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Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury

https://doi.org/10.1080/14728222.2020.1752182
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1 of the 71 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1016/j.jstrokecerebrovasdis.2018.11.028 (notice 2022-05-06).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-3-7091-0353-1_23openalex-snapshot
Mitogen-Activated Protein Kinases in Cerebral Vasospasm After Subarachnoid Hemorrhage: A Review
inferredcites →https://doi.org/10.1007/s11010-016-2804-0openalex-snapshot
The effect of lysophosphatidic acid on Toll-like receptor 4 expression and the nuclear factor-κB signaling pathway in THP-1 cells
inferredcites →https://doi.org/10.1007/s12035-016-0178-7openalex-snapshot
Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice
inferredcites →https://doi.org/10.1007/s12975-011-0070-8openalex-snapshot
Inflammation of the Choroid Plexus and Ependymal Layer of the Ventricle Following Intraventricular Hemorrhage
inferredcites →https://doi.org/10.1016/0163-4453(93)95291-popenalex-snapshot
The treatment of neonatal meningitis due to Gram-negative bacilli with ciprofloxacin: Evidence of satisfactory penetration into the cerebrospinal fluid
inferredcites →https://doi.org/10.1016/j.biomaterials.2018.06.024openalex-snapshot
Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors
inferredcites →https://doi.org/10.1016/j.cell.2020.02.041openalex-snapshot
Toll-like Receptors and the Control of Immunity
inferredcites →https://doi.org/10.1016/j.cyto.2008.01.006openalex-snapshot
LPS/TLR4 signal transduction pathway
inferredcites →https://doi.org/10.1016/j.ejphar.2018.08.014openalex-snapshot
Suppression of TLR4 activation by resveratrol is associated with STAT3 and Akt inhibition in oxidized low-density lipoprotein-activated platelets
inferredcites →https://doi.org/10.1016/j.emc.2012.06.003openalex-snapshot
Intracranial Hemorrhage
inferredcites →https://doi.org/10.1016/j.emc.2017.07.001openalex-snapshot
Subarachnoid Hemorrhage
inferredcites →https://doi.org/10.1016/j.fitote.2014.09.002openalex-snapshot
Identification of dehydroabietc acid from Boswellia thurifera resin as a positive GABAA receptor modulator
inferredcites →https://doi.org/10.1016/j.imbio.2010.07.011openalex-snapshot
Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway
inferredcites →https://doi.org/10.1016/j.jnutbio.2012.04.017openalex-snapshot
TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol
inferredcites →https://doi.org/10.1016/j.jri.2014.02.004openalex-snapshot
Fibrinogen, an endogenous ligand of Toll-like receptor 4, activates monocytes in pre-eclamptic patients
inferredcites →https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.11.028openalex-snapshot
RETRACTED: Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo
inferredcites →https://doi.org/10.1016/j.nbd.2013.01.007openalex-snapshot
Tenascin-C induces prolonged constriction of cerebral arteries in rats
inferredcites →https://doi.org/10.1016/j.ymthe.2018.05.019openalex-snapshot
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models
inferredcites →https://doi.org/10.1038/nm.4361openalex-snapshot
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
inferredcites →https://doi.org/10.1038/s41419-019-1716-9openalex-snapshot
Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke
inferredcites →https://doi.org/10.1038/s41467-019-13851-6openalex-snapshot
Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a
inferredcites →https://doi.org/10.1038/s41582-020-0321-yopenalex-snapshot
Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets
inferredcites →https://doi.org/10.1038/srep12300openalex-snapshot
Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation
inferredcites →https://doi.org/10.1038/srep14246openalex-snapshot
Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen
inferredcites →https://doi.org/10.1073/pnas.1432609100openalex-snapshot
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
inferredcites →https://doi.org/10.1074/jbc.272.34.21096openalex-snapshot
Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo
inferredcites →https://doi.org/10.1074/jbc.c400613200openalex-snapshot
Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-κB
inferredcites →https://doi.org/10.1074/jbc.m111.266528openalex-snapshot
Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response
inferredcites →https://doi.org/10.1074/jbc.m207453200openalex-snapshot
A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase
inferredcites →https://doi.org/10.1074/jbc.m610737200openalex-snapshot
Characterization of Heme as Activator of Toll-like Receptor 4
inferredcites →https://doi.org/10.1080/01616412.1995.11740296openalex-snapshot
Cytokine production in cerebrospinal fluid after subarachnoid haemorrhage
inferredcites →https://doi.org/10.1080/1062936x.2018.1431308openalex-snapshot
Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy
inferredcites →https://doi.org/10.1086/317462openalex-snapshot
Cerebrospinal Fluid Penetration of High Doses of Intravenous Ciprofloxacin in Meningitis
inferredcites →https://doi.org/10.1089/neu.2015.4173openalex-snapshot
The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI
inferredcites →https://doi.org/10.1097/00007611-198202000-00018openalex-snapshot
Effect of Low-dose Heparin on the Platelet County
inferredcites →https://doi.org/10.1111/j.1471-4159.2011.07594.xopenalex-snapshot
Resveratrol mitigates lipopolysaccharide‐ and Aβ‐mediated microglial inflammation by inhibiting the TLR4/NF‐κB/STAT signaling cascade
inferredcites →https://doi.org/10.1124/mol.110.068064openalex-snapshot
TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
inferredcites →https://doi.org/10.1128/aac.47.10.3104-3108.2003openalex-snapshot
Levofloxacin Disposition in Cerebrospinal Fluid in Patients with External Ventriculostomy
inferredcites →https://doi.org/10.1136/jnnp.70.4.534openalex-snapshot
Inflammatory cytokines in subarachnoid haemorrhage: association with abnormal blood flow velocities in basal cerebral arteries
inferredcites →https://doi.org/10.1155/2017/7353252openalex-snapshot
All-Trans Retinoic Acid Modulates TLR4/NF- κ B Signaling Pathway Targeting TNF- α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer
inferredcites →https://doi.org/10.1159/000240472openalex-snapshot
Post-Haemorrhagic Hydrocephalus in Infancy Anatomical Study
inferredcites →https://doi.org/10.1161/circgenetics.113.000398openalex-snapshot
Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation
inferredcites →https://doi.org/10.1161/str.0000000000000069openalex-snapshot
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage
inferredcites →https://doi.org/10.1161/strokeaha.107.183689openalex-snapshot
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage in Adults
inferredcites →https://doi.org/10.1172/jci79070openalex-snapshot
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets
inferredcites →https://doi.org/10.1177/1753425910369020openalex-snapshot
Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets
inferredcites →https://doi.org/10.1179/174313209x393564openalex-snapshot
Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
inferredcites →https://doi.org/10.1182/blood-2013-04-495887openalex-snapshot
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
inferredcites →https://doi.org/10.1186/1742-2094-10-100openalex-snapshot
Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation
inferredcites →https://doi.org/10.1186/1742-2094-10-83openalex-snapshot
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage
inferredcites →https://doi.org/10.1186/1742-2094-11-59openalex-snapshot
Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury
inferredcites →https://doi.org/10.1186/s12974-017-0887-5openalex-snapshot
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia
inferredcites →https://doi.org/10.1186/s12974-018-1388-xopenalex-snapshot
Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway
inferredcites →https://doi.org/10.1186/s12974-019-1538-9openalex-snapshot
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
inferredcites →https://doi.org/10.1186/s12974-019-1561-xopenalex-snapshot
Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling
inferredcites →https://doi.org/10.1189/jlb.1008647openalex-snapshot
The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
inferredcites →https://doi.org/10.1189/jlb.1209775openalex-snapshot
Endogenous ligands of TLR2 and TLR4: agonists or assistants?
inferredcites →https://doi.org/10.1213/ane.0b013e3181d568c8openalex-snapshot
The Acute Management of Intracerebral Hemorrhage
inferredcites →https://doi.org/10.2174/156720507781788873openalex-snapshot
TNF-α Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets
inferredcites →https://doi.org/10.2353/ajpath.2006.050924openalex-snapshot
Gangliosides Trigger Inflammatory Responses via TLR4 in Brain Glia
inferredcites →https://doi.org/10.3171/jns.1993.78.4.0562openalex-snapshot
Increased interleukin-6 levels in cerebrospinal fluid following subarachnoid hemorrhage
inferredcites →https://doi.org/10.3389/fneur.2018.00097openalex-snapshot
Heparin: The Silver Bullet of Aneurysmal Subarachnoid Hemorrhage?
inferredcites →https://doi.org/10.3390/ijms16035028openalex-snapshot
Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage
inferredcites →https://doi.org/10.3390/ijms17050618openalex-snapshot
Proteome Profile and Quantitative Proteomic Analysis of Buffalo (Bubalusbubalis) Follicular Fluid during Follicle Development
inferredcites →https://doi.org/10.3390/ijms17081331openalex-snapshot
Resveratrol Attenuates Acute Inflammatory Injury in Experimental Subarachnoid Hemorrhage in Rats via Inhibition of TLR4 Pathway
inferredcites →https://doi.org/10.3390/ijms19061812openalex-snapshot
Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
inferredcites →https://doi.org/10.3390/ijms20071593openalex-snapshot
Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways
inferredcites →https://doi.org/10.3390/molecules22050724openalex-snapshot
Heparin and Heparin-Derivatives in Post-Subarachnoid Hemorrhage Brain Injury: A Multimodal Therapy for a Multimodal Disease
inferredcites →https://doi.org/10.3892/mmr.2016.5719openalex-snapshot
Heparin inhibits the inflammation and proliferation of human rheumatoid arthritis fibroblast-like synoviocytes through the NF-κB pathway
inferredcites →https://doi.org/10.4049/jimmunol.1502220openalex-snapshot
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
inferredcites →https://doi.org/10.4103/1673-5374.200795openalex-snapshot
Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
inferred← citeshttps://doi.org/10.1007/s00381-023-05891-7openalex-snapshot
Novel concepts in the pathogenesis of hydrocephalus
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Elevated TNF-α in cerebrospinal fluid as a potential inflammatory marker in post-hemorrhagic hydrocephalus: a prospective study
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Curcumin attenuated neuroinflammation via the TLR4/MyD88/NF-κB signaling way in the juvenile rat hippocampus following kainic acid-induced epileptic seizures
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Target practice: Opportunities for therapeutic intervention in CHIP and CCUS
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Modulation of TLR4-mediated inflammatory pathways and oxidative stress by cerium oxide nanoparticles in traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.cell.2023.01.017openalex-snapshot
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
inferred← citeshttps://doi.org/10.1016/j.clineuro.2024.108440openalex-snapshot
The association between TLR2/4 and clinical outcome in intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174607openalex-snapshot
Quercetin reduces inflammation in a rat model of diabetic peripheral neuropathy by regulating the TLR4/MyD88/NF-κB signalling pathway
inferred← citeshttps://doi.org/10.1016/j.expneurol.2026.115750openalex-snapshot
CD4+ T cells as a missing mechanistic link in post-hemorrhagic hydrocephalus
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.150579openalex-snapshot
Anti-Parkinson's disease polysaccharide PFP50-1 attenuated neuroinflammation via inhibition of TLR4/NF-κB and PI3K/Akt pathways and suppression of NLRP3 inflammasome activation
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108486openalex-snapshot
Pharmacological Inhibition of TLR4-NF-κB Signaling by TAK-242 Attenuates Hydrocephalus after Intraventricular Hemorrhage
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108902openalex-snapshot
Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches
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Targeting to miR-130b-5p/TLR4: How sodium danshensu suppresses inflammatory response of microglia in cerebral ischemia-reperfusion injury
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Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation
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MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury
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α-Cyperone Improves Rat Spinal Cord Tissue Damage via Akt/Nrf2 and NF-κB Pathways
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Neuroinflammatory pathways and potential therapeutic targets in neonatal post-hemorrhagic hydrocephalus
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inferred← citeshttps://doi.org/10.1136/neurintsurg-2021-018484openalex-snapshot
Higher Hospital Frailty Risk Score is associated with increased complications and healthcare resource utilization after endovascular treatment of ruptured intracranial aneurysms
inferred← citeshttps://doi.org/10.1161/circresaha.121.319949openalex-snapshot
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inferred← citeshttps://doi.org/10.1161/strokeaha.124.046130openalex-snapshot
Pathophysiology of Intracerebral Hemorrhage: Recovery Trajectories
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The association between TLRs and clinical outcome in intracerebral hemorrhage
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Paclitaxel triggers molecular and cellular changes in the choroid plexus
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Specific signature biomarkers highlight the potential mechanisms of circulating neutrophils in aneurysmal subarachnoid hemorrhage
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TLR4 mediates post-traumatic depression via kynurenine pathway activation in a murine traumatic brain injury model
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Resveratrol attenuates pyroptosis and neuroinflammation by inhibiting the TLR4/NF-κB/AIM2 pathway in ischemic stroke rats
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The Molecular Mechanism by Which miR-129a-3p Targets the TLR4/NF-κB Signaling Pathway to Regulate Inflammatory Damage in 3D4/21 Cells Infected with Glaesserella parasuis
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Progress in Research on TLR4-Mediated Inflammatory Response Mechanisms in Brain Injury after Subarachnoid Hemorrhage
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Role of Adaptor Protein Myeloid Differentiation 88 (MyD88) in Post-Subarachnoid Hemorrhage Inflammation: A Systematic Review
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Toll-Like Receptor Signaling Pathways: Novel Therapeutic Targets for Cerebrovascular Disorders
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The Glymphatic System (En)during Inflammation
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Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
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Mechanisms and interventions in aneurysmal subarachnoid hemorrhage: Unraveling the role of inflammatory responses and cell death in early brain injury (Review)
inferred← citeshttps://doi.org/10.3923/ijp.2024.1098.1111openalex-snapshot
Resveratrol Extract on the Protein Expression of Inflammatory Factors in Osteoarthritis Chondrocytes
inferred← citeshttps://doi.org/10.4103/1735-5362.394821openalex-snapshot
PI3K/AKT and STAT3 pathways mediate the neuroprotective effect of dasatinib from acute cerebral injury in endotoxemic mice
inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-23-01462openalex-snapshot
Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage
inferred← citeshttps://doi.org/10.58209/ijwph.15.3.225openalex-snapshot
Protective Effect of Ipragliflozin on Acute Brain Injury Induced by Endotoxemia in Mice
inferred← citeshttps://doi.org/10.6084/m9.figshare.26597609openalex-snapshot
Additional file 5 of A role for P-selectin and complement in the pathological sequelae of germinal matrix hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.26608830openalex-snapshot
Additional file 1 of The impact of COVID-19 on clinical outcomes in people undergoing neurosurgery: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.7150/ijms.73007openalex-snapshot
Raddeanin A (RA) reduced acute inflammatory injury in mouse experimental cerebral hemorrhage by suppression of TLR4
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