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The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

https://doi.org/10.1073/pnas.1903020116
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT
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Coupled Global and Local Changes Direct Substrate Translocation by Neurotransmitter-Sodium Symporter Ortholog LeuT
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Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter
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The bright future of single-molecule fluorescence imaging
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The Mechanism of a Neurotransmitter:Sodium Symporter—Inward Release of Na+ and Substrate Is Triggered by Substrate in a Second Binding Site
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inferredcites →https://doi.org/10.1073/pnas.1613293114openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.1717444115openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.1718451115openalex-snapshot
Conformational transitions of the sodium-dependent sugar transporter, vSGLT
inferredcites →https://doi.org/10.1074/jbc.m114.584383openalex-snapshot
Identification of a Second Substrate-binding Site in Solute-Sodium Symporters
inferredcites →https://doi.org/10.1074/jbc.m115.675306openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m115.677658openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m115.692012openalex-snapshot
Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog
inferredcites →https://doi.org/10.1074/jbc.m116.757153openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m116.763565openalex-snapshot
Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization
inferredcites →https://doi.org/10.1074/jbc.m602438200openalex-snapshot
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inferredcites →https://doi.org/10.1074/jbc.m800475200openalex-snapshot
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inferredcites →https://doi.org/10.1103/physreva.31.1695openalex-snapshot
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inferredcites →https://doi.org/10.1124/mol.106.026120openalex-snapshot
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inferredcites →https://doi.org/10.1126/science.1166777openalex-snapshot
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inferredcites →https://doi.org/10.1145/1364782.1364802openalex-snapshot
Anton, a special-purpose machine for molecular dynamics simulation
inferredcites →https://doi.org/10.1146/annurev-biophys-083012-130429openalex-snapshot
Common Folds and Transport Mechanisms of Secondary Active Transporters
inferredcites →https://doi.org/10.1186/1471-2105-11-308openalex-snapshot
Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation
inferredcites →https://doi.org/10.1186/s12915-018-0495-6openalex-snapshot
How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties
inferredcites →https://doi.org/10.1371/journal.pcbi.1002246openalex-snapshot
Unbiased Simulations Reveal the Inward-Facing Conformation of the Human Serotonin Transporter and Na+ Ion Release
inferredcites →https://doi.org/10.1371/journal.pcbi.1003603openalex-snapshot
NbIT - A New Information Theory-Based Analysis of Allosteric Mechanisms Reveals Residues that Underlie Function in the Leucine Transporter LeuT
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Erwin Schrödinger
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R: A Language and Environment for Statistical Computing
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AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems
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N-body Information Theory (NbIT) Analysis of Rigid-Body Dynamics in Intracellular Loop 2 of the 5-HT2A Receptor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Single‐Molecule FRET of Membrane Transport Proteins
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Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology
inferred← citeshttps://doi.org/10.1007/s11064-019-02928-9openalex-snapshot
The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner
inferred← citeshttps://doi.org/10.1016/j.bpc.2022.106765openalex-snapshot
Effects of the N-Terminal Dynamics on the Conformational States of Human Dopamine Transporter
inferred← citeshttps://doi.org/10.1016/j.sbi.2022.102389openalex-snapshot
HATs meet structural biology
inferred← citeshttps://doi.org/10.1016/s0021-9258(17)49881-4openalex-snapshot
Transmembrane helix 6b links proton and metal release pathways and drives conformational change in an Nramp-family transition metal transporter
inferred← citeshttps://doi.org/10.1021/acs.jpcb.5c05660openalex-snapshot
Integrating Molecular Dynamics Simulations and Single-molecule FRET Spectroscopy: From Computational FRET Estimation to Experimental Data Interpretation
inferred← citeshttps://doi.org/10.1021/acschemneuro.3c00155openalex-snapshot
Multi-state Model-Based Identification of Cryptic Allosteric Sites on Human Serotonin Transporter
inferred← citeshttps://doi.org/10.1038/s41467-020-14735-wopenalex-snapshot
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
inferred← citeshttps://doi.org/10.1038/s41586-021-03274-zopenalex-snapshot
Structural insights into the inhibition of glycine reuptake
inferred← citeshttps://doi.org/10.1038/s41598-020-69908-wopenalex-snapshot
Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors
inferred← citeshttps://doi.org/10.1038/s41598-021-86318-8openalex-snapshot
Insight into the direct interaction of Na+ with NhaA and mechanistic implications
inferred← citeshttps://doi.org/10.1063/5.0047967openalex-snapshot
General principles of secondary active transporter function
inferred← citeshttps://doi.org/10.1073/pnas.2205874119openalex-snapshot
Flux coupling, not specificity, shapes the transport and phylogeny of SLC6 glycine transporters
inferred← citeshttps://doi.org/10.1074/jbc.ra119.011336openalex-snapshot
Transmembrane helix 6b links proton and metal release pathways and drives conformational change in an Nramp-family transition metal transporter
inferred← citeshttps://doi.org/10.1101/2020.04.03.022970openalex-snapshot
Role of transmembrane helix 6 in substrate recognition of the amino acid transporter MhsT
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1008293openalex-snapshot
Quantitative comparison between sub-millisecond time resolution single-molecule FRET measurements and 10-second molecular simulations of a biosensor protein
inferred← citeshttps://doi.org/10.15252/embj.2020105164openalex-snapshot
A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition
inferred← citeshttps://doi.org/10.15252/embj.2022110735openalex-snapshot
Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter
inferred← citeshttps://doi.org/10.3390/biom12101404openalex-snapshot
Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives
inferred← citeshttps://doi.org/10.3390/membranes12020227openalex-snapshot
New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility
inferred← citeshttps://doi.org/10.3390/molecules26103059openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules30224412openalex-snapshot
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