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Small molecule modulation of Smoothened activity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/bf00848156openalex-snapshot
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
inferredcites →https://doi.org/10.1016/0092-8674(89)90021-4openalex-snapshot
The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
inferredcites →https://doi.org/10.1016/s0092-8674(00)00056-8openalex-snapshot
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
inferredcites →https://doi.org/10.1016/s0092-8674(00)00129-xopenalex-snapshot
Transducing the Hedgehog Signal
inferredcites →https://doi.org/10.1016/s0092-8674(00)80094-xopenalex-snapshot
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal
inferredcites →https://doi.org/10.1016/s0092-8674(00)80292-5openalex-snapshot
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
inferredcites →https://doi.org/10.1016/s0092-8674(00)81960-1openalex-snapshot
Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression
inferredcites →https://doi.org/10.1016/s0092-8674(01)00385-3openalex-snapshot
Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node
inferredcites →https://doi.org/10.1016/s0304-3835(01)00676-0openalex-snapshot
The role of hedgehog signalling in tumorigenesis
inferredcites →https://doi.org/10.1016/s0896-6273(00)80645-5openalex-snapshot
Hedgehog and Patched in Neural Development and Disease
inferredcites →https://doi.org/10.1016/s0960-9822(00)00755-7openalex-snapshot
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
inferredcites →https://doi.org/10.1016/s0960-9822(02)00895-3openalex-snapshot
Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes
inferredcites →https://doi.org/10.1038/341508a0openalex-snapshot
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
inferredcites →https://doi.org/10.1038/35023008openalex-snapshot
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
inferredcites →https://doi.org/10.1038/35035110openalex-snapshot
arrow encodes an LDL-receptor-related protein essential for Wingless signalling
inferredcites →https://doi.org/10.1038/35035124openalex-snapshot
An LDL-receptor-related protein mediates Wnt signalling in mice
inferredcites →https://doi.org/10.1038/35077219openalex-snapshot
The Hedgehog and Wnt signalling pathways in cancer
inferredcites →https://doi.org/10.1038/35080071openalex-snapshot
How proteins move lipids and lipids move proteins
inferredcites →https://doi.org/10.1038/382225a0openalex-snapshot
A new member of the frizzled family from Drosophila functions as a Wingless receptor
inferredcites →https://doi.org/10.1038/382547a0openalex-snapshot
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
inferredcites →https://doi.org/10.1038/384129a0openalex-snapshot
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
inferredcites →https://doi.org/10.1038/384176a0openalex-snapshot
Biochemical evidence that Patched is the Hedgehog receptor
inferredcites →https://doi.org/10.1038/nature00989openalex-snapshot
Patched acts catalytically to suppress the activity of Smoothened
inferredcites →https://doi.org/10.1038/sj.onc.1202360openalex-snapshot
A frequent activated smoothened mutation in sporadic basal cell carcinomas
inferredcites →https://doi.org/10.1073/pnas.96.20.10992openalex-snapshot
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
inferredcites →https://doi.org/10.1101/gad.1025302openalex-snapshot
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
inferredcites →https://doi.org/10.1101/gad.938601openalex-snapshot
Hedgehog signaling in animal development: paradigms and principles
inferredcites →https://doi.org/10.1124/pr.54.2.323openalex-snapshot
G Protein-Coupled Receptor Allosterism and Complexing
inferredcites →https://doi.org/10.1126/science.1073733openalex-snapshot
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
inferredcites →https://doi.org/10.1126/science.277.5329.1109openalex-snapshot
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
inferredcites →https://doi.org/10.1126/science.280.5369.1603openalex-snapshot
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
inferredcites →https://doi.org/10.1126/science.290.5500.2295openalex-snapshot
Transmembrane Molecular Pump Activity of Niemann-Pick C1 Protein
inferredcites →https://doi.org/10.1186/1475-4924-1-10openalex-snapshot
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
inferredcites →https://doi.org/10.1242/dev.125.18.3553openalex-snapshot
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
inferredcites →https://doi.org/10.1242/dev.127.10.2189openalex-snapshot
The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
inferredcites →https://doi.org/10.1242/dev.128.12.2385openalex-snapshot
Analysis of the zebrafishsmoothenedmutant reveals conserved and divergent functions of hedgehog activity
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4162922openalex-extracted
Design, Synthesis and Activity Evaluation of Hedgehog Inhibitor Itraconazole Derivatives
inferred← citeshttps://doi.org/10.1002/9783527619375.ch7aopenalex-snapshot
Reverse Chemical Genetics – An Important Strategy for the Study of Protein Function in Chemical Biology and Drug Discovery
inferred← citeshttps://doi.org/10.1002/advs.202400063openalex-snapshot
Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development
inferred← citeshttps://doi.org/10.1002/advs.202506738openalex-snapshot
Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities
inferred← citeshttps://doi.org/10.1002/advs.202520749openalex-snapshot
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
inferred← citeshttps://doi.org/10.1002/ange.200805666openalex-snapshot
The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling
inferred← citeshttps://doi.org/10.1002/ange.201004284openalex-snapshot
Chemische Kontrolle des Schicksals und Entwicklungspotenzials von Stammzellen
inferred← citeshttps://doi.org/10.1002/ange.201306948openalex-snapshot
Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid‐Inspired Compound Collection
inferred← citeshttps://doi.org/10.1002/ange.201307392openalex-snapshot
Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling
inferred← citeshttps://doi.org/10.1002/ange.201602932openalex-snapshot
Organokatalytische Synthese von enantiomerenreinen 2H‐ und 3H‐Pyrrolen: Inhibitoren des Hedgehog‐Signalwegs
inferred← citeshttps://doi.org/10.1002/ange.201707394openalex-snapshot
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction
inferred← citeshttps://doi.org/10.1002/ange.201907632openalex-snapshot
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß
inferred← citeshttps://doi.org/10.1002/ange.202115193openalex-snapshot
The Pseudo‐Natural Product Rhonin Targets RHOGDI
inferred← citeshttps://doi.org/10.1002/anie.200805666openalex-snapshot
The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling
inferred← citeshttps://doi.org/10.1002/anie.201004284openalex-snapshot
Chemical Control of Stem Cell Fate and Developmental Potential
inferred← citeshttps://doi.org/10.1002/anie.201306948openalex-snapshot
Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid‐Inspired Compound Collection
inferred← citeshttps://doi.org/10.1002/anie.201307392openalex-snapshot
Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling
inferred← citeshttps://doi.org/10.1002/anie.201602932openalex-snapshot
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
inferred← citeshttps://doi.org/10.1002/anie.201707394openalex-snapshot
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction
inferred← citeshttps://doi.org/10.1002/anie.201907632openalex-snapshot
Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß
inferred← citeshttps://doi.org/10.1002/anie.202115193openalex-snapshot
The Pseudo‐Natural Product Rhonin Targets RHOGDI
inferred← citeshttps://doi.org/10.1002/art.41250openalex-snapshot
Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis
inferred← citeshttps://doi.org/10.1002/bdr2.2127openalex-snapshot
High‐throughput detection of craniofacial defects in fluorescent zebrafish
inferred← citeshttps://doi.org/10.1002/bdra.23571openalex-snapshot
Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice
inferred← citeshttps://doi.org/10.1002/bdrc.20076openalex-snapshot
Hedgehog signaling in skeletal development
inferred← citeshttps://doi.org/10.1002/bies.20663openalex-snapshot
Greased hedgehogs: New links between hedgehog signaling and cholesterol metabolism
inferred← citeshttps://doi.org/10.1002/cbic.200700403openalex-snapshot
A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway
inferred← citeshttps://doi.org/10.1002/cbic.201700631openalex-snapshot
Hedgehog Antagonist Pyrimidine–Indole Hybrid Molecule Inhibits Ciliogenesis through Microtubule Destabilisation
inferred← citeshttps://doi.org/10.1002/cbin.10544openalex-snapshot
Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract
inferred← citeshttps://doi.org/10.1002/cmdc.201300358openalex-snapshot
Hedgehog Pathway Agonism: Therapeutic Potential and Small‐Molecule Development
inferred← citeshttps://doi.org/10.1002/cmdc.202000169openalex-snapshot
Bicyclic Imidazolium Inhibitors of Gli Transcription Factor Activity
inferred← citeshttps://doi.org/10.1002/cncr.28439openalex-snapshot
Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma
inferred← citeshttps://doi.org/10.1002/dneu.22368openalex-snapshot
FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning
inferred← citeshttps://doi.org/10.1002/dvdy.21381openalex-snapshot
Developmental signaling pathways in brain tumor‐derived stem‐like cells
inferred← citeshttps://doi.org/10.1002/dvdy.21453openalex-snapshot
A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (mollusca) mantle
inferred← citeshttps://doi.org/10.1002/dvdy.21610openalex-snapshot
Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines
inferred← citeshttps://doi.org/10.1002/dvdy.21762openalex-snapshot
Signaling pathways regulating the expression of Prx1 and Prx2 in the chick mandibular mesenchyme
inferred← citeshttps://doi.org/10.1002/dvdy.22600openalex-snapshot
Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development
inferred← citeshttps://doi.org/10.1002/dvdy.24276openalex-snapshot
Cerebellar granule cells are predominantly generated by terminal symmetric divisions of granule cell precursors
inferred← citeshttps://doi.org/10.1002/dvdy.24361openalex-snapshot
Chronic up‐regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice
inferred← citeshttps://doi.org/10.1002/dvg.20820openalex-snapshot
An embryonic stem cell‐based system for rapid analysis of transcriptional enhancers
inferred← citeshttps://doi.org/10.1002/ejoc.201800667openalex-snapshot
New Spiro‐Lactam C‐nor‐ D ‐homo Steroids
inferred← citeshttps://doi.org/10.1002/gene.10208openalex-snapshot
Patched 1 conditional null allele in mice
inferred← citeshttps://doi.org/10.1002/glia.23967openalex-snapshot
Functional cooperation of the hedgehog and androgen signaling pathways during developmental and repairing myelination
inferred← citeshttps://doi.org/10.1002/hep.23649openalex-snapshot
Activation of Rac1 Promotes Hedgehog-Mediated Acquisition of the Myofibroblastic Phenotype in Rat and Human Hepatic Stellate Cells
inferred← citeshttps://doi.org/10.1002/humu.21117openalex-snapshot
Widening the mutation spectrum ofEVCandEVC2: ectopic expression of Weyer variants in NIH 3T3 fibroblasts disrupts hedgehog signaling
inferred← citeshttps://doi.org/10.1002/ijc.27820openalex-snapshot
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
inferred← citeshttps://doi.org/10.1002/ijc.31724openalex-snapshot
Synergistic cross‐talk of hedgehog and interleukin‐6 signaling drives growth of basal cell carcinoma
inferred← citeshttps://doi.org/10.1002/jbmr.4411openalex-snapshot
Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition
inferred← citeshttps://doi.org/10.1002/jcp.22227openalex-snapshot
Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice
inferred← citeshttps://doi.org/10.1002/jcp.26947openalex-snapshot
Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration
inferred← citeshttps://doi.org/10.1002/jcp.30787openalex-snapshot
Ciliary membrane, localised lipid modification and cilia function
inferred← citeshttps://doi.org/10.1002/jcp.30943openalex-snapshot
Inactivation of Sufu in cementoblasts accelerates external tooth root resorption
inferred← citeshttps://doi.org/10.1002/jnr.23343openalex-snapshot
Primary cilia mediate sonic hedgehog signaling to regulate neuronal‐like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro
inferred← citeshttps://doi.org/10.1002/jnr.25008openalex-snapshot
Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol‐induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder
inferred← citeshttps://doi.org/10.1002/jor.23913openalex-snapshot
ACTIVATION OF HEDGEHOG SIGNALING BY SYSTEMIC AGONIST IMPROVES FRACTURE HEALING IN AGED MICE
inferred← citeshttps://doi.org/10.1002/jor.24017openalex-snapshot
Activation of hedgehog signaling by systemic agonist improves fracture healing in aged mice
inferred← citeshttps://doi.org/10.1002/jor.25493openalex-snapshot
Sequential application of small molecule therapy enhances chondrogenesis and angiogenesis in murine segmental defect bone repair
inferred← citeshttps://doi.org/10.1002/mc.20394openalex-snapshot
Cyclopamine treatment of full‐blown Hh/Ptch‐associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth
inferred← citeshttps://doi.org/10.1002/med.20088openalex-snapshot
Pathogenesis of medulloblastoma and current treatment outlook
inferred← citeshttps://doi.org/10.1002/med.21482openalex-snapshot
Strategies to target the Hedgehog signaling pathway for cancer therapy
inferred← citeshttps://doi.org/10.1002/med.21555openalex-snapshot
Design of Hedgehog pathway inhibitors for cancer treatment
inferred← citeshttps://doi.org/10.1002/neu.20160openalex-snapshot
Brain as a paradigm of organ growth: Hedgehog–Gli signaling in neural stem cells and brain tumors
inferred← citeshttps://doi.org/10.1002/open.202500119openalex-snapshot
Evaluation of Benzo[ cd ]indol‐2(1 H )‐ones as Downstream Hedgehog Pathway Inhibitors
inferred← citeshttps://doi.org/10.1002/path.2877openalex-snapshot
miR‐338‐3p suppresses invasion of liver cancer cell by targeting smoothened
inferred← citeshttps://doi.org/10.1002/pbc.24427openalex-snapshot
Children's Oncology Group's 2013 blueprint for research: Central nervous system tumors
inferred← citeshttps://doi.org/10.1002/pros.21500openalex-snapshot
Paracrine hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli‐dependent manner
inferred← citeshttps://doi.org/10.1002/prot.20768openalex-snapshot
A chemogenomic analysis of the transmembrane binding cavity of human G‐protein‐coupled receptors
inferred← citeshttps://doi.org/10.1002/prp2.214openalex-snapshot
Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model
inferred← citeshttps://doi.org/10.1002/prp2.43openalex-snapshot
NL ‐103, a novel dual‐targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations
inferred← citeshttps://doi.org/10.1002/smll.201501905openalex-snapshot
Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform
inferred← citeshttps://doi.org/10.1002/stem.1204openalex-snapshot
Glycogen Synthase Kinase 3β and Activin/Nodal Inhibition in Human Embryonic Stem Cells Induces a Pre‐Neuroepithelial State That Is Required for Specification to a Floor Plate Cell Lineage
inferred← citeshttps://doi.org/10.1002/stem.1955openalex-snapshot
Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters
inferred← citeshttps://doi.org/10.1002/wdev.377openalex-snapshot
Signaling in the primary cilium through the lens of the Hedgehog pathway
inferred← citeshttps://doi.org/10.1002/wsbm.1193openalex-snapshot
Toward a systems‐level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile
inferred← citeshttps://doi.org/10.1002/wsbm.1537openalex-snapshot
The crucial role of model systems in understanding the complexity of cell signaling in human neurocristopathies
inferred← citeshttps://doi.org/10.1007/0-387-33777-6_1openalex-snapshot
How the Hedgehog Outfoxed the Crab
inferred← citeshttps://doi.org/10.1007/10_2017_30openalex-snapshot
Scalable Cardiac Differentiation of Pluripotent Stem Cells Using Specific Growth Factors and Small Molecules
inferred← citeshttps://doi.org/10.1007/2789_2007_051openalex-snapshot
The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies
inferred← citeshttps://doi.org/10.1007/3-540-27671-8_1openalex-snapshot
The Hedgehog Signaling Pathway in Cancer
inferred← citeshttps://doi.org/10.1007/7355_2014_61openalex-snapshot
Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design
inferred← citeshttps://doi.org/10.1007/7355_2014_64openalex-snapshot
Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-0-387-69062-9_20openalex-snapshot
Molecular Therapy for Rhabdomyosarcoma
inferred← citeshttps://doi.org/10.1007/978-0-387-69182-4_18openalex-snapshot
Atrophy and Altered Mesenchymal—Epithelial Signaling Preceding Gastric Cancer
inferred← citeshttps://doi.org/10.1007/978-1-0716-1701-4_17openalex-snapshot
NanoBRET and NanoBiT/BRET-Based Ligand Binding Assays Permit Quantitative Assessment of Small Molecule Ligand Binding to Smoothened
inferred← citeshttps://doi.org/10.1007/978-1-0716-1847-9_13openalex-snapshot
Engineering Epithelial–Mesenchymal Microtissues to Study Cell–Cell Interactions in Development
inferred← citeshttps://doi.org/10.1007/978-1-4419-7216-3_8openalex-snapshot
Epithelial-to-Mesenchymal Transition and Cellular Membrane Receptors in Ovarian Cancer: Moving Forward in the Era of Molecularly Targeted Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4419-8435-7_1openalex-snapshot
Overview of Hedgehog Signaling Pathway
inferred← citeshttps://doi.org/10.1007/978-1-4419-8435-7_11openalex-snapshot
Small-Molecule Inhibitors of the Hedgehog Pathway
inferred← citeshttps://doi.org/10.1007/978-1-4419-8435-7_12openalex-snapshot
Cyclopamine and Its Derivatives for Cancer Therapeutics
inferred← citeshttps://doi.org/10.1007/978-1-4939-2269-7_17openalex-snapshot
Practical Strategies for Small-Molecule Probe Development in Chemical Biology
inferred← citeshttps://doi.org/10.1007/978-1-4939-2772-2_7openalex-snapshot
Luciferase Reporter Assays to Study Transcriptional Activity of Hedgehog Signaling in Normal and Cancer Cells
inferred← citeshttps://doi.org/10.1007/978-1-59259-664-5_9openalex-snapshot
Growth Factor Signaling Pathways in Cancer
inferred← citeshttps://doi.org/10.1007/978-1-60327-933-8_20openalex-snapshot
Implications of Cancer Stem Cells for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-1-60761-543-9_13openalex-snapshot
PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
inferred← citeshttps://doi.org/10.1007/978-1-61779-012-6_12openalex-snapshot
Chemical Screening with Zebrafish Embryos
inferred← citeshttps://doi.org/10.1007/978-3-032-12741-9_3openalex-snapshot
The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects
inferred← citeshttps://doi.org/10.1007/978-90-481-3725-1_11openalex-snapshot
Molecular Mechanisms of Central Nervous System Metastasis
inferred← citeshttps://doi.org/10.1007/s00018-014-1690-4openalex-snapshot
The growth plate’s response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium
inferred← citeshttps://doi.org/10.1007/s00018-015-2127-4openalex-snapshot
Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction
inferred← citeshttps://doi.org/10.1007/s00018-018-2942-5openalex-snapshot
DYRK1B regulates Hedgehog-induced microtubule acetylation
inferred← citeshttps://doi.org/10.1007/s00216-019-01950-8openalex-snapshot
Highly sensitive detection of Smoothened based on the drug binding and rolling cycle amplification
inferred← citeshttps://doi.org/10.1007/s00280-015-2812-xopenalex-snapshot
AT-101 inhibits hedgehog pathway activity and cancer growth
inferred← citeshttps://doi.org/10.1007/s00280-016-2962-5openalex-snapshot
Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors
inferred← citeshttps://doi.org/10.1007/s00381-012-1704-1openalex-snapshot
Matching mice to malignancy: molecular subgroups and models of medulloblastoma
inferred← citeshttps://doi.org/10.1007/s10495-009-0327-9openalex-snapshot
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
inferred← citeshttps://doi.org/10.1007/s10549-008-0093-3openalex-snapshot
Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo)
inferred← citeshttps://doi.org/10.1007/s10549-009-0423-0openalex-snapshot
The hedgehog pathway as a therapeutic target for treatment of breast cancer
inferred← citeshttps://doi.org/10.1007/s10571-020-01010-1openalex-snapshot
Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals
inferred← citeshttps://doi.org/10.1007/s10637-012-9908-5openalex-snapshot
Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells with the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons
inferred← citeshttps://doi.org/10.1007/s11033-019-05058-1openalex-snapshot
Markers of pancreatic cancer stem cells and their clinical and therapeutic implications
inferred← citeshttps://doi.org/10.1007/s11060-013-1216-1openalex-snapshot
Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma
inferred← citeshttps://doi.org/10.1007/s11064-023-03864-5openalex-snapshot
Sonic Hedgehog Signaling Pathway: A Role in Pain Processing
inferred← citeshttps://doi.org/10.1007/s11418-015-0922-8openalex-snapshot
Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum
inferred← citeshttps://doi.org/10.1007/s11418-022-01603-8openalex-snapshot
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway
inferred← citeshttps://doi.org/10.1007/s11515-011-1146-2openalex-snapshot
Hedgehog signaling: mechanisms and evolution
inferred← citeshttps://doi.org/10.1007/s11912-008-0018-7openalex-snapshot
Hedgehog signaling pathway: Development of antagonists for cancer therapy
inferred← citeshttps://doi.org/10.1007/s12015-022-10391-3openalex-snapshot
Optimizing Generation of Stem Cell-Derived Islet Cells
inferred← citeshttps://doi.org/10.1007/s12032-022-01794-wopenalex-snapshot
ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli
inferred← citeshttps://doi.org/10.1007/s12035-019-01839-8openalex-snapshot
Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons
inferred← citeshttps://doi.org/10.1007/s12272-012-0801-8openalex-snapshot
Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer
inferred← citeshttps://doi.org/10.1007/s12311-017-0895-0openalex-snapshot
Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury
inferred← citeshttps://doi.org/10.1007/s13311-019-00810-8openalex-snapshot
Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1007/s13402-025-01050-zopenalex-snapshot
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells
inferred← citeshttps://doi.org/10.1007/s13577-022-00796-0openalex-snapshot
Hedgehog pathway is negatively regulated during the development of Drosophila melanogaster PheRS-m (Drosophila homologs gene of human FARS2) mutants
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00229-1openalex-snapshot
Hedgehog Signaling in Development and Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-382026-6.00010-5openalex-snapshot
Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
inferred← citeshttps://doi.org/10.1016/b978-0-12-385975-4.00010-3openalex-snapshot
Sonic Hedgehog Signaling in the Developing CNS
inferred← citeshttps://doi.org/10.1016/b978-0-12-386015-6.00030-5openalex-snapshot
Glucocorticoid Hedgehog Agonists in Neurogenesis
inferred← citeshttps://doi.org/10.1016/b978-0-12-394447-4.30007-4openalex-snapshot
Hedgehog Signaling in Development and Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-394622-5.00002-xopenalex-snapshot
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
inferred← citeshttps://doi.org/10.1016/b978-0-12-394622-5.00006-7openalex-snapshot
Identification, Functional Characterization, and Pathobiological Significance of GLI1 Isoforms in Human Cancers
inferred← citeshttps://doi.org/10.1016/b978-0-12-394622-5.00018-3openalex-snapshot
Sonic Hedgehog on Microparticles and Neovascularization
inferred← citeshttps://doi.org/10.1016/b978-0-12-394622-5.00023-7openalex-snapshot
Hedgehog Inhibition as an Anti-Cancer Strategy
inferred← citeshttps://doi.org/10.1016/b978-0-12-809470-9.00008-4openalex-snapshot
Chemical probes for dynein
inferred← citeshttps://doi.org/10.1016/b978-0-12-809954-4.00004-9openalex-snapshot
Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00124-3openalex-snapshot
Hedgehog Signalling in Development and Disease
inferred← citeshttps://doi.org/10.1016/b978-0-444-54299-1.00011-xopenalex-snapshot
A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome
inferred← citeshttps://doi.org/10.1016/b978-012088410-0/50067-6openalex-snapshot
Chemotherapy of Medulloblastoma
inferred← citeshttps://doi.org/10.1016/b978-012088561-9/50002-8openalex-snapshot
A SURVEY OF NOVEL MOLECULAR TARGETS FOR ANTICANCER DRUG DISCOVERY
inferred← citeshttps://doi.org/10.1016/b978-1-4377-2250-5.00049-7openalex-snapshot
The management of eyelid tumors
inferred← citeshttps://doi.org/10.1016/j.antiviral.2018.06.017openalex-snapshot
Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2022.738849openalex-snapshot
Hypoxia mediates Hif-1α to affect myofiber development and Vc regulates the influence by activating Shh-Gli pathway in channel catfish (Ictalurus punctatus)
inferred← citeshttps://doi.org/10.1016/j.bbagen.2024.130692openalex-snapshot
Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays
inferred← citeshttps://doi.org/10.1016/j.bbagrm.2023.194924openalex-snapshot
GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2010.03.008openalex-snapshot
Hedgehog signaling and gastrointestinal cancer
inferred← citeshttps://doi.org/10.1016/j.bbamem.2010.02.015openalex-snapshot
Stability study of the human G-protein coupled receptor, Smoothened
inferred← citeshttps://doi.org/10.1016/j.bbcan.2010.01.003openalex-snapshot
Hedgehog beyond medulloblastoma and basal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.bbi.2025.106226openalex-snapshot
Smoothened-mediated signaling contributes to immune and non-immune functions of microglia
inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.03.188openalex-snapshot
Sonic hedgehog stimulates the proliferation of rat gastric mucosal cells through ERK activation by elevating intracellular calcium concentration
inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.07.216openalex-snapshot
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15
inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.01.087openalex-snapshot
Metabolites in vertebrate Hedgehog signaling
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.03.027openalex-snapshot
The mammalian Hedgehog pathway is modulated by ANP32 proteins
inferred← citeshttps://doi.org/10.1016/j.bcp.2004.01.002openalex-snapshot
Regulation of Hedgehog signaling: a complex story
inferred← citeshttps://doi.org/10.1016/j.bcp.2004.04.025openalex-snapshot
Hedgehog signalling in foregut malignancy
inferred← citeshttps://doi.org/10.1016/j.bcp.2010.04.016openalex-snapshot
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114593openalex-snapshot
Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114647openalex-snapshot
Sterol regulation of developmental and oncogenic Hedgehog signaling
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2013.03.089openalex-snapshot
Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.124171openalex-snapshot
Mechanical confinement balances ECM remodeling in chondrocytes via MAPK and Hedgehog signaling
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107681openalex-snapshot
New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109452openalex-snapshot
Natural products as payloads for antibody-drug conjugates: Cyclopamine linked to cetuximab for hedgehog pathway inhibition
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119624openalex-snapshot
20(S)-hydroxycholesterol, a natural allosteric agonist of Smoothened, exerts neuroprotective effects associated with angiogenesis and vascular plasticity following ischemia
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.09.053openalex-snapshot
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.06.008openalex-snapshot
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.08.026openalex-snapshot
Potent small molecule Hedgehog agonists induce VEGF expression in vitro
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.09.030openalex-snapshot
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.06.058openalex-snapshot
Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116166openalex-snapshot
Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.08.049openalex-snapshot
GDC-0449—A potent inhibitor of the hedgehog pathway
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.09.089openalex-snapshot
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.06.006openalex-snapshot
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.06.033openalex-snapshot
Smoothened antagonists for hair inhibition
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.11.126openalex-snapshot
New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.04.103openalex-snapshot
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.07.073openalex-snapshot
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.01.006openalex-snapshot
Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.03.079openalex-snapshot
Scaffold hopping approach to a new series of smoothened antagonists
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.06.081openalex-snapshot
Hedgehog inhibitors from Withania somnifera
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.129011openalex-snapshot
Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells
inferred← citeshttps://doi.org/10.1016/j.bone.2016.02.017openalex-snapshot
Bardet-Biedl syndrome 3 regulates the development of cranial base midline structures
inferred← citeshttps://doi.org/10.1016/j.bpj.2018.11.3136openalex-snapshot
Revealing Nanoscale Morphology of the Primary Cilium Using Super-Resolution Fluorescence Microscopy
inferred← citeshttps://doi.org/10.1016/j.canlet.2004.10.003openalex-snapshot
Sonic hedgehog signaling in basal cell carcinomas
inferred← citeshttps://doi.org/10.1016/j.canlet.2004.11.030openalex-snapshot
Hedgehog signaling pathway as a therapeutic target in breast cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2012.10.002openalex-snapshot
Identification of Hedgehog pathway responsive glioblastomas by isocitrate dehydrogenase mutation
inferred← citeshttps://doi.org/10.1016/j.canlet.2013.03.025openalex-snapshot
Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner
inferred← citeshttps://doi.org/10.1016/j.ccell.2014.09.001openalex-snapshot
Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
inferred← citeshttps://doi.org/10.1016/j.cclet.2015.06.017openalex-snapshot
Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
inferred← citeshttps://doi.org/10.1016/j.ccr.2010.02.027openalex-snapshot
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
inferred← citeshttps://doi.org/10.1016/j.cdip.2003.11.005openalex-snapshot
The Hedgehog signalling pathways in human pathology
inferred← citeshttps://doi.org/10.1016/j.ceb.2017.10.004openalex-snapshot
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
inferred← citeshttps://doi.org/10.1016/j.cell.2008.02.047openalex-snapshot
Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
inferred← citeshttps://doi.org/10.1016/j.cell.2012.09.021openalex-snapshot
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
inferred← citeshttps://doi.org/10.1016/j.cell.2013.08.060openalex-snapshot
Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division
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