On the public citation graph

Crystal Structure of Human Cytochrome P450 2D6

0 signed · 492 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcc.540040211openalex-snapshot

CHARMM : A program for macromolecular energy, minimization, and dynamics calculations

inferredcites →https://doi.org/10.1002/jcc.540150503openalex-snapshot

ICM—A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

inferredcites →https://doi.org/10.1002/prot.10192openalex-snapshot

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6

inferredcites →https://doi.org/10.1002/prot.20399openalex-snapshot

Functional analysis of CYP2D6.31 variant: Homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution

inferredcites →https://doi.org/10.1006/abbi.1993.1069openalex-snapshot

Purification and Characterization of Recombinant-Expressed Cytochrome P450 2C3 from Escherichia coli: 2C3 Encodes the 6β-Hydroxylase Deficient Form of P450-3b

inferredcites →https://doi.org/10.1006/abbi.1993.1335openalex-snapshot

Deletion of a Conserved Tetrapeptide, PPGP, in P450 2C2 Results in Loss of Enzymatic Activity without a Change in Its Cellular Location

inferredcites →https://doi.org/10.1006/abbi.1993.1401openalex-snapshot

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

inferredcites →https://doi.org/10.1006/abbi.1996.9859openalex-snapshot

Microsomal P450 2C3 Is Expressed as a Soluble Dimer inEscherichia coliFollowing Modifications of Its N-terminus

inferredcites →https://doi.org/10.1006/abbi.1997.0265openalex-snapshot

A General Strategy for the Expression of Recombinant Human Cytochrome P450s inEscherichia coliUsing Bacterial Signal Peptides: Expression of CYP3A4, CYP2A6, and CYP2E1

inferredcites →https://doi.org/10.1006/abbi.2001.2510openalex-snapshot

Heterologous Expression of Cytochrome P450 2D6 Mutants, Electron Transfer, and Catalysis of Bufuralol Hydroxylation: The Role of Aspartate 301 in Structural Integrity

inferredcites →https://doi.org/10.1006/bbrc.1999.0569openalex-snapshot

Cumene Hydroperoxide-Supported Demethylation Reactions Catalyzed by Cytochrome P450 2B4 Lacking the NH2-Terminal Sequence

inferredcites →https://doi.org/10.1007/bf00125503openalex-snapshot

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

inferredcites →https://doi.org/10.1007/bf00225204openalex-snapshot

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

inferredcites →https://doi.org/10.1016/0163-7258(90)90096-kopenalex-snapshot

The genetic polymorphism of debrisoquine/sparteine metabolism—molecular mechanisms

inferredcites →https://doi.org/10.1016/j.bcp.2004.08.013openalex-snapshot

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism

inferredcites →https://doi.org/10.1016/j.bcp.2005.07.002openalex-snapshot

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent

inferredcites →https://doi.org/10.1016/s0021-9258(18)48462-1openalex-snapshot

Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.

inferredcites →https://doi.org/10.1016/s0021-9258(20)82245-5openalex-snapshot

The Carbon Monoxide-binding Pigment of Liver Microsomes

inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot

[20] Processing of X-ray diffraction data collected in oscillation mode

inferredcites →https://doi.org/10.1016/s0090-9556(24)11801-6openalex-snapshot

Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity

inferredcites →https://doi.org/10.1016/s0959-440x(96)80056-xopenalex-snapshot

Hidden Markov models

inferredcites →https://doi.org/10.1016/s1097-2765(00)80408-6openalex-snapshot

Mammalian Microsomal Cytochrome P450 Monooxygenase

inferredcites →https://doi.org/10.1016/s1359-6446(97)01081-7openalex-snapshot

Properties of cytochrome P450 isoenzymes and their substrates Part 1: active site characteristics

inferredcites →https://doi.org/10.1021/bi027085wopenalex-snapshot

Role of Glutamic Acid 216 in Cytochrome P450 2D6 Substrate Binding and Catalysis

inferredcites →https://doi.org/10.1021/bi952742oopenalex-snapshot

A Model for Human Cytochrome P450 2D6 Based on Homology Modeling and NMR Studies of Substrate Binding

inferredcites →https://doi.org/10.1021/jm0209578openalex-snapshot

Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities

inferredcites →https://doi.org/10.1021/jm040180dopenalex-snapshot

Cytochrome P450 in Silico: An Integrative Modeling Approach

inferredcites →https://doi.org/10.1021/jm981118hopenalex-snapshot

Novel Approach To Predicting P450-Mediated Drug Metabolism: Development of a Combined Protein and Pharmacophore Model for CYP2D6

inferredcites →https://doi.org/10.1021/jm991058vopenalex-snapshot

A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6

inferredcites →https://doi.org/10.1021/tx0002583openalex-snapshot

Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

inferredcites →https://doi.org/10.1021/tx00026a010openalex-snapshot

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

inferredcites →https://doi.org/10.1021/tx960003iopenalex-snapshot

A Three-Dimensional Protein Model for Human Cytochrome P450 2D6 Based on the Crystal Structures of P450 101, P450 102, and P450 108

inferredcites →https://doi.org/10.1023/a:1008187802746openalex-snapshot

Theoretical investigation of substrate specificity for cytochromes P450 IA2, P450 IID6 and P450 IIIA4

inferredcites →https://doi.org/10.1038/331442a0openalex-snapshot

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

inferredcites →https://doi.org/10.1038/347773a0openalex-snapshot

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

inferredcites →https://doi.org/10.1038/nature01862openalex-snapshot

Crystal structure of human cytochrome P450 2C9 with bound warfarin

inferredcites →https://doi.org/10.1038/nsmb971openalex-snapshot

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

inferredcites →https://doi.org/10.1038/sj.embor.7400420openalex-snapshot

Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

inferredcites →https://doi.org/10.1039/b410729bopenalex-snapshot

Mechanism and structure–reactivity relationships for aromatic hydroxylation by cytochrome P450

inferredcites →https://doi.org/10.1042/0264-6021:3450565openalex-snapshot

Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6

inferredcites →https://doi.org/10.1042/0264-6021:3550373openalex-snapshot

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6

inferredcites →https://doi.org/10.1042/bj20040062openalex-snapshot

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite

inferredcites →https://doi.org/10.1042/bj3160647openalex-snapshot

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

inferredcites →https://doi.org/10.1073/pnas.88.13.5597openalex-snapshot

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

inferredcites →https://doi.org/10.1074/jbc.270.49.29055openalex-snapshot

Evidence That Aspartic Acid 301 Is a Critical Substrate-Contact Residue in the Active Site of Cytochrome P450 2D6

inferredcites →https://doi.org/10.1074/jbc.c400293200openalex-snapshot

The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution

inferredcites →https://doi.org/10.1074/jbc.m209519200openalex-snapshot

Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6

inferredcites →https://doi.org/10.1074/jbc.m312516200openalex-snapshot

Structure of Human Microsomal Cytochrome P450 2C8

inferredcites →https://doi.org/10.1074/jbc.m405427200openalex-snapshot

The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution

inferredcites →https://doi.org/10.1074/jbc.m505974200openalex-snapshot

Why Is Quinidine an Inhibitor of Cytochrome P450 2D6?

inferredcites →https://doi.org/10.1080/004982500237622openalex-snapshot

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

inferredcites →https://doi.org/10.1080/00498250110112015openalex-snapshot

Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure

inferredcites →https://doi.org/10.1080/004982597240497openalex-snapshot

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism

inferredcites →https://doi.org/10.1093/nar/25.17.3389openalex-snapshot

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

inferredcites →https://doi.org/10.1107/s0021889892009944openalex-snapshot

PROCHECK: a program to check the stereochemical quality of protein structures

inferredcites →https://doi.org/10.1107/s0907444900014736openalex-snapshot

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

inferredcites →https://doi.org/10.1107/s0907444903028956openalex-snapshot

Likelihood-enhanced fast rotation functions

inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot

Coot : model-building tools for molecular graphics

inferredcites →https://doi.org/10.1107/s0907444993011333openalex-snapshot

Detection, delineation, measurement and display of cavities in macromolecular structures

inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot

The CCP4 suite: programs for protein crystallography

inferredcites →https://doi.org/10.1107/s0907444995016477openalex-snapshot

Use of Non-crystallographic Symmetry in Protein Structure Refinement

inferredcites →https://doi.org/10.1107/s0907444996012255openalex-snapshot

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

inferredcites →https://doi.org/10.1111/j.1600-0773.1990.tb00830.xopenalex-snapshot

Genetic Polymorphism of Sparteine/Debrisoquine Oxidation: A Reappraisal

inferredcites →https://doi.org/10.1124/dmd.30.9.970openalex-snapshot

Catalytic Specificity of CYP2D Isoforms in Rat and Human

inferredcites →https://doi.org/10.1126/science.1099736openalex-snapshot

Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

inferredcites →https://doi.org/10.1126/science.287.5458.1615openalex-snapshot

The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution

inferredcites →https://doi.org/10.1126/science.8342039openalex-snapshot

Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's

inferredcites →https://doi.org/10.2165/00003088-199732030-00004openalex-snapshot

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

inferredcites →https://doi.org/10.3109/00498259509061857openalex-snapshot

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450bm3)

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112626zenodo-depositor-declared

P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata

inferred← citeshttps://doi.org/10.1002/9780470439265.ch18openalex-snapshot

Characterization of Cytochrome P450 Mechanism‐Based Inhibition

inferred← citeshttps://doi.org/10.1002/9780470571224.pse117openalex-snapshot

Characterization of Cytochrome P 450 Mechanism‐Based Inhibition

inferred← citeshttps://doi.org/10.1002/9780470574898.ch4openalex-snapshot

Cytochrome P450: Structure, Function, and Application in Drug Discovery and Development

inferred← citeshttps://doi.org/10.1002/9780470921920.edm006openalex-snapshot

Structure and Function of Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1002/9780470921920.edm007openalex-snapshot

Mechanisms of Cytochrome P450‐Mediated Reactions

inferred← citeshttps://doi.org/10.1002/9780470921920.edm009openalex-snapshot

Cytochrome P450 Polymorphisms

inferred← citeshttps://doi.org/10.1002/9780470921920.edm145openalex-snapshot

Oxidative Drug Metabolism by Mammalian Cytochrome P450 Enzymes Using Their Monooxygenase and Peroxygenase Functions

inferred← citeshttps://doi.org/10.1002/9780470929278.ch5openalex-snapshot

Experimental Models of Drug Metabolism and Disposition

inferred← citeshttps://doi.org/10.1002/9781118409343.ch1openalex-snapshot

Enzymes Involved in Redox Reactions: Natural Sources and Mechanistic Overview

inferred← citeshttps://doi.org/10.1002/9781118541203.xen0005openalex-snapshot

Drug‐metabolizing Enzymes: A Group of Promiscuous Catalysts

inferred← citeshttps://doi.org/10.1002/9781118541203.xen0019openalex-snapshot

Computational Approaches in Drug Biotransformation Studies: Metabolite Prediction

inferred← citeshttps://doi.org/10.1002/9781118832431.ch27openalex-snapshot

Superoxide dismutase mimics and other redox‐active therapeutics

inferred← citeshttps://doi.org/10.1002/9781119460053.ch14openalex-snapshot

Production of Yeast Derived Microsomal Human CYP450 Enzymes (Sacchrosomes) in High Yields, and Activities Superior to Commercially Available Microsomal Enzymes

inferred← citeshttps://doi.org/10.1002/9781119851042.ch15openalex-snapshot

Characterization of Cytochrome P450 Mechanism Based Inhibition

inferred← citeshttps://doi.org/10.1002/9781119967309.ch1openalex-snapshot

Cytochrome P450 Pharmacogenetics: From Bench to bedside

inferred← citeshttps://doi.org/10.1002/9783527621460.ch10openalex-snapshot

Site of Metabolism Predictions: Facts and Experiences

inferred← citeshttps://doi.org/10.1002/9783527630905.ch2openalex-snapshot

Cytochromes P450

inferred← citeshttps://doi.org/10.1002/9783527632039.ch12openalex-snapshot

Biooxidation with Cytochrome P450 Monooxygenases

inferred← citeshttps://doi.org/10.1002/9783527645763.ch7openalex-snapshot

Metabolic (Hepatic) Clearance

inferred← citeshttps://doi.org/10.1002/9783527673261.ch04openalex-snapshot

Structure and Dynamics of Human Drug‐Metabolizing Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1002/9783527673261.ch05openalex-snapshot

Cytochrome P450 Substrate Recognition and Binding

inferred← citeshttps://doi.org/10.1002/9783527673261.ch10openalex-snapshot

Structure‐Based Methods for Predicting the Sites and Products of Metabolism

inferred← citeshttps://doi.org/10.1002/9783527673261.ch13openalex-snapshot

Quantitative Structure–Activity Relationship (QSAR) Methods for the Prediction of Substrates, Inhibitors, and Inducers of Metabolic Enzymes

inferred← citeshttps://doi.org/10.1002/ange.202409217openalex-snapshot

Rational Molecular Design of a Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2D6

inferred← citeshttps://doi.org/10.1002/anie.202409217openalex-snapshot

Rational Molecular Design of a Fluorescent Probe for Selectively Sensing Human Cytochrome P450 2D6

inferred← citeshttps://doi.org/10.1002/ardp.200800042openalex-snapshot

Refined Docking as a Valuable Tool for Lead Optimization: Application to Histamine H3 Receptor Antagonists

inferred← citeshttps://doi.org/10.1002/bab.1074openalex-snapshot

Conformational diversity and ligand tunnels of mammalian cytochrome P 450s

inferred← citeshttps://doi.org/10.1002/bio.4605openalex-snapshot

Interactions studies of CYP2D6 with quercetin and hyperoside by spectral analysis and molecular dynamics simulations

inferred← citeshttps://doi.org/10.1002/bip.23108openalex-snapshot

Exploring the structure characteristics and major channels of cytochrome P450 2A6, 2A13, and 2E1 with pilocarpine

inferred← citeshttps://doi.org/10.1002/bmc.3721openalex-snapshot

An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug–drug and drug–herb interaction by LC‐ESI/MS/MS

inferred← citeshttps://doi.org/10.1002/bmc.5039openalex-snapshot

Inhibitory effects of astilbin, neoastilbin and isoastilbin on human cytochrome CYP3A4 and 2D6 activities

inferred← citeshttps://doi.org/10.1002/cbdv.200900078openalex-snapshot

Probabilistic Prediction of the Human CYP3A4 and CYP2D6 Metabolism Sites

inferred← citeshttps://doi.org/10.1002/cbic.202400297openalex-snapshot

Understanding Cytochrome P450 Enzyme Substrate Inhibition and Prospects for Elimination Strategies

inferred← citeshttps://doi.org/10.1002/cctc.201801644openalex-snapshot

Engineering Thermostable CYP2D Enzymes for Biocatalysis Using Combinatorial Libraries of Ancestors for Directed Evolution (CLADE)

inferred← citeshttps://doi.org/10.1002/chir.20412openalex-snapshot

Stereoselective hexobarbital 3′‐hydroxylation by CYP2C19 expressed in yeast cells and the roles of amino acid residues at positions 300 and 476

inferred← citeshttps://doi.org/10.1002/cmdc.201000358openalex-snapshot

Probing Small‐Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts

inferred← citeshttps://doi.org/10.1002/cmdc.201200160openalex-snapshot

Predicting Drug Metabolism by Cytochrome P450 2C9: Comparison with the 2D6 and 3A4 Isoforms

inferred← citeshttps://doi.org/10.1002/cpt.3680openalex-snapshot

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

inferred← citeshttps://doi.org/10.1002/ddr.20108openalex-snapshot

In silico prediction of cytochrome P450 inhibitors

inferred← citeshttps://doi.org/10.1002/etc.2595openalex-snapshot

A computational approach predicting CYP450 metabolism and estrogenic activity of an endocrine disrupting compound (PCB-30)

inferred← citeshttps://doi.org/10.1002/j.2055-2335.2009.tb00705.xopenalex-snapshot

Cytochrome P450 Part 3: Impact of Drug‐Drug Interactions

inferred← citeshttps://doi.org/10.1002/jcc.21922openalex-snapshot

Quantum mechanically derived AMBER‐compatible heme parameters for various states of the cytochrome P450 catalytic cycle

inferred← citeshttps://doi.org/10.1002/jcc.23680openalex-snapshot

Including ligand‐induced protein flexibility into protein tunnel prediction

inferred← citeshttps://doi.org/10.1002/jmr.2251openalex-snapshot

Prediction of amino acid residues participated in substrate recognition by cytochrome P450 subfamilies with broad substrate specificity

inferred← citeshttps://doi.org/10.1002/minf.200900040openalex-snapshot

Forecasting CYP2D6 and CYP3A4 Risk with a Global/Local Fusion Model of CYP450 Inhibition

inferred← citeshttps://doi.org/10.1002/minf.201200065openalex-snapshot

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug‐Like Molecules

inferred← citeshttps://doi.org/10.1002/pro.2307openalex-snapshot

Molecular dynamics simulations give insight into the conformational change, complex formation, and electron transfer pathway for cytochrome P450 reductase

inferred← citeshttps://doi.org/10.1002/pro.2737openalex-snapshot

Comparison of intrinsic dynamics of cytochrome p450 proteins using normal mode analysis

inferred← citeshttps://doi.org/10.1002/prot.21778openalex-snapshot

Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking

inferred← citeshttps://doi.org/10.1002/prp2.314openalex-snapshot

In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17β‐dihydroexemestane

inferred← citeshttps://doi.org/10.1002/qsar.200630143openalex-snapshot

A Virtual Screening Filter for Identification of Cytochrome P450 2C9 (CYP2C9) Inhibitors

inferred← citeshttps://doi.org/10.1002/qsar.200860181openalex-snapshot

Reduced vdW Radius Improves Site of Metabolism Predictions Using X‐Ray Structure of CYP2D6

inferred← citeshttps://doi.org/10.1002/wcms.1366openalex-snapshot

Out‐compute drug side effects: Focus on cytochrome P450 2D6 modeling

inferred← citeshttps://doi.org/10.1007/7355_2013_25openalex-snapshot

Tactics to Avoid Inhibition of Cytochrome P450s

inferred← citeshttps://doi.org/10.1007/978-1-0716-1554-6_7openalex-snapshot

Crystal Structures of Drug-Metabolizing CYPs

inferred← citeshttps://doi.org/10.1007/978-1-4419-0840-7_6openalex-snapshot

In Silico Approaches to Predict DDIs

inferred← citeshttps://doi.org/10.1007/978-1-4939-9161-7_3openalex-snapshot

Automated Family-Wide Annotation of Secondary Structure Elements

inferred← citeshttps://doi.org/10.1007/978-1-60327-058-8_25openalex-snapshot

Efficient Macromolecular Crystallization Using Microfluidics and Randomized Design of Screening Reagents

inferred← citeshttps://doi.org/10.1007/978-1-60761-569-9_5openalex-snapshot

Mimics of Autoimmune Hepatitis: Drug Induced and Immune Mediated Liver Disease

inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_1openalex-snapshot

Structures of Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1007/978-3-319-12108-6_9openalex-snapshot

Human Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1007/978-3-319-17972-8_3openalex-snapshot

Structure, Function and Inhibition of Aromatase

inferred← citeshttps://doi.org/10.1007/s00204-009-0504-1openalex-snapshot

Functional characterization of human cytochrome P450 2E1 allelic variants: in vitro metabolism of benzene and toluene by recombinant enzymes expressed in yeast cells

inferred← citeshttps://doi.org/10.1007/s00210-019-01651-0openalex-snapshot

Functional and structural characterisation of common cytochrome P450 2D6 allelic variants—roles of Pro34 and Thr107 in catalysis and inhibition

inferred← citeshttps://doi.org/10.1007/s00216-008-2248-9openalex-snapshot

Engineering and assaying of cytochrome P450 biocatalysts

inferred← citeshttps://doi.org/10.1007/s00239-010-9402-7openalex-snapshot

Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family

inferred← citeshttps://doi.org/10.1007/s00239-010-9424-1openalex-snapshot

Isolation and Characterization of the CYP2D6 Gene in Felidae with Comparison to Other Mammals

inferred← citeshttps://doi.org/10.1007/s00249-006-0126-yopenalex-snapshot

Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations

inferred← citeshttps://doi.org/10.1007/s00249-012-0865-xopenalex-snapshot

Rationalization of stereospecific binding of propranolol to cytochrome P450 2D6 by free energy calculations

inferred← citeshttps://doi.org/10.1007/s00705-006-0927-4openalex-snapshot

Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns

inferred← citeshttps://doi.org/10.1007/s00775-007-0210-5openalex-snapshot

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

inferred← citeshttps://doi.org/10.1007/s00775-010-0708-0openalex-snapshot

Understanding uncoupling in the multiredox centre P450 3A4–BMR model system

inferred← citeshttps://doi.org/10.1007/s00894-011-1105-5openalex-snapshot

CYP isoform specificity toward drug metabolism: analysis using common feature hypothesis

inferred← citeshttps://doi.org/10.1007/s00894-012-1472-6openalex-snapshot

In silico and in vivo evaluation of flavonoid extracts on CYP2D6-mediated herb-drug interaction

inferred← citeshttps://doi.org/10.1007/s10637-007-9089-9openalex-snapshot

Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat

inferred← citeshttps://doi.org/10.1007/s10822-007-9139-6openalex-snapshot

Generation of in-silico cytochrome P450 1A2, 2C9, 2C19, 2D6, and 3A4 inhibition QSAR models

inferred← citeshttps://doi.org/10.1007/s10822-010-9336-6openalex-snapshot

Using a homology model of cytochrome P450 2D6 to predict substrate site of metabolism

inferred← citeshttps://doi.org/10.1007/s11030-022-10437-1openalex-snapshot

Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

inferred← citeshttps://doi.org/10.1007/s11064-017-2384-8openalex-snapshot

Cytochrome P450 2D6 and Parkinson’s Disease: Polymorphism, Metabolic Role, Risk and Protection

inferred← citeshttps://doi.org/10.1007/s11434-009-3697-zopenalex-snapshot

Docking and molecular dynamics studies on CYP2D6

inferred← citeshttps://doi.org/10.1007/s12010-018-2728-0openalex-snapshot

Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants

inferred← citeshttps://doi.org/10.1007/s12072-010-9173-7openalex-snapshot

Postgraduate Course: Integrating Basic Science into Clinical Practice

inferred← citeshttps://doi.org/10.1007/s12272-013-0212-5openalex-snapshot

Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C

inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00149-8openalex-snapshot

Molecular Modeling and Quantitative Structure–Activity Relationship of Substrates and Inhibitors of Drug Metabolism Enzymes

inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00277-7openalex-snapshot

New Applications for Structure-Based Drug Design

inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.00404-8openalex-snapshot

Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1016/b978-0-08-100098-4.00007-7openalex-snapshot

In Silico ADMET Profiling

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12659-9openalex-snapshot

Molecular Fields to Assess Recognition Forces and Property Spaces☆

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.13514-0openalex-snapshot

Cytochromes P450 Redox Activity

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.01960-7openalex-snapshot

Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1016/b978-0-12-819680-9.00002-0openalex-snapshot

Interaction of alcohol with drugs of abuse and medicines

inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00067-0openalex-snapshot

Prediction of Drug Metabolism: Use of Structural Biology and In Silico Tools

inferred← citeshttps://doi.org/10.1016/b978-0-12-820546-4.00008-8openalex-snapshot

Water mapping: Analysis of binding site spaces to enhance binding

inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00163-7openalex-snapshot

Cytochrome P450 Enzymes

inferred← citeshttps://doi.org/10.1016/j.abb.2006.11.030openalex-snapshot

Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies

inferred← citeshttps://doi.org/10.1016/j.abb.2007.03.028openalex-snapshot

Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2

inferred← citeshttps://doi.org/10.1016/j.abb.2007.04.028openalex-snapshot

Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants

inferred← citeshttps://doi.org/10.1016/j.abb.2007.04.033openalex-snapshot

Extending the capabilities of nature’s most versatile catalysts: Directed evolution of mammalian xenobiotic-metabolizing P450s

inferred← citeshttps://doi.org/10.1016/j.abb.2007.09.014openalex-snapshot

Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis

inferred← citeshttps://doi.org/10.1016/j.addr.2015.04.020openalex-snapshot

Prediction of cytochrome P450 mediated metabolism

inferred← citeshttps://doi.org/10.1016/j.bbagen.2006.07.005openalex-snapshot

The ins and outs of cytochrome P450s

inferred← citeshttps://doi.org/10.1016/j.bbagen.2006.09.013openalex-snapshot

What common structural features and variations of mammalian P450s are known to date?

inferred← citeshttps://doi.org/10.1016/j.bbagen.2015.03.014openalex-snapshot

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies

inferred← citeshttps://doi.org/10.1016/j.bbamem.2015.07.015openalex-snapshot

Incorporation of charged residues in the CYP2J2 F-G loop disrupts CYP2J2–lipid bilayer interactions

inferred← citeshttps://doi.org/10.1016/j.bbapap.2006.01.013openalex-snapshot

Functional interaction of nitrogenous organic bases with cytochrome P450: A critical assessment and update of substrate features and predicted key active-site elements steering the access, binding, and orientation of amines

inferred← citeshttps://doi.org/10.1016/j.bbapap.2010.07.017openalex-snapshot

Flexibility of human cytochrome P450 enzymes: Molecular dynamics and spectroscopy reveal important function-related variations

inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.03.027openalex-snapshot

Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.07.062openalex-snapshot

Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105)

inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.02.103openalex-snapshot

Crystal structure of CYP76AH1 in 4-PI-bound state from Salvia miltiorrhiza

inferred← citeshttps://doi.org/10.1016/j.bcp.2006.01.019openalex-snapshot

Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: In vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.bcp.2008.11.006openalex-snapshot

The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol

inferred← citeshttps://doi.org/10.1016/j.bcp.2019.113721openalex-snapshot

The marmoset cytochrome P450 superfamily: Sequence/phylogenetic analyses, genomic structure, and catalytic function

inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107607openalex-snapshot

Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114454openalex-snapshot

Combined and independent effects of OCT1 and CYP2D6 on the cellular disposition of drugs

inferred← citeshttps://doi.org/10.1016/j.bmc.2008.03.023openalex-snapshot

An epoxidation mechanism of carbamazepine by CYP3A4

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.11.045openalex-snapshot

Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.02.004openalex-snapshot

Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2

inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.12.016openalex-snapshot

Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition

inferred← citeshttps://doi.org/10.1016/j.bpj.2016.02.026openalex-snapshot

Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy

inferred← citeshttps://doi.org/10.1016/j.bpj.2018.08.026openalex-snapshot

Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450BM3 Variant

inferred← citeshttps://doi.org/10.1016/j.cattod.2008.04.028openalex-snapshot

Biocatalysis and substrate chemodiversity: Adaptation of aerobic living organisms to their chemical environment

inferred← citeshttps://doi.org/10.1016/j.cbi.2007.11.010openalex-snapshot

The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2

inferred← citeshttps://doi.org/10.1016/j.cbi.2017.01.003openalex-snapshot

Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro

inferred← citeshttps://doi.org/10.1016/j.cbi.2019.108840openalex-snapshot

Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro

inferred← citeshttps://doi.org/10.1016/j.cbi.2019.108896openalex-snapshot

Preclinical toxicity of innovative molecules: In vitro, in vivo and metabolism prediction

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2010.07.010openalex-snapshot

Characterization of hybrid bilayer membranes on silver electrodes as biocompatible SERS substrates to study membrane–protein interactions

inferred← citeshttps://doi.org/10.1016/j.comtox.2023.100284openalex-snapshot

Interactions of coumarin and amine ligands with six cytochrome P450 2D6 allelic variants: Molecular docking

inferred← citeshttps://doi.org/10.1016/j.csbj.2022.10.005openalex-snapshot

Generation of new inhibitors of selected cytochrome P450 subtypes– In silico study

inferred← citeshttps://doi.org/10.1016/j.ddtec.2012.11.001openalex-snapshot

Exposition and reactivity optimization to predict sites of metabolism in chemicals

inferred← citeshttps://doi.org/10.1016/j.dmpk.2018.06.001openalex-snapshot

Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variants

inferred← citeshttps://doi.org/10.1016/j.dmpk.2018.08.004openalex-snapshot

Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation

inferred← citeshttps://doi.org/10.1016/j.dmpk.2019.07.003openalex-snapshot

CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity

inferred← citeshttps://doi.org/10.1016/j.dmpk.2019.11.006openalex-snapshot

Computational prediction of cytochrome P450 inhibition and induction

inferred← citeshttps://doi.org/10.1016/j.drudis.2006.05.001openalex-snapshot

Designing better drugs: predicting cytochrome P450 metabolism

inferred← citeshttps://doi.org/10.1016/j.drudis.2008.06.006openalex-snapshot

Limitations and lessons in the use of X-ray structural information in drug design

inferred← citeshttps://doi.org/10.1016/j.drudis.2009.07.005openalex-snapshot

Understanding CYP2D6 interactions

inferred← citeshttps://doi.org/10.1016/j.drudis.2011.04.008openalex-snapshot

Utility of protein structures in overcoming ADMET-related issues of drug-like compounds

inferred← citeshttps://doi.org/10.1016/j.drudis.2011.10.023openalex-snapshot

Toward in silico structure-based ADMET prediction in drug discovery

inferred← citeshttps://doi.org/10.1016/j.dyepig.2021.109959openalex-snapshot

A hemicyanine-based fluorescence probe for selective detection of CYP2D6 in living cells and tumor-bearing mice

inferred← citeshttps://doi.org/10.1016/j.ejmech.2009.05.003openalex-snapshot

An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.06.033openalex-snapshot

Exploring benzcyclo derivatives as potent aromatase inhibitors using ligand-based modeling studies

inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.05.067openalex-snapshot

Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structures

inferred← citeshttps://doi.org/10.1016/j.ejphar.2013.12.025openalex-snapshot

The endogenous substrates of brain CYP2D

inferred← citeshttps://doi.org/10.1016/j.eng.2025.07.029openalex-snapshot

Elucidating the Substrate Specificity of Cytochrome P450 Enzymes: Insights into N- and S-Containing Small-Molecule Metabolism

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.02.038openalex-snapshot

Nitric oxide blocks cellular heme insertion into a broad range of heme proteins

inferred← citeshttps://doi.org/10.1016/j.gene.2026.150094openalex-snapshot

Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population

inferred← citeshttps://doi.org/10.1016/j.ibmb.2023.103958openalex-snapshot

Development of an efficient insecticide substrate and inhibitor screening system of insect P450s using fission yeast

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2008.01.009openalex-snapshot

Molecular modelling of human CYP2D6 and molecular docking of a series of ajmalicine- and quinidine-like inhibitors

inferred← citeshttps://doi.org/10.1016/j.jaut.2011.06.005openalex-snapshot

Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model

inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102237openalex-snapshot

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases

inferred← citeshttps://doi.org/10.1016/j.jelechem.2014.09.012openalex-snapshot

Nanohybrids of quantum dots and cytochrome P450 for light-driven drug metabolism

inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2012.02.010openalex-snapshot

Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site

inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2023.112150openalex-snapshot

Key regulators in the architecture of substrate access/egress channels in mammalian cytochromes P450 governing flexibility in substrate oxyfunctionalization

inferred← citeshttps://doi.org/10.1016/j.jmgm.2007.07.004openalex-snapshot

Analysis of CYP2D6 substrate interactions by computational methods

inferred← citeshttps://doi.org/10.1016/j.jmgm.2009.06.002openalex-snapshot

Molecular modeling of human cytochrome P450 2W1 and its interactions with substrates

inferred← citeshttps://doi.org/10.1016/j.jpba.2014.10.008openalex-snapshot

Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography–high resolution mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2009.09.012openalex-snapshot

X-ray structure of human aromatase reveals an androgen-specific active site

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2016.02.021openalex-snapshot

Androgen-metabolizing enzymes: A structural perspective

inferred← citeshttps://doi.org/10.1016/j.legalmed.2010.08.007openalex-snapshot

Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers

inferred← citeshttps://doi.org/10.1016/j.lfs.2007.09.002openalex-snapshot

Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2009.05.011openalex-snapshot

Cooperative properties of cytochromes P450

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2012.12.007openalex-snapshot

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107601openalex-snapshot

CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design

inferred← citeshttps://doi.org/10.1016/j.phymed.2012.01.005openalex-snapshot

Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes

inferred← citeshttps://doi.org/10.1016/j.phymed.2016.12.001openalex-snapshot

Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells

inferred← citeshttps://doi.org/10.1016/j.phytochem.2011.05.001openalex-snapshot

Homology modeling of the three membrane proteins of the dhurrin metabolon: Catalytic sites, membrane surface association and protein–protein interactions

inferred← citeshttps://doi.org/10.1016/j.saa.2018.10.045openalex-snapshot

Investigation on drug-binding in heme pocket of CYP2C19 with UV–visible and resonance Raman spectroscopies

inferred← citeshttps://doi.org/10.1016/j.saa.2021.120311openalex-snapshot

Interaction study of engeletin toward cytochrome P450 3A4 and 2D6 by multi-spectroscopy and molecular docking

inferred← citeshttps://doi.org/10.1016/j.tips.2016.05.006openalex-snapshot

Recent Structural Insights into Cytochrome P450 Function

inferred← citeshttps://doi.org/10.1016/j.tox.2022.153116openalex-snapshot

The impact of legacy and novel perfluoroalkyl substances on human cytochrome P450: An in vitro study on the inhibitory potential and underlying mechanisms

inferred← citeshttps://doi.org/10.1016/j.ymgme.2009.08.009openalex-snapshot

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting

inferred← citeshttps://doi.org/10.1016/s0074-7696(06)60002-8openalex-snapshot

Molecular Mechanism of Phase I and Phase II Drug‐Metabolizing Enzymes: Implications for Detoxification

inferred← citeshttps://doi.org/10.1016/s0079-6468(08)00206-3openalex-snapshot

6 Cytochrome P450 Metabolism and Inhibition: Analysis for Drug Discovery

inferred← citeshttps://doi.org/10.1016/s1574-1400(07)03005-8openalex-snapshot

Chapter 5 Linear Quantitative Structure–Activity Relationships for the Interaction of Small Molecules with Human Cytochrome P450 Isoenzymes

inferred← citeshttps://doi.org/10.1017/cts.2026.10592openalex-snapshot

448 A systematic review of real-world evidence on the clinical relevance, characterization, and utility of CYP2D6 biomarker testing

inferred← citeshttps://doi.org/10.1021/ac200119bopenalex-snapshot

Enzyme-Based Amperometric Platform to Determine the Polymorphic Response in Drug Metabolism by Cytochromes P450

inferred← citeshttps://doi.org/10.1021/acs.biochem.3c00126openalex-snapshot

Catalytic Site Constraints in the P450s Mediating Loganic Acid (7DLH) and Secologanic Acid Synthesis (SLAS) in Camptotheca

inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00286openalex-snapshot

Effect of Cholesterol on the Interaction of Cytochrome P450 Substrate Drug Chlorzoxazone with the Phosphatidylcholine Bilayer

inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00715openalex-snapshot

Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs

inferred← citeshttps://doi.org/10.1021/acs.biomac.5b01434openalex-snapshot

Layer-by-Layer Assembly of Supported Lipid Bilayer Poly- l -Lysine Multilayers

inferred← citeshttps://doi.org/10.1021/acs.jcim.5c02705openalex-snapshot

Binding Site Vectors Enable Mapping of Cytochrome P450 Functional Landscapes

inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00080openalex-snapshot

Molecular Dynamics Simulations Reveal Structural Differences among Allelic Variants of Membrane-Anchored Cytochrome P450 2D6

inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00801openalex-snapshot

ADMET Evaluation in Drug Discovery. 19. Reliable Prediction of Human Cytochrome P450 Inhibition Using Artificial Intelligence Approaches

inferred← citeshttps://doi.org/10.1021/acs.jcim.9b01202openalex-snapshot

Emulating Docking Results Using a Deep Neural Network: A New Perspective for Virtual Screening

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01498openalex-snapshot

Strategies for Assessing Acceptable Intakes for Novel N -Nitrosamines Derived from Active Pharmaceutical Ingredients

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01281openalex-snapshot

Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure–Function Perspective

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00938openalex-snapshot

Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02359openalex-snapshot

Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00624openalex-snapshot

Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)

inferred← citeshttps://doi.org/10.1021/acs.jpcb.4c03097openalex-snapshot

Effect of Lipid Bilayer Anchoring on the Conformational Properties of the Cytochrome P450 2D6 Binding Site

inferred← citeshttps://doi.org/10.1021/acs.jpcb.7b08299openalex-snapshot

Homology Modeling and Molecular Dynamics Simulation Combined with X-ray Solution Scattering Defining Protein Structures of Thromboxane and Prostacyclin Synthases

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00444openalex-snapshot

Cytochrome-P450-Mediated Drug – Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification System

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00110openalex-snapshot

Prediction of Human Cytochrome P450 Inhibition Using a Multitask Deep Autoencoder Neural Network

inferred← citeshttps://doi.org/10.1021/acsomega.8b00809openalex-snapshot

Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme

inferred← citeshttps://doi.org/10.1021/bi700876aopenalex-snapshot

Unusual Regioselectivity and Active Site Topology of Human Cytochrome P450 2J2

inferred← citeshttps://doi.org/10.1021/bi801231mopenalex-snapshot

Functional Analysis of Phenylalanine Residues in the Active Site of Cytochrome P450 2C9

inferred← citeshttps://doi.org/10.1021/bk-2019-1318.ch009openalex-snapshot

Resources for Teaching Project-Based Undergraduate Medicinal Chemistry Courses

inferred← citeshttps://doi.org/10.1021/ci1000554openalex-snapshot

A 3D Model of CYP1B1 Explains the Dominant 4-Hydroxylation of Estradiol

inferred← citeshttps://doi.org/10.1021/ci2000506openalex-snapshot

Quantitatively Interpreted Enhanced Inhibition of Cytochrome P450s by Heteroaromatic Rings Containing Nitrogen

showing the first 200 of 423

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.