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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

https://doi.org/10.1073/pnas.94.12.6048
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-4652(199603)166:3<631::aid-jcp18>3.0.co;2-9openalex-snapshot
Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanism
inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05678.xopenalex-snapshot
mdm2 expression is induced by wild type p53 activity.
inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06543.xopenalex-snapshot
A temperature‐sensitive mutant of human p53.
inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06807.xopenalex-snapshot
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
inferredcites →https://doi.org/10.1016/0076-6879(88)59041-9openalex-snapshot
[39] Protein phosphatase-2C from rabbit skeletal muscle and liver: An Mg2+-dependent enzyme
inferredcites →https://doi.org/10.1016/0092-8674(92)90593-2openalex-snapshot
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
inferredcites →https://doi.org/10.1016/0092-8674(93)90499-gopenalex-snapshot
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
inferredcites →https://doi.org/10.1016/0092-8674(93)90500-popenalex-snapshot
WAF1, a potential mediator of p53 tumor suppression
inferredcites →https://doi.org/10.1016/0092-8674(93)90509-oopenalex-snapshot
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
inferredcites →https://doi.org/10.1016/0092-8674(95)90039-xopenalex-snapshot
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
inferredcites →https://doi.org/10.1016/0092-8674(95)90412-3openalex-snapshot
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
inferredcites →https://doi.org/10.1016/0092-8674(95)90513-8openalex-snapshot
A novel form of Epstein-Barr virus latency in normal B cells in vivo
inferredcites →https://doi.org/10.1016/s0021-9258(18)35858-7openalex-snapshot
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
inferredcites →https://doi.org/10.1016/s0021-9258(20)30058-2openalex-snapshot
A membrane-bound protein phosphatase type 2C from Paramecium tetraurelia. Purification, characterization, and cloning
inferredcites →https://doi.org/10.1016/s0959-437x(96)90004-0openalex-snapshot
p53 in signaling checkpoint arrest or apoptosis
inferredcites →https://doi.org/10.1038/356215a0openalex-snapshot
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
inferredcites →https://doi.org/10.1038/362847a0openalex-snapshot
p53 is required for radiation-induced apoptosis in mouse thymocytes
inferredcites →https://doi.org/10.1038/362849a0openalex-snapshot
Thymocyte apoptosis induced by p53-dependent and independent pathways
inferredcites →https://doi.org/10.1038/366701a0openalex-snapshot
p21 is a universal inhibitor of cyclin kinases
inferredcites →https://doi.org/10.1038/377552a0openalex-snapshot
Radiation-induced cell cycle arrest compromised by p21 deficiency
inferredcites →https://doi.org/10.1038/377646a0openalex-snapshot
Induction of the growth inhibitor IGF-binding protein 3 by p53
inferredcites →https://doi.org/10.1073/pnas.90.9.3988openalex-snapshot
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
inferredcites →https://doi.org/10.1073/pnas.92.18.8493openalex-snapshot
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.
inferredcites →https://doi.org/10.1073/pnas.92.20.9019openalex-snapshot
Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.
inferredcites →https://doi.org/10.1101/gad.7.7a.1126openalex-snapshot
The p53-mdm-2 autoregulatory feedback loop.
inferredcites →https://doi.org/10.1101/gad.9.17.2170openalex-snapshot
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
inferredcites →https://doi.org/10.1101/gad.9.17.2184openalex-snapshot
Essential role for p53-mediated transcription in E1A-induced apoptosis.
inferredcites →https://doi.org/10.1126/science.1354393openalex-snapshot
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
inferredcites →https://doi.org/10.1126/science.1905840openalex-snapshot
p53 Mutations in Human Cancers
inferredcites →https://doi.org/10.1126/science.271.5256.1744openalex-snapshot
Abnormal Centrosome Amplification in the Absence of p53
inferredcites →https://doi.org/10.1126/science.274.5293.1744openalex-snapshot
A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue
inferredcites →https://doi.org/10.1126/science.7973727openalex-snapshot
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4518202openalex-extracted
Effects of Wip1 and Microrna Mir-192 on P53 Oscillation Dynamics in Single Cell and Cell Population: A Computational Study
inferred← citeshttps://doi.org/10.1002/(sici)1097-4644(1998)72:30/31+<50::aid-jcb8>3.0.co;2-8openalex-snapshot
Checking on the cell cycle
inferred← citeshttps://doi.org/10.1002/ajh.26989openalex-snapshot
NPM1 ‐mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions
inferred← citeshttps://doi.org/10.1002/ajmg.a.34302openalex-snapshot
Two new cases with microdeletion of 17q23.2 suggest presence of a candidate gene for sensorineural hearing loss within this region
inferred← citeshttps://doi.org/10.1002/cmdc.200700281openalex-snapshot
A Small Molecular Scaffold for Selective Inhibition of Wip1 Phosphatase
inferred← citeshttps://doi.org/10.1002/cmdc.201700779openalex-snapshot
Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain
inferred← citeshttps://doi.org/10.1002/em.21938openalex-snapshot
Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in F anconi anemia cells
inferred← citeshttps://doi.org/10.1002/ijc.23188openalex-snapshot
Multiple end‐point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testing
inferred← citeshttps://doi.org/10.1002/jcb.20079openalex-snapshot
Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts
inferred← citeshttps://doi.org/10.1002/jcb.21091openalex-snapshot
p53 modulation of the DNA damage response
inferred← citeshttps://doi.org/10.1002/jcb.25114openalex-snapshot
Timely Degradation of Wip1 Phosphatase by APC/C Activator Protein Cdh1 is Necessary for Normal Mitotic Progression
inferred← citeshttps://doi.org/10.1002/jcb.28840openalex-snapshot
Wip1 cooperates with KPNA2 to modulate the cell proliferation and migration of colorectal cancer via a p53‐dependent manner
inferred← citeshttps://doi.org/10.1002/jcla.23171openalex-snapshot
Potentiality of Protein phosphatase Mg 2+ /Mn 2+ dependent 1D as a biomarker for predicting prognosis in acute myeloid leukemia patients
inferred← citeshttps://doi.org/10.1002/jso.22004openalex-snapshot
Wip1 over‐expression correlated with TP53/p14ARF pathway disruption in human astrocytomas
inferred← citeshttps://doi.org/10.1002/mc.20191openalex-snapshot
Protein phosphatase 1α activity prevents oncogenic transformation
inferred← citeshttps://doi.org/10.1002/mc.20195openalex-snapshot
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice
inferred← citeshttps://doi.org/10.1002/mc.22205openalex-snapshot
Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability
inferred← citeshttps://doi.org/10.1002/med.21871openalex-snapshot
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery
inferred← citeshttps://doi.org/10.1002/mrd.20688openalex-snapshot
PP2Cδ (Ppm1d, WIP1), an endogenous inhibitor of p38 MAPK, is regulated along With Trp53 and Cdkn2a following p38 MAPK inhibition during mouse preimplantation development
inferred← citeshttps://doi.org/10.1002/path.5097openalex-snapshot
Integrating the DNA damage and protein stress responses during cancer development and treatment
inferred← citeshttps://doi.org/10.1002/stem.121openalex-snapshot
Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways
inferred← citeshttps://doi.org/10.1002/stem.65openalex-snapshot
Wip1 Regulates the Generation of New Neural Cells in the Adult Olfactory Bulb through p53-Dependent Cell Cycle Control
inferred← citeshttps://doi.org/10.1006/geno.2000.6134openalex-snapshot
The Structure and Expression of the Murine Wildtype p53-Induced Phosphatase 1 (Wip1) Gene
inferred← citeshttps://doi.org/10.1006/jmbi.2001.4967openalex-snapshot
Uniquely Conserved Non-translated Regions are Involved in Generation of the Two Major Transcripts of Protein Phosphatase 2Cβ
inferred← citeshttps://doi.org/10.1006/scbi.1998.0097openalex-snapshot
Regulation ofp53downstream genes
inferred← citeshttps://doi.org/10.1007/0-387-30127-5openalex-snapshot
The p53 Tumor Suppressor Pathway and Cancer
inferred← citeshttps://doi.org/10.1007/0-387-30127-5_5openalex-snapshot
Posttranslational Modifications of p53: Upstream Signaling Pathways
inferred← citeshttps://doi.org/10.1007/978-0-387-09794-7_2openalex-snapshot
Oscillations by the p53-Mdm2 Feedback Loop
inferred← citeshttps://doi.org/10.1007/978-1-4020-2922-6_1openalex-snapshot
The First Twenty-Five Years of p53 Research
inferred← citeshttps://doi.org/10.1007/978-1-4020-2922-6_5openalex-snapshot
Regulation of the p53 Response by Cellular Growth and Survival Factors
inferred← citeshttps://doi.org/10.1007/978-1-59259-125-1_5openalex-snapshot
Inactivation of Negative Growth Regulators During Neoplastic Transformation
inferred← citeshttps://doi.org/10.1007/978-1-59259-735-2_6openalex-snapshot
Stress-Activated Signal Transduction Pathways in DNA Damage Response
inferred← citeshttps://doi.org/10.1007/978-3-540-40035-6_1openalex-snapshot
Overview of protein serine/threonine phosphatases
inferred← citeshttps://doi.org/10.1007/978-3-540-40035-6_5openalex-snapshot
Roles of mammalian protein phosphatase 2C family members in the regulation of cellular functions
inferred← citeshttps://doi.org/10.1007/978-3-540-69184-6_8openalex-snapshot
The p53 Tumor Suppressor Gene: Structure, Function and Mechanism of Action
inferred← citeshttps://doi.org/10.1007/978-3-642-18932-6_7openalex-snapshot
The p53 Transcription Factor as Therapeutic Target in Cancer
inferred← citeshttps://doi.org/10.1007/978-94-017-0669-8_8openalex-snapshot
The p53 Pathway, Cancer and Aging
inferred← citeshttps://doi.org/10.1007/s00011-016-0952-zopenalex-snapshot
Up-regulation of Wip1 involves in neuroinflammation of retinal astrocytes after optic nerve crush via NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1007/s00018-003-3304-4openalex-snapshot
The common and distinct target genes of the p53 family transcription factors
inferred← citeshttps://doi.org/10.1007/s00018-007-7268-7openalex-snapshot
Wip1 protects hydrogen peroxide-induced colonic epithelial barrier dysfunction
inferred← citeshttps://doi.org/10.1007/s00018-020-03665-xopenalex-snapshot
Wip1 controls the translocation of the chromosomal passenger complex to the central spindle for faithful mitotic exit
inferred← citeshttps://doi.org/10.1007/s00109-017-1536-2openalex-snapshot
WIP1 phosphatase as pharmacological target in cancer therapy
inferred← citeshttps://doi.org/10.1007/s00294-004-0513-9openalex-snapshot
The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA
inferred← citeshttps://doi.org/10.1007/s00401-018-1842-yopenalex-snapshot
Reconstructing the molecular life history of gliomas
inferred← citeshttps://doi.org/10.1007/s10014-016-0252-xopenalex-snapshot
Expression and gene doses changes of the p53-regulator PPM1D in meningiomas: a role in meningioma progression?
inferred← citeshttps://doi.org/10.1007/s10495-009-0417-8openalex-snapshot
Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues
inferred← citeshttps://doi.org/10.1007/s10549-005-9017-7openalex-snapshot
The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours
inferred← citeshttps://doi.org/10.1007/s10549-006-9304-yopenalex-snapshot
Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers
inferred← citeshttps://doi.org/10.1007/s10549-011-1579-yopenalex-snapshot
Prognostic value of acquired uniparental disomy (aUPD) in primary breast cancer
inferred← citeshttps://doi.org/10.1007/s10555-008-9127-xopenalex-snapshot
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
inferred← citeshttps://doi.org/10.1007/s11033-024-10029-2openalex-snapshot
PPM1D/Wip1 is amplified, overexpressed, and mutated in human non-Hodgkin's lymphomas
inferred← citeshttps://doi.org/10.1007/s11060-007-9470-8openalex-snapshot
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D
inferred← citeshttps://doi.org/10.1007/s11434-011-4679-5openalex-snapshot
Serine/threonine protein phosphatases in DNA damage response
inferred← citeshttps://doi.org/10.1007/s11538-024-01346-5openalex-snapshot
p53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect
inferred← citeshttps://doi.org/10.1007/s11596-011-0157-1openalex-snapshot
PPM1D silencing by lentiviral-mediated RNA interference inhibits proliferation and invasion of human glioma cells
inferred← citeshttps://doi.org/10.1007/s11684-016-0433-3openalex-snapshot
Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s11888-009-0027-4openalex-snapshot
Wip1, an oncogene targeting tumor suppressors expressed in intestinal stem cells
inferred← citeshttps://doi.org/10.1007/s12015-020-10065-yopenalex-snapshot
Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?
inferred← citeshttps://doi.org/10.1007/s12031-013-0080-yopenalex-snapshot
Wip1 Phosphatase Involved in Lipopolysaccharide-Induced Neuroinflammation
inferred← citeshttps://doi.org/10.1007/s12253-018-0518-1openalex-snapshot
PPM1D Functions as Oncogene and is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1007/s13277-014-2034-6openalex-snapshot
WIP1 regulates the proliferation and invasion of nasopharyngeal carcinoma in vitro
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00097-8openalex-snapshot
MAP Kinase Phosphatases
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00250-3openalex-snapshot
FOXO Transcription Factors
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00264-3openalex-snapshot
Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses
inferred← citeshttps://doi.org/10.1016/b978-0-12-380916-2.00003-6openalex-snapshot
MDM2 and MDMX in Cancer and Development
inferred← citeshttps://doi.org/10.1016/b978-0-12-396456-4.00001-8openalex-snapshot
Wip1-Dependent Signaling Pathways in Health and Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-443-21727-2.00004-6openalex-snapshot
Plant biology and ionizing radiation: a stress response context
inferred← citeshttps://doi.org/10.1016/b978-012124546-7/50645-8openalex-snapshot
FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway That Regulate Cell Proliferation, Survival, and Organismal Aging
inferred← citeshttps://doi.org/10.1016/b978-012476249-7/50005-9openalex-snapshot
p53 and Its Targets
inferred← citeshttps://doi.org/10.1016/bs.acr.2018.12.003openalex-snapshot
Clonal hematopoiesis: Pre-cancer PLUS
inferred← citeshttps://doi.org/10.1016/j.bbaexp.2003.09.004openalex-snapshot
Molecular cloning of PP2Cη, a novel member of the protein phosphatase 2C family
inferred← citeshttps://doi.org/10.1016/j.bbaexp.2005.01.016openalex-snapshot
Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase
inferred← citeshttps://doi.org/10.1016/j.bbapap.2013.09.019openalex-snapshot
The p53 protein and its molecular network: Modelling a missing link between DNA damage and cell fate
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189442openalex-snapshot
The role of clonal hematopoiesis of indeterminate potential in non-hematological malignancies of various origins
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.04.084openalex-snapshot
PPM1B depletion in U2OS cells supresses cell growth through RB1-E2F1 pathway and stimulates bleomycin-induced cell death
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.10.010openalex-snapshot
Wip1 phosphatase deficiency impairs spatial learning and memory
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.114362openalex-snapshot
Phosphatase magnesium-dependent 1 δ (PPM1D), serine/threonine protein phosphatase and novel pharmacological target in cancer
inferred← citeshttps://doi.org/10.1016/j.biocel.2010.12.009openalex-snapshot
Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation
inferred← citeshttps://doi.org/10.1016/j.biocel.2012.02.013openalex-snapshot
p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.01.075openalex-snapshot
NF-κB-induced WIP1 expression promotes colorectal cancer cell proliferation through mTOR signaling
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.109956openalex-snapshot
The role of PPM1D in cancer and advances in studies of its inhibitors
inferred← citeshttps://doi.org/10.1016/j.blre.2019.100587openalex-snapshot
From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities?
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.08.042openalex-snapshot
Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.10.084openalex-snapshot
A small molecule inhibitor of p53-inducible protein phosphatase PPM1D
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.10.093openalex-snapshot
Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line
inferred← citeshttps://doi.org/10.1016/j.braindev.2019.02.007openalex-snapshot
Two unrelated girls with intellectual disability associated with a truncating mutation in the PPM1D penultimate exon
inferred← citeshttps://doi.org/10.1016/j.brainres.2011.12.052openalex-snapshot
Over-expression of Wild-type p53-induced phosphatase 1 confers poor prognosis of patients with gliomas
inferred← citeshttps://doi.org/10.1016/j.burns.2023.05.005openalex-snapshot
Wip1 regulates wound healing by affecting activities of keratinocytes and endothelial cells through ATM-p53 and mTOR signaling
inferred← citeshttps://doi.org/10.1016/j.cancergencyto.2007.12.013openalex-snapshot
PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53
inferred← citeshttps://doi.org/10.1016/j.canlet.2007.09.019openalex-snapshot
Identification of differentially expressed genes after PPM1D silencing in breast cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2022.215691openalex-snapshot
Early detection and intervention of clonal hematopoiesis for preventing hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.ccr.2007.08.033openalex-snapshot
The Wip1 Phosphatase Acts as a Gatekeeper in the p53-Mdm2 Autoregulatory Loop
inferred← citeshttps://doi.org/10.1016/j.cell.2010.05.031openalex-snapshot
Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells
inferred← citeshttps://doi.org/10.1016/j.cellsig.2010.10.012openalex-snapshot
Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging
inferred← citeshttps://doi.org/10.1016/j.cellsig.2011.04.002openalex-snapshot
Roles of VRK1 as a new player in the control of biological processes required for cell division
inferred← citeshttps://doi.org/10.1016/j.cellsig.2017.02.005openalex-snapshot
Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression
inferred← citeshttps://doi.org/10.1016/j.cellsig.2021.110061openalex-snapshot
Metal dependent protein phosphatase PPM family in cardiac health and diseases
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.03.082openalex-snapshot
Retracted: Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity
inferred← citeshttps://doi.org/10.1016/j.csbj.2014.05.007openalex-snapshot
Reaction–diffusion systems for spatio-temporal intracellular protein networks: A beginner's guide with two examples
inferred← citeshttps://doi.org/10.1016/j.cub.2007.01.008openalex-snapshot
FOXO transcription factors
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.09.003openalex-snapshot
Negative regulation of RelA phosphorylation: Emerging players and their roles in cancer
inferred← citeshttps://doi.org/10.1016/j.devcel.2009.05.009openalex-snapshot
p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age
inferred← citeshttps://doi.org/10.1016/j.dnarep.2009.04.012openalex-snapshot
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
inferred← citeshttps://doi.org/10.1016/j.dnarep.2010.04.005openalex-snapshot
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair
inferred← citeshttps://doi.org/10.1016/j.dnarep.2010.09.004openalex-snapshot
UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells
inferred← citeshttps://doi.org/10.1016/j.dnarep.2017.03.004openalex-snapshot
Wip1: A candidate phosphatase for cancer diagnosis and treatment
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114763openalex-snapshot
Alkyl-substituted N-methylaryl-N′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase
inferred← citeshttps://doi.org/10.1016/j.febslet.2004.04.066openalex-snapshot
Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA‐damaging stress‐induced phospho‐serine 15 of p53
inferred← citeshttps://doi.org/10.1016/j.febslet.2012.03.020openalex-snapshot
Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.gene.2012.01.099openalex-snapshot
Involvement of p53 in gemcitabine mediated cytotoxicity and radiosensitivity in breast cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.genrep.2021.101144openalex-snapshot
Targeting oncogenic WIP1 phosphatase sensitizes hypoxic breast cancer cells to doxorubicin induced apoptosis via activation of p53-p21 axis
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2006.08.004openalex-snapshot
Microarray analysis of radiation response genes in primary human fibroblasts
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2006.12.050openalex-snapshot
Radiosensitivity of Human Fibroblasts is Associated With Amino Acid Substitution Variants in Susceptible Genes And Correlates With The Number of Risk Alleles
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108117openalex-snapshot
WIP1 is a novel specific target for growth hormone action
inferred← citeshttps://doi.org/10.1016/j.it.2008.07.007openalex-snapshot
Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?
inferred← citeshttps://doi.org/10.1016/j.jaci.2017.06.026openalex-snapshot
Phosphatase wild-type p53-induced phosphatase 1 controls the development of TH9 cells and allergic airway inflammation
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107561openalex-snapshot
Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain
inferred← citeshttps://doi.org/10.1016/j.jfma.2021.12.022openalex-snapshot
Short stature leads to a diagnosis of Jansen–de Vries syndrome in two unrelated Taiwanese girls: A case report and literature review
inferred← citeshttps://doi.org/10.1016/j.jma.2025.02.010openalex-snapshot
Mechanism and application prospect of magnesium-based materials in cancer treatment
inferred← citeshttps://doi.org/10.1016/j.jtbi.2014.03.017openalex-snapshot
Investigation of oscillation accumulation triggered genetic switch in gene regulatory networks
inferred← citeshttps://doi.org/10.1016/j.jtbi.2015.09.025openalex-snapshot
PDCD5 functions as a regulator of p53 dynamics in the DNA damage response
inferred← citeshttps://doi.org/10.1016/j.jtbi.2017.01.038openalex-snapshot
Positive effect of Mdm2 on p53 expression explains excitability of p53 in response to DNA damage
inferred← citeshttps://doi.org/10.1016/j.jtbi.2023.111562openalex-snapshot
Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jtemb.2024.127512openalex-snapshot
Effects of tauroursodeoxycholate on arsenic-induced hepatic injury in mice: A comparative transcriptomic analysis
inferred← citeshttps://doi.org/10.1016/j.kint.2024.02.009openalex-snapshot
Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy
inferred← citeshttps://doi.org/10.1016/j.leukres.2007.06.022openalex-snapshot
Identification of a novel, transactivation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1016/j.mad.2014.03.003openalex-snapshot
PPM1B depletion induces premature senescence in human IMR-90 fibroblasts
inferred← citeshttps://doi.org/10.1016/j.mbs.2014.10.010openalex-snapshot
Mathematical modelling of p53 basal dynamics and DNA damage response
inferred← citeshttps://doi.org/10.1016/j.micpath.2018.10.021openalex-snapshot
p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis
inferred← citeshttps://doi.org/10.1016/j.molcel.2004.08.007openalex-snapshot
The p53-Induced Oncogenic Phosphatase PPM1D Interacts with Uracil DNA Glycosylase and Suppresses Base Excision Repair
inferred← citeshttps://doi.org/10.1016/j.molcel.2006.07.010openalex-snapshot
Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways
inferred← citeshttps://doi.org/10.1016/j.molcel.2008.03.016openalex-snapshot
Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage
inferred← citeshttps://doi.org/10.1016/j.molcel.2013.06.010openalex-snapshot
WIP1, a Homeostatic Regulator of the DNA Damage Response, Is Targeted by HIPK2 for Phosphorylation and Degradation
inferred← citeshttps://doi.org/10.1016/j.molimm.2017.09.020openalex-snapshot
Wip1 regulates blood-brain barrier function and neuro-inflammation induced by lipopolysaccharide via the sonic hedgehog signaling signaling pathway
inferred← citeshttps://doi.org/10.1016/j.molmed.2004.06.010openalex-snapshot
Wip1-deficient mice are resistant to common cancer genes
inferred← citeshttps://doi.org/10.1016/j.molmed.2007.03.002openalex-snapshot
Classic and novel roles of p53: prospects for anticancer therapy
inferred← citeshttps://doi.org/10.1016/j.mrrev.2012.06.002openalex-snapshot
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
inferred← citeshttps://doi.org/10.1016/j.mrrev.2014.10.003openalex-snapshot
The fork and the kinase: A DNA replication tale from a CHK1 perspective
inferred← citeshttps://doi.org/10.1016/j.nbd.2019.104648openalex-snapshot
Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2015.02.037openalex-snapshot
Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2015.08.017openalex-snapshot
Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107622openalex-snapshot
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors
inferred← citeshttps://doi.org/10.1016/j.physd.2024.134281openalex-snapshot
Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
inferred← citeshttps://doi.org/10.1016/j.rbmo.2021.05.007openalex-snapshot
The inhibition of WIP1 phosphatase accelerates the depletion of primordial follicles
inferred← citeshttps://doi.org/10.1016/j.stem.2007.05.020openalex-snapshot
Wip1 Phosphatase Regulates p53-Dependent Apoptosis of Stem Cells and Tumorigenesis in the Mouse Intestine
inferred← citeshttps://doi.org/10.1016/j.stem.2018.10.004openalex-snapshot
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy
inferred← citeshttps://doi.org/10.1016/j.tibs.2009.09.005openalex-snapshot
WIP1 phosphatase at the crossroads of cancer and aging
inferred← citeshttps://doi.org/10.1016/j.toxlet.2014.12.019openalex-snapshot
Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis
inferred← citeshttps://doi.org/10.1016/j.trsl.2022.11.004openalex-snapshot
Clonal hematopoiesis and bone marrow inflammation
inferred← citeshttps://doi.org/10.1016/s0014-5793(03)00153-4openalex-snapshot
A novel protein phosphatase 2C family member (PP2Cζ) is able to associate with ubiquitin conjugating enzyme 91
inferred← citeshttps://doi.org/10.1016/s0014-5793(98)00604-8openalex-snapshot
Isoform specific phosphorylation of protein phosphatase 2C expressed in COS7 cells
inferred← citeshttps://doi.org/10.1016/s0021-9258(19)84043-7openalex-snapshot
E2F1 Modulates p38 MAPK Phosphorylation via Transcriptional Regulation of ASK1 and Wip1
inferred← citeshttps://doi.org/10.1016/s0027-5107(02)00084-2openalex-snapshot
DNA damage response pathway in radioadaptive response
inferred← citeshttps://doi.org/10.1016/s0076-6879(03)66025-8openalex-snapshot
An Inducible System to Study the Growth Arrest Properties of Protein Phosphatase 2C
inferred← citeshttps://doi.org/10.1016/s0167-4781(02)00293-2openalex-snapshot
Molecular cloning and expression analysis of MPPα-2, a novel mouse transcript detected in a differential screen of pituitary libraries
inferred← citeshttps://doi.org/10.1016/s0169-328x(98)00237-xopenalex-snapshot
Cytokine-induced transcription of protein-tyrosine-phosphatases in human astrocytoma cells
inferred← citeshttps://doi.org/10.1016/s0304-3835(01)00561-4openalex-snapshot
Role of serine/threonine protein phosphatase 2A in cancer
inferred← citeshttps://doi.org/10.1016/s0306-4522(98)00484-9openalex-snapshot
The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia
inferred← citeshttps://doi.org/10.1016/s0959-8049(98)00414-6openalex-snapshot
Cellular responses to radiation and risk of breast cancer
inferred← citeshttps://doi.org/10.1016/s1097-2765(03)00058-3openalex-snapshot
PP2C Phosphatases Ptc2 and Ptc3 Are Required for DNA Checkpoint Inactivation after a Double-Strand Break
inferred← citeshttps://doi.org/10.1016/s1387-2656(01)07035-1openalex-snapshot
P53-responsive genes and the potential for cancer diagnostics and therapeutics development
inferred← citeshttps://doi.org/10.1021/acsptsci.2c00147openalex-snapshot
Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen
inferred← citeshttps://doi.org/10.1021/bi101949topenalex-snapshot
Optimization of a Cyclic Peptide Inhibitor of Ser/Thr Phosphatase PPM1D (Wip1)
inferred← citeshttps://doi.org/10.1021/bi4005649openalex-snapshot
Binding of a Third Metal Ion by the Human Phosphatases PP2Cα and Wip1 Is Required for Phosphatase Activity
inferred← citeshttps://doi.org/10.1021/bi800067popenalex-snapshot
Phosphorylation of Protein Phosphatase 2Cζ by c-Jun NH2-Terminal Kinase at Ser92 Attenuates Its Phosphatase Activity
inferred← citeshttps://doi.org/10.1023/a:1023081624133openalex-snapshot
The 17q23 Amplicon and Breast Cancer
inferred← citeshttps://doi.org/10.1034/j.1399-3054.2002.1140318.xopenalex-snapshot
Molecular cloning of a functional protein phosphatase 2C (FsPP2C2) with unusual features and synergistically up‐regulated by ABA and calcium in dormant seeds of Fagus sylvatica
inferred← citeshttps://doi.org/10.1038/cdd.2008.33openalex-snapshot
The dark side of a tumor suppressor: anti-apoptotic p53
inferred← citeshttps://doi.org/10.1038/cdd.2009.138openalex-snapshot
Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14ARF-MDM2-p53 axis
inferred← citeshttps://doi.org/10.1038/cdd.2009.68openalex-snapshot
Mdm2-mediated ubiquitylation: p53 and beyond
inferred← citeshttps://doi.org/10.1038/cdd.2011.45openalex-snapshot
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX
inferred← citeshttps://doi.org/10.1038/cddis.2013.252openalex-snapshot
Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation
inferred← citeshttps://doi.org/10.1038/cddiscovery.2017.18openalex-snapshot
DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation
inferred← citeshttps://doi.org/10.1038/emboj.2009.246openalex-snapshot
Wip1 confers G2 checkpoint recovery competence by counteracting p53‐dependent transcriptional repression
inferred← citeshttps://doi.org/10.1038/modpathol.2010.121openalex-snapshot
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study
inferred← citeshttps://doi.org/10.1038/msb.2011.20openalex-snapshot
Stimulus‐dependent dynamics of p53 in single cells
inferred← citeshttps://doi.org/10.1038/nature11725openalex-snapshot
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
inferred← citeshttps://doi.org/10.1038/nchembio.1427openalex-snapshot
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
inferred← citeshttps://doi.org/10.1038/ng0404-319openalex-snapshot
Wip-ing out cancer
inferred← citeshttps://doi.org/10.1038/ng1317openalex-snapshot
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway
inferred← citeshttps://doi.org/10.1038/ng894openalex-snapshot
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
inferred← citeshttps://doi.org/10.1038/nrc864openalex-snapshot
Live or let die: the cell's response to p53
inferred← citeshttps://doi.org/10.1038/nrm2126openalex-snapshot
Emerging roles of nuclear protein phosphatases
inferred← citeshttps://doi.org/10.1038/onc.2009.501openalex-snapshot
Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition
inferred← citeshttps://doi.org/10.1038/onc.2010.262openalex-snapshot
BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells
inferred← citeshttps://doi.org/10.1038/onc.2010.371openalex-snapshot
Serine/threonine phosphatases in the DNA damage response and cancer
inferred← citeshttps://doi.org/10.1038/onc.2011.303openalex-snapshot
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice
inferred← citeshttps://doi.org/10.1038/onc.2011.35openalex-snapshot
The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
inferred← citeshttps://doi.org/10.1038/onc.2011.451openalex-snapshot
Checkpoint control and cancer
inferred← citeshttps://doi.org/10.1038/onc.2012.502openalex-snapshot
WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function
inferred← citeshttps://doi.org/10.1038/onc.2014.37openalex-snapshot
The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants
inferred← citeshttps://doi.org/10.1038/onc.2014.375openalex-snapshot
Wip1 phosphatase in breast cancer
inferred← citeshttps://doi.org/10.1038/onc.2015.31openalex-snapshot
PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38
inferred← citeshttps://doi.org/10.1038/oncsis.2017.12openalex-snapshot
Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner
inferred← citeshttps://doi.org/10.1038/s10038-019-0589-1openalex-snapshot
Detectible mosaic truncating PPM1D mutations, age and breast cancer risk
inferred← citeshttps://doi.org/10.1038/s12276-022-00863-4openalex-snapshot
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
inferred← citeshttps://doi.org/10.1038/s41375-021-01155-yopenalex-snapshot
PPM1D mutations appear in complete remission after exposure to chemotherapy without predicting emerging AML relapse
inferred← citeshttps://doi.org/10.1038/s41375-023-02030-8openalex-snapshot
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML
inferred← citeshttps://doi.org/10.1038/s41392-022-01038-3openalex-snapshot
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
inferred← citeshttps://doi.org/10.1038/s41419-024-07269-2openalex-snapshot
PP2C phosphatases—terminators of suicidal thoughts
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