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Interleukin‐12 and Interleukin‐27 Regulate Macrophage Control of Mycobacterium tuberculosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Cloning and Characterization of a Novel Class I Cytokine Receptor
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Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates
inferredcites →https://doi.org/10.1016/1074-7613(95)90001-2openalex-snapshot
Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
inferredcites →https://doi.org/10.1016/j.micpath.2007.02.001openalex-snapshot
Modulation of virulence factors in Francisella tularensis determines human macrophage responses
inferredcites →https://doi.org/10.1016/s1074-7613(01)00206-0openalex-snapshot
WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection
inferredcites →https://doi.org/10.1016/s1074-7613(02)00324-2openalex-snapshot
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
inferredcites →https://doi.org/10.1016/s1074-7613(03)00298-xopenalex-snapshot
WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
inferredcites →https://doi.org/10.1016/s1074-7613(03)00300-5openalex-snapshot
The IL-27R (WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection
inferredcites →https://doi.org/10.1016/s1359-6101(03)00054-6openalex-snapshot
Chemokines and tuberculosis
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IFN-γ production by antigen-presenting cells: mechanisms emerge
inferredcites →https://doi.org/10.1038/35038103openalex-snapshot
Development of Th1-type immune responses requires the type I cytokine receptor TCCR
inferredcites →https://doi.org/10.1038/7701openalex-snapshot
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection
inferredcites →https://doi.org/10.1038/nri1264openalex-snapshot
The human model: a genetic dissection of immunity to infection in natural conditions
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A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection
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Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection
inferredcites →https://doi.org/10.1056/nejmoa011110openalex-snapshot
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
inferredcites →https://doi.org/10.1073/pnas.022649799openalex-snapshot
Human macrophage activation programs induced by bacterial pathogens
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Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.
inferredcites →https://doi.org/10.1084/jem.175.4.1111openalex-snapshot
Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.
inferredcites →https://doi.org/10.1084/jem.178.6.2243openalex-snapshot
Disseminated tuberculosis in interferon gamma gene-disrupted mice.
inferredcites →https://doi.org/10.1084/jem.178.6.2249openalex-snapshot
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
inferredcites →https://doi.org/10.1084/jem.186.1.39openalex-snapshot
Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1084/jem.187.12.2009openalex-snapshot
Interferon–inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3
inferredcites →https://doi.org/10.1084/jem.20060471openalex-snapshot
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
inferredcites →https://doi.org/10.1128/iai.65.12.5149-5156.1997openalex-snapshot
Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/iai.69.3.1722-1728.2001openalex-snapshot
Temporal and Spatial Arrangement of Lymphocytes within Lung Granulomas Induced by Aerosol Infection withMycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/iai.69.3.1847-1855.2001openalex-snapshot
Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology
inferredcites →https://doi.org/10.1128/iai.72.5.2976-2988.2004openalex-snapshot
Interleukin-12 Therapy Reduces the Number of Immune Cells and Pathology in Lungs of Mice Infected withMycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/jvi.70.2.1143-1153.1996openalex-snapshot
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
inferredcites →https://doi.org/10.1172/jci111852openalex-snapshot
Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.
inferredcites →https://doi.org/10.1189/jlb.68.6.897openalex-snapshot
Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction
inferredcites →https://doi.org/10.4049/jimmunol.154.10.5071openalex-snapshot
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
inferredcites →https://doi.org/10.4049/jimmunol.159.7.3595openalex-snapshot
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha
inferredcites →https://doi.org/10.4049/jimmunol.162.6.3504openalex-snapshot
Structural Deficiencies in Granuloma Formation in TNF Gene-Targeted Mice Underlie the Heightened Susceptibility to Aerosol Mycobacterium tuberculosis Infection, Which Is Not Compensated for by Lymphotoxin
inferredcites →https://doi.org/10.4049/jimmunol.167.1.221openalex-snapshot
Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-γ
inferredcites →https://doi.org/10.4049/jimmunol.167.12.6957openalex-snapshot
A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection
inferredcites →https://doi.org/10.4049/jimmunol.168.9.4636openalex-snapshot
Mycobacterium tuberculosis Induces Differential Cytokine Production from Dendritic Cells and Macrophages with Divergent Effects on Naive T Cell Polarization
inferredcites →https://doi.org/10.4049/jimmunol.170.10.5203openalex-snapshot
Cumulative Toll-Like Receptor Activation in Human Macrophages Treated with Whole Bacteria
inferredcites →https://doi.org/10.4049/jimmunol.172.4.2225openalex-snapshot
WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27
inferredcites →https://doi.org/10.4049/jimmunol.173.12.7490openalex-snapshot
IL-27 Signaling Compromises Control of Bacterial Growth in Mycobacteria-Infected Mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Macrophage plasticity as a therapeutic target in tuberculosis
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Production of IL ‐27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses
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IL-27 in Health and Disease
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Recruitment of IL-27-Producing CD4+ T Cells and Effect of IL-27 on Pleural Mesothelial Cells in Tuberculous Pleurisy
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Development of new antituberculous drugs based on bacterial virulence factors interfering with host cytokine networks
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The Immunobiology of IL-27
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Pathogenic Exploitation of Fc Activity
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Host-pathogen dynamics in Mycobacterium tuberculosis: The impact of PE/PPE proteins on innate and adaptive immunity
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The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae
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Serum Creatinine as a Potential Biomarker for the Diagnosis of Tuberculous Pleural Effusion
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IL-27-induced modulation of autoimmunity and its therapeutic potential
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IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected macrophages
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Macrophages in pancreatic cancer: An immunometabolic perspective
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A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity
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Interleukin-27 impairs BCG antigen clearance and T cell stimulatory potential by neonatal dendritic cells
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Interferon-γ, tumor necrosis factor, and interleukin-18 cooperate to control growth of Mycobacterium tuberculosis in human macrophages
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Interleukin-27 inhibits phagosomal acidification by blocking vacuolar ATPases
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Interleukin-27 inhibits malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages
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The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers
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Association between IL-27 and Tr1 cells in severe form of paracoccidioidomycosis
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IL12RB1 allele bias in human TH cells is regulated by functional SNPs in its 3′UTR
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ESAT-6 impedes IL-18 mediated phagosome lysosome fusion via microRNA-30a upon Calcimycin treatment in mycobacteria infected macrophages
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Association of IL27 and STAT3 genetic polymorphism on the susceptibility of tuberculosis in Western Chinese Han population
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Exogenous intrapleural injection of interleukin-27 may improves outcome and prognosis in patients with tuberculous pleural effusion
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A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM Operon gene expression. Does an heterogeneous population exist in intracellular mycobacteria?
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SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis
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IL-27 and IL-27-producing CD4+ T cells in human tuberculous pleural effusion
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IL-27 Inhibits Anti-Mycobacterium Tuberculosis Innate Immune Activity of Primary Human Macrophages
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IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination
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Experimental infection of a bovine model with human isolates of Mycobacterium avium subsp. paratuberculosis
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Eje interleucina 12/interferón gamma en pacientes de tuberculosis en una región europea con alta incidencia de enfermedad
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Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes
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IL-27 Suppresses Antimicrobial Activity in Human Leprosy
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IL-27 amplifies cytokine responses to Gram-negative bacterial products and Salmonella typhimurium infection
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Low Mononuclear Cell IL-18 and IL-27 Response in Children: Susceptibility to Tuberculosis Infection after Contact
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IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization
inferred← citeshttps://doi.org/10.1074/jbc.m110.112599openalex-snapshot
Interleukin-27 Induces a STAT1/3- and NF-κB-dependent Proinflammatory Cytokine Profile in Human Monocytes
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Role of PE family of proteins in mycobacterial virulence: Potential on anti-TB vaccine and drug design
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NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy
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Cytokine Milieu in Infectious Disease: A Sword or a Boon?
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IL-27 producers in a neonatal BCG vaccination model are a heterogenous population of myeloid cells that are diverse in phenotype and function
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Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy
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Role of bronchoalveolar lavage fluid and serum interleukin-27 in the diagnosis of smear-negative pulmonary tuberculosis
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IL-27: a double agent in the IL-6 family
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ESX-1 exploits type I IFN-signalling to promote a regulatory macrophage phenotype refractory to IFNγ-mediated autophagy and growth restriction of intracellular mycobacteria
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Murine myeloid‐derived suppressor cells are a source of elevated levels of interleukin‐27 in early life and compromise control of bacterial infection
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Neonatal macrophages express elevated levels of interleukin‐27 that oppose immune responses
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The presence of interleukin‐27 during monocyte‐derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells
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Elevated interleukin‐27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT ‐1 and STAT ‐3‐dependent manner
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Regulation of immune responses by interleukin‐27
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Development of a Murine Mycobacterial Growth Inhibition Assay for Evaluating Vaccines againstMycobacterium tuberculosis
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Influence of Advanced Age onMycobacterium bovisBCG Vaccination in Guinea Pigs Aerogenically Infected withMycobacterium tuberculosis
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Francisella tularensis Δ pyrF Mutants Show that Replication in Nonmacrophages Is Sufficient for Pathogenesis In Vivo
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Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis
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Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy
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The Immunobiology of Interleukin-27
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Different Transcriptional Profiles of Human Monocyte-Derived Dendritic Cells Infected with Distinct Strains ofMycobacterium tuberculosisandMycobacterium bovisBacillus Calmette-Guérin
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Expression of Proinflammatory and Regulatory Cytokines via NF-κB and MAPK-Dependent and IFN Regulatory Factor-3-Independent Mechanisms in Human Primary Monocytes Infected byMycobacterium tuberculosis
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Cytokines Involved in Interferon-γ Production by Human Macrophages
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Diagnostic Accuracy of Interleukin-27 between Tuberculous Pleural Effusion and Malignant Pleural Effusion: A Meta-Analysis
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Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis
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Interleukin 27 polymorphisms in HCV RNA positive patients: is there an impact on response to interferon therapy?
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IL-12 and IL-27 regulate the phagolysosomal pathway in mycobacteria-infected human macrophages
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Interleukin 27: a double-edged sword for offense and defense
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Cell Origins and Diagnostic Accuracy of Interleukin 27 in Pleural Effusions
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Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation
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Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus
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SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS
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IL-27 neutralization combined with antibiotics: a promising approach to treating neonatal sepsis
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IL-27 Regulation of Innate Immunity and Control of Microbial Growth
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In Vitro Evaluation of Immunogenicity of Recombinant OMP25 Protein Obtained from Endemic Brucella abortus Biovar 3 as Vaccine Candidate Molecule Against Animal Brucellosis
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The IL-12 Family of Cytokines in Infection, Inflammation and Autoimmune Disorders
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Elevation of CD56brightCD16- Lymphocytes in MDR Pulmonary Tuberculosis
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The use of resazurin as a novel antimicrobial agent against Francisella tularensis
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Striking the Right Balance Determines TB or Not TB
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Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis
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Filarial Coinfection Is Associated With Higher Bacterial Burdens and Altered Plasma Cytokine and Chemokine Responses in Tuberculous Lymphadenitis
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Interleukin-27 and Its Diverse Effects on Bacterial Infections
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Interleukin-27-dependent transcriptome signatures during neonatal sepsis
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1217098openalex-snapshot
IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1653355openalex-snapshot
Inhibition of IL-27 signaling regulates chemokine levels and sustains CXCR2 receptor expression on mononuclear cells to improve disease outcomes during gram-negative neonatal sepsis
inferred← citeshttps://doi.org/10.3390/antibiotics11101431openalex-snapshot
Antibiotic Resistance to Mycobacterium tuberculosis and Potential Use of Natural and Biological Products as Alternative Anti-Mycobacterial Agents
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Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies
inferred← citeshttps://doi.org/10.3390/ijms26073106openalex-snapshot
The Role and Potential Application of IL-12 in the Immune Regulation of Tuberculosis
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Effect of Immunomodulating Extract and Some Isolates from Etlingera rubroloba A.D. Poulsen Fruits on Diabetic Patients with Tuberculosis
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Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy
inferred← citeshttps://doi.org/10.4049/jimmunol.0904019openalex-snapshot
Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection
inferred← citeshttps://doi.org/10.4049/jimmunol.1801139openalex-snapshot
Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish
inferred← citeshttps://doi.org/10.4103/njbcs.njbcs_88_23openalex-snapshot
A Pilot Study for Drug-Resistant Tuberculosis Disease Patients Suggests that A964G (rs153109)—Interleukin 27 may be Protective
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Interleukin 27 Could Be Useful in the Diagnosis of Tuberculous Pleural Effusions
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Association Between IL12A rs568408, IL12B rs3212227 and IL-12 Receptor rs383483 Polymorphisms and Risk of Pulmonary Tuberculosis
inferred← citeshttps://doi.org/10.70675/5d4c388cz886bz4dd8z84c1z2f2d1a758af4openalex-snapshot
Intéractions hôte-pathogène : rôle des pattern recognition receptors (PRR) dans l'induction de la réponse immunitaire aux mycobactéries et modulation de cette réponse par des composés mycobactériens
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Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis
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