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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

https://doi.org/10.1073/pnas.192461099
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The shared tumor-specific antigen encoded by mouse geneP1A is a target not only for cytolytic T lymphocytes but also for tumor rejection
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Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model
inferredcites →https://doi.org/10.1016/s0165-2478(02)00142-6openalex-snapshot
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
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Cancer vaccines based on the identification of genes encoding cancer regression antigens
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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
inferredcites →https://doi.org/10.1016/s1074-7613(00)80366-0openalex-snapshot
The Emerging Role of CTLA-4 as an Immune Attenuator
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Serological analysis of human tumor antigens: molecular definition and implications
inferredcites →https://doi.org/10.1016/s1471-4906(01)01888-9openalex-snapshot
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance
inferredcites →https://doi.org/10.1038/35051113openalex-snapshot
ICOS is essential for effective T-helper-cell responses
inferredcites →https://doi.org/10.1038/85330openalex-snapshot
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
inferredcites →https://doi.org/10.1084/jem.173.6.1373openalex-snapshot
The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice.
inferredcites →https://doi.org/10.1084/jem.192.7.1027openalex-snapshot
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
inferredcites →https://doi.org/10.1093/intimm/10.10.1563openalex-snapshot
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
inferredcites →https://doi.org/10.1093/intimm/8.5.765openalex-snapshot
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
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The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond
inferredcites →https://doi.org/10.1126/science.270.5238.985openalex-snapshot
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
inferredcites →https://doi.org/10.1126/science.271.5256.1734openalex-snapshot
Enhancement of Antitumor Immunity by CTLA-4 Blockade
inferredcites →https://doi.org/10.1126/science.291.5502.319openalex-snapshot
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
inferredcites →https://doi.org/10.1126/science.7513904openalex-snapshot
Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens
inferredcites →https://doi.org/10.1146/annurev.immunol.19.1.565openalex-snapshot
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
inferredcites →https://doi.org/10.1146/annurev.iy.12.040194.002005openalex-snapshot
Tumor Antigens Recognized by T Lymphocytes
inferredcites →https://doi.org/10.1159/000453569openalex-snapshot
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
inferredcites →https://doi.org/10.1159/000455014openalex-snapshot
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
inferredcites →https://doi.org/10.4049/jimmunol.155.11.5323openalex-snapshot
Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected
inferredcites →https://doi.org/10.4049/jimmunol.157.2.670openalex-snapshot
Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
inferredcites →https://doi.org/10.4049/jimmunol.167.9.5092openalex-snapshot
Targeting of Tumor Cells for Human γδ T Cells by Nonpeptide Antigens

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inferred← citeshttps://doi.org/10.1002/jso.24266openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jso.24642openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/mco2.111openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/mco2.70176openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/med.21530openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/pbc.25284openalex-snapshot
The role of programmed cell death‐1 (PD‐1) and its ligands in pediatric cancer
inferred← citeshttps://doi.org/10.1002/pros.23260openalex-snapshot
Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey–Holden Prostate Cancer Academy Meeting
inferred← citeshttps://doi.org/10.1002/psp4.12133openalex-snapshot
Quantitative Characterization of the Exposure-Response Relationship for Cancer Immunotherapy: A Case Study of Nivolumab in Patients With Advanced Melanoma
inferred← citeshttps://doi.org/10.1002/psp4.12143openalex-snapshot
Model-Based Population Pharmacokinetic Analysis of Nivolumab in Patients With Solid Tumors
inferred← citeshttps://doi.org/10.1002/psp4.12406openalex-snapshot
Time‐Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma
inferred← citeshttps://doi.org/10.1002/resp.70220openalex-snapshot
T‐Cell Immunity and Lung Cancer
inferred← citeshttps://doi.org/10.1002/rmv.2486openalex-snapshot
The programed death‐1/programed death ligand‐1 axis and its potential as a therapeutic target for virus‐associated tumours
inferred← citeshttps://doi.org/10.1002/sim.10048openalex-snapshot
Two‐stage stratified designs with survival outcomes and adjustment for misclassification in predictive biomarkers
inferred← citeshttps://doi.org/10.1002/slct.201800095openalex-snapshot
Identification of Small‐Molecule Inhibitors of PD‐1/PD‐L1 Protein‐Protein Interaction
inferred← citeshttps://doi.org/10.1002/smll.202005728openalex-snapshot
A Multifunctional Nanovaccine based on L‐Arginine‐Loaded Black Mesoporous Titania: Ultrasound‐Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy
inferred← citeshttps://doi.org/10.1002/smll.202100003openalex-snapshot
Advanced Devices for Tumor Diagnosis and Therapy
inferred← citeshttps://doi.org/10.1002/smll.202307337openalex-snapshot
Photocrosslinked Co‐Assembled Amino Acid Nanoparticles for Controlled Chemo/Photothermal Combined Anticancer Therapy
inferred← citeshttps://doi.org/10.1002/smll.202400770openalex-snapshot
Lysosome‐Targeting Bacterial Outer Membrane Vesicles for Tumor Specific Degradation of PD‐L1
inferred← citeshttps://doi.org/10.1002/smll.202507293openalex-snapshot
Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles
inferred← citeshttps://doi.org/10.1002/smll.202512553openalex-snapshot
Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet‐Based Cell Mechanoporation Platform
inferred← citeshttps://doi.org/10.1002/smtd.202400358openalex-snapshot
Assessment of PD‐L1 Expression in Non‐Small Cell Lung Cancers Using [ 68 Ga]Ga‐DOTA‐WL12 PET/CT
inferred← citeshttps://doi.org/10.1002/wsbm.1210openalex-snapshot
Developing melanoma therapeutics: overview and update
inferred← citeshttps://doi.org/10.1007/0-387-34944-8_15openalex-snapshot
B7 Family Molecules in the Placenta
inferred← citeshttps://doi.org/10.1007/16833_2024_391openalex-snapshot
Tumor Microenvironment Role in Cancer Immunotherapy Response
inferred← citeshttps://doi.org/10.1007/82_2010_116openalex-snapshot
Role of PD-1 in Regulating T-Cell Immunity
inferred← citeshttps://doi.org/10.1007/82_2010_70openalex-snapshot
Identification of Human Idiotype-Specific T Cells in Lymphoma and Myeloma
inferred← citeshttps://doi.org/10.1007/82_2010_81openalex-snapshot
Immunobiology of Cancer Therapies Targeting CD137 and B7-H1/PD-1 Cosignal Pathways
inferred← citeshttps://doi.org/10.1007/82_2011_136openalex-snapshot
The Dermis as a Portal for Dendritic Cell-Targeted Immunotherapy of Cutaneous Melanoma
inferred← citeshttps://doi.org/10.1007/82_2017_67openalex-snapshot
Role of PD-1 in Immunity and Diseases
inferred← citeshttps://doi.org/10.1007/978-0-387-68564-9_8openalex-snapshot
Models for the Immune Response to Cancer
inferred← citeshttps://doi.org/10.1007/978-0-387-68969-2_21openalex-snapshot
Inhibitory B7 Family Members in Human Ovarian Carcinoma
inferred← citeshttps://doi.org/10.1007/978-0-387-69118-3_3openalex-snapshot
Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer
inferred← citeshttps://doi.org/10.1007/978-0-387-77574-6_15openalex-snapshot
Melanoma and Nonmelanoma Skin Cancers and the Immune System
inferred← citeshttps://doi.org/10.1007/978-1-0716-0247-8_18openalex-snapshot
Immunoblotting Analysis of Intracellular PD-L1 Levels in Interferon-γ-Treated Ovarian Cancer Cells Stably Transfected with Bcl3 shRNA
inferred← citeshttps://doi.org/10.1007/978-1-0716-0247-8_19openalex-snapshot
Flow Cytometry Analysis of Surface PD-L1 Expression Induced by IFNγ and Romidepsin in Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1007/978-1-0716-0247-8_8openalex-snapshot
Analysis of IFNγ-Induced Migration of Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1007/978-1-0716-1205-7_41openalex-snapshot
Use of Nanoparticles in Delivery of Nucleic Acids for Melanoma Treatment
inferred← citeshttps://doi.org/10.1007/978-1-0716-1278-1_4openalex-snapshot
Detection of Programmed Cell Death Ligand 1 Expression in Lung Cancer Clinical Samples by an Automated Immunohistochemistry System
inferred← citeshttps://doi.org/10.1007/978-1-0716-4734-9_6openalex-snapshot
A PD-1/PD-L1-Sensitive Co-culture-Based Primary T-Cell Activation Assay
inferred← citeshttps://doi.org/10.1007/978-1-0716-4901-5_19openalex-snapshot
Analysis of PD-L1 Transcriptional Activity by Chromatin Immunoprecipitation
inferred← citeshttps://doi.org/10.1007/978-1-0716-4901-5_3openalex-snapshot
Flow Cytometry Analysis of IFNγ-Induced PD-L1 Cell Surface Expression in Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1007/978-1-4020-6087-8openalex-snapshot
General Principles of Tumor Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-1-4020-6087-8_16openalex-snapshot
Checkpoint Blockade and Combinatorial Immunotherapies
inferred← citeshttps://doi.org/10.1007/978-1-4020-6087-8_5openalex-snapshot
Immunomodulatory Molecules of the Immune System
inferred← citeshttps://doi.org/10.1007/978-1-4020-6750-1_1openalex-snapshot
Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression
inferred← citeshttps://doi.org/10.1007/978-1-4020-6750-1_4openalex-snapshot
Insights into Mechanisms of Immune Resistance in the Tumor Microenvironment through Molecular Profiling
inferred← citeshttps://doi.org/10.1007/978-1-4614-1445-2_9openalex-snapshot
Tumor Dormancy: Long-Term Survival in a Hostile Environment
inferred← citeshttps://doi.org/10.1007/978-1-4614-3146-6_5openalex-snapshot
Mechanisms of Immune Evasion by Gliomas
inferred← citeshttps://doi.org/10.1007/978-1-4614-4732-0_4openalex-snapshot
Dendritic Cell-Based Cancer Immunotherapy: Achievements and Novel Concepts
inferred← citeshttps://doi.org/10.1007/978-1-4614-4732-0_8openalex-snapshot
Immune Co-signaling to Treat Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4614-8809-5_14openalex-snapshot
T Cell Co-regulatory Signals and Their Role in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4899-8056-4_16openalex-snapshot
Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4939-2724-1_7openalex-snapshot
Inflammation and Lung Cancer: Addressing Inflammation with Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-1-4939-8958-4_2openalex-snapshot
Cancer Immunotherapy: The Dawn of Antibody Cocktails
inferred← citeshttps://doi.org/10.1007/978-1-59745-035-5_31openalex-snapshot
Tumor Immune Escape Mechanisms
inferred← citeshttps://doi.org/10.1007/978-1-59745-332-5_24openalex-snapshot
Molecular Markers for Predicting Prognosis of Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.1007/978-1-60327-829-4_29openalex-snapshot
GM-CSF Gene-Transduced Prostate Cancer Vaccines: GVAX
inferred← citeshttps://doi.org/10.1007/978-1-61779-407-0_15openalex-snapshot
Anti-PD-1 and Anti-B7-H1/PD-L1 Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/978-1-61779-407-0_18openalex-snapshot
Modulating the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1007/978-1-62703-727-3_19openalex-snapshot
B7-H Abnormalities in Melanoma and Clinical Relevance
inferred← citeshttps://doi.org/10.1007/978-1-62703-727-3_3openalex-snapshot
Integrating Molecular Biomarkers into Current Clinical Management in Melanoma
inferred← citeshttps://doi.org/10.1007/978-3-030-04861-7_10openalex-snapshot
From Molecular Classification to Targeted Therapy for Gastric Cancer in the Precision Medicine Era
inferred← citeshttps://doi.org/10.1007/978-3-030-16792-9_36openalex-snapshot
Immunotherapy in Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-18797-2_2openalex-snapshot
Non-melanoma Skin Cancer and Cutaneous Melanoma from the Oncological Point of View
inferred← citeshttps://doi.org/10.1007/978-3-030-22254-3_17openalex-snapshot
Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-3-030-30845-2_2openalex-snapshot
Role of Innate Immunity in Cancers and Antitumor Response
inferred← citeshttps://doi.org/10.1007/978-3-030-50224-9_9openalex-snapshot
Tight Interplay Between Therapeutic Monoclonal Antibodies and the Tumour Microenvironment in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-3-030-50287-4_6openalex-snapshot
Overcoming Cancer Tolerance with Immune Checkpoint Blockade
inferred← citeshttps://doi.org/10.1007/978-3-030-56051-5_15openalex-snapshot
Response Assessment to Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-3-030-57949-4_3openalex-snapshot
Immunotherapeutic Strategies for Multiple Myeloma
inferred← citeshttps://doi.org/10.1007/978-3-030-58174-9_15openalex-snapshot
Industrial Perspective on Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-3-030-59038-3_18openalex-snapshot
Tumor Microenvironment in Penile Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-59558-6_15openalex-snapshot
Emerging Meningioma Therapies II: Immunotherapies, Novel Radiotherapy Techniques, and Other Experimental Approaches
inferred← citeshttps://doi.org/10.1007/978-3-030-73119-9_16openalex-snapshot
Current Treatment Modalities Targeting Tumor Microenvironment in Castration-Resistant Prostate Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-80546-3_18openalex-snapshot
Safety of Immune Checkpoint Inhibitors in the Peri-operative Setting
inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_172-1openalex-snapshot
Endocrine Consequences Following Immune Checkpoint Inhibitors Therapy
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