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Transcriptional burst frequency and burst size are equally modulated across the human genome

https://doi.org/10.1073/pnas.1213530109
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation.
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A general method for numerically simulating the stochastic time evolution of coupled chemical reactions
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Use of the human elongation factor 1α promoter as a versatile and efficient expression system
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Transcriptional Bursting from the HIV-1 Promoter Is a Significant Source of Stochastic Noise in HIV-1 Gene Expression
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Origins and consequences of transcriptional discontinuity
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Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
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Real-Time Kinetics of Gene Activity in Individual Bacteria
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The sorting direct method for stochastic simulation of biochemical systems with varying reaction execution behavior
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Frequency domain chemical Langevin analysis of stochasticity in gene transcriptional regulation
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Stochasticity in Transcriptional Regulation: Origins, Consequences, and Mathematical Representations
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HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
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NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II
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Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
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Dynamics of protein noise can distinguish between alternate sources of gene‐expression variability
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Noise in eukaryotic gene expression
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Gene network shaping of inherent noise spectra
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Stochastic protein expression in individual cells at the single molecule level
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Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
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Variability and memory of protein levels in human cells
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Frequency-modulated nuclear localization bursts coordinate gene regulation
inferredcites →https://doi.org/10.1038/ng.116openalex-snapshot
Transient-mediated fate determination in a transcriptional circuit of HIV
inferredcites →https://doi.org/10.1038/ng.821openalex-snapshot
General properties of transcriptional time series in Escherichia coli
inferredcites →https://doi.org/10.1038/ng1807openalex-snapshot
Noise in protein expression scales with natural protein abundance
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Single-allele analysis of transcription kinetics in living mammalian cells
inferredcites →https://doi.org/10.1038/sj.emboj.7600900openalex-snapshot
NF‐κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation
inferredcites →https://doi.org/10.1073/pnas.0804829105openalex-snapshot
Using noise to probe and characterize gene circuits
inferredcites →https://doi.org/10.1093/emboj/20.7.1726openalex-snapshot
The site of HIV‐1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation
inferredcites →https://doi.org/10.1101/gad.1228704openalex-snapshot
Signaling to NF-κB
inferredcites →https://doi.org/10.1126/science.1071914openalex-snapshot
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
inferredcites →https://doi.org/10.1126/science.1144331openalex-snapshot
Effects of Molecular Memory and Bursting on Fluctuations in Gene Expression
inferredcites →https://doi.org/10.1126/science.1160165openalex-snapshot
Dynamic Proteomics of Individual Cancer Cells in Response to a Drug
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Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells
inferredcites →https://doi.org/10.1126/science.1198817openalex-snapshot
Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics
inferredcites →https://doi.org/10.1128/jvi.02074-06openalex-snapshot
Sustained Induction of NF-κB Is Required for Efficient Expression of Latent Human Immunodeficiency Virus Type 1
inferredcites →https://doi.org/10.1128/jvi.75.18.8524-8537.2001openalex-snapshot
Activation of Human Immunodeficiency Virus Transcription in T Cells Revisited: NF-κB p65 Stimulates Transcriptional Elongation
inferredcites →https://doi.org/10.1146/annurev.immunol.021908.132641openalex-snapshot
Regulation and Function of NF-κB Transcription Factors in the Immune System
inferredcites →https://doi.org/10.1371/journal.pbio.0020234openalex-snapshot
Retroviral DNA Integration: ASLV, HIV, and MLV Show Distinct Target Site Preferences
inferredcites →https://doi.org/10.1371/journal.pbio.0040309openalex-snapshot
Stochastic mRNA Synthesis in Mammalian Cells
inferredcites →https://doi.org/10.1371/journal.pbio.0050009openalex-snapshot
An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer
inferredcites →https://doi.org/10.1371/journal.pbio.0050067openalex-snapshot
Arkadia Enhances Nodal/TGF-β Signaling by Coupling Phospho-Smad2/3 Activity and Turnover
inferredcites →https://doi.org/10.1371/journal.pbio.1000607openalex-snapshot
Dynamic Analysis of Stochastic Transcription Cycles
inferredcites →https://doi.org/10.1371/journal.pcbi.1000952openalex-snapshot
HIV Promoter Integration Site Primarily Modulates Transcriptional Burst Size Rather Than Frequency
inferredcites →https://doi.org/10.1371/journal.pone.0037130openalex-snapshot
Rapid Transcriptional Pulsing Dynamics of High Expressing Retroviral Transgenes in Embryonic Stem Cells
inferredcites →https://doi.org/10.1371/journal.ppat.1002184openalex-snapshot
Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Self-Organization Controls Expression More than Abundance of Molecular Components of Transcription and Translation in Confined Cell-Free Gene Expression
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Mitochondria and the non‐genetic origins of cell‐to‐cell variability: More is different
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STREAMING-Tag System: Technology to Enable Visualization of Transcriptional Activity and Subnuclear Localization of Specific Endogenous Genes
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Controlling Noisy Expression Through Auto Regulation of Burst Frequency and Protein Stability
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Stationary Distributions and Metastable Behaviour for Self-regulating Proteins with General Lifetime Distributions
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Gene expression noise is affected differentially by feedback in burst frequency and burst size
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Exponential equilibration of genetic circuits using entropy methods
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Assessing Markovian and Delay Models for Single-Nucleus RNA Sequencing
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A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks
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Stochastic Modeling and Optimal Control of HIV-1 Infection Dynamics Under Combination Antiretroviral Therapy
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Distribution of Initiation Times Reveals Mechanisms of Transcriptional Regulation in Single Cells
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Stochastic Modeling of Gene Regulation by Noncoding Small RNAs in the Strong Interaction Limit
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A Hardwired HIV Latency Program
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Cell-to-Cell Transcript Variability: Seeing Signal in the Noise
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A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization
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Diverse Spatial Expression Patterns Emerge from Unified Kinetics of Transcriptional Bursting
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Transcription Factors Modulate c-Fos Transcriptional Bursts
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Cellular Levels of Signaling Factors Are Sensed by β-actin Alleles to Modulate Transcriptional Pulse Intensity
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Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale
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Nuclear Retention of mRNA in Mammalian Tissues
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NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise
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Cell Size-Based Decision-Making of a Viral Gene Circuit
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Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes
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Activation domains can decouple the mean and noise of gene expression
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Transcriptional noise, gene activation, and roles of SAGA and Mediator Tail measured using nucleotide recoding single-cell RNA-seq
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Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity
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Cell-Size-Dependent Transcription of FLC and Its Antisense Long Non-coding RNA COOLAIR Explain Cell-to-Cell Expression Variation
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Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation
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Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability
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Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling
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High-throughput functional characterization of combinations of transcriptional activators and repressors
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Decoupled degradation and translation enables noise modulation by poly(A) tails
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Global transcription regulation revealed from dynamical correlations in time-resolved single-cell RNA sequencing
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Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread
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On the applicability of deterministic approximations to model genetic circuits**This work has been partially supported by Ministerio de Economia y Competitividad AGL2012-39951-C02-01. M. Pájaro acknowledge support from grant BES-2013-063112.
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Stability of stochastic gene regulatory networks using entropy methods**This work has been partially supported by Ministerio de Economia y Competitividad AGL2012-39951-C02-01. M. Pajaro acknowledge support from grants BES-2013-063112 and EEBB-I-16-10540.
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Regulating gene expression to achieve temporal precision
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Feedback control of stochastic gene switches using PIDE models
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First Responders Shape a Prompt and Sharp NF-κB-Mediated Transcriptional Response to TNF-α
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A transient heritable memory regulates HIV reactivation from latency
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The nonequilibrium mechanism of noise-enhanced drug synergy in HIV latency reactivation
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N-terminal tagging of RNA Polymerase II shapes transcriptomes more than C-terminal alterations
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Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation
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Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability
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Phase separation reduces cell-to-cell variability of transcriptional bursting
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Bursty Gene Expression in the Intact Mammalian Liver
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Single Mammalian Cells Compensate for Differences in Cellular Volume and DNA Copy Number through Independent Global Transcriptional Mechanisms
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Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping
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Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation
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Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility
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Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens
inferred← citeshttps://doi.org/10.1016/j.molcel.2025.04.011openalex-snapshot
Regulation of RNA polymerase II transcription through re-initiation and bursting
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2015.01.002openalex-snapshot
Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles
inferred← citeshttps://doi.org/10.1016/j.neo.2024.101071openalex-snapshot
Doxorubicin resistance involves modulation of interferon signaling, transcriptional bursting, and gene co-expression patterns of U-ISGF3-related genes
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2026.05.006openalex-snapshot
Stochastic thresholds in hemostasis and thrombosis: A multiscale biophysical framework from transcriptional bursting to thrombin propagation
inferred← citeshttps://doi.org/10.1016/j.physa.2019.121779openalex-snapshot
Most probable transition pathways and maximal likely trajectories in a genetic regulatory system
inferred← citeshttps://doi.org/10.1016/j.tcb.2013.02.001openalex-snapshot
Cell length sensing for neuronal growth control
inferred← citeshttps://doi.org/10.1016/j.tcb.2025.08.004openalex-snapshot
What makes genes burst
inferred← citeshttps://doi.org/10.1016/j.tcb.2026.03.013openalex-snapshot
Noninvasive methods to monitor dynamic single-cell events
inferred← citeshttps://doi.org/10.1016/j.tig.2013.04.001openalex-snapshot
Are gene loops the cause of transcriptional noise?
inferred← citeshttps://doi.org/10.1016/j.ymeth.2015.11.015openalex-snapshot
Single molecule approaches for quantifying transcription and degradation rates in intact mammalian tissues
inferred← citeshttps://doi.org/10.1016/j.ymeth.2018.12.010openalex-snapshot
Using time-lapse fluorescence microscopy to study gene regulation
inferred← citeshttps://doi.org/10.1021/acs.jpclett.4c02050openalex-snapshot
How Transcription Factors Binding Stimulates Transcriptional Bursting
inferred← citeshttps://doi.org/10.1021/acssynbio.6b00189openalex-snapshot
Resource Sharing Controls Gene Expression Bursting
inferred← citeshttps://doi.org/10.1021/acssynbio.8b00139openalex-snapshot
Macromolecular Crowding Induces Spatial Correlations That Control Gene Expression Bursting Patterns
inferred← citeshttps://doi.org/10.1021/cr400496qopenalex-snapshot
Single Molecule Fluorescence Approaches Shed Light on Intracellular RNAs
inferred← citeshttps://doi.org/10.1021/sb400028copenalex-snapshot
Probing Cell-Free Gene Expression Noise in Femtoliter Volumes
inferred← citeshttps://doi.org/10.1038/msb.2013.27openalex-snapshot
Synthetic mammalian transgene negative autoregulation
inferred← citeshttps://doi.org/10.1038/nbt.2642openalex-snapshot
Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments
inferred← citeshttps://doi.org/10.1038/ncomms10865openalex-snapshot
Single-cell differences in matrix gene expression do not predict matrix deposition
inferred← citeshttps://doi.org/10.1038/ncomms15006openalex-snapshot
Similarity in viral and host promoters couples viral reactivation with host cell migration
inferred← citeshttps://doi.org/10.1038/ncomms7753openalex-snapshot
Transcriptional refractoriness is dependent on core promoter architecture
inferred← citeshttps://doi.org/10.1038/nmeth.2772openalex-snapshot
Quantitative single-cell RNA-seq with unique molecular identifiers
inferred← citeshttps://doi.org/10.1038/s41392-022-00990-4openalex-snapshot
High-throughput single-сell sequencing in cancer research
inferred← citeshttps://doi.org/10.1038/s41467-017-00052-2openalex-snapshot
Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression
inferred← citeshttps://doi.org/10.1038/s41467-017-02285-7openalex-snapshot
Stochastic gene expression in Arabidopsis thaliana
inferred← citeshttps://doi.org/10.1038/s41467-018-07391-8openalex-snapshot
Central dogma rates and the trade-off between precision and economy in gene expression
inferred← citeshttps://doi.org/10.1038/s41467-019-12344-wopenalex-snapshot
Transient hysteresis and inherent stochasticity in gene regulatory networks
inferred← citeshttps://doi.org/10.1038/s41467-022-29261-0openalex-snapshot
Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin
inferred← citeshttps://doi.org/10.1038/s41467-022-31192-9openalex-snapshot
Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
inferred← citeshttps://doi.org/10.1038/s41467-022-33977-4openalex-snapshot
On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation
inferred← citeshttps://doi.org/10.1038/s41467-022-34857-7openalex-snapshot
Interpretable and tractable models of transcriptional noise for the rational design of single-molecule quantification experiments
inferred← citeshttps://doi.org/10.1038/s41467-023-41408-1openalex-snapshot
Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development
inferred← citeshttps://doi.org/10.1038/s41467-024-49727-7openalex-snapshot
Transcription regulates the spatio-temporal dynamics of genes through micro-compartmentalization
inferred← citeshttps://doi.org/10.1038/s41467-025-58127-4openalex-snapshot
Transient power-law behaviour following induction distinguishes between competing models of stochastic gene expression
inferred← citeshttps://doi.org/10.1038/s41467-025-64817-wopenalex-snapshot
Multi-layered dosage compensation of the avian Z chromosome by increased transcriptional burst frequency and elevated translational rates
inferred← citeshttps://doi.org/10.1038/s41540-025-00490-5openalex-snapshot
Deterministic patterns in single-cell transcriptomic data
inferred← citeshttps://doi.org/10.1038/s41540-025-00538-6openalex-snapshot
Mathematical modeling and mechanisms of HIV latency for personalized anti latency therapies
inferred← citeshttps://doi.org/10.1038/s41556-024-01486-9openalex-snapshot
Single-cell new RNA sequencing reveals principles of transcription at the resolution of individual bursts
inferred← citeshttps://doi.org/10.1038/s41571-020-00449-xopenalex-snapshot
Applying high-dimensional single-cell technologies to the analysis of cancer immunotherapy
inferred← citeshttps://doi.org/10.1038/s41586-018-0836-1openalex-snapshot
Genomic encoding of transcriptional burst kinetics
inferred← citeshttps://doi.org/10.1038/s41592-024-02365-9openalex-snapshot
Biophysical modeling with variational autoencoders for bimodal, single-cell RNA sequencing data
inferred← citeshttps://doi.org/10.1038/s41592-025-02832-xopenalex-snapshot
Monod: model-based discovery and integration through fitting stochastic transcriptional dynamics to single-cell sequencing data
inferred← citeshttps://doi.org/10.1038/s41594-025-01615-4openalex-snapshot
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics
inferred← citeshttps://doi.org/10.1038/s41598-017-12723-7openalex-snapshot
Transcriptional Output Transiently Spikes Upon Mitotic Exit
inferred← citeshttps://doi.org/10.1038/s41598-020-59008-0openalex-snapshot
Differences in Transcriptional Dynamics Between T-cells and Macrophages as Determined by a Three-State Mathematical Model
inferred← citeshttps://doi.org/10.1038/s41598-020-65750-2openalex-snapshot
Enhancement of gene expression noise from transcription factor binding to genomic decoy sites
inferred← citeshttps://doi.org/10.1038/s41598-020-77638-2openalex-snapshot
Identifying chromatin features that regulate gene expression distribution
inferred← citeshttps://doi.org/10.1038/s41598-021-85905-zopenalex-snapshot
Investigating heterogeneities of live mesenchymal stromal cells using AI-based label-free imaging
inferred← citeshttps://doi.org/10.1038/s41598-024-75505-yopenalex-snapshot
Sequestration of gene products by decoys enhances precision in the timing of intracellular events
inferred← citeshttps://doi.org/10.1038/srep07137openalex-snapshot
Transcriptome-wide Variability in Single Embryonic Development Cells
inferred← citeshttps://doi.org/10.1038/srep12310openalex-snapshot
Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice
inferred← citeshttps://doi.org/10.1038/srep17470openalex-snapshot
Fine-tuned SRF activity controls asymmetrical neuronal outgrowth: implications for cortical migration, neural tissue lamination and circuit assembly
inferred← citeshttps://doi.org/10.1038/srep17661openalex-snapshot
Distinct promoter activation mechanisms modulate noise-driven HIV gene expression
inferred← citeshttps://doi.org/10.1039/c7mb00154aopenalex-snapshot
What shapes eukaryotic transcriptional bursting?
inferred← citeshttps://doi.org/10.1039/c8lc00193fopenalex-snapshot
A sharp-edge-based acoustofluidic chemical signal generator
inferred← citeshttps://doi.org/10.1039/d1cp03665copenalex-snapshot
Understanding the molecular mechanisms of transcriptional bursting
inferred← citeshttps://doi.org/10.1042/bst20231286openalex-snapshot
Transcriptional bursting: from fundamentals to novel insights
inferred← citeshttps://doi.org/10.1063/1.4936670openalex-snapshot
Fundamental principles of energy consumption for gene expression
inferred← citeshttps://doi.org/10.1063/1.5010026openalex-snapshot
Likelihood for transcriptions in a genetic regulatory system under asymmetric stable Lévy noise
inferred← citeshttps://doi.org/10.1063/1.5021183openalex-snapshot
Fine-tuning of noise in gene expression with nucleosome remodeling
inferred← citeshttps://doi.org/10.1063/1.5025033openalex-snapshot
Perspective: Engineering noise in biological systems towards predictive stochastic design
inferred← citeshttps://doi.org/10.1063/1.5025235openalex-snapshot
Lévy noise induced transition and enhanced stability in a gene regulatory network
inferred← citeshttps://doi.org/10.1073/pnas.1312465110openalex-snapshot
Creating memories of transcription
inferred← citeshttps://doi.org/10.1073/pnas.1413362111openalex-snapshot
Stochastic variability in HIV affects viral eradication
inferred← citeshttps://doi.org/10.1073/pnas.1609012114openalex-snapshot
First-passage time approach to controlling noise in the timing of intracellular events
inferred← citeshttps://doi.org/10.1073/pnas.1721085115openalex-snapshot
Gene expression distribution deconvolution in single-cell RNA sequencing
inferred← citeshttps://doi.org/10.1073/pnas.1722330115openalex-snapshot
Modulation of transcriptional burst frequency by histone acetylation
inferred← citeshttps://doi.org/10.1073/pnas.1910888117openalex-snapshot
Analytical distributions for detailed models of stochastic gene expression in eukaryotic cells
inferred← citeshttps://doi.org/10.1073/pnas.2012191118openalex-snapshot
Screening for gene expression fluctuations reveals latency-promoting agents of HIV
inferred← citeshttps://doi.org/10.1073/pnas.2018640118openalex-snapshot
Reduction in gene expression noise by targeted increase in accessibility at gene loci
inferred← citeshttps://doi.org/10.1073/pnas.2100099118openalex-snapshot
Physical theory of biological noise buffering by multicomponent phase separation
inferred← citeshttps://doi.org/10.1073/pnas.2207392119openalex-snapshot
Inferring gene regulation from stochastic transcriptional variation across single cells at steady state
inferred← citeshttps://doi.org/10.1073/pnas.2305295120openalex-snapshot
Pairwise biosynthesis of ion channels stabilizes excitability and mitigates arrhythmias
inferred← citeshttps://doi.org/10.1073/pnas.2509560123openalex-snapshot
Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection
inferred← citeshttps://doi.org/10.1080/00036811.2016.1226286openalex-snapshot
Noise tunability in a gene model with star-type promoter structure
inferred← citeshttps://doi.org/10.1080/19491034.2017.1419112openalex-snapshot
Discontinuous transcription
inferred← citeshttps://doi.org/10.1088/1478-3975/12/1/016010openalex-snapshot
Dynamical analysis of mCAT2 gene models with CTN-RNA nuclear retention
inferred← citeshttps://doi.org/10.1088/1478-3975/aafbefopenalex-snapshot
A stochastic model for post-transcriptional regulation of rare events in gene expression
inferred← citeshttps://doi.org/10.1088/1478-3975/aba50fopenalex-snapshot
Urn models for stochastic gene expression yield intuitive insights into the probability distributions of single-cell mRNA and protein counts
inferred← citeshttps://doi.org/10.1088/1742-5468/ac2edbopenalex-snapshot
Heavy-tailed distributions in a stochastic gene autoregulation model
inferred← citeshttps://doi.org/10.1089/ars.2017.7236openalex-snapshot
Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits
inferred← citeshttps://doi.org/10.1091/mbc.e14-08-1296openalex-snapshot
The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise
inferred← citeshttps://doi.org/10.1091/mbc.e17-06-0408openalex-snapshot
Differential context-specific impact of individual core promoter elements on transcriptional dynamics
inferred← citeshttps://doi.org/10.1093/bib/bbac464openalex-snapshot
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data
inferred← citeshttps://doi.org/10.1093/bioadv/vbaf185openalex-snapshot
Marker genes reveal dynamic features of cell evolving processes
inferred← citeshttps://doi.org/10.1093/bioinformatics/btab765openalex-snapshot
Scalable inference of transcriptional kinetic parameters from MS2 time series data
inferred← citeshttps://doi.org/10.1093/bioinformatics/btac277openalex-snapshot
Quantification of transcription noise’s impact on cell fate commitment with digital resolutions
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaf581openalex-snapshot
Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data
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