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Mitochondrial membrane biogenesis: A new pathway for lipid transport mediated by PERK/E-Syt1 complex

https://doi.org/10.1083/jcb.202301132
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.mitoco.2022.10.002openalex-snapshot
The metabolism and function of phospholipids in Mitochondria
inferredcites →https://doi.org/10.1038/cdd.2012.74openalex-snapshot
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
inferredcites →https://doi.org/10.1073/pnas.2205425119openalex-snapshot
A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane
inferredcites →https://doi.org/10.1083/jcb.202206008openalex-snapshot
PERK recruits E-Syt1 at ER–mitochondria contacts for mitochondrial lipid transport and respiration
inferredcites →https://doi.org/10.1101/2022.11.14.516495openalex-snapshot
ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis
inferredcites →https://doi.org/10.1111/brv.12860openalex-snapshot
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases
inferredcites →https://doi.org/10.1177/25152564211052392openalex-snapshot
Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca 2+ Signalling
inferredcites →https://doi.org/10.15252/embj.201797359openalex-snapshot
Ca2+ releases E‐Syt1 autoinhibition to couple ER‐plasma membrane tethering with lipid transport
inferredcites →https://doi.org/10.3389/fcell.2022.988014openalex-snapshot
ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport
inferredcites →https://doi.org/10.3390/ijms22062905openalex-snapshot
The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4639349openalex-extracted
Protein-Rich Foods, Sea Foods, and Gut Microbiota Amplify Immune Responses in Chronic Diseases and Cancers – Targeting Perk as a Novel Therapeutic Strategy for Cancer
inferred← citeshttps://doi.org/10.1002/mco2.70259openalex-snapshot
Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103131openalex-snapshot
Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117915openalex-snapshot
Targeting PERK signaling: mechanisms and roles in myocardial protection
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108604openalex-snapshot
Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers – Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103467openalex-snapshot
Sarcopenic obesity is attenuated by E-syt1 inhibition via improving skeletal muscle mitochondrial function
inferred← citeshttps://doi.org/10.1038/s44321-026-00497-3openalex-snapshot
Comprehensive functional testing in fibroblasts has strong utility to diagnose mitochondrial disease
inferred← citeshttps://doi.org/10.2147/jir.s606604openalex-snapshot
Endoplasmic Reticulum Stress as a Stage-Dependent Regulatory Hub in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.26508/lsa.202302335openalex-snapshot
ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis
inferred← citeshttps://doi.org/10.70675/47385dd8z5ab0z4e4eza1dazd02d1eb2d3e3openalex-snapshot
Characterization of the MTL complex and AtVPS13M1 : two actors involved in phosphate starvation-induced membrane lipid remodeling in Arabidopsis thaliana
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