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Combination therapies for hypertension – why we need to look beyond RAS blockers
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1 of the 99 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1056/nejmoa1712231 (notice 2020-01-29).
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/archinte.167.2.141openalex-snapshot
Outpatient Hypertension Treatment, Treatment Intensification, and Control in Western Europe and the United States
inferredcites →https://doi.org/10.1001/jama.2010.650openalex-snapshot
US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008
inferredcites →https://doi.org/10.1001/jama.289.19.2560openalex-snapshot
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure The JNC 7 Report
inferredcites →https://doi.org/10.1001/jama.290.21.2805openalex-snapshot
A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease
inferredcites →https://doi.org/10.1007/bf03256570openalex-snapshot
Management of Hypertension with the Fixed Combination of Perindopril and Amlodipine in Daily Clinical Practice
inferredcites →https://doi.org/10.1007/s11906-007-0045-zopenalex-snapshot
Combinations as a first-step therapy in hypertension
inferredcites →https://doi.org/10.1007/s12325-008-0054-6openalex-snapshot
Effective and safe reduction of blood pressure with the combination of amlodipine 5 mg and valsartan 160 mg in hypertensive patients not controlled by calcium channel blocker monotherapy
inferredcites →https://doi.org/10.1007/s12325-009-0015-8openalex-snapshot
Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria
inferredcites →https://doi.org/10.1007/s12325-011-0095-0openalex-snapshot
Amlodipine/Valsartan Single-Pill Combination: A Prospective, Observational Evaluation of the Real-Life Safety and Effectiveness in the Routine Treatment of Hypertension
inferredcites →https://doi.org/10.1007/s12325-012-0019-7openalex-snapshot
Blood Pressure Control with Angiotensin Receptor Blocker-Based Three-Drug Combinations: Key Trials
inferredcites →https://doi.org/10.1007/s12325-012-0030-zopenalex-snapshot
Efficacy of Amlodipine/Olmesartan ± Hydrochlorothiazide in Patients Uncontrolled on Prior Calcium Channel Blocker or Angiotensin II Receptor Blocker Monotherapy
inferredcites →https://doi.org/10.1007/s12325-013-0020-9openalex-snapshot
Combination Therapy in Hypertension
inferredcites →https://doi.org/10.1007/s12325-018-0675-3openalex-snapshot
Effectiveness of a Fixed-Dose, Single-Pill Combination of Perindopril and Amlodipine in Patients with Hypertension: A Non-Interventional Study
inferredcites →https://doi.org/10.1016/j.ahj.2011.05.010openalex-snapshot
Combination therapy as initial treatment for newly diagnosed hypertension
inferredcites →https://doi.org/10.1016/j.amjmed.2006.08.033openalex-snapshot
Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis
inferredcites →https://doi.org/10.1016/j.amjmed.2008.09.038openalex-snapshot
Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials
inferredcites →https://doi.org/10.1016/j.amjmed.2010.08.007openalex-snapshot
Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema
inferredcites →https://doi.org/10.1016/j.amjmed.2011.12.010openalex-snapshot
Angiotensin II Receptor Blocker-based Therapy in Japanese Elderly, High-risk, Hypertensive Patients
inferredcites →https://doi.org/10.1016/j.amjmed.2011.12.013openalex-snapshot
Adherence to Drugs That Prevent Cardiovascular Disease: Meta-analysis on 376,162 Patients
inferredcites →https://doi.org/10.1016/j.clinthera.2007.02.003openalex-snapshot
Tolerability and blood pressure-lowering efficacy of the combination of amlodipine plus valsartan compared with lisinopril plus hydrochlorothiazide in adult patients with stage 2 hypertension
inferredcites →https://doi.org/10.1016/j.clinthera.2007.03.018openalex-snapshot
Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension
inferredcites →https://doi.org/10.1016/j.clinthera.2008.04.002openalex-snapshot
The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8-week factorial efficacy and safety study
inferredcites →https://doi.org/10.1016/j.clinthera.2010.07.008openalex-snapshot
Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study
inferredcites →https://doi.org/10.1016/j.clinthera.2014.07.003openalex-snapshot
Efficacy and Tolerability of Amlodipine Camsylate/Losartan 5/100-mg Versus Losartan/Hydrochlorothiazide 100/12.5-mg Fixed-Dose Combination in Hypertensive Patients Nonresponsive to Losartan 100-mg Monotherapy
inferredcites →https://doi.org/10.1016/j.jash.2010.03.001openalex-snapshot
Combination therapy in hypertension
inferredcites →https://doi.org/10.1016/j.jash.2013.01.006openalex-snapshot
Effect of a fixed combination of Perindopril and Amlodipine on blood pressure control in 6256 patients with not-at-goal hypertension: the AVANT’AGE study
inferredcites →https://doi.org/10.1016/s0140-6736(02)11911-8openalex-snapshot
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
inferredcites →https://doi.org/10.1016/s0140-6736(04)16456-8openalex-snapshot
Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial
inferredcites →https://doi.org/10.1016/s0140-6736(05)67185-1openalex-snapshot
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled…
inferredcites →https://doi.org/10.1016/s0140-6736(07)61303-8openalex-snapshot
Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
inferredcites →https://doi.org/10.1016/s0140-6736(08)60655-8openalex-snapshot
Global burden of blood-pressure-related disease, 2001
inferredcites →https://doi.org/10.1016/s0140-6736(10)62003-xopenalex-snapshot
Aliskiren and the calcium channel blocker amlodipine combination as an initial treatment strategy for hypertension control (ACCELERATE): a randomised, parallel-group trial
inferredcites →https://doi.org/10.1016/s0140-6736(12)61766-8openalex-snapshot
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
inferredcites →https://doi.org/10.1016/s0140-6736(14)60685-1openalex-snapshot
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
inferredcites →https://doi.org/10.1016/s0140-6736(17)30260-xopenalex-snapshot
Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review
inferredcites →https://doi.org/10.1016/s0140-6736(97)05381-6openalex-snapshot
Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension
inferredcites →https://doi.org/10.1016/s0140-6736(98)04311-6openalex-snapshot
Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
inferredcites →https://doi.org/10.1038/hr.2011.100openalex-snapshot
Abnormalities in ambulatory blood pressure monitoring in hypertensive patients with diabetes
inferredcites →https://doi.org/10.1038/jhh.2008.153openalex-snapshot
Efficacy and safety of initial combination therapy with amlodipine/valsartan compared with amlodipine monotherapy in black patients with stage 2 hypertension: the EX-STAND study
inferredcites →https://doi.org/10.1038/jhh.2008.157openalex-snapshot
Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin–angiotensin system
inferredcites →https://doi.org/10.1038/jhh.2010.104openalex-snapshot
Olmesartan/amlodipine vs olmesartan/hydrochlorothiazide in hypertensive patients with metabolic syndrome: the OLAS study
inferredcites →https://doi.org/10.1038/sj.jhh.1001655openalex-snapshot
Comparison of the antihypertensive effects of the fixed dose combination enalapril 10 mg/nitrendipine 20 mg vs losartan 50 mg/hydrochlorothiazide 12.5 mg, assessed by 24-h ambulatory blood pressure monitoring, in essential hypertensive patients
inferredcites →https://doi.org/10.1038/sj.jhh.1002248openalex-snapshot
Lercanidipine, enalapril and their combination in the treatment of elderly hypertensive patients: placebo-controlled, randomized, crossover study with four ABPM
inferredcites →https://doi.org/10.1053/j.ajkd.2013.03.025openalex-snapshot
Differences Between Office and 24-Hour Blood Pressure Control in Hypertensive Patients With CKD: A 5,693-Patient Cross-sectional Analysis From Spain
inferredcites →https://doi.org/10.1056/nejmcp041698openalex-snapshot
Resistant or Difficult-to-Control Hypertension
inferredcites →https://doi.org/10.1056/nejmoa0801369openalex-snapshot
Treatment of Hypertension in Patients 80 Years of Age or Older
inferredcites →https://doi.org/10.1056/nejmoa0806182openalex-snapshot
Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients
inferredcites →https://doi.org/10.1056/nejmoa1712231openalex-snapshot
RETRACTED: Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality
inferredcites →https://doi.org/10.1056/nejmsa0903829openalex-snapshot
The Hypertension Paradox — More Uncontrolled Disease despite Improved Therapy
inferredcites →https://doi.org/10.1080/17512433.2018.1412826openalex-snapshot
Adhering to the principles of clinical pharmacology - the correct fixed combinations of antihypertensive drugs
inferredcites →https://doi.org/10.1093/eurheartj/ehu016openalex-snapshot
High prevalence of masked uncontrolled hypertension in people with treated hypertension
inferredcites →https://doi.org/10.1097/00004872-200403000-00001openalex-snapshot
Office compared with ambulatory blood pressure in assessing response to antihypertensive treatment
inferredcites →https://doi.org/10.1097/00005344-200112000-00005openalex-snapshot
Nitrendipine and Enalapril Combination Therapy in Mild to Moderate Hypertension: Assessment of Dose-Response Relationship by a Clinical Trial of Factorial Design
inferredcites →https://doi.org/10.1097/01.hjh.0000198987.34588.11openalex-snapshot
Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension
inferredcites →https://doi.org/10.1097/01.hjh.0000431740.32696.ccopenalex-snapshot
2013 ESH/ESC Guidelines for the management of arterial hypertension
inferredcites →https://doi.org/10.1097/01.mnh.0000174397.59100.89openalex-snapshot
Antihypertensive, cardiovascular, and pleiotropic effects of angiotensin-receptor blockers
inferredcites →https://doi.org/10.1097/hjh.0000000000000331openalex-snapshot
Nifedipine plus candesartan combination increases blood pressure control regardless of race and improves the side effect profile
inferredcites →https://doi.org/10.1097/hjh.0000000000000440openalex-snapshot
Randomized evaluation of a novel, fixed-dose combination of perindopril 3.5 mg/amlodipine 2.5 mg as a first-step treatment in hypertension
inferredcites →https://doi.org/10.1097/hjh.0000000000000502openalex-snapshot
Evolution of clinical profile, treatment and blood pressure control in treated hypertensive patients according to the sex from 2002 to 2010 in Spain
inferredcites →https://doi.org/10.1097/hjh.0000000000001359openalex-snapshot
Blood pressure-lowering efficacy and safety of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled essential hypertension
inferredcites →https://doi.org/10.1097/hjh.0b013e32809874a2openalex-snapshot
Ambulatory blood pressure monitoring in hypertensive patients with high cardiovascular risk: a cross-sectional analysis of a 20 000-patient database in Spain
inferredcites →https://doi.org/10.1097/hjh.0b013e3281fc975aopenalex-snapshot
2007 Guidelines for the Management of Arterial Hypertension
inferredcites →https://doi.org/10.1097/hjh.0b013e3282f3b5f0openalex-snapshot
Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes
inferredcites →https://doi.org/10.1097/hjh.0b013e328333146dopenalex-snapshot
Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document
inferredcites →https://doi.org/10.1097/hjh.0b013e328339f9faopenalex-snapshot
Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice
inferredcites →https://doi.org/10.1097/hjh.0b013e32833a50d4openalex-snapshot
Blood pressure control in the hypertensive population. What else the doctor can do?
inferredcites →https://doi.org/10.1097/hjh.0b013e328342ef04openalex-snapshot
Blood pressure control by the nifedipine GITS–telmisartan combination in patients at high cardiovascular risk: the TALENT study
inferredcites →https://doi.org/10.1097/hjh.0b013e32834a8a42openalex-snapshot
Baseline predictors of resistant hypertension in the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT)
inferredcites →https://doi.org/10.1097/hjh.0b013e328353634eopenalex-snapshot
Clinical differences between resistant hypertensives and patients treated and controlled with three or less drugs
inferredcites →https://doi.org/10.1097/hjh.0b013e328356b8eaopenalex-snapshot
Clinic and ambulatory blood pressure lowering effect of aliskiren/amlodipine/hydrochlorothiazide combination in patients with moderate-to-severe hypertension
inferredcites →https://doi.org/10.1097/md.0000000000004071openalex-snapshot
Treatment efficacy of anti-hypertensive drugs in monotherapy or combination
inferredcites →https://doi.org/10.1111/j.1751-7176.2011.00492.xopenalex-snapshot
Combination Angiotensin‐Receptor Blocker (ARB)/Calcium Channel Blocker With HCTZ vs the Maximal Recommended Dose of an ARB With HCTZ in Patients With Stage 2 Hypertension: The Exforge As Compared to Losartan Treatment in Stage 2 Systolic Hypertension (EXALT) Study
inferredcites →https://doi.org/10.1111/j.1751-7176.2012.00595.xopenalex-snapshot
Single‐Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study
inferredcites →https://doi.org/10.1111/j.1751-7176.2012.00706.xopenalex-snapshot
Safety and Efficacy of Aliskiren/Amlodipine/Hydrochlorothiazide Triple Combination in Patients With Moderate to Severe Hypertension: A 54‐Week, Open‐Label Study
inferredcites →https://doi.org/10.1111/jch.12618openalex-snapshot
Differing Effects of Aliskiren/Amlodipine Combination and High‐Dose Amlodipine Monotherapy on Ambulatory Blood Pressure and Target Organ Protection
inferredcites →https://doi.org/10.1111/jch.12623openalex-snapshot
Ambulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class
inferredcites →https://doi.org/10.1136/bmj.b1665openalex-snapshot
Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
inferredcites →https://doi.org/10.1157/13079069openalex-snapshot
Estudio doble ciego de la eficacia y la seguridad de la combinación a dosis fija de 10mg de enalapril/20mg de nitrendipino en comparación con el incremento de dosis de amlodipino en pacientes con hipertensión esencial no controlada con 5mg de amlodipino
inferredcites →https://doi.org/10.1161/01.hyp.0000103630.72812.10openalex-snapshot
Hypertension Treatment and Control in Five European Countries, Canada, and the United States
inferredcites →https://doi.org/10.1161/01.hyp.0000250557.63490.55openalex-snapshot
Effectiveness of Blood Pressure Control Outside the Medical Setting
inferredcites →https://doi.org/10.1161/circulationaha.105.595496openalex-snapshot
Differential Impact of Blood Pressure–Lowering Drugs on Central Aortic Pressure and Clinical Outcomes
inferredcites →https://doi.org/10.1161/circulationaha.107.750745openalex-snapshot
Long-Term Antihypertensive Efficacy and Safety of the Oral Direct Renin Inhibitor Aliskiren
inferredcites →https://doi.org/10.1161/circulationaha.111.030189openalex-snapshot
Uncontrolled and Apparent Treatment Resistant Hypertension in the United States, 1988 to 2008
inferredcites →https://doi.org/10.1161/circulationaha.117.032582openalex-snapshot
Potential US Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline
inferredcites →https://doi.org/10.1161/circulationaha.118.034619openalex-snapshot
Prevalence of Masked Hypertension in Untreated and Treated Patients With Office Blood Pressure Below 130/80 mm Hg
inferredcites →https://doi.org/10.1161/hypertensionaha.108.189141openalex-snapshot
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
inferredcites →https://doi.org/10.1161/hypertensionaha.109.131300openalex-snapshot
Triple Antihypertensive Therapy With Amlodipine, Valsartan, and Hydrochlorothiazide
inferredcites →https://doi.org/10.1161/hypertensionaha.109.139816openalex-snapshot
Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents
inferredcites →https://doi.org/10.1161/hypertensionaha.109.148999openalex-snapshot
Amlodipine-Valsartan Combination Decreases Central Systolic Blood Pressure More Effectively Than the Amlodipine-Atenolol Combination
inferredcites →https://doi.org/10.1161/hypertensionaha.111.177592openalex-snapshot
Cardiovascular Protection by Initial and Subsequent Combination of Antihypertensive Drugs in Daily Life Practice
inferredcites →https://doi.org/10.1161/hypertensionaha.112.193078openalex-snapshot
Achievement of Cardiometabolic Goals in Aware Hypertensive Patients in Spain
inferredcites →https://doi.org/10.1161/hypertensionaha.112.194167openalex-snapshot
Initial Monotherapy and Combination Therapy and Hypertension Control the First Year
inferredcites →https://doi.org/10.1161/hypertensionaha.112.201566openalex-snapshot
Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients
inferredcites →https://doi.org/10.1185/03007990903251193openalex-snapshot
Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy
inferredcites →https://doi.org/10.1586/erc.11.164openalex-snapshot
Renin–angiotensin system blockade and reduction of cardiovascular risk: future perspectives
inferredcites →https://doi.org/10.2147/vhrm.s9404openalex-snapshot
Valsartan addition to amlodipine is more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine
inferredcites →https://doi.org/10.2165/00044011-200929070-00001openalex-snapshot
Olmesartan Medoxomil plus Amlodipine Increases Efficacy in Patients with Moderate-to-Severe Hypertension after Monotherapy
inferredcites →https://doi.org/10.2165/11598110-000000000-00000openalex-snapshot
Combination of Amlodipine plus Angiotensin Receptor Blocker or Diuretics in High-Risk Hypertensive Patients
inferredcites →https://doi.org/10.2174/157016112803520765openalex-snapshot
Antihypertensive Efficacy and Tolerability of Aliskiren/Amlodipine Single- Pill Combinations in Patients with an Inadequate Response to Aliskiren Monotherapy¥
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Losartan Potassium and Verapamil Hydrochloride Compound Transdermal Drug Delivery System: Formulation and Characterization
inferred← citeshttps://doi.org/10.1002/cpdd.1321openalex-snapshot
Pharmacokinetics and Drug–Drug Interaction of Allisartan Isoproxil and Indapamide Sustained‐Release Formulation
inferred← citeshttps://doi.org/10.1002/prp2.532openalex-snapshot
Pharmacological plasticity—How do you hit a moving target?
inferred← citeshttps://doi.org/10.1016/j.foodres.2026.118792openalex-snapshot
Antihypertensive effect and mechanism of Mytilus edulis-derived peptide in spontaneously hypertensive rats
inferred← citeshttps://doi.org/10.1016/j.hipert.2022.09.002openalex-snapshot
Guía práctica sobre el diagnóstico y tratamiento de la hipertensión arterial en España, 2022. Sociedad Española de Hipertensión - Liga Española para la Lucha contra la Hipertensión Arterial (SEH-LELHA)
inferred← citeshttps://doi.org/10.1016/j.hipert.2024.12.004openalex-snapshot
Refractory arterial hypertension. What can we offer these patients?
inferred← citeshttps://doi.org/10.1080/14656566.2020.1735356openalex-snapshot
An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension
inferred← citeshttps://doi.org/10.1080/14737167.2020.1734456openalex-snapshot
Fixed dose drug combinations – are they pharmacoeconomically sound? Findings and implications especially for lower- and middle-income countries
inferred← citeshttps://doi.org/10.1371/journal.pone.0321078openalex-snapshot
Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model
inferred← citeshttps://doi.org/10.18203/2319-2003.ijbcp20195275openalex-snapshot
Analysis of prescription pattern of antihypertensive medication and adherence to Beers criteria in geriatric department of a tertiary care hospital in Mysuru
inferred← citeshttps://doi.org/10.2147/ceor.s231210openalex-snapshot
A Multicenter Retrospective Analysis on Clinical Effectiveness and Economic Assessment of Compound Reserpine and Hydrochlorothiazide Tablets (CRH) for Hypertension
inferred← citeshttps://doi.org/10.61186/jmp.22.85.1openalex-snapshot
Clinical antihypertensive efficacy and safety of Iran plants: a systematic review
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