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Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-γ–mediated pathways

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.20848openalex-snapshot
Expression of IL‐27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals
inferredcites →https://doi.org/10.1006/meth.2001.1266openalex-snapshot
Use of Real-Time Quantitative PCR to Validate the Results of cDNA Array and Differential Display PCR Technologies
inferredcites →https://doi.org/10.1007/s00005-006-0002-6openalex-snapshot
Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27
inferredcites →https://doi.org/10.1016/0092-8674(93)90681-fopenalex-snapshot
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
inferredcites →https://doi.org/10.1016/j.immuni.2004.07.017openalex-snapshot
The Immunobiology of Cancer Immunosurveillance and Immunoediting
inferredcites →https://doi.org/10.1016/j.jns.2004.12.013openalex-snapshot
IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis
inferredcites →https://doi.org/10.1016/s1074-7613(00)80443-4openalex-snapshot
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
inferredcites →https://doi.org/10.1016/s1074-7613(01)00206-0openalex-snapshot
WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection
inferredcites →https://doi.org/10.1016/s1074-7613(02)00324-2openalex-snapshot
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
inferredcites →https://doi.org/10.1016/s1074-7613(03)00298-xopenalex-snapshot
WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
inferredcites →https://doi.org/10.1016/s1074-7613(03)00300-5openalex-snapshot
The IL-27R (WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection
inferredcites →https://doi.org/10.1038/35636openalex-snapshot
Requirement for IRF-1 in the microenvironment supporting development of natural killer cells
inferredcites →https://doi.org/10.1038/ni1308openalex-snapshot
MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA
inferredcites →https://doi.org/10.1038/ni1375openalex-snapshot
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
inferredcites →https://doi.org/10.1038/ni1376openalex-snapshot
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
inferredcites →https://doi.org/10.1074/jbc.272.16.10389openalex-snapshot
Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter
inferredcites →https://doi.org/10.1074/jbc.m406565200openalex-snapshot
Synergistic Activation of Interleukin-12 p35 Gene Transcription by Interferon Regulatory Factor-1 and Interferon Consensus Sequence-binding Protein
inferredcites →https://doi.org/10.1074/jbc.m500973200openalex-snapshot
Interferon Regulatory Factor 1 Is an Essential and Direct Transcriptional Activator for Interferon γ-induced RANTES/CCl5 Expression in Macrophages
inferredcites →https://doi.org/10.1084/jem.183.1.147openalex-snapshot
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
inferredcites →https://doi.org/10.1084/jem.184.5.2043openalex-snapshot
The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.
inferredcites →https://doi.org/10.1084/jem.187.6.967openalex-snapshot
The Transcription Factor Interferon Regulatory Factor 1 (IRF-1) Is Important during the Maturation of Natural Killer 1.1+ T Cell Receptor–α/β+ (NK1+ T) Cells, Natural Killer Cells, and Intestinal Intraepithelial T Cells
inferredcites →https://doi.org/10.1084/jem.192.3.325openalex-snapshot
Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells
inferredcites →https://doi.org/10.1084/jem.194.8.1021openalex-snapshot
C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription
inferredcites →https://doi.org/10.1084/jem.194.8.1123openalex-snapshot
Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1084/jem.20030026openalex-snapshot
Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1
inferredcites →https://doi.org/10.1093/nar/17.15.6419openalex-snapshot
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
inferredcites →https://doi.org/10.1097/00054725-200501000-00003openalex-snapshot
Expression of Interleukin-12-Related Cytokine Transcripts in Inflammatory Bowel Disease: Elevated Interleukin-23p19 and Interleukin-27p28 in Crohnʼs Disease But Not in Ulcerative Colitis
inferredcites →https://doi.org/10.1097/01.mib.0000191611.05466.1fopenalex-snapshot
T Helper 1-Inducing Property of II-27/WSX-1 Signaling Is Required for the Induction of Experimental Colitis
inferredcites →https://doi.org/10.1101/gad.13.10.1240openalex-snapshot
Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53
inferredcites →https://doi.org/10.1128/mcb.13.8.4531openalex-snapshot
Recognition DNA Sequences of Interferon Regulatory Factor 1 (IRF-1) and IRF-2, Regulators of Cell Growth and the Interferon System
inferredcites →https://doi.org/10.1146/annurev.immunol.15.1.749openalex-snapshot
CELLULAR RESPONSES TO INTERFERON-γ
inferredcites →https://doi.org/10.1146/annurev.immunol.19.1.623openalex-snapshot
IRF Family of Transcription Factors as Regulators of Host Defense
inferredcites →https://doi.org/10.1146/annurev.immunol.21.120601.141126openalex-snapshot
Toll-Like Receptors
inferredcites →https://doi.org/10.1158/0008-5472.can-03-2084openalex-snapshot
Potent Antitumor Activity of Interleukin-27
inferredcites →https://doi.org/10.1189/jlb.0603252openalex-snapshot
Interferon-γ: an overview of signals, mechanisms and functions
inferredcites →https://doi.org/10.4049/jimmunol.164.7.3476openalex-snapshot
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
inferredcites →https://doi.org/10.4049/jimmunol.172.6.3590openalex-snapshot
Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis
inferredcites →https://doi.org/10.4049/jimmunol.172.8.4672openalex-snapshot
Cutting Edge: Early IL-4 Production Governs the Requirement for IL-27-WSX-1 Signaling in the Development of Protective Th1 Cytokine Responses following Leishmania major Infection
inferredcites →https://doi.org/10.4049/jimmunol.173.12.7170openalex-snapshot
IL-27 Mediates Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors: Role for CD8+ T Cells
inferredcites →https://doi.org/10.4049/jimmunol.173.2.1171openalex-snapshot
Suppression of Ongoing Adjuvant-Induced Arthritis by Neutralizing the Function of the p28 Subunit of IL-27
inferredcites →https://doi.org/10.4049/jimmunol.175.4.2401openalex-snapshot
Exacerbation of Experimental Allergic Asthma by Augmented Th2 Responses in WSX-1-Deficient Mice
inferredcites →https://doi.org/10.4049/jimmunol.176.1.237openalex-snapshot
IL-27 Limits IL-2 Production during Th1 Differentiation
inferredcites →https://doi.org/10.4049/jimmunol.176.12.7317openalex-snapshot
Antiangiogenic and Antitumor Activities of IL-27
inferredcites →https://doi.org/10.4049/jimmunol.176.5.2773openalex-snapshot
IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3
inferredcites →https://doi.org/10.4049/jimmunol.177.8.5377openalex-snapshot
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4148192openalex-extracted
inferred← citeshttps://doi.org/10.1002/eji.200737566openalex-snapshot
IFN‐β modulates the response to TLR stimulation in human DC: Involvement of IFN regulatory factor‐1 (IRF‐1) in IL‐27 gene expression
inferred← citeshttps://doi.org/10.1002/eji.201242526openalex-snapshot
Production of interleukin‐27 by human neutrophils regulates their function during bacterial infection
inferred← citeshttps://doi.org/10.1002/eji.201445217openalex-snapshot
Human tolerogenic dendritic cells produce IL‐35 in the absence of other IL‐12 family members
inferred← citeshttps://doi.org/10.1002/glia.22948openalex-snapshot
Production of IL ‐27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses
inferred← citeshttps://doi.org/10.1002/hep.24814openalex-snapshot
Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury
inferred← citeshttps://doi.org/10.1002/hep.26166openalex-snapshot
High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-γ dysregulation of CD4+ T cells
inferred← citeshttps://doi.org/10.1007/978-3-319-39664-4openalex-snapshot
Interleukin-27: Biological Properties and Clinical Application
inferred← citeshttps://doi.org/10.1007/978-3-319-39664-4_1openalex-snapshot
IL-27: Structure, Regulation, and Variability
inferred← citeshttps://doi.org/10.1007/978-3-642-02155-8_2openalex-snapshot
Effects of Sex Steroids on Innate and Adaptive Immunity
inferred← citeshttps://doi.org/10.1007/978-4-431-54442-5_14openalex-snapshot
Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties
inferred← citeshttps://doi.org/10.1007/978-94-024-0921-5_9openalex-snapshot
Regulation and Immune Function of IL-27
inferred← citeshttps://doi.org/10.1007/s00005-010-0098-6openalex-snapshot
Interleukin-27: Biological Properties and Clinical Application
inferred← citeshttps://doi.org/10.1007/s00011-024-01986-2openalex-snapshot
IL-27 regulates macrophage ferroptosis by inhibiting the Nrf2/HO1 signaling pathway in sepsis-induced ARDS
inferred← citeshttps://doi.org/10.1007/s00018-008-8540-1openalex-snapshot
The pathogenic role of interleukin-27 in autoimmune diabetes
inferred← citeshttps://doi.org/10.1007/s00262-018-2263-4openalex-snapshot
Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment
inferred← citeshttps://doi.org/10.1007/s11033-020-05871-zopenalex-snapshot
IL-27 variants might be genetic risk factors for preeclampsia: based on genetic polymorphisms, haplotypes and in silico approach
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00338-7openalex-snapshot
Advances in Understanding the Pathogenesis of Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-394299-9.00001-1openalex-snapshot
The Immunobiology of IL-27
inferred← citeshttps://doi.org/10.1016/b978-0-12-801121-8.00002-6openalex-snapshot
Interleukin-1 Superfamily and Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-801121-8.00007-5openalex-snapshot
Interleukin-12 Superfamily and Cancer
inferred← citeshttps://doi.org/10.1016/j.ajpath.2014.02.004openalex-snapshot
IL-27R–Mediated Regulation of IL-17 Controls the Development of Respiratory Syncytial Virus–Associated Pathogenesis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.03.136openalex-snapshot
A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2015.07.055openalex-snapshot
LNA aptamer based multi-modal, Fe 3 O 4 -saturated lactoferrin (Fe 3 O 4 -bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.11.010openalex-snapshot
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.01.090openalex-snapshot
Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo
inferred← citeshttps://doi.org/10.1016/j.coi.2011.07.016openalex-snapshot
The pathogenesis of influenza virus infections: the contributions of virus and host factors
inferred← citeshttps://doi.org/10.1016/j.cyto.2010.04.015openalex-snapshot
Interleukin-27 expression following infection with the murine gammaherpesvirus 68☆
inferred← citeshttps://doi.org/10.1016/j.cyto.2016.08.006openalex-snapshot
Interleukin-27 is elevated in sepsis-induced myocardial dysfunction and mediates inflammation
inferred← citeshttps://doi.org/10.1016/j.cyto.2017.08.012openalex-snapshot
Association between maternal circulating IL-27 levels and preeclampsia
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2007.10.005openalex-snapshot
IFN regulation and functions in myeloid dendritic cells
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2012.10.001openalex-snapshot
The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2013.07.001openalex-snapshot
Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2016.07.005openalex-snapshot
The untold story of IFN-γ in cancer biology
inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2010.12.019openalex-snapshot
3,4-Methylenedioxymethamphetamine (MDMA) alters acute gammaherpesvirus burden and limits interleukin 27 responses in a mouse model of viral infection
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108530openalex-snapshot
IL-27 suppresses spring viremia of carp virus replication in zebrafish
inferred← citeshttps://doi.org/10.1016/j.imbio.2013.06.001openalex-snapshot
IFN-γ-induced IL-27 and IL-27p28 expression are differentially regulated through JNK MAPK and PI3K pathways independent of Jak/STAT in human monocytic cells
inferred← citeshttps://doi.org/10.1016/j.imlet.2008.01.011openalex-snapshot
Advances in understanding the anti-inflammatory properties of IL-27
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.02.011openalex-snapshot
Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity during Malaria Parasite Infection
inferred← citeshttps://doi.org/10.1016/j.immuni.2019.03.027openalex-snapshot
Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines
inferred← citeshttps://doi.org/10.1016/j.intimp.2015.03.016openalex-snapshot
Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107979openalex-snapshot
AIRE-overexpressing BMDCs suppress TFH cells through ICOSL to prevent and attenuate autoimmune diabetes in NOD mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111464openalex-snapshot
Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.isci.2021.103588openalex-snapshot
IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107544openalex-snapshot
IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting pro-inflammatory macrophage polarization and pyroptosis
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112308openalex-snapshot
Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance
inferred← citeshttps://doi.org/10.1016/j.isci.2025.113982openalex-snapshot
Interleukin-27 is a multitarget regulator of fibroblast remodeling in thyroid-associated ophthalmopathy
inferred← citeshttps://doi.org/10.1016/j.jaci.2010.11.050openalex-snapshot
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases
inferred← citeshttps://doi.org/10.1016/j.jff.2018.07.010openalex-snapshot
A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice
inferred← citeshttps://doi.org/10.1016/j.jhep.2009.04.026openalex-snapshot
Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2015.09.010openalex-snapshot
Serum interleukin-27 expression in patients with myasthenia gravis
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2016.07.004openalex-snapshot
IL-27: a potential biomarker for responders to glatiramer acetate therapy
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2023.11.029openalex-snapshot
Plasma cytokine and growth factor response to acute psychosocial stress in major depressive disorder
inferred← citeshttps://doi.org/10.1016/j.mehy.2019.109319openalex-snapshot
Exogenous intrapleural injection of interleukin-27 may improves outcome and prognosis in patients with tuberculous pleural effusion
inferred← citeshttps://doi.org/10.1016/j.molimm.2011.04.006openalex-snapshot
A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members
inferred← citeshttps://doi.org/10.1016/j.molimm.2016.02.006openalex-snapshot
Transcription factor Fli-1 positively regulates lipopolysaccharide-induced interleukin-27 production in macrophages
inferred← citeshttps://doi.org/10.1016/j.molimm.2021.08.001openalex-snapshot
The dual role of IL-27 in CD4+T cells
inferred← citeshttps://doi.org/10.1016/j.molmed.2012.12.002openalex-snapshot
IL-27 in tumor immunity and immunotherapy
inferred← citeshttps://doi.org/10.1016/j.neuron.2014.07.027openalex-snapshot
TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord
inferred← citeshttps://doi.org/10.1016/j.tube.2023.102326openalex-snapshot
IL-27 Inhibits Anti-Mycobacterium Tuberculosis Innate Immune Activity of Primary Human Macrophages
inferred← citeshttps://doi.org/10.1016/s1569-9056(19)30439-7openalex-snapshot
Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment
inferred← citeshttps://doi.org/10.1038/jid.2009.349openalex-snapshot
Possible Roles of IL-27 in the Pathogenesis of Psoriasis
inferred← citeshttps://doi.org/10.1038/jid.2015.195openalex-snapshot
IL-27 Suppresses Antimicrobial Activity in Human Leprosy
inferred← citeshttps://doi.org/10.1038/ni.1957openalex-snapshot
A role for IL-27p28 as an antagonist of gp130-mediated signaling
inferred← citeshttps://doi.org/10.1038/nri2225openalex-snapshot
How microorganisms tip the balance between interleukin-12 family members
inferred← citeshttps://doi.org/10.1038/s12276-021-00630-xopenalex-snapshot
IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer
inferred← citeshttps://doi.org/10.1038/s12276-024-01187-1openalex-snapshot
IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner
inferred← citeshttps://doi.org/10.1038/s41385-018-0026-3openalex-snapshot
The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells
inferred← citeshttps://doi.org/10.1038/s41421-025-00784-2openalex-snapshot
Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis
inferred← citeshttps://doi.org/10.1038/s41467-017-00770-7openalex-snapshot
Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1038/s41467-017-00892-yopenalex-snapshot
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
inferred← citeshttps://doi.org/10.1038/s41590-023-01667-yopenalex-snapshot
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity
inferred← citeshttps://doi.org/10.1038/srep34884openalex-snapshot
Dual Roles of IFN-γ and IL-4 in the Natural History of Murine Autoimmune Cholangitis: IL-30 and Implications for Precision Medicine
inferred← citeshttps://doi.org/10.1053/j.gastro.2019.12.027openalex-snapshot
Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice
inferred← citeshttps://doi.org/10.1074/jbc.m110.100818openalex-snapshot
Activation of IL-27 p28 Gene Transcription by Interferon Regulatory Factor 8 in Cooperation with Interferon Regulatory Factor 1
inferred← citeshttps://doi.org/10.1074/jbc.m110.112599openalex-snapshot
Interleukin-27 Induces a STAT1/3- and NF-κB-dependent Proinflammatory Cytokine Profile in Human Monocytes
inferred← citeshttps://doi.org/10.1080/15321819.2016.1195746openalex-snapshot
IL-27 plasma level in relapsing remitting multiple sclerosis subjects: The double-faced cytokine
inferred← citeshttps://doi.org/10.1084/jem.20190347openalex-snapshot
Historical overview of the interleukin-6 family cytokine
inferred← citeshttps://doi.org/10.1084/jem.20210021openalex-snapshot
Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes
inferred← citeshttps://doi.org/10.1084/jem.20231967openalex-snapshot
Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
inferred← citeshttps://doi.org/10.1093/immadv/ltab012openalex-snapshot
α2-3 Sialic acid binding and uptake by human monocyte-derived dendritic cells alters metabolism and cytokine release and initiates tolerizing T cell programming
inferred← citeshttps://doi.org/10.1093/intimm/dxm139openalex-snapshot
IL-27 inhibits the development of regulatory T cells via STAT3
inferred← citeshttps://doi.org/10.1093/intimm/dxq470openalex-snapshot
Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints
inferred← citeshttps://doi.org/10.1096/fj.11-191205openalex-snapshot
MyD88‐dependent production of IL‐17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway
inferred← citeshttps://doi.org/10.1097/qad.0000000000002288openalex-snapshot
IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells
inferred← citeshttps://doi.org/10.1101/2020.01.10.901223openalex-snapshot
Amino-alcohol Bio-conjugate of Naproxen Exhibits Anti-inflammatory Activity through NF-κB Signaling Pathway
inferred← citeshttps://doi.org/10.1101/2023.05.03.539212openalex-snapshot
The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon β
inferred← citeshttps://doi.org/10.1101/2024.06.25.600597openalex-snapshot
Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer
inferred← citeshttps://doi.org/10.1111/aji.13942openalex-snapshot
Emerging Roles of IL‐27 in Trophoblast Cells and Pregnancy Complications
inferred← citeshttps://doi.org/10.1111/imr.12058openalex-snapshot
The emerging role of micro RNA s in regulating immune and inflammatory responses in the lung
inferred← citeshttps://doi.org/10.1111/imr.12554openalex-snapshot
Type two innate lymphoid cells: the Janus cells in health and disease
inferred← citeshttps://doi.org/10.1111/j.1365-3083.2010.02460.xopenalex-snapshot
Stimulatory Effect of LPS and Feedback Effect of PGE2 on IL-27 production
inferred← citeshttps://doi.org/10.1111/j.1600-065x.2008.00704.xopenalex-snapshot
Interleukin‐35: odd one out or part of the family?
inferred← citeshttps://doi.org/10.1111/j.1600-065x.2008.00710.xopenalex-snapshot
Regulation of immune responses by interleukin‐27
inferred← citeshttps://doi.org/10.1111/sji.12959openalex-snapshot
The immunomodulatory potentials of interleukin‐27 in airway allergies
inferred← citeshttps://doi.org/10.1126/sciadv.adg6874openalex-snapshot
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions
inferred← citeshttps://doi.org/10.1126/scisignal.aaw1347openalex-snapshot
TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection
inferred← citeshttps://doi.org/10.1128/9781555816650.ch20openalex-snapshot
The Functional Heterogeneity of Activated Macrophages
inferred← citeshttps://doi.org/10.1128/jvi.02196-17openalex-snapshot
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection
inferred← citeshttps://doi.org/10.1146/annurev-immunol-032414-112134openalex-snapshot
The Immunobiology of Interleukin-27
inferred← citeshttps://doi.org/10.1152/ajpendo.00243.2024openalex-snapshot
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis
inferred← citeshttps://doi.org/10.1155/2011/463412openalex-snapshot
Regulatory T‐Cell‐Associated Cytokines in Systemic Lupus Erythematosus
inferred← citeshttps://doi.org/10.1155/2017/3958069openalex-snapshot
Dual Roles of IL-27 in Cancer Biology and Immunotherapy
inferred← citeshttps://doi.org/10.1155/2022/2054879openalex-snapshot
Interleukin-27 Ameliorates Atherosclerosis in ApoE-/- Mice through Regulatory T Cell Augmentation and Dendritic Cell Tolerance
inferred← citeshttps://doi.org/10.1155/jimr/6176816openalex-snapshot
IL‐27: A Double‐Edged Sword in Immune Regulation via JAK‐STAT Orchestration
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-13-2240openalex-snapshot
Interleukin-30 Expression in Prostate Cancer and Its Draining Lymph Nodes Correlates with Advanced Grade and Stage
inferred← citeshttps://doi.org/10.11606/d.42.2012.tde-01082012-090046openalex-snapshot
Caracterização da fase inicial da artrite induzida pelo pristane em camundongos selecionados para alta ou baixa produção de anticorpos: envolvimento celular e molecular.
inferred← citeshttps://doi.org/10.1172/jci33342openalex-snapshot
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
inferred← citeshttps://doi.org/10.1186/s12882-021-02645-yopenalex-snapshot
The effect of BKV reactivation on cytokines behavior in kidney transplanted patients
inferred← citeshttps://doi.org/10.1186/s40425-019-0668-zopenalex-snapshot
Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival
inferred← citeshttps://doi.org/10.1186/s43168-021-00073-yopenalex-snapshot
Dynamic role of LMW-hyaluronan fragments and Toll-like receptors 2,4 in progression of bleomycin induced lung parenchymal injury to fibrosis
inferred← citeshttps://doi.org/10.1189/jlb.0213107openalex-snapshot
Modulation of inflammation by interleukin-27
inferred← citeshttps://doi.org/10.1189/jlb.0307157openalex-snapshot
IFN-α regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages
inferred← citeshttps://doi.org/10.1189/jlb.0609445openalex-snapshot
Interleukin 27: a double-edged sword for offense and defense
inferred← citeshttps://doi.org/10.1189/jlb.0711357openalex-snapshot
Emerging roles of pulmonary macrophages in driving the development of severe asthma
inferred← citeshttps://doi.org/10.1189/jlb.3a0316-098ropenalex-snapshot
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages
inferred← citeshttps://doi.org/10.1189/jlb.3a1013-541ropenalex-snapshot
Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27
inferred← citeshttps://doi.org/10.1189/jlb.3hi0616-280ropenalex-snapshot
Frontline Science: Human bone cells as a source of IL-27 under inflammatory conditions: role of TLRs and cytokines
inferred← citeshttps://doi.org/10.1189/jlb.4a0716-332rropenalex-snapshot
HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways
inferred← citeshttps://doi.org/10.1371/journal.pone.0057866openalex-snapshot
Molecules Altering the Intracellular Thiol Content Modulate NF-kB and STAT-1/IRF-1 Signalling Pathways and IL-12 p40 and IL-27 p28 Production in Murine Macrophages
inferred← citeshttps://doi.org/10.1371/journal.pone.0141265openalex-snapshot
Soluble CD40 Ligand in Sera of Subjects Exposed to Leishmania infantum Infection Reduces the Parasite Load in Macrophages
inferred← citeshttps://doi.org/10.1371/journal.ppat.1004110openalex-snapshot
Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005507openalex-snapshot
Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis
inferred← citeshttps://doi.org/10.1517/14712590802646936openalex-snapshot
Therapeutic potential of IL-27 in multiple sclerosis?
inferred← citeshttps://doi.org/10.1517/14728221003769911openalex-snapshot
Therapeutic potential of IL-27 in systemic lupus erythematosus
inferred← citeshttps://doi.org/10.15171/apb.2015.081openalex-snapshot
New Approaches to the Immunotherapy of Type 1 Diabetes Mellitus Using Interleukin-27
inferred← citeshttps://doi.org/10.1556/030.63.2016.1.1openalex-snapshot
IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways
inferred← citeshttps://doi.org/10.20381/ruor-3180openalex-snapshot
SHP-1/ Src Complex is a Master Regulator of the IL-12/IL-23 pro- and IL-10/IL-27 Anti-inflammatory Axis in TLR4-activated Signaling Pathways in Human Monocytes and Macrophages
inferred← citeshttps://doi.org/10.20381/ruor-3302openalex-snapshot
Regulation of IL-12, IL-23, IL-27 in Response to IFN-γ/LPS in Human Monocytes and Macrophages
inferred← citeshttps://doi.org/10.20381/ruor-3938openalex-snapshot
Molecular Mechanism Involved in HIV-Tat Mediated inhibition of LPS-Induced IL-23 and IL-27 Production in Human Macrophages
inferred← citeshttps://doi.org/10.20381/ruor-5966openalex-snapshot
The Effects of HIV on the Regulation of IL-12 Family Cytokines, IL-12, IL-23, and IL-27 Production in Human Monocyte-derived Macrophages
inferred← citeshttps://doi.org/10.2174/187152809787582507openalex-snapshot
The IL-12 Family of Cytokines in Infection, Inflammation and Autoimmune Disorders
inferred← citeshttps://doi.org/10.2174/1876894601002040187openalex-snapshot
Diverse and Opposing Roles of IL-27 in Immunity~!2009-11-04~!2009-12-16~!2010-07-14~!
inferred← citeshttps://doi.org/10.2353/ajpath.2009.080752openalex-snapshot
Epstein-Barr Virus-Induced Gene-3 Is Expressed in Human Atheroma Plaques
inferred← citeshttps://doi.org/10.2353/ajpath.2010.090111openalex-snapshot
Dendritic Cells Express Hematopoietic Prostaglandin D Synthase and Function as a Source of Prostaglandin D2 in the Skin
inferred← citeshttps://doi.org/10.2486/indhealth.ms1364openalex-snapshot
The Increases in mRNA Expressions of Inflammatory Cytokines by Adding Cleaning Solvent or Tetrachloroethylene in the Murine Macrophage Cell Line J774.1 Evaluated by Real-time PCR
inferred← citeshttps://doi.org/10.32657/10356/66024openalex-snapshot
Transcriptional regulation of type I interferon responses of myeloid antigen presenting cells
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01213openalex-snapshot
Ebi3 Prevents Trypanosoma cruzi-Induced Myocarditis by Dampening IFN-γ-Driven Inflammation
inferred← citeshttps://doi.org/10.3389/fimmu.2021.647019openalex-snapshot
Monocytic-Myeloid Derived Suppressor Cells of HIV-Infected Individuals With Viral Suppression Exhibit Suppressed Innate Immunity to Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.678515openalex-snapshot
Interleukin-27 and Its Diverse Effects on Bacterial Infections
inferred← citeshttps://doi.org/10.3389/fimmu.2021.787252openalex-snapshot
Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil?
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1219953openalex-snapshot
CD11a regulates hematopoietic stem and progenitor cells
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1395921openalex-snapshot
IL-27 expression regulation and its effects on adaptive immunity against viruses
inferred← citeshttps://doi.org/10.3390/biology14010033openalex-snapshot
NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the Il12b Promoter in Macrophages
inferred← citeshttps://doi.org/10.3390/biom14121489openalex-snapshot
Interleukin-27 and Autoimmune Disorders: A Compressive Review of Immunological Functions
inferred← citeshttps://doi.org/10.3390/cells9030615openalex-snapshot
Decoding the Role of Interleukin-30 in the Crosstalk between Cancer and Myeloid Cells
inferred← citeshttps://doi.org/10.3390/molecules17067595openalex-snapshot
Down Regulation of CIAPIN1 Reverses Multidrug Resistance in Human Breast Cancer Cells by Inhibiting MDR1
inferred← citeshttps://doi.org/10.4049/immunohorizons.1700054openalex-snapshot
IL-27p28 Production by XCR1+ Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8+ T Cell Responses
inferred← citeshttps://doi.org/10.4049/jimmunol.0802091openalex-snapshot
IL-27 Abrogates Receptor Activator of NF-κB Ligand-Mediated Osteoclastogenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos
inferred← citeshttps://doi.org/10.4049/jimmunol.0901464openalex-snapshot
The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling
inferred← citeshttps://doi.org/10.4049/jimmunol.0902005openalex-snapshot
Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process
inferred← citeshttps://doi.org/10.4049/jimmunol.1001039openalex-snapshot
IL-27/IFN-γ Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages
inferred← citeshttps://doi.org/10.4049/jimmunol.1001290openalex-snapshot
Suppression of TNF-α and IL-1 Signaling Identifies a Mechanism of Homeostatic Regulation of Macrophages by IL-27
inferred← citeshttps://doi.org/10.4049/jimmunol.1002041openalex-snapshot
Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages
inferred← citeshttps://doi.org/10.4049/jimmunol.1003447openalex-snapshot
Transcriptional Suppression of IL-27 Production by Mycobacterium tuberculosis-Activated p38 MAPK via Inhibition of AP-1 Binding
inferred← citeshttps://doi.org/10.4049/jimmunol.1003588openalex-snapshot
IL-27 and IL-21 Are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis
inferred← citeshttps://doi.org/10.4049/jimmunol.1003988openalex-snapshot
Regulation of IFN-λ1 Promoter Activity (IFN-λ1/IL-29) in Human Airway Epithelial Cells
inferred← citeshttps://doi.org/10.4049/jimmunol.1100224openalex-snapshot
IL-12p35 Subunit Contributes to Autoimmunity by Limiting IL-27–Driven Regulatory Responses
inferred← citeshttps://doi.org/10.4049/jimmunol.1100883openalex-snapshot
Coordination between TLR9 Signaling in Macrophages and CD3 Signaling in T Cells Induces Robust Expression of IL-30
inferred← citeshttps://doi.org/10.4049/jimmunol.1101654openalex-snapshot
TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice
inferred← citeshttps://doi.org/10.4049/jimmunol.1101908openalex-snapshot
Memory CD4 T Cells Induce Selective Expression of IL-27 in CD8+ Dendritic Cells and Regulate Homeostatic Naive T Cell Proliferation
inferred← citeshttps://doi.org/10.4049/jimmunol.1101912openalex-snapshot
IL-27 Enhances LPS-Induced Proinflammatory Cytokine Production via Upregulation of TLR4 Expression and Signaling in Human Monocytes
inferred← citeshttps://doi.org/10.4049/jimmunol.1102914openalex-snapshot
Complement Activation Product C5a Is a Selective Suppressor of TLR4-Induced, but Not TLR3-Induced, Production of IL-27(p28) from Macrophages
inferred← citeshttps://doi.org/10.4049/jimmunol.1103660openalex-snapshot
Development of Mature and Functional Human Myeloid Subsets in Hematopoietic Stem Cell-Engrafted NOD/SCID/IL2rγKO Mice
inferred← citeshttps://doi.org/10.4049/jimmunol.1300126openalex-snapshot
Suppression of IL-12 Production by Tristetraprolin through Blocking NF-кB Nuclear Translocation
inferred← citeshttps://doi.org/10.4049/jimmunol.1300419openalex-snapshot
The Interdependent, Overlapping, and Differential Roles of Type I and II IFNs in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
inferred← citeshttps://doi.org/10.4049/jimmunol.1302280openalex-snapshot
Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3
inferred← citeshttps://doi.org/10.4049/jimmunol.1501204openalex-snapshot
IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance
inferred← citeshttps://doi.org/10.4049/jimmunol.1502114openalex-snapshot
Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice
inferred← citeshttps://doi.org/10.4049/jimmunol.1601073openalex-snapshot
Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1
inferred← citeshttps://doi.org/10.4049/jimmunol.1601950openalex-snapshot
Identification of IFN-γ and IL-27 as Critical Regulators of Respiratory Syncytial Virus–Induced Exacerbation of Allergic Airways Disease in a Mouse Model
inferred← citeshttps://doi.org/10.4049/jimmunol.1700199openalex-snapshot
cIAP1/2–TRAF2–SHP-1–Src–MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages
inferred← citeshttps://doi.org/10.4049/jimmunol.1700687openalex-snapshot
Neuroendocrine Modulation of IL-27 in Macrophages
inferred← citeshttps://doi.org/10.4049/jimmunol.1701373openalex-snapshot
IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism
inferred← citeshttps://doi.org/10.4049/jimmunol.178.12.7607openalex-snapshot
IL-27 Synthesis Induced by TLR Ligation Critically Depends on IFN Regulatory Factor 3
inferred← citeshttps://doi.org/10.4049/jimmunol.180.3.1471openalex-snapshot
IFN-γ Arms Human Dendritic Cells to Perform Multiple Effector Functions
inferred← citeshttps://doi.org/10.4049/jimmunol.2200420openalex-snapshot
Role of IL-27 in HSV-1–Induced Herpetic Stromal Keratitis
inferred← citeshttps://doi.org/10.4081/aiua.2023.11691openalex-snapshot
Study the mRNA level of IL-27/IL-27R pathway molecules in kidney transplant rejection
inferred← citeshttps://doi.org/10.5109/1957499openalex-snapshot
Editorial
inferred← citeshttps://doi.org/10.5530/pj.2016.2.2openalex-snapshot
Inhibition of MDR1 in mammary cell carcinoma reverses Multidrug Resistance by SOCS1.
inferred← citeshttps://doi.org/10.6084/m9.figshare.18070648openalex-snapshot
Additional file 1 of The effect of BKV reactivation on cytokines behavior in kidney transplanted patients
inferred← citeshttps://doi.org/10.70675/2431523ez2962z4420zbb9ezd6110a90a7f0openalex-snapshot
Étude des mécanismes physiopathologiques impliqués dans la toxicité des particules ultrafines chez un modèle murin : une approche multi-organes
inferred← citeshttps://doi.org/10.7150/ijbs.10464openalex-snapshot
Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
inferred← citeshttps://doi.org/10.71781/27957openalex-snapshot
Expression des SOCS-1 et SOCS-3 par les lymphocytes T humains en réponse à des cytokines immuno-modulatrices
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.