalex-snapshot

The pseudokinases SgK269 and SgK223: A novel oncogenic alliance in human cancer

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Regulation of Cellular-Signaling Pathways by Mammalian Proteins Containing Bacterial EPIYA or EPIYA-Like Motifs Predicted to be Phosphorylated

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Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment

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Recent advances in Helicobacter pylori pathogenesis

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CagA 3′ region polymorphism of Helicobacter pylori and its association with chronic gastritis in the Chinese population

inferred← citeshttps://doi.org/10.1101/2021.02.17.431740openalex-snapshot

PEAK3 pseudokinase represents a pro-migratory and -invasive signalling scaffold

inferred← citeshttps://doi.org/10.1101/2022.09.01.506260openalex-snapshot

When two’s a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3/Crk signaling

inferred← citeshttps://doi.org/10.1111/cas.12962openalex-snapshot

C‐terminal Src kinase‐mediated EPIYA phosphorylation of Pragmin creates a feed‐forward C‐terminal Src kinase activation loop that promotes cell motility

inferred← citeshttps://doi.org/10.1111/cmi.12040openalex-snapshot

Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?

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The PEAK family of pseudokinases, their role in cell signalling and cancer

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A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity

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Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

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Emerging concepts in pseudoenzyme classification, evolution, and signaling

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Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family

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Host Genome-Wide Association Study of Infant Susceptibility toShigella-Associated Diarrhea

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NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

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Étude biochimique et structurale de composants essentiels à la biogenèse du pilus du système de sécrétion de type IV de la bactérie Helicobacter pylori

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Helicobacter Pylori CagA and Gastric Carcinogenesis

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