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The Presenilin-2 Loop Peptide Perturbs Intracellular Ca2+ Homeostasis and Accelerates Apoptosis

https://doi.org/10.1074/jbc.m512026200

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Alzheimer‐associated presenilin‐2 confers increased sensitivity to poptosis in PC12 cells

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Identification of caspases that cleave presenilin‐1 and presenilin‐2

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Presenilin-Mediated Modulation of Capacitative Calcium Entry

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Presenilin structure, function and role in Alzheimer disease

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Protein transduction: unrestricted delivery into all cells?

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

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The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

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Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

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Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca 2+ channel by ligand tuning of Ca 2+ inhibition

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Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

inferredcites →https://doi.org/10.1074/jbc.271.49.31025openalex-snapshot

Requirement of the Familial Alzheimer's Disease Gene PS2 for Apoptosis

inferredcites →https://doi.org/10.1074/jbc.272.17.11006openalex-snapshot

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells

inferredcites →https://doi.org/10.1074/jbc.272.45.28415openalex-snapshot

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

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Abrogation of the Presenilin 1/β-Catenin Interaction and Preservation of the Heterodimeric Presenilin 1 Complex following Caspase Activation

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The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

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Unreliability of the Cytochromec-Enhanced Green Fluorescent Fusion Protein as a Marker of Cytochrome c Release in Cells That Overexpress Bcl-2

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The C-terminal Fragment of Presenilin 2 Triggers p53-mediated Staurosporine-induced Apoptosis, a Function Independent of the Presenilinase-derived N-terminal Counterpart

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Depletion of Intracellular Ca2+ by Caffeine and Ryanodine Induces Apoptosis of Chinese Hamster Ovary Cells Transfected with Ryanodine Receptor

inferredcites →https://doi.org/10.1083/jcb.139.2.485openalex-snapshot

Increased Apoptosis Arising from Increased Expression of the Alzheimer's Disease–associated Presenilin-2 Mutation (N141I)

inferredcites →https://doi.org/10.1083/jcb.149.4.793openalex-snapshot

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

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Inhibition of mechanosensitive cation channels inhibits myogenic differentiation by suppressing the expression of myogenic regulatory factors and caspase‐3 activity

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Interfering with Apoptosis: Ca 2+ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

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Book Reviews Science and Dissent in Post-Mao China, reviewed by M. Goldman * Comparative Vertebrate Neuroanatomy, E. G. Jones * Particle Physics, P. Forman * Vignette * Browsings

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Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

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Mechanisms of capacitative calcium entry

inferredcites →https://doi.org/10.1523/jneurosci.17-11-04212.1997openalex-snapshot

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

inferredcites →https://doi.org/10.1523/jneurosci.18-23-09790.1998openalex-snapshot

Overexpression in Neurons of Human Presenilin-1 or a Presenilin-1 Familial Alzheimer Disease Mutant Does Not Enhance Apoptosis

inferredcites →https://doi.org/10.1523/jneurosci.4386-03.2004openalex-snapshot

Dysregulated IP3Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation inPresenilin1Results in Exaggerated Ca2+Signals and Altered Membrane Excitability

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.nbd.2007.05.002openalex-snapshot

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Presenilin-like GxGD Membrane Proteases Have Dual Roles as Proteolytic Enzymes and Ion Channels

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High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1

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Glucose and Endoplasmic Reticulum Calcium Channels Regulate HIF-1β via Presenilin in Pancreatic β-Cells

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Potential Therapeutic Benefits of Strategies Directed to Mitochondria

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Calcium Signaling and Pathogenesis of Neurodegenerative Disorders: Potential Therapeutic Opportunities

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Interleukin‐18 prevents apoptosis via PI3K/Akt pathway in normal human keratinocytes

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γ‐secretase complexes containing caspase‐cleaved presenilin‐1 increase intracellular Aβ42/Aβ40 ratio

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Oxidoreductase, morphogenesis, extracellular matrix, and calcium ion-binding gene expression in streptozotocin-induced diabetic rat heart

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Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells

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A novel PSEN2 mutation associated with a peculiar phenotype

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Correction: Intracellular Calcium Deficits in Drosophila Cholinergic Neurons Expressing Wild Type or FAD-Mutant Presenilin

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