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Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/dbio.2002.0708openalex-snapshot
Meiotic Prophase Abnormalities and Metaphase Cell Death in MLH1-Deficient Mouse Spermatocytes: Insights into Regulation of Spermatogenic Progress
inferredcites →https://doi.org/10.1006/excr.1996.0198openalex-snapshot
Organization of SCP1 Protein Molecules within Synaptonemal Complexes of the Rat
inferredcites →https://doi.org/10.1007/s004120050241openalex-snapshot
Rad51 immunocytology in rat and mouse spermatocytes and oocytes
inferredcites →https://doi.org/10.1007/s004120050340openalex-snapshot
Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat
inferredcites →https://doi.org/10.1016/j.cell.2012.01.052openalex-snapshot
COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers
inferredcites →https://doi.org/10.1016/j.exphem.2007.11.006openalex-snapshot
CXCR4 induction in hematopoietic progenitor cells from Fanca−/−, -c−/−, and -d2−/− mice
inferredcites →https://doi.org/10.1016/s0092-8674(00)81312-4openalex-snapshot
Meiotic Pachytene Arrest in MLH1-Deficient Mice
inferredcites →https://doi.org/10.1016/s0092-8674(01)00430-5openalex-snapshot
The Single-End Invasion
inferredcites →https://doi.org/10.1016/s1097-2765(00)00098-8openalex-snapshot
Chromosome Synapsis Defects and Sexually Dimorphic Meiotic Progression in Mice Lacking Spo11
inferredcites →https://doi.org/10.1016/s1097-2765(00)80069-6openalex-snapshot
Meiotic Prophase Arrest with Failure of Chromosome Synapsis in Mice Deficient for Dmc1 , a Germline-Specific RecA Homolog
inferredcites →https://doi.org/10.1016/s1097-2765(00)80070-2openalex-snapshot
The Mouse RecA-like Gene Dmc1 Is Required for Homologous Chromosome Synapsis during Meiosis
inferredcites →https://doi.org/10.1016/s1097-2765(00)80404-9openalex-snapshot
The Murine SCP3 Gene Is Required for Synaptonemal Complex Assembly, Chromosome Synapsis, and Male Fertility
inferredcites →https://doi.org/10.1023/a:1018445520117openalex-snapshot
SHORT COMMUNICATIONS A drying-down technique for the spreading of mammalian meiocytes from the male and female germline
inferredcites →https://doi.org/10.1038/85781openalex-snapshot
γ-H2AX illuminates meiosis
inferredcites →https://doi.org/10.1038/85830openalex-snapshot
Recombinational DNA double-strand breaks in mice precede synapsis
inferredcites →https://doi.org/10.1038/ncb2451openalex-snapshot
Homeostatic control of recombination is implemented progressively in mouse meiosis
inferredcites →https://doi.org/10.1038/ng.2541openalex-snapshot
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis
inferredcites →https://doi.org/10.1038/ng.2858openalex-snapshot
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination
inferredcites →https://doi.org/10.1038/ng0796-336openalex-snapshot
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
inferredcites →https://doi.org/10.1038/ng861openalex-snapshot
Genetic analysis of the mouse brain proteome
inferredcites →https://doi.org/10.1038/ng931openalex-snapshot
Meiotic arrest and aneuploidy in MLH3-deficient mice
inferredcites →https://doi.org/10.1038/sj.onc.1210282openalex-snapshot
HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins
inferredcites →https://doi.org/10.1083/jcb.200506170openalex-snapshot
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
inferredcites →https://doi.org/10.1083/jcb.200909048openalex-snapshot
Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination
inferredcites →https://doi.org/10.1093/genetics/165.4.2283openalex-snapshot
MLH1p and MLH3p Localize to Precociously Induced Chiasmata of Okadaic-Acid-Treated Mouse Spermatocytes
inferredcites →https://doi.org/10.1093/humrep/dem427openalex-snapshot
Premature separation of sister chromatids in human male meiosis
inferredcites →https://doi.org/10.1096/fj.14.11.1539openalex-snapshot
MSH4 acts in conjunction with MLH1 during mammalian meiosis
inferredcites →https://doi.org/10.1101/gad.14.9.1085openalex-snapshot
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
inferredcites →https://doi.org/10.1128/mcb.23.6.2109-2122.2003openalex-snapshot
A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels
inferredcites →https://doi.org/10.1159/000078188openalex-snapshot
Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment
inferredcites →https://doi.org/10.1159/000129818openalex-snapshot
An Air-Drying Method for Meiotic Preparations from Mammalian Testes
inferredcites →https://doi.org/10.1186/1741-7007-6-49openalex-snapshot
A comprehensive functional analysis of tissue specificity of human gene expression
inferredcites →https://doi.org/10.1210/er.2005-0017openalex-snapshot
Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals
inferredcites →https://doi.org/10.1242/jcs.114.4.685openalex-snapshot
Localization of two mammalian cyclin dependent kinases during mammalian meiosis
inferredcites →https://doi.org/10.1371/journal.pgen.0030139openalex-snapshot
Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over
inferredcites →https://doi.org/10.1371/journal.pgen.1000186openalex-snapshot
MUS81 Generates a Subset of MLH1-MLH3–Independent Crossovers in Mammalian Meiosis
inferredcites →https://doi.org/10.1371/journal.pgen.1002094openalex-snapshot
Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis
inferredcites →https://doi.org/10.1371/journal.pgen.1002799openalex-snapshot
The Arabidopsis HEI10 Is a New ZMM Protein Related to Zip3
inferredcites →https://doi.org/10.1371/journal.pgen.1002809openalex-snapshot
The Role of Rice HEI10 in the Formation of Meiotic Crossovers
inferredcites →https://doi.org/10.1371/journal.pgen.1003320openalex-snapshot
Conditional Inactivation of the DNA Damage Response Gene Hus1 in Mouse Testis Reveals Separable Roles for Components of the RAD9-RAD1-HUS1 Complex in Meiotic Chromosome Maintenance
inferredcites →https://doi.org/10.1371/journal.pone.0001854openalex-snapshot
Using Ribosomal Protein Genes as Reference: A Tale of Caution
inferredcites →https://doi.org/10.1534/genetics.107.084798openalex-snapshot
Distinct Functions of MLH3 at Recombination Hot Spots in the Mouse
inferredcites →https://doi.org/10.3390/genes1030440openalex-snapshot
Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3155549openalex-extracted
EWSR1 Regulates PRDM9-Dependent Histone 3 Methylation and Links Recombination Hotspots With the Chromosomal Axis
inferred← citeshttps://doi.org/10.1002/1873-3468.13627openalex-snapshot
Diverse roles for CDK‐associated activity during spermatogenesis
inferred← citeshttps://doi.org/10.1007/978-3-032-19509-8_10openalex-snapshot
Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development
inferred← citeshttps://doi.org/10.1007/978-3-319-44820-6_5openalex-snapshot
Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
inferred← citeshttps://doi.org/10.1007/978-981-92-1439-6_4openalex-snapshot
Meiotic Recombination in Teleosts
inferred← citeshttps://doi.org/10.1007/s00018-019-03262-7openalex-snapshot
Atypical cyclins: the extended family portrait
inferred← citeshttps://doi.org/10.1007/s00018-024-05216-0openalex-snapshot
Recent advances in mechanisms ensuring the pairing, synapsis and segregation of XY chromosomes in mice and humans
inferred← citeshttps://doi.org/10.1007/s00412-015-0549-2openalex-snapshot
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice
inferred← citeshttps://doi.org/10.1007/s00412-015-0552-7openalex-snapshot
RPA homologs and ssDNA processing during meiotic recombination
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.64701-3openalex-snapshot
Meiosis Overview
inferred← citeshttps://doi.org/10.1016/b978-0-443-21477-6.00514-9openalex-snapshot
Meiosis Overview
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.742347openalex-snapshot
Triploidy induction through cntd1 knockout in red crucian carp (Carassius auratus red var.)
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.107858openalex-snapshot
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner
inferred← citeshttps://doi.org/10.1016/j.gendis.2025.101900openalex-snapshot
Identification of the homozygous truncating mutation in CNTD1 as a novel genetic cause of diminished ovarian reserve
inferred← citeshttps://doi.org/10.1016/j.molcel.2023.07.022openalex-snapshot
Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.01.008openalex-snapshot
Becoming a crossover-competent DSB
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.02.021openalex-snapshot
DNA double-strand break formation and repair in Tetrahymena meiosis
inferred← citeshttps://doi.org/10.1038/s41421-023-00577-5openalex-snapshot
A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation
inferred← citeshttps://doi.org/10.1038/s41467-020-16885-3openalex-snapshot
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse
inferred← citeshttps://doi.org/10.1038/s41467-021-25028-1openalex-snapshot
Human MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging
inferred← citeshttps://doi.org/10.1038/s41467-023-37408-wopenalex-snapshot
A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis
inferred← citeshttps://doi.org/10.1038/s41556-025-01688-9openalex-snapshot
Crossover patterning through condensation and coarsening of pro-crossover factors
inferred← citeshttps://doi.org/10.1038/s41576-023-00669-8openalex-snapshot
Divergence and conservation of the meiotic recombination machinery
inferred← citeshttps://doi.org/10.1038/s41588-020-0657-7openalex-snapshot
The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility
inferred← citeshttps://doi.org/10.1073/pnas.1807871115openalex-snapshot
HEIP1 regulates crossover formation during meiosis in rice
inferred← citeshttps://doi.org/10.1073/pnas.2117865119openalex-snapshot
Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutSγ complex
inferred← citeshttps://doi.org/10.1073/pnas.2320995121openalex-snapshot
RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse
inferred← citeshttps://doi.org/10.1073/pnas.2412961121openalex-snapshot
Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis
inferred← citeshttps://doi.org/10.1073/pnas.2515747122openalex-snapshot
HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis
inferred← citeshttps://doi.org/10.1083/jcb.201910086openalex-snapshot
Multivalent weak interactions between assembly units drive synaptonemal complex formation
inferred← citeshttps://doi.org/10.1083/jcb.202401021openalex-snapshot
CNTD1 is crucial for crossover formation in female meiosis and for establishing the ovarian reserve
inferred← citeshttps://doi.org/10.1083/jcb.2055ifopenalex-snapshot
CNTD1’s crossover act
inferred← citeshttps://doi.org/10.1091/mbc.e16-09-0678openalex-snapshot
A Zip3-like protein plays a role in crossover formation in the SC-less meiosis of the protistTetrahymena
inferred← citeshttps://doi.org/10.1091/mbc.e20-09-0604openalex-snapshot
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8
inferred← citeshttps://doi.org/10.1093/biolre/iox040openalex-snapshot
Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks†
inferred← citeshttps://doi.org/10.1093/g3journal/jkac079openalex-snapshot
Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation
inferred← citeshttps://doi.org/10.1093/humupd/dmac024openalex-snapshot
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia
inferred← citeshttps://doi.org/10.1093/molbev/msae047openalex-snapshot
Formation of Different Polyploids Through Disrupting Meiotic Crossover Frequencies Based on cntd1 Knockout in Zebrafish
inferred← citeshttps://doi.org/10.1093/nar/gkaa1016openalex-snapshot
The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination
inferred← citeshttps://doi.org/10.1093/nar/gkac616openalex-snapshot
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
inferred← citeshttps://doi.org/10.1093/nar/gkae130openalex-snapshot
COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans
inferred← citeshttps://doi.org/10.1101/2021.08.26.457865openalex-snapshot
Crossover patterning through kinase-regulated condensation and coarsening of recombination nodules
inferred← citeshttps://doi.org/10.1101/2022.08.19.504615openalex-snapshot
Meiotic gene transcription programs are mediated by A-MYB and BRDT-dependent RNA polymerase II pause release during mammalian prophase I
inferred← citeshttps://doi.org/10.1101/2023.05.31.543071openalex-snapshot
A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
inferred← citeshttps://doi.org/10.1101/2023.09.25.559118openalex-snapshot
CNTD1 plays crucial roles in prophase I progression and crossover designation during female meiosis and is critical for establishing the ovarian reserve
inferred← citeshttps://doi.org/10.1101/2025.05.13.653822openalex-snapshot
Meiotic prophase I disruption as a strategy for non-hormonal male contraception using small-molecule inhibitor JQ1
inferred← citeshttps://doi.org/10.1101/cshperspect.a016618openalex-snapshot
Meiotic Recombination: The Essence of Heredity
inferred← citeshttps://doi.org/10.1111/brv.12680openalex-snapshot
Meiosis and beyond – understanding the mechanistic and evolutionary processes shaping the germline genome
inferred← citeshttps://doi.org/10.1111/evo.13850openalex-snapshot
Molecular evolution of the meiotic recombination pathway in mammals
inferred← citeshttps://doi.org/10.1126/sciadv.abb6606openalex-snapshot
Sexual dimorphism in the meiotic requirement for PRDM9: A mammalian evolutionary safeguard
inferred← citeshttps://doi.org/10.1146/annurev-genet-120215-035111openalex-snapshot
Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation
inferred← citeshttps://doi.org/10.1242/dev.199414openalex-snapshot
Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis
inferred← citeshttps://doi.org/10.1242/dev.204227openalex-snapshot
BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary
inferred← citeshttps://doi.org/10.1242/jcs.255745openalex-snapshot
Let's get physical – mechanisms of crossover interference
inferred← citeshttps://doi.org/10.1371/journal.pbio.1002412openalex-snapshot
Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance
inferred← citeshttps://doi.org/10.1371/journal.pbio.3000903openalex-snapshot
A novel function for CDK2 activity at meiotic crossover sites
inferred← citeshttps://doi.org/10.1371/journal.pbio.3003868openalex-snapshot
Ubiquitin-proteasome system regulates pro-crossover protein dynamics during meiosis in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1371/journal.pgen.1004949openalex-snapshot
Estrogenic Exposure Alters the Spermatogonial Stem Cells in the Developing Testis, Permanently Reducing Crossover Levels in the Adult
inferred← citeshttps://doi.org/10.1371/journal.pgen.1006670openalex-snapshot
Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007453openalex-snapshot
The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007653openalex-snapshot
BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007701openalex-snapshot
The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007876openalex-snapshot
CDK contribution to DSB formation and recombination in fission yeast meiosis
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008177openalex-snapshot
A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009663openalex-snapshot
Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex
inferred← citeshttps://doi.org/10.1371/journal.pone.0283590openalex-snapshot
Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity
inferred← citeshttps://doi.org/10.1534/g3.119.400074openalex-snapshot
Mutation of the ATPase Domain of MutS Homolog-5 (MSH5) Reveals a Requirement for a Functional MutSγ Complex for All Crossovers in Mammalian Meiosis
inferred← citeshttps://doi.org/10.1534/genetics.114.161513openalex-snapshot
DNA Helicase HIM-6/BLM Both Promotes MutSγ-Dependent Crossovers and Antagonizes MutSγ-Independent Interhomolog Associations During Caenorhabditis elegans Meiosis
inferred← citeshttps://doi.org/10.1534/genetics.114.169698openalex-snapshot
Msh4 and Msh5 Function in SC-Independent Chiasma Formation During the Streamlined Meiosis ofTetrahymena
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1971629/v1openalex-snapshot
A novel recombination protein C12ORF40/REDIC1 is required for meiotic crossover formation
inferred← citeshttps://doi.org/10.3389/fcell.2021.667073openalex-snapshot
Phospho-Regulation of Meiotic Prophase
inferred← citeshttps://doi.org/10.3389/fcell.2021.667306openalex-snapshot
Regulation of Meiotic Prophase One in Mammalian Oocytes
inferred← citeshttps://doi.org/10.3389/fcell.2022.1069064openalex-snapshot
Cyclins and CDKs in the regulation of meiosis-specific events
inferred← citeshttps://doi.org/10.3389/fcell.2023.1127440openalex-snapshot
Genetic control of meiosis surveillance mechanisms in mammals
inferred← citeshttps://doi.org/10.3390/ijms22115483openalex-snapshot
The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture
inferred← citeshttps://doi.org/10.3791/55378openalex-snapshot
Preparation of Meiotic Chromosome Spreads from Mouse Spermatocytes
inferred← citeshttps://doi.org/10.64898/2026.06.16.731784openalex-snapshot
A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I
inferred← citeshttps://doi.org/10.70675/2efd335dz7767z49fezb1f0z678daab8ce8bopenalex-snapshot
Crossover Pathways of Brassica napus Allopolyploid Meiosis
inferred← citeshttps://doi.org/10.7554/elife.12039openalex-snapshot
The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis
inferred← citeshttps://doi.org/10.7554/elife.68648openalex-snapshot
Phosphoproteomics of ATR signaling in mouse testes
inferred← citeshttps://doi.org/10.7554/elife.90887openalex-snapshot
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
inferred← citeshttps://doi.org/10.7554/elife.90887.1openalex-snapshot
A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
inferred← citeshttps://doi.org/10.7554/elife.90887.1.sa2openalex-snapshot
Reviewer #1 (Public Review): A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
inferred← citeshttps://doi.org/10.7554/elife.90887.1.sa3openalex-snapshot
eLife Assessment: A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
inferred← citeshttps://doi.org/10.7554/elife.90887.2openalex-snapshot
A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation
inferred← citeshttps://doi.org/10.7554/elife.90887.3openalex-snapshot
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
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