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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

https://doi.org/10.1073/pnas.1419945112

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-62703-670-2_3openalex-snapshot

The Fate of HIV-1 Capsid: A Biochemical Assay for HIV-1 Uncoating

inferredcites →https://doi.org/10.1016/j.cell.2007.08.018openalex-snapshot

Structure of Full-Length HIV-1 CA: A Model for the Mature Capsid Lattice

inferredcites →https://doi.org/10.1016/j.cell.2009.04.063openalex-snapshot

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

inferredcites →https://doi.org/10.1016/j.cell.2009.10.010openalex-snapshot

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

inferredcites →https://doi.org/10.1016/j.chom.2010.02.007openalex-snapshot

Flexible Use of Nuclear Import Pathways by HIV-1

inferredcites →https://doi.org/10.1016/j.jmb.2010.06.042openalex-snapshot

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus

inferredcites →https://doi.org/10.1016/j.sbi.2008.02.001openalex-snapshot

The structural biology of HIV assembly

inferredcites →https://doi.org/10.1038/nature07724openalex-snapshot

Visualization of a missing link in retrovirus capsid assembly

inferredcites →https://doi.org/10.1038/nature09640openalex-snapshot

Atomic-level modelling of the HIV capsid

inferredcites →https://doi.org/10.1038/nature12162openalex-snapshot

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

inferredcites →https://doi.org/10.1038/nature12769openalex-snapshot

HIV-1 evades innate immune recognition through specific cofactor recruitment

inferredcites →https://doi.org/10.1073/pnas.0509996103openalex-snapshot

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

inferredcites →https://doi.org/10.1073/pnas.1203536109openalex-snapshot

Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

inferredcites →https://doi.org/10.1073/pnas.1401455111openalex-snapshot

Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly

inferredcites →https://doi.org/10.1126/science.278.5339.849openalex-snapshot

Structure of the Carboxyl-Terminal Dimerization Domain of the HIV-1 Capsid Protein

inferredcites →https://doi.org/10.1128/jvi.00451-12openalex-snapshot

TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core

inferredcites →https://doi.org/10.1128/jvi.01406-10openalex-snapshot

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

inferredcites →https://doi.org/10.1128/jvi.01543-07openalex-snapshot

Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication

inferredcites →https://doi.org/10.1128/jvi.01705-13openalex-snapshot

Human Cytosolic Extracts Stabilize the HIV-1 Core

inferredcites →https://doi.org/10.1128/jvi.01899-09openalex-snapshot

The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase

inferredcites →https://doi.org/10.1128/jvi.05887-11openalex-snapshot

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

inferredcites →https://doi.org/10.1128/jvi.06607-11openalex-snapshot

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

inferredcites →https://doi.org/10.1186/1742-4690-10-46openalex-snapshot

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

inferredcites →https://doi.org/10.1186/1742-4690-8-98openalex-snapshot

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

inferredcites →https://doi.org/10.1371/journal.ppat.1001220openalex-snapshot

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

inferredcites →https://doi.org/10.1371/journal.ppat.1002439openalex-snapshot

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

inferredcites →https://doi.org/10.1371/journal.ppat.1002896openalex-snapshot

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

inferredcites →https://doi.org/10.1371/journal.ppat.1003693openalex-snapshot

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

inferredcites →https://doi.org/10.1371/journal.ppat.1003868openalex-snapshot

In Vivo Functions of CPSF6 for HIV-1 as Revealed by HIV-1 Capsid Evolution in HLA-B27-Positive Subjects

inferredcites →https://doi.org/10.1371/journal.ppat.1004459openalex-snapshot

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Import in Non-Dividing Cells

inferred← citeshttps://doi.org/10.1002/1873-3468.12131openalex-snapshot

Labeling of virus components for advanced, quantitative imaging analyses

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Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

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Development of Quantum Chemical Method to Calculate Half Maximal Inhibitory Concentration (IC 50 )

inferred← citeshttps://doi.org/10.1007/978-1-0716-3862-0_8openalex-snapshot

Characterization of Nuclear HIV-Induced Membraneless Organelles Through Fluorescence Microscopy

inferred← citeshttps://doi.org/10.1007/978-1-4614-9610-6_370-1openalex-snapshot

TRIM5alpha

inferred← citeshttps://doi.org/10.1007/978-1-4939-7101-5_370openalex-snapshot

TRIM5alpha

inferred← citeshttps://doi.org/10.1007/978-981-10-8456-0_8openalex-snapshot

The Retrovirus Capsid Core

inferred← citeshttps://doi.org/10.1007/s00018-018-2772-5openalex-snapshot

Cellular and molecular mechanisms of HIV-1 integration targeting

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tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation

inferred← citeshttps://doi.org/10.1007/s00044-024-03305-0openalex-snapshot

Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis

inferred← citeshttps://doi.org/10.1007/s00044-025-03495-1openalex-snapshot

Lenacapavir, a first-in-class, long-acting capsid inhibitor approved for both HIV-1 treatment and prevention

inferred← citeshttps://doi.org/10.1007/s10822-022-00446-5openalex-snapshot

Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid

inferred← citeshttps://doi.org/10.1007/s12250-019-00095-3openalex-snapshot

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

inferred← citeshttps://doi.org/10.1016/b978-0-12-811185-7.00002-9openalex-snapshot

Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription

inferred← citeshttps://doi.org/10.1016/b978-0-12-811185-7.00003-0openalex-snapshot

Nucleoporins in Retroviral Replication

inferred← citeshttps://doi.org/10.1016/b978-0-443-23932-8.00018-2openalex-snapshot

Lenacapavir: a first-in-class HIV-1 capsid inhibitor for the treatment of multidrug-resistant HIV infections

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2017.11.001openalex-snapshot

Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2016.08.006openalex-snapshot

The Multifaceted Contributions of Chromatin to HIV-1 Integration, Transcription, and Latency

inferred← citeshttps://doi.org/10.1016/j.antiviral.2026.106552openalex-snapshot

Identification of novel HIV-1 capsid protein (CA) inhibitors (ACAi-010 and ACAi-024) that promotes hyper-stabilization of HIV-1 CA in vitro

inferred← citeshttps://doi.org/10.1016/j.apsb.2020.07.016openalex-snapshot

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116414openalex-snapshot

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.12.087openalex-snapshot

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer

inferred← citeshttps://doi.org/10.1016/j.bpj.2022.02.014openalex-snapshot

Antiviral compounds modulate elasticity, strength and material fatigue of a virus capsid framework

inferred← citeshttps://doi.org/10.1016/j.bpj.2024.12.016openalex-snapshot

IP6, PF74 affect HIV-1 capsid stability through modulation of hexamer-hexamer tilt angle preference

inferred← citeshttps://doi.org/10.1016/j.cclet.2022.06.034openalex-snapshot

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

inferred← citeshttps://doi.org/10.1016/j.cell.2024.12.008openalex-snapshot

Passage of the HIV capsid cracks the nuclear pore

inferred← citeshttps://doi.org/10.1016/j.celrep.2015.10.036openalex-snapshot

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.07.079openalex-snapshot

FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115245openalex-snapshot

Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM

inferred← citeshttps://doi.org/10.1016/j.chembiol.2024.02.012openalex-snapshot

Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition

inferred← citeshttps://doi.org/10.1016/j.chom.2018.03.009openalex-snapshot

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

inferred← citeshttps://doi.org/10.1016/j.chom.2019.07.007openalex-snapshot

Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms

inferred← citeshttps://doi.org/10.1016/j.coviro.2020.07.001openalex-snapshot

Viral structural proteins as targets for antivirals

inferred← citeshttps://doi.org/10.1016/j.coviro.2021.03.005openalex-snapshot

Integrative structural biology of HIV-1 capsid protein assemblies: combining experiment and computation

inferred← citeshttps://doi.org/10.1016/j.coviro.2022.101203openalex-snapshot

Teaching old dogmas new tricks: recent insights into the nuclear import of HIV-1

inferred← citeshttps://doi.org/10.1016/j.crstbi.2020.10.002openalex-snapshot

A snapshot of HIV-1 capsid–host interactions

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.09.029openalex-snapshot

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112085openalex-snapshot

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112427openalex-snapshot

Chemical profiling of HIV-1 capsid-targeting antiviral PF74

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113380openalex-snapshot

An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113848openalex-snapshot

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

inferred← citeshttps://doi.org/10.1016/j.isci.2021.103593openalex-snapshot

GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

inferred← citeshttps://doi.org/10.1016/j.isci.2026.116378openalex-snapshot

Capsid and integrase play essential apposing roles in viral ribonucleoprotein assembly during HIV-1 core morphogenesis

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107701openalex-snapshot

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167691openalex-snapshot

CP-MAS and Solution NMR Studies of Allosteric Communication in CA-assemblies of HIV-1

inferred← citeshttps://doi.org/10.1016/j.jmgm.2017.10.021openalex-snapshot

FLIP: An assisting software in structure based drug design using fingerprint of protein-ligand interaction profiles

inferred← citeshttps://doi.org/10.1016/j.jviromet.2023.114834openalex-snapshot

Label-free imaging of nuclear membrane for analysis of nuclear import of viral complexes

inferred← citeshttps://doi.org/10.1016/j.molcel.2022.06.010openalex-snapshot

Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA

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The intersection of viral mimicry and nuclear entry

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Capsid-Dependent Host Factors in HIV-1 Infection

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HIV-1-induced translocation of CPSF6 to biomolecular condensates

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FAITH – Fast Assembly Inhibitor Test for HIV

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HIV-1 is more dependent on the K182 capsid residue than HIV-2 for interactions with CPSF6

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Identification of a Potential Inhibitor of the FIV p24 Capsid Protein and Characterization of Its Binding Site

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Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly

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HIV Capsid Assembly, Mechanism, and Structure

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Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

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Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold

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Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

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All-Atom Molecular Dynamics of Virus Capsids as Drug Targets

inferred← citeshttps://doi.org/10.1021/acs.langmuir.0c00103openalex-snapshot

Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders

inferred← citeshttps://doi.org/10.1021/acsami.9b08521openalex-snapshot

Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes

inferred← citeshttps://doi.org/10.1021/acsinfecdis.3c00708openalex-snapshot

A Branched SELEX Approach Identifies RNA Aptamers That Bind Distinct HIV-1 Capsid Structural Components

inferred← citeshttps://doi.org/10.1021/acsnano.5c06724openalex-snapshot

Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV-1 Capsid

inferred← citeshttps://doi.org/10.1021/jacs.2c10937openalex-snapshot

Engineering Metastability into a Virus-like Particle to Enable Triggered Dissociation

inferred← citeshttps://doi.org/10.1021/jacs.9b01413openalex-snapshot

Off-Pathway Assembly: A Broad-Spectrum Mechanism of Action for Drugs That Undermine Controlled HIV-1 Viral Capsid Formation

inferred← citeshttps://doi.org/10.1038/cmi.2016.06openalex-snapshot

Viral evasion of DNA-stimulated innate immune responses

inferred← citeshttps://doi.org/10.1038/ncomms7483openalex-snapshot

Chromatin organization at the nuclear pore favours HIV replication

inferred← citeshttps://doi.org/10.1038/nrmicro.2016.162openalex-snapshot

Nuclear landscape of HIV-1 infection and integration

inferred← citeshttps://doi.org/10.1038/nrmicro3490openalex-snapshot

HIV-1 assembly, release and maturation

inferred← citeshttps://doi.org/10.1038/nrmicro3503openalex-snapshot

HIV-1 capsid: the multifaceted key player in HIV-1 infection

inferred← citeshttps://doi.org/10.1038/s41467-020-17256-8openalex-snapshot

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

inferred← citeshttps://doi.org/10.1038/s41467-022-33662-6openalex-snapshot

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

inferred← citeshttps://doi.org/10.1038/s41467-023-41197-7openalex-snapshot

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

inferred← citeshttps://doi.org/10.1038/s41467-025-63363-9openalex-snapshot

Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging

inferred← citeshttps://doi.org/10.1038/s41564-020-0735-8openalex-snapshot

Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus

inferred← citeshttps://doi.org/10.1038/s41564-025-02054-zopenalex-snapshot

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability

inferred← citeshttps://doi.org/10.1038/s41564-025-02071-yopenalex-snapshot

HIV-1 capsid found guilty of breaking and entering

inferred← citeshttps://doi.org/10.1038/s41579-019-0225-2openalex-snapshot

Restriction of HIV-1 and other retroviruses by TRIM5

inferred← citeshttps://doi.org/10.1038/s41586-020-2443-1openalex-snapshot

Clinical targeting of HIV capsid protein with a long-acting small molecule

inferred← citeshttps://doi.org/10.1038/s41586-023-06966-wopenalex-snapshot

HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor

inferred← citeshttps://doi.org/10.1038/s41591-019-0560-xopenalex-snapshot

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

inferred← citeshttps://doi.org/10.1038/s41594-020-0467-8openalex-snapshot

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

inferred← citeshttps://doi.org/10.1038/s41594-022-00913-5openalex-snapshot

A molecular switch modulates assembly and host factor binding of the HIV-1 capsid

inferred← citeshttps://doi.org/10.1038/s41594-023-00925-9openalex-snapshot

Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels

inferred← citeshttps://doi.org/10.1038/s41594-025-01684-5openalex-snapshot

Nuclear pore passage of the HIV capsid is driven by its unusual surface amino acid composition

inferred← citeshttps://doi.org/10.1038/s41598-018-37150-0openalex-snapshot

Quantitative monitoring of the cytoplasmic release of NCp7 proteins from individual HIV-1 viral cores during the early steps of infection

inferred← citeshttps://doi.org/10.1038/s41598-019-53483-wopenalex-snapshot

A simple, high-throughput stabilization assay to test HIV-1 uncoating inhibitors

inferred← citeshttps://doi.org/10.1038/s44318-024-00316-wopenalex-snapshot

In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription

inferred← citeshttps://doi.org/10.1038/s44318-025-00652-5openalex-snapshot

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles

inferred← citeshttps://doi.org/10.1038/s44319-025-00567-6openalex-snapshot

Direct visualization of HIV-1 core nuclear import and its interplay with the nuclear pore

inferred← citeshttps://doi.org/10.1038/s44573-026-00005-1openalex-snapshot

Molecular mechanisms of HIV-1 entry into host cells and emerging therapeutic strategies

inferred← citeshttps://doi.org/10.1039/c9ra05869aopenalex-snapshot

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

inferred← citeshttps://doi.org/10.1039/d5md00111kopenalex-snapshot

Understanding the HIV-CA protein and the ligands that bind at the N-terminal domain (NTD) - C-terminal domain (CTD) interface

inferred← citeshttps://doi.org/10.1042/ebc20220047openalex-snapshot

How viral proteins bind short linear motifs and intrinsically disordered domains

inferred← citeshttps://doi.org/10.1073/pnas.1818059116openalex-snapshot

Derivation of simian tropic HIV-1 infectious clone reveals virus adaptation to a new host

inferred← citeshttps://doi.org/10.1073/pnas.1913754117openalex-snapshot

Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome

inferred← citeshttps://doi.org/10.1073/pnas.2019467118openalex-snapshot

HIV-1 cores retain their integrity until minutes before uncoating in the nucleus

inferred← citeshttps://doi.org/10.1073/pnas.2117781119openalex-snapshot

Strain and rupture of HIV-1 capsids during uncoating

inferred← citeshttps://doi.org/10.1073/pnas.2202815120openalex-snapshot

The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores

inferred← citeshttps://doi.org/10.1073/pnas.2220545120openalex-snapshot

Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM

inferred← citeshttps://doi.org/10.1073/pnas.2220557120openalex-snapshot

Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding

inferred← citeshttps://doi.org/10.1073/pnas.2420497122openalex-snapshot

Lenacapavir disrupts HIV-1 core integrity while stabilizing the capsid lattice

inferred← citeshttps://doi.org/10.1073/pnas.2524995123openalex-snapshot

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly

inferred← citeshttps://doi.org/10.1073/pnas.2534919123openalex-snapshot

HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient

inferred← citeshttps://doi.org/10.1074/jbc.m116.721647openalex-snapshot

The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes

inferred← citeshttps://doi.org/10.1074/jbc.m117.777029openalex-snapshot

N-terminal half of transportin SR2 interacts with HIV integrase

inferred← citeshttps://doi.org/10.1074/jbc.ra119.010534openalex-snapshot

The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b

inferred← citeshttps://doi.org/10.1080/10409238.2016.1215406openalex-snapshot

Oligomeric viral proteins: small in size, large in presence

inferred← citeshttps://doi.org/10.1080/17460441.2023.2157401openalex-snapshot

The discovery and design of novel HIV-1 capsid modulators and future perspectives

inferred← citeshttps://doi.org/10.1089/aid.2019.0250openalex-snapshot

The 4th and 112th Residues of Viral Capsid Cooperatively Modulate Capsid-CPSF6 Interactions of HIV-1

inferred← citeshttps://doi.org/10.1089/aid.2022.0161openalex-snapshot

The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration

inferred← citeshttps://doi.org/10.1093/jmcb/mjad076openalex-snapshot

The capsid revolution

inferred← citeshttps://doi.org/10.1093/nar/gkaa1207openalex-snapshot

Factors that mold the nuclear landscape of HIV-1 integration

inferred← citeshttps://doi.org/10.1093/nar/gkaa536openalex-snapshot

The chromatin landscape at the HIV-1 provirus integration site determines viral expression

inferred← citeshttps://doi.org/10.1093/nar/gkab1293openalex-snapshot

Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication

inferred← citeshttps://doi.org/10.1093/nar/gkae769openalex-snapshot

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration

inferred← citeshttps://doi.org/10.1097/coh.0000000000000472openalex-snapshot

Inhibitors of the HIV-1 capsid, a target of opportunity

inferred← citeshttps://doi.org/10.1099/jgv.0.002057openalex-snapshot

HIV capsids: orchestrators of innate immune evasion, pathogenesis and pandemicity

inferred← citeshttps://doi.org/10.1099/jgv.0.002104openalex-snapshot

The identification of a novel interaction site for the human immunodeficiency virus capsid on nucleoporin 153

inferred← citeshttps://doi.org/10.1101/2020.08.10.245522openalex-snapshot

A DNA-origami nuclear pore mimic reveals nuclear entry mechanisms of HIV-1 capsid

inferred← citeshttps://doi.org/10.1101/2020.09.17.302315openalex-snapshot

Chemical Stabilization of the HIV-1 Capsid Results in Efficient HIV-1 Reverse Transcription in vitro

inferred← citeshttps://doi.org/10.1101/2022.01.10.472699openalex-snapshot

Recognition of HIV-1 Capsid Licenses Innate Immune Response to Viral Infection

inferred← citeshttps://doi.org/10.1101/2023.03.23.534032openalex-snapshot

Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores

inferred← citeshttps://doi.org/10.1101/2023.08.16.553511openalex-snapshot

Structure of a benzosulfonamide based inhibitor – 11l - bound to a disulfide stabilised HIV-1 capsid hexamer

inferred← citeshttps://doi.org/10.1101/2023.12.11.571135openalex-snapshot

Differentiation SELEX approach identifies RNA aptamers with different specificities for HIV-1 capsid assembly forms

inferred← citeshttps://doi.org/10.1101/2024.06.15.599180openalex-snapshot

Cyclophilin A Facilitates HIV-1 DNA Integration

inferred← citeshttps://doi.org/10.1101/2024.12.05.627050openalex-snapshot

Kinetic Implications of IP 6 Anion Binding on the Molecular Switch of the HIV-1 Capsid Assembly

inferred← citeshttps://doi.org/10.1101/2025.02.09.637297openalex-snapshot

Structural basis for HIV-1 capsid adaption to rescue IP6-packaging deficiency

inferred← citeshttps://doi.org/10.1101/2025.03.13.643050openalex-snapshot

Governed by surface amino acid composition: HIV capsid passage through the NPC barrier

inferred← citeshttps://doi.org/10.1101/2025.07.24.662752openalex-snapshot

Characterization of antiviral compounds using Bio-Layer Interferometry

inferred← citeshttps://doi.org/10.1101/2025.08.11.669633openalex-snapshot

Competitive binding and geometric changes allow fast, complete translocation of intact HIV-1 capsids through the nuclear pore complex

inferred← citeshttps://doi.org/10.1101/2025.10.02.680059openalex-snapshot

Translocation of HIV capsid core through the Nuclear Pore Complex by affinity gradient

inferred← citeshttps://doi.org/10.1101/774943openalex-snapshot

Identification of Chikungunya virus nucleocapsid core assembly modulators

inferred← citeshttps://doi.org/10.1101/837120openalex-snapshot

Selection of HIV-1 for Resistance to Fifth Generation Protease Inhibitors Reveals Two Independent Pathways to High-Level Resistance

inferred← citeshttps://doi.org/10.1109/jtehm.2020.2963894openalex-snapshot

Extra-Low-Frequency Pulse Stimulated Conformational Change in Blood-Cell Proteins and Consequent Immune Activity Transformation

inferred← citeshttps://doi.org/10.1126/sciadv.abc6465openalex-snapshot

Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP 6 )

inferred← citeshttps://doi.org/10.1126/sciadv.abj5715openalex-snapshot

Structure of native HIV-1 cores and their interactions with IP6 and CypA

inferred← citeshttps://doi.org/10.1126/sciadv.adt7818openalex-snapshot

Kinetic implications of IP 6 anion binding on the molecular switch of HIV-1 capsid assembly

inferred← citeshttps://doi.org/10.1126/sciadv.aed8384openalex-snapshot

Lenacapavir allosterically remodels the HIV-1 capsid

inferred← citeshttps://doi.org/10.1126/science.aaa5936openalex-snapshot

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

inferred← citeshttps://doi.org/10.1126/science.abb4808openalex-snapshot

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

inferred← citeshttps://doi.org/10.1128/aac.00309-25openalex-snapshot

Preclinical virology profiles of the HIV-1 capsid inhibitors VH4004280 and VH4011499

inferred← citeshttps://doi.org/10.1128/aac.00646-15openalex-snapshot

Microplate-Based Assay for Identifying Small Molecules That Bind a Specific Intersubunit Interface within the Assembled HIV-1 Capsid

inferred← citeshttps://doi.org/10.1128/aac.01694-22openalex-snapshot

Antiviral Properties of HIV-1 Capsid Inhibitor GSK878

inferred← citeshttps://doi.org/10.1128/aac.02574-15openalex-snapshot

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

inferred← citeshttps://doi.org/10.1128/jvi.00019-16openalex-snapshot

Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo

inferred← citeshttps://doi.org/10.1128/jvi.00340-15openalex-snapshot

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry

inferred← citeshttps://doi.org/10.1128/jvi.00368-18openalex-snapshot

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid

inferred← citeshttps://doi.org/10.1128/jvi.00476-15openalex-snapshot

Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells

inferred← citeshttps://doi.org/10.1128/jvi.00490-25openalex-snapshot

CPSF6 promotes HIV-1 preintegration complex function

inferred← citeshttps://doi.org/10.1128/jvi.00558-19openalex-snapshot

K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α

inferred← citeshttps://doi.org/10.1128/jvi.00640-20openalex-snapshot

TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein Is Independent of the Cargo-Binding Domain

inferred← citeshttps://doi.org/10.1128/jvi.00648-18openalex-snapshot

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells

inferred← citeshttps://doi.org/10.1128/jvi.00706-19openalex-snapshot

A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing

inferred← citeshttps://doi.org/10.1128/jvi.00845-18openalex-snapshot

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating

inferred← citeshttps://doi.org/10.1128/jvi.00883-20openalex-snapshot

Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly

inferred← citeshttps://doi.org/10.1128/jvi.00947-24openalex-snapshot

Cyclophilin A facilitates HIV-1 integration

inferred← citeshttps://doi.org/10.1128/jvi.00984-20openalex-snapshot

Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection

inferred← citeshttps://doi.org/10.1128/jvi.00986-19openalex-snapshot

Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid

inferred← citeshttps://doi.org/10.1128/jvi.00991-20openalex-snapshot

In Vitro Quantification of the Effects of IP6 and Other Small Polyanions on Immature HIV-1 Particle Assembly and Core Stability

inferred← citeshttps://doi.org/10.1128/jvi.01024-19openalex-snapshot

Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration

inferred← citeshttps://doi.org/10.1128/jvi.01338-20openalex-snapshot

Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz

inferred← citeshttps://doi.org/10.1128/jvi.01445-21openalex-snapshot

HIV-1 CA Inhibitors Are Antagonized by Inositol Phosphate Stabilization of the Viral Capsid in Cells

inferred← citeshttps://doi.org/10.1128/jvi.01741-18openalex-snapshot

PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex

inferred← citeshttps://doi.org/10.1128/jvi.02155-16openalex-snapshot

Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein

inferred← citeshttps://doi.org/10.1128/jvi.03116-15openalex-snapshot

Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74

inferred← citeshttps://doi.org/10.1128/jvi.03202-15openalex-snapshot

SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV

inferred← citeshttps://doi.org/10.1128/mbio.00169-25openalex-snapshot

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

inferred← citeshttps://doi.org/10.1128/mbio.00212-22openalex-snapshot

HIV-1 capsid and viral DNA integration

inferred← citeshttps://doi.org/10.1128/mbio.01959-22openalex-snapshot

Direct Capsid Labeling of Infectious HIV-1 by Genetic Code Expansion Allows Detection of Largely Complete Nuclear Capsids and Suggests Nuclear Entry of HIV-1 Complexes via Common Routes

inferred← citeshttps://doi.org/10.1128/mbio.02254-20openalex-snapshot

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

inferred← citeshttps://doi.org/10.1128/mbio.02501-19openalex-snapshot

Analysis of CA Content and CPSF6 Dependence of Early HIV-1 Replication Complexes in SupT1-R5 Cells

inferred← citeshttps://doi.org/10.1128/mbio.02572-21openalex-snapshot

The innate immune factor RPRD2/REAF and its role in the Lv2 restriction of HIV

inferred← citeshttps://doi.org/10.1128/mbio.02820-20openalex-snapshot

The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid

inferred← citeshttps://doi.org/10.1128/mbio.03613-24openalex-snapshot

Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir

inferred← citeshttps://doi.org/10.1128/mmbr.00048-22openalex-snapshot

Capsid–host interactions for HIV-1 ingress

inferred← citeshttps://doi.org/10.1146/annurev-virology-020922-110929openalex-snapshot

Nuclear Capsid Uncoating and Reverse Transcription of HIV-1

inferred← citeshttps://doi.org/10.1146/annurev-virology-100424-125355openalex-snapshot

Visualizing Viral Transport Through the Nuclear Pore by Cryo–Electron Microscopy and Cryo–Electron Tomography

inferred← citeshttps://doi.org/10.1186/s12977-016-0262-0openalex-snapshot

HIV-1 capsid is involved in post-nuclear entry steps

inferred← citeshttps://doi.org/10.1186/s12977-019-0472-3openalex-snapshot

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

inferred← citeshttps://doi.org/10.1186/s12977-020-00524-2openalex-snapshot

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

inferred← citeshttps://doi.org/10.1186/s12977-021-00577-xopenalex-snapshot

HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules

inferred← citeshttps://doi.org/10.1186/s12977-021-00583-zopenalex-snapshot

Rotten to the core: antivirals targeting the HIV-1 capsid core

inferred← citeshttps://doi.org/10.1186/s12977-024-00645-yopenalex-snapshot

Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005085openalex-snapshot

Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005700openalex-snapshot

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005709openalex-snapshot

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005897openalex-snapshot

A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection

inferred← citeshttps://doi.org/10.1371/journal.ppat.1006460openalex-snapshot

Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

inferred← citeshttps://doi.org/10.1371/journal.ppat.1009484openalex-snapshot

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

inferred← citeshttps://doi.org/10.1371/journal.ppat.1010754openalex-snapshot

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012206openalex-snapshot

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012354openalex-snapshot

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection

inferred← citeshttps://doi.org/10.1371/journal.ppat.1012537openalex-snapshot

Elasticity of the HIV-1 core facilitates nuclear entry and infection

inferred← citeshttps://doi.org/10.1557/s43580-026-01619-2openalex-snapshot

Characterization of Lenacapavir by DFT: Evaluation of electronic properties and improvement of antiviral potential

inferred← citeshttps://doi.org/10.2174/1568026615666150902102143openalex-snapshot

HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors

inferred← citeshttps://doi.org/10.2174/1568026619666190712204603openalex-snapshot

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

inferred← citeshttps://doi.org/10.2174/1570162x14999160224094914openalex-snapshot

The Early Bird Catches the Worm - Can Evolution Teach us Lessons in Fighting HIV?

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