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Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

https://doi.org/10.1073/pnas.1607984113
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s12253-009-9227-0openalex-snapshot
Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction
inferredcites →https://doi.org/10.1016/j.cell.2007.04.030openalex-snapshot
Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression
inferredcites →https://doi.org/10.1016/j.cell.2009.04.050openalex-snapshot
Modes of p53 Regulation
inferredcites →https://doi.org/10.1016/j.cell.2010.05.031openalex-snapshot
Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells
inferredcites →https://doi.org/10.1016/j.celrep.2014.09.021openalex-snapshot
Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data
inferredcites →https://doi.org/10.1016/j.conb.2013.02.018openalex-snapshot
Circadian timekeeping and output mechanisms in animals
inferredcites →https://doi.org/10.1016/j.drup.2003.10.004openalex-snapshot
The importance of p53 location: nuclear or cytoplasmic zip code?
inferredcites →https://doi.org/10.1016/j.molcel.2008.03.016openalex-snapshot
Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
inferredcites →https://doi.org/10.1016/s0076-6879(05)93020-6openalex-snapshot
Nucleocytoplasmic Shuttling of Clock Proteins
inferredcites →https://doi.org/10.1016/s0092-8674(02)00961-3openalex-snapshot
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
inferredcites →https://doi.org/10.1021/bi5007354openalex-snapshot
Circadian Clock, Cancer, and Chemotherapy
inferredcites →https://doi.org/10.1038/cdd.2009.173openalex-snapshot
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding
inferredcites →https://doi.org/10.1038/msb.2012.62openalex-snapshot
A mechanism for robust circadian timekeeping via stoichiometric balance
inferredcites →https://doi.org/10.1038/msb4100128openalex-snapshot
Functioning and robustness of a bacterial circadian clock
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NIH Image to ImageJ: 25 years of image analysis
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The genetics of mammalian circadian order and disorder: implications for physiology and disease
inferredcites →https://doi.org/10.1038/sj.cgt.7701061openalex-snapshot
Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice
inferredcites →https://doi.org/10.1038/sj.onc.1200949openalex-snapshot
The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited
inferredcites →https://doi.org/10.1049/iet-syb.2015.0090openalex-snapshot
Protein sequestration versus Hill‐type repression in circadian clock models
inferredcites →https://doi.org/10.1073/pnas.0409763102openalex-snapshot
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo
inferredcites →https://doi.org/10.1073/pnas.0605420103openalex-snapshot
Quantification of protein half-lives in the budding yeast proteome
inferredcites →https://doi.org/10.1073/pnas.1320474111openalex-snapshot
Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle
inferredcites →https://doi.org/10.1073/pnas.1432104100openalex-snapshot
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
inferredcites →https://doi.org/10.1091/mbc.e14-05-0993openalex-snapshot
The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells
inferredcites →https://doi.org/10.1091/mbc.e14-05-0994openalex-snapshot
Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling
inferredcites →https://doi.org/10.1093/bioinformatics/btl522openalex-snapshot
Parameter estimation using Simulated Annealing for S-system models of biochemical networks
inferredcites →https://doi.org/10.1093/jb/mvn167openalex-snapshot
-Catenin Induces -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice
inferredcites →https://doi.org/10.1093/nar/17.15.6419openalex-snapshot
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
inferredcites →https://doi.org/10.1101/sqb.2007.72.001openalex-snapshot
The Multiple Facets of Per2
inferredcites →https://doi.org/10.1101/sqb.2007.72.036openalex-snapshot
Role of Phosphorylation in the Mammalian Circadian Clock
inferredcites →https://doi.org/10.1124/jpet.109.151415openalex-snapshot
Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period
inferredcites →https://doi.org/10.1126/science.1091362openalex-snapshot
Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
inferredcites →https://doi.org/10.1126/science.1218351openalex-snapshot
p53 Dynamics Control Cell Fate
inferredcites →https://doi.org/10.1126/science.289.5488.2344openalex-snapshot
Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling
inferredcites →https://doi.org/10.1137/120867809openalex-snapshot
On the Existence and Uniqueness of Biological Clock Models Matching Experimental Data
inferredcites →https://doi.org/10.1146/annurev-neuro-060909-153128openalex-snapshot
Central and Peripheral Circadian Clocks in Mammals
inferredcites →https://doi.org/10.1177/0748730410379711openalex-snapshot
JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets
inferredcites →https://doi.org/10.1186/1740-3391-8-3openalex-snapshot
Circadian rhythm and its role in malignancy
inferredcites →https://doi.org/10.1186/1752-0509-2-22openalex-snapshot
Global parameter search reveals design principles of the mammalian circadian clock
inferredcites →https://doi.org/10.1371/journal.pone.0065242openalex-snapshot
Mechanisms That Enhance Sustainability of p53 Pulses
inferredcites →https://doi.org/10.15252/msb.20145218openalex-snapshot
Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells
inferredcites →https://doi.org/10.4161/cc.26614openalex-snapshot
Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis
inferredcites →https://doi.org/10.4161/cc.9.6.11046openalex-snapshot
Circadian rhythms and cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114407openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bpj.2018.07.029openalex-snapshot
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Three limit cycles in the Kim–Forger model of the mammalian circadian clock
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A primer on model selection using the Akaike Information Criterion
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105546openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.isci.2025.112269openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.molp.2019.08.005openalex-snapshot
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EP300 as a potential mediator of stress-induced sleep disruption through blood-brain barrier dysfunction and neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.tem.2019.05.001openalex-snapshot
Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism
inferred← citeshttps://doi.org/10.1016/j.trecan.2019.07.002openalex-snapshot
Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment
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inferred← citeshttps://doi.org/10.1038/s41567-025-02882-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41568-020-0291-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-020-61087-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1073/pnas.2101416118openalex-snapshot
CRY2 missense mutations suppress P53 and enhance cell growth
inferred← citeshttps://doi.org/10.1073/pnas.2113403119openalex-snapshot
Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons
inferred← citeshttps://doi.org/10.1073/pnas.2311854121openalex-snapshot
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer
inferred← citeshttps://doi.org/10.1073/pnas.2401496121openalex-snapshot
Telling time in tumor samples reveals diversity of clock disruption
inferred← citeshttps://doi.org/10.1080/07420528.2019.1681440openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/07853890.2025.2528449openalex-snapshot
Clock genes in pancreatic disease progression: from circadian regulation to dysfunction
inferred← citeshttps://doi.org/10.1080/15384101.2018.1558638openalex-snapshot
The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1
inferred← citeshttps://doi.org/10.1093/bioinformatics/btab297openalex-snapshot
Model learning to identify systemic regulators of the peripheral circadian clock
inferred← citeshttps://doi.org/10.1093/bioinformatics/btab623openalex-snapshot
Inferring causality in biological oscillators
inferred← citeshttps://doi.org/10.1098/rsfs.2021.0084openalex-snapshot
Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations
inferred← citeshttps://doi.org/10.1098/rsfs.2022.0011openalex-snapshot
Time-keeping and decision-making in living cells: Part I
inferred← citeshttps://doi.org/10.1101/2020.09.15.297648openalex-snapshot
Mathematical Analysis of Robustness of Oscillations in Models of the Mammalian Circadian Clock
inferred← citeshttps://doi.org/10.1101/2023.05.17.540386openalex-snapshot
Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis
inferred← citeshttps://doi.org/10.1101/2023.08.06.23293720openalex-snapshot
WITHDRAWN: Period2-mediated downregulation of ERK/MAPK phosphorylation in nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1109/tcbb.2020.3040368openalex-snapshot
Circadian Rhythm Regulated by Tumor Suppressor p53 and Time Delay in Unstressed Cells
inferred← citeshttps://doi.org/10.1109/tnnls.2024.3424784openalex-snapshot
Oscillatory Dynamics and Regulatory Mechanisms of the p53–Per2 Network in DNA-Damaged Cells
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Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2
inferred← citeshttps://doi.org/10.1146/annurev-cancerbio-030617-050216openalex-snapshot
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inferred← citeshttps://doi.org/10.1155/2020/8587458openalex-snapshot
Aberrant Expression and Subcellular Localization of PER2 Promote the Progression of Oral Squamous Cell Carcinoma
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inferred← citeshttps://doi.org/10.1186/s40170-026-00424-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1371/journal.pbio.3000228openalex-snapshot
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Modeling the interactions of sense and antisense Period transcripts in the mammalian circadian clock network
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mTOR signaling regulates central and peripheral circadian clock function
inferred← citeshttps://doi.org/10.1371/journal.pone.0221180openalex-snapshot
Thermal stability analyses of human PERIOD-2 C-terminal domain using dynamic light scattering and circular dichroism
inferred← citeshttps://doi.org/10.1371/journal.pone.0227786openalex-snapshot
Frequency switching between oscillatory homeostats and the regulation of p53
inferred← citeshttps://doi.org/10.14336/ad.2024.0533openalex-snapshot
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inferred← citeshttps://doi.org/10.15252/msb.20198838openalex-snapshot
Systems approach reveals photosensitivity and PER2 level as determinants of clock‐modulator efficacy
inferred← citeshttps://doi.org/10.18632/oncotarget.20835openalex-snapshot
Aberrant rhythmic expression ofcryptochrome2regulates the radiosensitivity of rat gliomas
inferred← citeshttps://doi.org/10.3389/fendo.2020.00638openalex-snapshot
Circadian Genes as Therapeutic Targets in Pancreatic Cancer
inferred← citeshttps://doi.org/10.3389/fmolb.2021.747629openalex-snapshot
Circadian Clock Genes Modulate Immune, Cell Cycle and Apoptosis in the Diagnosis and Prognosis of Pan-Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1264553openalex-snapshot
Period2 is associated with immune cell infiltration and is a potential diagnostic and prognostic marker for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3389/fneur.2017.00025openalex-snapshot
Systems Biology-Derived Discoveries of Intrinsic Clocks
inferred← citeshttps://doi.org/10.3389/fphys.2020.00327openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fphys.2026.1895249openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/biomedicines13061500openalex-snapshot
Regulation of Stemness by NR1D2 in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/cancers12040853openalex-snapshot
The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model
inferred← citeshttps://doi.org/10.3390/cancers14061578openalex-snapshot
Circadian and Immunity Cycle Talk in Cancer Destination: From Biological Aspects to In Silico Analysis
inferred← citeshttps://doi.org/10.3390/cancers14143458openalex-snapshot
Core-Clock Genes Regulate Proliferation and Invasion via a Reciprocal Interplay with MACC1 in Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.3390/cells12030490openalex-snapshot
Encoding and Decoding of p53 Dynamics in Cellular Response to Stresses
inferred← citeshttps://doi.org/10.3390/cells12232724openalex-snapshot
Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases
inferred← citeshttps://doi.org/10.3390/ijms18040873openalex-snapshot
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism
inferred← citeshttps://doi.org/10.3390/ijms22158289openalex-snapshot
Adjusting the Molecular Clock: The Importance of Circadian Rhythms in the Development of Glioblastomas and Its Intervention as a Therapeutic Strategy
inferred← citeshttps://doi.org/10.3390/ijms252010926openalex-snapshot
The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging
inferred← citeshttps://doi.org/10.3390/ijms26178296openalex-snapshot
Daytime-Dependent Effects of Thiamine on the Thiamine Pool and Pyruvate Dehydrogenase Regulation in the Brain and Heart
inferred← citeshttps://doi.org/10.3892/or.2020.7624openalex-snapshot
PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β‑catenin signaling pathway
inferred← citeshttps://doi.org/10.48550/arxiv.2110.10604openalex-snapshot
Bayesian Model Calibration and Sensitivity Analysis for Oscillating Biological Experiments
inferred← citeshttps://doi.org/10.6084/m9.figshare.14576688openalex-snapshot
Additional file 1 of A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation
inferred← citeshttps://doi.org/10.6084/m9.figshare.14576691openalex-snapshot
Additional file 2 of A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation
inferred← citeshttps://doi.org/10.70675/5488e904z57a3z4fd6z83d2z795ca0557b09openalex-snapshot
On learning mechanistic models from time series data with applications to personalised chronotherapies
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