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Thrombin Differentiates Normal Lung Fibroblasts to a Myofibroblast Phenotype via the Proteolytically Activated Receptor-1 and a Protein Kinase C-dependent Pathway

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1529-0131(200011)43:11<2437::aid-anr10>3.0.co;2-uopenalex-snapshot

Severe organ involvement in systemic sclerosis with diffuse scleroderma

inferredcites →https://doi.org/10.1002/1529-0131(200106)44:6<1370::aid-art230>3.0.co;2-2openalex-snapshot

Depletion of protein kinase C? in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression

inferredcites →https://doi.org/10.1002/art.1780370903openalex-snapshot

Severe restrictive lung disease in systemic sclerosis

inferredcites →https://doi.org/10.1006/excr.2000.4869openalex-snapshot

Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast

inferredcites →https://doi.org/10.1007/978-3-642-58456-5_3openalex-snapshot

Modulation of Myofibroblast and Smooth-Muscle Phenotypes in the Lung

inferredcites →https://doi.org/10.1016/0006-2952(94)00404-aopenalex-snapshot

Involvement of inositol 1,4,5-triphosphate and protein kinase C in thrombin-induced contraction of porcine pulmonary artery

inferredcites →https://doi.org/10.1016/0014-5793(95)01025-aopenalex-snapshot

PKC α regulates thrombin‐induced PDGF‐B chain gene expression in mesangial cells

inferredcites →https://doi.org/10.1016/0049-3848(95)00025-9openalex-snapshot

Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis

inferredcites →https://doi.org/10.1016/b978-0-12-632310-8.x5000-1openalex-snapshot

The Vascular Smooth Muscle Cell

inferredcites →https://doi.org/10.1016/s0021-9258(17)42032-1openalex-snapshot

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling.

inferredcites →https://doi.org/10.1016/s0065-2571(99)00038-2openalex-snapshot

Implication of atypical protein kinase C isozymes λ and ζ in ras mediated reorganization of the actin cytoskeleton and cyclin D1—induction

inferredcites →https://doi.org/10.1016/s0140-6736(95)91744-6openalex-snapshot

Role of thrombin in pulmonary fibrosis

inferredcites →https://doi.org/10.1016/s0898-6568(97)00121-6openalex-snapshot

Protein Kinase C and the Cytoskeleton

inferredcites →https://doi.org/10.1021/bi00171a023openalex-snapshot

Identification and Characterization of .alpha.-Protein Kinase C Binding Proteins in Normal and Transformed REF52 Cells

inferredcites →https://doi.org/10.1021/bi00171a024openalex-snapshot

Protein Kinase C Domains Involved in Interactions with Other Proteins

inferredcites →https://doi.org/10.1021/bi9916527openalex-snapshot

Interaction of Protein Kinase C with Filamentous Actin: Isozyme Specificity Resulting from Divergent Phorbol Ester and Calcium Dependencies

inferredcites →https://doi.org/10.1038/35025229openalex-snapshot

Thrombin signalling and protease-activated receptors

inferredcites →https://doi.org/10.1038/38284openalex-snapshot

Defective platelet activation in Gαq-deficient mice

inferredcites →https://doi.org/10.1042/bj3130353openalex-snapshot

Cellular consequences of thrombin-receptor activation

inferredcites →https://doi.org/10.1055/s-0037-1615000openalex-snapshot

Thrombin Stimulates Smooth Muscle Cell Procollagen Synthesis and mRNA Levels via a PAR-1 Mediated Mechanism

inferredcites →https://doi.org/10.1055/s-0038-1642727openalex-snapshot

Thrombin Functions and Antithrombotic Intervention

inferredcites →https://doi.org/10.1073/pnas.97.22.12062openalex-snapshot

Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton

inferredcites →https://doi.org/10.1074/jbc.270.22.13326openalex-snapshot

Regulation of Alternative Splicing of Protein Kinase Cβ by Insulin

inferredcites →https://doi.org/10.1074/jbc.270.41.23887openalex-snapshot

Selective Inhibition of Thrombin Receptor-mediated Ca2+ Entry by Protein Kinase C β

inferredcites →https://doi.org/10.1074/jbc.271.40.24962openalex-snapshot

A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function

inferredcites →https://doi.org/10.1074/jbc.272.46.29200openalex-snapshot

The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε

inferredcites →https://doi.org/10.1074/jbc.272.49.30945openalex-snapshot

A Selective ε-Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death

inferredcites →https://doi.org/10.1074/jbc.273.20.12155openalex-snapshot

Receptor Subtype-specific Regulation of Muscarinic Acetylcholine Receptor Sequestration by Dynamin

inferredcites →https://doi.org/10.1074/jbc.273.31.19482openalex-snapshot

A Major, Transformation-sensitive PKC-binding Protein Is Also a PKC Substrate Involved in Cytoskeletal Remodeling

inferredcites →https://doi.org/10.1074/jbc.273.41.26790openalex-snapshot

Molecular Analysis of the Interactions between Protein Kinase C-ε and Filamentous Actin

inferredcites →https://doi.org/10.1074/jbc.274.18.12355openalex-snapshot

Activation of the Mitogen-activated Protein Kinase Pathway by a Gq/11-coupled Muscarinic Receptor Is Independent of Receptor Internalization

inferredcites →https://doi.org/10.1074/jbc.275.12.9026openalex-snapshot

Identification of Gβγ Binding Sites in the Third Intracellular Loop of the M3-muscarinic Receptor and Their Role in Receptor Regulation

inferredcites →https://doi.org/10.1074/jbc.m909194199openalex-snapshot

Phosphatidylinositol 3-Kinase Activity Regulates α-Thrombin-stimulated G1 Progression by Its Effect on Cyclin D1 Expression and Cyclin-dependent Kinase 4 Activity

inferredcites →https://doi.org/10.1083/jcb.120.6.1491openalex-snapshot

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

inferredcites →https://doi.org/10.1083/jcb.132.1.77openalex-snapshot

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

inferredcites →https://doi.org/10.1084/jem.182.3.829openalex-snapshot

A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages.

inferredcites →https://doi.org/10.1096/fasebj.12.1.35openalex-snapshot

Anchoring proteins for protein kinase C: a means for isozyme selectivity

inferredcites →https://doi.org/10.1111/j.1476-5381.1995.tb15063.xopenalex-snapshot

Stimulation by endothelin‐1 of mitogen‐activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells

inferredcites →https://doi.org/10.1111/j.1476-5381.1995.tb15895.xopenalex-snapshot

Mode of action of thrombin in the rabbit aorta

inferredcites →https://doi.org/10.1126/science.280.5372.2109openalex-snapshot

p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13

inferredcites →https://doi.org/10.1126/science.7716516openalex-snapshot

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

inferredcites →https://doi.org/10.1152/ajpcell.1997.272.4.c1112openalex-snapshot

Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells

inferredcites →https://doi.org/10.1159/000159200openalex-snapshot

α-Thrombin Induces Transforming Growth Factor-β 1 mRNA and Protein in Cultured Vascular Smooth Muscle Cells via a Proteolytically Activated Receptor

inferredcites →https://doi.org/10.1159/000168813openalex-snapshot

Interstitial Myofibroblasts in IgA Glomerulonephritis

inferredcites →https://doi.org/10.1164/ajrccm.152.6.8520791openalex-snapshot

Cytoskeletal Protein Modulation in Pulmonary Alveolar Myofibroblasts During Idiopathic Pulmonary Fibrosis. Possible Role of Transforming Growth Factor Beta and Tumor Necrosis Factor Alpha

inferredcites →https://doi.org/10.1165/ajrcmb.10.4.7510986openalex-snapshot

Scleroderma Bronchoalveolar Lavage Fluid Contains Thrombin, a Mediator of Human Lung Fibroblast Proliferation via Induction of Platelet-Derived Growth Factor α-Receptor

inferredcites →https://doi.org/10.1165/ajrcmb.12.6.7766431openalex-snapshot

Partially Degraded Fibrin(ogen) Stimulates Fibroblast Proliferation In Vitro

inferredcites →https://doi.org/10.1165/ajrcmb.21.6.3720openalex-snapshot

Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β1

inferredcites →https://doi.org/10.1165/ajrcmb.22.2.3642openalex-snapshot

Thrombin Upregulates Interleukin-8 in Lung Fibroblasts via Cleavage of Proteolytically Activated Receptor-I and Protein Kinase C - γ Activation

inferredcites →https://doi.org/10.1165/ajrcmb/5.1.34openalex-snapshot

Thrombin Enhances Lung Fibroblast Proliferation in Bleomycin-induced Pulmonary Fibrosis

inferredcites →https://doi.org/10.1172/jci116206openalex-snapshot

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.

inferredcites →https://doi.org/10.1177/39.4.2005371openalex-snapshot

Thrombin stimulation of synthesis and secretion of fibronectin by human A549 epithelial cells and mouse LB fibroblasts.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Vorapaxar Prove to Be a Promising Candidate for Pulmonary Fibrosis by Intervening Thrombin/PAR1/JAK/STAT Signaling Pathway

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Fibroblasts

inferred← citeshttps://doi.org/10.1002/acr2.11049openalex-snapshot

Safety and Tolerability of Thrombin Inhibition in Scleroderma‐Associated Interstitial Lung Disease

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Human Adventitial Fibroblast Phenotype Depends on the Progression of Changes in Substrate Stiffness

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Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts

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Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease

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Tissue factor–thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up‐regulation of endothelin receptor A

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Editorial: Fate of Fat Tissue Adipocytes: Do They Transform Into Myofibroblasts in Scleroderma?

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Critical Role of LMCD1 in Promoting Profibrotic Characteristics of Lung Myofibroblasts in Experimental and Scleroderma‐Associated Lung Fibrosis

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Probing vocal fold fibroblast response to hyaluronan in 3D contexts

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Clinicopathological significance of microRNA‐21 in extracellular vesicles of pleural lavage fluid of lung adenocarcinoma and its functions inducing the mesothelial to mesenchymal transition

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Proteinase‐activated receptors and the pathophysiology of pulmonary fibrosis

inferred← citeshttps://doi.org/10.1002/hed.21863openalex-snapshot

Thrombin‐stimulated connective tissue growth factor (CTGF/CCN2) production in human buccal mucosal fibroblasts: Inhibition by epigallocatechin‐3‐gallate

inferred← citeshttps://doi.org/10.1002/jcp.20972openalex-snapshot

Therapies for bleomycin induced lung fibrosis through regulation of TGF‐β1 induced collagen gene expression

inferred← citeshttps://doi.org/10.1002/jcp.24061openalex-snapshot

PAR‐1‐dependent and PAR‐independent pro‐inflammatory signaling in human lung fibroblasts exposed to thrombin

inferred← citeshttps://doi.org/10.1002/jcp.25341openalex-snapshot

miR‐19a, ‐19b, and ‐26b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation

inferred← citeshttps://doi.org/10.1002/jcp.28256openalex-snapshot

Activation of PERK in ET‐1‐ and thrombin‐induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin

inferred← citeshttps://doi.org/10.1002/path.1398openalex-snapshot

Role of tissue stroma in cancer cell invasion

inferred← citeshttps://doi.org/10.1007/0-387-33650-8_3openalex-snapshot

Scleroderma Lung Fibroblasts

inferred← citeshttps://doi.org/10.1007/3-540-30328-6openalex-snapshot

Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

inferred← citeshttps://doi.org/10.1007/3-540-30328-6_9openalex-snapshot

Fibrosis in the Acute Respiratory Distress Syndrome

inferred← citeshttps://doi.org/10.1007/978-3-0348-0157-7_7openalex-snapshot

Proteases and Fibrosis

inferred← citeshttps://doi.org/10.1007/978-3-7643-7650-5_5openalex-snapshot

The fibroblast and myofibroblast in inflammatory angiogenesis

inferred← citeshttps://doi.org/10.1007/s00408-007-9012-3openalex-snapshot

Interstitial Lung Disease in Systemic Sclerosis

inferred← citeshttps://doi.org/10.1007/s00418-005-0109-6openalex-snapshot

Induction of the myofibroblast phenotype following elastolytic injury to mouse lung

inferred← citeshttps://doi.org/10.1007/s10238-023-01222-xopenalex-snapshot

A journey to vasculopathy in systemic sclerosis: focus on haemostasis and thrombosis

inferred← citeshttps://doi.org/10.1007/s11926-010-0143-9openalex-snapshot

Biomarkers of Scleroderma Lung Disease: Recent Progress

inferred← citeshttps://doi.org/10.1007/s11926-014-0411-1openalex-snapshot

Recent Advances in Understanding the Pathogenesis of Scleroderma-Interstitial Lung Disease

inferred← citeshttps://doi.org/10.1007/s12079-009-0082-2openalex-snapshot

Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma

inferred← citeshttps://doi.org/10.1007/s13770-019-00201-2openalex-snapshot

Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering

inferred← citeshttps://doi.org/10.1007/s40674-022-00196-3openalex-snapshot

Biomarkers in Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)

inferred← citeshttps://doi.org/10.1016/b978-0-323-54431-3.00003-2openalex-snapshot

Mechanisms of Fibrosis

inferred← citeshttps://doi.org/10.1016/bs.apha.2023.04.002openalex-snapshot

Anti-fibrotic strategies and pulmonary fibrosis

inferred← citeshttps://doi.org/10.1016/j.ancard.2008.02.015openalex-snapshot

Rôle de l’endothélium dans les dommages radio-induits aux tissus sains

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2009.01.011openalex-snapshot

FXa-induced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis

inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.10.207openalex-snapshot

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation

inferred← citeshttps://doi.org/10.1016/j.bbrc.2005.11.127openalex-snapshot

Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis

inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111475openalex-snapshot

Salvianolic acid B inhalation solution enhances antifibrotic and anticoagulant effects in a rat model of pulmonary fibrosis

inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111701openalex-snapshot

Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma

inferred← citeshttps://doi.org/10.1016/j.ccm.2004.04.003openalex-snapshot

Idiopathic pulmonary fibrosis: new insights into pathogenesis

inferred← citeshttps://doi.org/10.1016/j.ccm.2010.05.004openalex-snapshot

Pulmonary Manifestations of Scleroderma and Mixed Connective Tissue Disease

inferred← citeshttps://doi.org/10.1016/j.cej.2020.125414openalex-snapshot

Promoting coagulation and activating SMAD3 phosphorylation in wound healing via a dual-release thrombin-hydrogel

inferred← citeshttps://doi.org/10.1016/j.cell.2005.02.034openalex-snapshot

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

inferred← citeshttps://doi.org/10.1016/j.coph.2004.01.012openalex-snapshot

Shooting for PARs in lung diseases

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Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice

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A direct thrombin inhibitor, dabigatran etexilate protects from renal fibrosis by inhibiting protease activated receptor-1

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Vorapaxar proven to be a promising candidate for pulmonary fibrosis by intervening in the PAR1/JAK2/STAT1/3 signaling pathway-an experimental in vitro and vivo study

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Role of C/EBPβ/STAT3/AP-1 transcriptional complex formation in thrombin-induced connective tissue growth factor expression in human lung fibroblasts

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Critical role of the Rho-kinase pathway in TGF-β2-dependent collagen gel contraction by retinal pigment epithelial cells

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Endothelin-1 stimulates oral fibroblasts to promote oral cancer invasion

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The impaired proteases and anti-proteases balance in Idiopathic Pulmonary Fibrosis

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A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors

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Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway

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Coagulation and Autoimmunity in Scleroderma Interstitial Lung Disease

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M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo

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MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype

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ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts

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Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice

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Absence of Proteinase-Activated Receptor-1 Signaling Affords Protection from Bleomycin-Induced Lung Inflammation and Fibrosis

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Differentiation of vascular myofibroblasts induced by transforming growth factor-β1 requires the involvement of protein kinase Cα

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Fibroblast Differentiation in Wound Healing and Fibrosis

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Idiopathic pulmonary fibrosis

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Cytokine regulation of pulmonary fibrosis in scleroderma

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New insights into the pathogenesis of systemic sclerosis

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New Insights into the Mechanism of Fibroblast to Myofibroblast Transformation and Associated Pathologies

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Pulmonary fibrosis: pathogenesis, etiology and regulation

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Melanoma miRNA trafficking controls tumour primary niche formation

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Targeting proteinase-activated receptors: therapeutic potential and challenges

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Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b

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Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

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Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension

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Transforming Growth Factor-β1 Induces Expression of Human Coagulation Factor XII via Smad3 and JNK Signaling Pathways in Human Lung Fibroblasts

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Thrombin Induces Nitric-oxide Synthase via Gα12/13-coupled Protein Kinase C-dependent I-κBα Phosphorylation and JNK-mediated I-κBα Degradation

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Opposing Effects of Protein Kinase Cα and Protein Kinase Cϵ on Collagen Expression by Human Lung Fibroblasts Are Mediated via MEK/ERK and Caveolin-1 Signaling

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Current immunosuppressive and antifibrotic therapies of systemic sclerosis and emerging therapeutic strategies

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Thrombin and Its Protease-Activated Receptor-1 (PAR1) Participate in the Endothelial–Mesenchymal Transdifferentiation Process

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Safety and Tolerability of Inhaled Heparin in Idiopathic Pulmonary Fibrosis

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Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts

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YB-1 Coordinates Vascular Smooth Muscle α-Actin Gene Activation by Transforming Growth Factor β1 and Thrombin during Differentiation of Human Pulmonary Myofibroblasts

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Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

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Protein Kinase C- (PKC- ): Its Unique Structure and Function

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Histopathology and bronchoalveolar lavage

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Peptide Angio‐3 Attenuates Pulmonary Fibrosis Via Modulation of the Coagulation Factor Xa—Protease‐Activated Receptor‐1 Signaling Axis

inferred← citeshttps://doi.org/10.1097/01.bor.0000181534.67685.5aopenalex-snapshot

New Developments in Scleroderma Interstitial Lung Disease

inferred← citeshttps://doi.org/10.1097/01.fjc.0000179432.73007.45openalex-snapshot

Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiotensin II

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Normal and Pathologic Soft Tissue Remodeling: Role of the Myofibroblast, with Special Emphasis on Liver and Kidney Fibrosis

inferred← citeshttps://doi.org/10.1097/bor.0000000000000111openalex-snapshot

Update on scleroderma-associated interstitial lung disease

inferred← citeshttps://doi.org/10.1097/bor.0b013e3283126985openalex-snapshot

Scleroderma lung disease: evolving understanding in light of newer studies

inferred← citeshttps://doi.org/10.1101/2023.01.16.524219openalex-snapshot

Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

inferred← citeshttps://doi.org/10.1111/j.1067-1927.2005.130102.xopenalex-snapshot

Perspective Article: Tissue repair, contraction, and the myofibroblast

inferred← citeshttps://doi.org/10.1111/j.1398-9995.2009.02305.xopenalex-snapshot

IPF: new insight on pathogenesis and treatment

inferred← citeshttps://doi.org/10.1111/j.1447-0756.2006.00367.xopenalex-snapshot

Natural nutrient mixture effectively reduces collagen matrix contraction driven by human uterine smooth muscle cells

inferred← citeshttps://doi.org/10.1111/j.1476-5381.2009.00449.xopenalex-snapshot

Protease‐activated receptors and prostaglandins in inflammatory lung disease

inferred← citeshttps://doi.org/10.1111/j.1742-4658.2008.06511.xopenalex-snapshot

Downregulation of protease‐activated receptor‐1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A

inferred← citeshttps://doi.org/10.1111/jcmm.12520openalex-snapshot

Protease‐activated receptor ( PAR )‐2 is required for PAR ‐1 signalling in pulmonary fibrosis

inferred← citeshttps://doi.org/10.1111/jcmm.12891openalex-snapshot

High endogenous activated protein C levels attenuates bleomycin‐induced pulmonary fibrosis

inferred← citeshttps://doi.org/10.1111/jth.13191openalex-snapshot

Actions of thrombin in the interstitium

inferred← citeshttps://doi.org/10.1111/jth.13623openalex-snapshot

Targeting coagulation factor receptors – protease‐activated receptors in idiopathic pulmonary fibrosis

inferred← citeshttps://doi.org/10.1136/gut.2003.032136openalex-snapshot

A role for thrombin in liver fibrosis

inferred← citeshttps://doi.org/10.1136/thoraxjnl-2013-203877openalex-snapshot

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

inferred← citeshttps://doi.org/10.1146/annurev.med.55.091902.103810openalex-snapshot

Mechanisms of Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1152/ajpcell.00169.2003openalex-snapshot

Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts

inferred← citeshttps://doi.org/10.1152/ajpcell.00416.2009openalex-snapshot

Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension

inferred← citeshttps://doi.org/10.1152/ajplung.00098.2005openalex-snapshot

Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway

inferred← citeshttps://doi.org/10.1152/ajplung.00166.2011openalex-snapshot

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

inferred← citeshttps://doi.org/10.1152/ajplung.00226.2006openalex-snapshot

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4

inferred← citeshttps://doi.org/10.1152/ajplung.00242.2004openalex-snapshot

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways

inferred← citeshttps://doi.org/10.1152/ajplung.00295.2007openalex-snapshot

Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo

inferred← citeshttps://doi.org/10.1152/ajplung.00343.2004openalex-snapshot

Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2

inferred← citeshttps://doi.org/10.1152/ajplung.00417.2002openalex-snapshot

Contractile activity and smooth muscle α-actin organization in thrombin-induced human lung myofibroblasts

inferred← citeshttps://doi.org/10.1152/ajplung.00447.2003openalex-snapshot

Connective tissue growth factor expression and induction by transforming growth factor-β is abrogated by simvastatin via a Rho signaling mechanism

inferred← citeshttps://doi.org/10.1152/ajplung.00448.2003openalex-snapshot

Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts

inferred← citeshttps://doi.org/10.1152/ajplung.00509.2016openalex-snapshot

Human airway trypsin-like protease, a serine protease involved in respiratory diseases

inferred← citeshttps://doi.org/10.1152/physrev.00044.2021openalex-snapshot

Protease-activated receptors in health and disease

inferred← citeshttps://doi.org/10.1155/2012/584219openalex-snapshot

Malignant Melanoma and Its Stromal Nonimmune Microecosystem

inferred← citeshttps://doi.org/10.11575/prism/24770openalex-snapshot

Allergen Proteinases and Allergic Airway Inflammation: Signaling via Proteinase-Activated Receptors

inferred← citeshttps://doi.org/10.1158/0008-5472.22415271openalex-snapshot

Supplementary data from Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation

inferred← citeshttps://doi.org/10.1158/0008-5472.22415271.v1openalex-snapshot

Supplementary data from Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation

inferred← citeshttps://doi.org/10.1159/000086228openalex-snapshot

Thrombin Is a Pro-Fibrotic Factor for Rat Renal Fibroblasts in vitro

inferred← citeshttps://doi.org/10.1159/000320826openalex-snapshot

Proteinase-activated receptor-1 inhibitors

inferred← citeshttps://doi.org/10.1159/000430102openalex-snapshot

Protomyofibroblast Pathway in Early Thermal Burn Healing

inferred← citeshttps://doi.org/10.1159/000547814openalex-snapshot

A Review of Proteases and Antiproteases for Immune Regulation and Potential Therapeutic Application in Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1160/th07-11-0666openalex-snapshot

Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases

inferred← citeshttps://doi.org/10.1161/01.res.0000056770.30922.e6openalex-snapshot

Oxygen Sensing by Primary Cardiac Fibroblasts

inferred← citeshttps://doi.org/10.1164/rccm.200308-1156ocopenalex-snapshot

Increased Thrombin Activity after Allergen Challenge

inferred← citeshttps://doi.org/10.1164/rccm.201412-2281leopenalex-snapshot

We Should Prohibit Warfarin in Idiopathic Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1165/rcmb.2003-0159suopenalex-snapshot

Idiopathic Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1165/rcmb.2005-0026ocopenalex-snapshot

Thrombin and TNF-α/IL-1β Synergistically Induce Fibroblast-Mediated Collagen Gel Degradation

inferred← citeshttps://doi.org/10.1165/rcmb.2006-0033ocopenalex-snapshot

PKCα Mediates CCL18-Stimulated Collagen Production in Pulmonary Fibroblasts

inferred← citeshttps://doi.org/10.1165/rcmb.2009-0388tropenalex-snapshot

Endothelin in Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1165/rcmb.2013-0317ocopenalex-snapshot

Thrombin Increases Lung Fibroblast Survival while Promoting Alveolar Epithelial Cell Apoptosis via the Endoplasmic Reticulum Stress Marker, CCAAT Enhancer–Binding Homologous Protein

inferred← citeshttps://doi.org/10.1165/rcmb.2016-0104ocopenalex-snapshot

Tensin 1 Is Essential for Myofibroblast Differentiation and Extracellular Matrix Formation

inferred← citeshttps://doi.org/10.1167/iovs.15-16388openalex-snapshot

The Role of Thrombin and Cell Contractility in Regulating Clustering and Collective Migration of Corneal Fibroblasts in Different ECM Environments

inferred← citeshttps://doi.org/10.1167/iovs.18-25376openalex-snapshot

Critical Role of mTORC2-Akt Signaling in TGF-β1-Induced Myofibroblast Differentiation of Human Pterygium Fibroblasts

inferred← citeshttps://doi.org/10.1172/jci.insight.86608openalex-snapshot

Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis

inferred← citeshttps://doi.org/10.1172/jci33288openalex-snapshot

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury

inferred← citeshttps://doi.org/10.1172/jci93554openalex-snapshot

The fibrotic tumor stroma

inferred← citeshttps://doi.org/10.1177/1076029615618023openalex-snapshot

Mean Platelet Volume as a Surrogate Marker for Platelet Activation in Patients With Idiopathic Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.1177/23971983241311625openalex-snapshot

Anti-fibrotic effects of thrombin inhibition in systemic sclerosis-associated interstitial lung disease: Proof of concept

inferred← citeshttps://doi.org/10.1182/blood-2011-09-377648openalex-snapshot

Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

inferred← citeshttps://doi.org/10.1182/bloodadvances.2018018283openalex-snapshot

Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice

inferred← citeshttps://doi.org/10.1183/09031936.00073012openalex-snapshot

The pathogenesis of pulmonary fibrosis: a moving target

inferred← citeshttps://doi.org/10.1183/09031936.00135205openalex-snapshot

BALF-derived fibroblasts differ from biopsy-derived fibroblasts in systemic sclerosis

inferred← citeshttps://doi.org/10.1183/09031936.03.00001003openalex-snapshot

Role of coagulation cascade proteases in lung repair and fibrosis

inferred← citeshttps://doi.org/10.1183/09031936.04.00005704openalex-snapshot

Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-ϵ

inferred← citeshttps://doi.org/10.1183/16000617.00008414openalex-snapshot

Coagulation and anticoagulation in idiopathic pulmonary fibrosis

inferred← citeshttps://doi.org/10.1186/1477-7827-7-2openalex-snapshot

Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin

inferred← citeshttps://doi.org/10.1186/1755-1536-5-11openalex-snapshot

Molecular and cellular mechanisms of pulmonary fibrosis

inferred← citeshttps://doi.org/10.1186/cc7780openalex-snapshot

Markers of collagen synthesis and degradation are increased in serum in severe sepsis: a longitudinal study of 44 patients

inferred← citeshttps://doi.org/10.1186/s12929-023-00931-5openalex-snapshot

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

inferred← citeshttps://doi.org/10.1186/s12931-016-0418-4openalex-snapshot

Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis

inferred← citeshttps://doi.org/10.1186/s12931-022-02192-6openalex-snapshot

Human umbilical cord mesenchymal stem cells combined with pirfenidone upregulates the expression of RGS2 in the pulmonary fibrosis in mice

inferred← citeshttps://doi.org/10.1242/jcs.018689openalex-snapshot

Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells

inferred← citeshttps://doi.org/10.12681/eadd/39093openalex-snapshot

Ο ρόλος της έψιλον ισομορφής της πρωτεϊνικής κινάσης C-ε στο μηχανισμό διαφοροποίησης των νευροβλαστών και των νευρώνων

inferred← citeshttps://doi.org/10.1290/1543-706x(2003)039<0204:anivdw>2.0.co;2openalex-snapshot

A NOVEL IN VITRO DERMAL WOUND-HEALING MODEL INCORPORATING A RESPONSE TO MECHANICAL WOUNDING AND REPOPULATION OF A FIBRIN PROVISIONAL MATRIX

inferred← citeshttps://doi.org/10.1371/journal.pone.0162357openalex-snapshot

D1398G Variant of MET Is Associated with Impaired Signaling of Hepatocyte Growth Factor in Alveolar Epithelial Cells and Lung Fibroblasts

inferred← citeshttps://doi.org/10.1378/chest.122.6_suppl.326sopenalex-snapshot

Hypoxic Activation of Adventitial Fibroblasts*

inferred← citeshttps://doi.org/10.1378/chest.127.5.1793openalex-snapshot

Bone Marrow-Derived Cells Contribute to Pulmonary Vascular Remodeling in Hypoxia-Induced Pulmonary Hypertension

inferred← citeshttps://doi.org/10.14814/phy2.12295openalex-snapshot

Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts

inferred← citeshttps://doi.org/10.1517/13543784.2014.848852openalex-snapshot

Novel investigational agents for the treatment of scleroderma

inferred← citeshttps://doi.org/10.1586/17476348.1.3.377openalex-snapshot

Idiopathic pulmonary fibrosis

inferred← citeshttps://doi.org/10.1586/ers.10.62openalex-snapshot

Lung epithelial wound healing in health and disease

inferred← citeshttps://doi.org/10.1681/asn.2005070694openalex-snapshot

Deletion of Protein Kinase C-ε Signaling Pathway Induces Glomerulosclerosis and Tubulointerstitial Fibrosis In Vivo

inferred← citeshttps://doi.org/10.17116/patol20248604158openalex-snapshot

Pathogenesis of pulmonary fibrosis

inferred← citeshttps://doi.org/10.18297/etd/720openalex-snapshot

The role of PKC-epsilon in models of alcohol- and toxin-induced liver disease.

inferred← citeshttps://doi.org/10.18632/oncotarget.6095openalex-snapshot

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis

inferred← citeshttps://doi.org/10.2152/jmi.65.258openalex-snapshot

Human airway trypsin‐like protease (HAT) is released into saliva

inferred← citeshttps://doi.org/10.2165/00151829-200605050-00004openalex-snapshot

Idiopathic Pulmonary Fibrosis

inferred← citeshttps://doi.org/10.2174/1874312901206010116openalex-snapshot

Caveolin-1 Signaling in Lung Fibrosis

inferred← citeshttps://doi.org/10.2174/2212703802666150127002032openalex-snapshot

Idiopathic Pulmonary Fibrosis, Opportunities and Challenges

inferred← citeshttps://doi.org/10.2353/ajpath.2006.050658openalex-snapshot

Protease-Activated Receptor-2 Activation

inferred← citeshttps://doi.org/10.2353/ajpath.2008.070347openalex-snapshot

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

inferred← citeshttps://doi.org/10.2741/a798openalex-snapshot

Molecular aspects of scleroderma

inferred← citeshttps://doi.org/10.3109/01902148.2010.490288openalex-snapshot

Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts

inferred← citeshttps://doi.org/10.3109/01902148.2013.820809openalex-snapshot

Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells

inferred← citeshttps://doi.org/10.31219/osf.io/gq8hxopenalex-snapshot

Fundamental role of Warburg effect in various pathophysiological processes

inferred← citeshttps://doi.org/10.3390/biom13010089openalex-snapshot

Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis

inferred← citeshttps://doi.org/10.3390/cells13242099openalex-snapshot

The Intricate Relationship Between Pulmonary Fibrosis and Thrombotic Pathology: A Narrative Review

inferred← citeshttps://doi.org/10.3390/ijms20205076openalex-snapshot

Thrombin Upregulates PAI-1 and Mesothelial–Mesenchymal Transition Through PAR-1 and Contributes to Tuberculous Pleural Fibrosis

inferred← citeshttps://doi.org/10.3390/ijms24043149openalex-snapshot

Immune Mechanisms of Pulmonary Fibrosis with Bleomycin

inferred← citeshttps://doi.org/10.3892/mmr.2011.739openalex-snapshot

Effect of hirudin on the levels of acute lung injury rat tumor necrosis factor-α and matrix metalloproteinase-12

inferred← citeshttps://doi.org/10.4103/ijcep.ijcep_55_17openalex-snapshot

Fundamental role of warburg effect in various pathophysiological processes

inferred← citeshttps://doi.org/10.4155/fmc-2019-0111openalex-snapshot

Current Advances in Idiopathic Pulmonary Fibrosis: The pathogenesis, Therapeutic Strategies and Candidate Molecules

inferred← citeshttps://doi.org/10.4172/2161-1149.s1-005openalex-snapshot

Inhibitory Effects of the Dual Endothelin Receptor Blocker Bosentan on Thrombin-Activated Lung Fibroblasts Isolated from Scleroderma Patients

inferred← citeshttps://doi.org/10.5772/25568openalex-snapshot

Inhibition of Thrombin as a Novel Strategy in the Treatment of Scleroderma-Associated Interstitial Lung Disease

inferred← citeshttps://doi.org/10.6084/m9.figshare.21258279openalex-snapshot

Additional file 1 of Human umbilical cord mesenchymal stem cells combined with pirfenidone upregulates the expression of RGS2 in the pulmonary fibrosis in mice

inferred← citeshttps://doi.org/10.70675/3890835fzb557z430aza571z697de58045ddopenalex-snapshot

Sénescence cellulaire radio-induite : application à l'irradiation pulmonaire en conditions stéréotaxiques

inferred← citeshttps://doi.org/10.70675/b5564f90zc43cz4a7az9e2dzf77a62264effopenalex-snapshot

Cellules dendritiques et fibrose pulmonaire : étude sur un modèle animal de fibrose induite par la bléomycine chez la souris

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