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FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/geno.2000.6196openalex-snapshot
cDNA Cloning, Genomic Structure, and Chromosomal Localization of Three Members of the Human Fatty Acid Desaturase Family
inferredcites →https://doi.org/10.1007/s00125-011-2384-1openalex-snapshot
Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?
inferredcites →https://doi.org/10.1007/s13361-017-1668-1openalex-snapshot
Detailed Structural Characterization of Sphingolipids via 193 nm Ultraviolet Photodissociation and Ultra High Resolution Tandem Mass Spectrometry
inferredcites →https://doi.org/10.1016/0005-2760(70)90078-0openalex-snapshot
Presence of sphingadienine and trans-monoenoic fatty acids in ceramide monohexosides of human plasma
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.03.011openalex-snapshot
Plasma C20-Sphingolipids predict cardiovascular events independently from conventional cardiovascular risk factors in patients undergoing coronary angiography
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.05.037openalex-snapshot
Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.10.104openalex-snapshot
Association between parental history and genetic risk scores for coronary heart disease prediction: The population-based CoLaus study
inferredcites →https://doi.org/10.1016/j.biochi.2010.03.002openalex-snapshot
Fatty Acid Desaturase 3 (Fads3) is a singular member of the Fads cluster
inferredcites →https://doi.org/10.1016/j.chembiol.2018.10.008openalex-snapshot
High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors
inferredcites →https://doi.org/10.1016/j.gene.2009.06.016openalex-snapshot
Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing
inferredcites →https://doi.org/10.1016/j.plefa.2010.02.011openalex-snapshot
Alternative transcripts of fatty acid desaturase (FADS) genes
inferredcites →https://doi.org/10.1016/j.plefa.2012.02.003openalex-snapshot
Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts
inferredcites →https://doi.org/10.1016/j.plefa.2017.07.001openalex-snapshot
Fads3 modulates docosahexaenoic acid in liver and brain
inferredcites →https://doi.org/10.1016/j.plipres.2019.100988openalex-snapshot
Mammalian sphingoid bases: Biophysical, physiological and pathological properties
inferredcites →https://doi.org/10.1016/s0022-2275(20)43032-9openalex-snapshot
Structure of plasma sphingadienine
inferredcites →https://doi.org/10.1038/ng2088openalex-snapshot
A new multipoint method for genome-wide association studies by imputation of genotypes
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/s42255-019-0123-yopenalex-snapshot
1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
inferredcites →https://doi.org/10.1056/nejmoa1815111openalex-snapshot
Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy
inferredcites →https://doi.org/10.1074/jbc.m109.092973openalex-snapshot
Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/biostatistics/kxq039openalex-snapshot
Methods for testing association between uncertain genotypes and quantitative traits
inferredcites →https://doi.org/10.1093/jn/134.5.1157openalex-snapshot
Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and Apc/+ Mice
inferredcites →https://doi.org/10.1096/fj.15-271783openalex-snapshot
The fatty acid desaturase 2 ( FADS2 ) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells
inferredcites →https://doi.org/10.1124/jpet.103.062760openalex-snapshot
Novel Ceramide Analogs as Potential Chemotherapeutic Agents in Breast Cancer
inferredcites →https://doi.org/10.1136/bmjdrc-2014-000073openalex-snapshot
Plasma 1-deoxysphingolipids are predictive biomarkers for type 2 diabetes mellitus
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2341openalex-snapshot
Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis
inferredcites →https://doi.org/10.1172/jci.insight.126925openalex-snapshot
Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence
inferredcites →https://doi.org/10.1172/jci124159openalex-snapshot
DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans
inferredcites →https://doi.org/10.1186/1471-2261-8-6openalex-snapshot
The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome
inferredcites →https://doi.org/10.1194/jlr.m000588openalex-snapshot
The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues
inferredcites →https://doi.org/10.1194/jlr.m042572openalex-snapshot
Trans-vaccenate is Δ13-desaturated by FADS3 in rodents
inferredcites →https://doi.org/10.1194/jlr.m058750openalex-snapshot
Regulation of mitochondrial ceramide distribution by members of the BCL-2 family
inferredcites →https://doi.org/10.1194/jlr.m067033openalex-snapshot
Elucidating the chemical structure of native 1-deoxysphingosine
inferredcites →https://doi.org/10.1194/jlr.m072421openalex-snapshot
Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway
inferredcites →https://doi.org/10.1194/jlr.m900039-jlr200openalex-snapshot
Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration
inferredcites →https://doi.org/10.1271/bbb.60318openalex-snapshot
Isolation of Sphingoid Bases of Sea Cucumber Cerebrosides and Their Cytotoxicity against Human Colon Cancer Cells
inferredcites →https://doi.org/10.1371/journal.pgen.1000642openalex-snapshot
A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia
inferredcites →https://doi.org/10.1371/journal.pgen.1000672openalex-snapshot
Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations
inferredcites →https://doi.org/10.1371/journal.pone.0028186openalex-snapshot
FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids
inferredcites →https://doi.org/10.1371/journal.pone.0175776openalex-snapshot
Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus
inferredcites →https://doi.org/10.3945/ajcn.110.006189openalex-snapshot
Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children
inferredcites →https://doi.org/10.7554/elife.45100openalex-snapshot
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The role of sphingolipids in endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1002/jimd.12734openalex-snapshot
Disorders of fatty acid homeostasis
inferred← citeshttps://doi.org/10.1007/978-1-0716-4116-3_14openalex-snapshot
Long Chain Base Profiling with Multiple Reaction Monitoring Mass Spectrometry
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Role of Canonical and Non-Canonical Sphingolipids and their Metabolic Enzymes in Bone Health
inferred← citeshttps://doi.org/10.1007/s40291-025-00796-4openalex-snapshot
Fatty Acid Desaturase: The Yin or Yang of Disease Pathology
inferred← citeshttps://doi.org/10.1016/b978-0-323-95582-9.00016-4openalex-snapshot
Structure and function of mammalian sphingolipids in health and disease
inferred← citeshttps://doi.org/10.1016/j.arres.2026.100178openalex-snapshot
Insulin resistance overrides FADS3 genetic variation in determining omega-6 desaturase activity in early type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2023.117274openalex-snapshot
Effect of biological sex on human circulating lipidome: An overview of the literature
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2024.119091openalex-snapshot
Sphingoid Base Diversity
inferred← citeshttps://doi.org/10.1016/j.bbalip.2021.158939openalex-snapshot
Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
inferred← citeshttps://doi.org/10.1016/j.bbalip.2023.159335openalex-snapshot
Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS3
inferred← citeshttps://doi.org/10.1016/j.bbalip.2024.159564openalex-snapshot
Recent advances on the physiological and pathophysiological roles of polyunsaturated fatty acids and their biosynthetic pathway
inferred← citeshttps://doi.org/10.1016/j.bbamem.2021.183628openalex-snapshot
The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2022.107989openalex-snapshot
Towards engineered yeast as production platform for capsaicinoids
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Serum phospholipids are potential biomarkers for the early diagnosis of gastric cancer
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The noncanonical chronicles: Emerging roles of sphingolipid structural variants
inferred← citeshttps://doi.org/10.1016/j.cellsig.2021.109949openalex-snapshot
Sphingolipids as multifaceted mediators in ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109250openalex-snapshot
A reference map of sphingolipids in murine tissues
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109488openalex-snapshot
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109797openalex-snapshot
Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.10.016openalex-snapshot
Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104802openalex-snapshot
Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115697openalex-snapshot
Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens
inferred← citeshttps://doi.org/10.1016/j.jad.2026.122140openalex-snapshot
Integrative genomic characterization of the FADS1-2-3 mood disorder risk locus: implications for the role of polyunsaturated fatty acids
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113258openalex-snapshot
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Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts
inferred← citeshttps://doi.org/10.1016/j.jlr.2022.100255openalex-snapshot
Skin fibroblast metabolomic profiling reveals that lipid dysfunction predicts the severity of Friedreich’s ataxia
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100464openalex-snapshot
The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy
inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100832openalex-snapshot
Deep sphingolipidomic and metabolomic analyses of ceramide synthase 2 null mice reveal complex pathway-specific effects
inferred← citeshttps://doi.org/10.1016/j.jlr.2025.100860openalex-snapshot
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants
inferred← citeshttps://doi.org/10.1016/j.molmet.2023.101716openalex-snapshot
Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108681openalex-snapshot
Bioactive lipids in the skin barrier mediate its functionality in health and disease
inferred← citeshttps://doi.org/10.1016/j.plefa.2020.102183openalex-snapshot
Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19✰,✰✰,★,★★
inferred← citeshttps://doi.org/10.1016/j.plipres.2019.100988openalex-snapshot
Mammalian sphingoid bases: Biophysical, physiological and pathological properties
inferred← citeshttps://doi.org/10.1016/j.plipres.2022.101165openalex-snapshot
Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions
inferred← citeshttps://doi.org/10.1016/j.plipres.2023.101236openalex-snapshot
The pathophysiological role of dihydroceramide desaturase in the nervous system
inferred← citeshttps://doi.org/10.1016/j.plipres.2023.101242openalex-snapshot
FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer
inferred← citeshttps://doi.org/10.1016/j.semcancer.2024.12.002openalex-snapshot
Theoretical framework and emerging challenges of lipid metabolism in cancer
inferred← citeshttps://doi.org/10.1016/j.xcrm.2021.100407openalex-snapshot
AdipoAtlas: A reference lipidome for human white adipose tissue
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c03502openalex-snapshot
Resolving Modifications on Sphingoid Base and N ‑Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02598openalex-snapshot
Omic-Scale High-Throughput Quantitative LC–MS/MS Approach for Circulatory Lipid Phenotyping in Clinical Research
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c02445openalex-snapshot
Accurate Sphingolipid Quantification Reducing Fragmentation Bias by Nonlinear Models
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Profiling Intact Glycosphingolipids with Automated Structural Annotation and Quantitation from Human Samples with Nanoflow Liquid Chromatography Mass Spectrometry
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Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
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Illuminating the dark space of neutral glycosphingolipidome by selective enrichment and profiling at multi-structural levels
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Very long-chain fatty acids drive 1-deoxySphingolipid toxicity
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A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility
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ReTimeML: a retention time predictor that supports the LC–MS/MS analysis of sphingolipids
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Computational mass spectrometry accelerates C = C position-resolved untargeted lipidomics using oxygen attachment dissociation
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Click and count: specific detection of acid ceramidase activity in live cells
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Mapping the distribution of double bond location isomers in lipids across mouse tissues
inferred← citeshttps://doi.org/10.1073/pnas.2002391117openalex-snapshot
Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases
inferred← citeshttps://doi.org/10.1093/clinchem/hvae115openalex-snapshot
Development of a Multiplexed Sphingolipids Method for Diagnosis of Inborn Errors of Ceramide Metabolism
inferred← citeshttps://doi.org/10.1093/cvr/cvaf093openalex-snapshot
Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets
inferred← citeshttps://doi.org/10.1093/plphys/kiab064openalex-snapshot
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New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis
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Overexpression of fatty acid desaturase 3 predicts poor prognosis in head and neck squamous cell carcinoma
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The meadow jumping mouse genome and transcriptome suggest mechanisms of hibernation
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SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
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An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis
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Very long chain fatty acids drive 1-deoxy-Sphingolipid toxicity
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Effects of Aging on Glucose and Lipid Metabolism in Mice
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SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins
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Proteomic analysis of mitochondria-ER contacts reveals key proteins involved in metabolic regulation in hepatocytes
inferred← citeshttps://doi.org/10.1186/s40170-020-00237-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1212/nxi.0000000000000951openalex-snapshot
Altered CSF Albumin Quotient Links Peripheral Inflammation and Brain Damage in MS
inferred← citeshttps://doi.org/10.12998/wjcc.v9.i35.10884openalex-snapshot
Development of a lipid metabolism-related gene model to predict prognosis in patients with pancreatic cancer
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High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies
inferred← citeshttps://doi.org/10.2337/db22-1018openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fimmu.2026.1817492openalex-snapshot
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inferred← citeshttps://doi.org/10.3389/fmolb.2021.683767openalex-snapshot
The Functional Role of Sphingosine Kinase 2
inferred← citeshttps://doi.org/10.3389/fnut.2026.1929742openalex-snapshot
Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence
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The n-10 Fatty Acids Family in the Lipidome of Human Prostatic Adenocarcinoma Cell Membranes and Extracellular Vesicles
inferred← citeshttps://doi.org/10.3390/cancers15072183openalex-snapshot
Biosynthesis and Significance of Fatty Acids, Glycerophospholipids, and Triacylglycerol in the Processes of Glioblastoma Tumorigenesis
inferred← citeshttps://doi.org/10.3390/ijms22158171openalex-snapshot
Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx
inferred← citeshttps://doi.org/10.3390/ijms242115693openalex-snapshot
Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids
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Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies
inferred← citeshttps://doi.org/10.3390/medicina57070729openalex-snapshot
Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer
inferred← citeshttps://doi.org/10.3390/metabo10060236openalex-snapshot
A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids
inferred← citeshttps://doi.org/10.64898/2026.05.11.724297openalex-snapshot
CYP4F2-mediated ω-hydroxylation of 1-deoxysphingolipids reveals a new hepatic detoxification pathway
inferred← citeshttps://doi.org/10.7554/elife.72779openalex-snapshot
Ontogeny of circulating lipid metabolism in pregnancy and early childhood – a longitudinal population study
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