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Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s00262-016-1834-5openalex-snapshot
Designing therapeutic cancer vaccines by mimicking viral infections
inferredcites →https://doi.org/10.1007/s00262-016-1859-9openalex-snapshot
Modulation of innate immunity in the tumor microenvironment
inferredcites →https://doi.org/10.1016/j.cell.2017.08.027openalex-snapshot
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy
inferredcites →https://doi.org/10.1016/j.trecan.2016.05.002openalex-snapshot
Radiotherapy: Changing the Game in Immunotherapy
inferredcites →https://doi.org/10.1016/j.ygyno.2017.03.507openalex-snapshot
A phase II, randomized, double-blind, placebo-controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: A Gynecologic Oncology Group partners study
inferredcites →https://doi.org/10.1016/s1470-2045(15)00054-6openalex-snapshot
Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
inferredcites →https://doi.org/10.1038/nrc3258openalex-snapshot
Cancer immunotherapy via dendritic cells
inferredcites →https://doi.org/10.1038/nrc3973openalex-snapshot
Evolving synergistic combinations of targeted immunotherapies to combat cancer
inferredcites →https://doi.org/10.1084/jem.20111171openalex-snapshot
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
inferredcites →https://doi.org/10.1093/annonc/mdt245openalex-snapshot
A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients
inferredcites →https://doi.org/10.1093/annonc/mdx049openalex-snapshot
A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a Gynecologic Oncology Group partners study
inferredcites →https://doi.org/10.1093/infdis/132.4.434openalex-snapshot
A Modified Polyriboinosinic-Polyribocytidylic Acid Complex That Induces Interferon in Primates
inferredcites →https://doi.org/10.1097/cji.0b013e3182811ae4openalex-snapshot
Comparison of Glioma-associated Antigen Peptide-loaded Versus Autologous Tumor Lysate-loaded Dendritic Cell Vaccination in Malignant Glioma Patients
inferredcites →https://doi.org/10.1126/science.aaa3828openalex-snapshot
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
inferredcites →https://doi.org/10.1146/annurev-immunol-100311-102839openalex-snapshot
Decisions About Dendritic Cells: Past, Present, and Future
inferredcites →https://doi.org/10.1158/0008-5472.can-16-0549openalex-snapshot
Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-0265openalex-snapshot
Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-2563openalex-snapshot
Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-1185openalex-snapshot
A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-2116openalex-snapshot
Intratumoral Immunization: A New Paradigm for Cancer Therapy
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-1399openalex-snapshot
Dendritic Cell–Based Immunotherapy: State of the Art and Beyond
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-1453openalex-snapshot
Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemoimmunotherapy
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0510openalex-snapshot
Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti–PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells
inferredcites →https://doi.org/10.1158/2326-6066.cir-13-0115openalex-snapshot
An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/2326-6066.cir-14-0024openalex-snapshot
Therapeutic In Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case Report, Hypothesis, and Clinical Trial
inferredcites →https://doi.org/10.1186/s12967-017-1202-zopenalex-snapshot
A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients
inferredcites →https://doi.org/10.1196/annals.1443.020openalex-snapshot
Toll‐like Receptor and RIG‐1‐like Receptor Signaling
inferredcites →https://doi.org/10.1200/jco.2010.28.9793openalex-snapshot
In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study
inferredcites →https://doi.org/10.1200/jco.2010.30.7744openalex-snapshot
Induction of CD8+T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma
inferredcites →https://doi.org/10.1586/14760584.2015.966085openalex-snapshot
Vaccine adjuvant uses of poly-IC and derivatives
inferredcites →https://doi.org/10.2147/jhc.s136652openalex-snapshot
A Phase I trial using local regional treatment, nonlethal irradiation, intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect
inferredcites →https://doi.org/10.4049/jimmunol.1102209openalex-snapshot
Pilot Clinical Trial of Type 1 Dendritic Cells Loaded with Autologous Tumor Lysates Combined with GM-CSF, Pegylated IFN, and Cyclophosphamide for Metastatic Cancer Patients
inferredcites →https://doi.org/10.4049/jimmunol.1601145openalex-snapshot
Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Overcoming intratumoral transport barriers: Advances in local immunotherapy delivery platforms
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TLR3 agonist nanoscale coordination polymer synergizes with immune checkpoint blockade for immunotherapy of cancer
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Carbon ion (12C6+) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls pathway
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IFN-γ enhances Poly(I:C)-induced necroptosis and immunogenic cell death via TLR3 upregulation in cholangiocarcinoma cells
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Production of dendritic cell vaccines using different methods with equivalent results: Implications for emerging centers
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Th1 adjuvant ARNAX, in combination with radiation therapy, enhances tumor regression in mouse tumor-implant models
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Therapeutic Effect of Irreversible Electroporation in Combination with Poly-ICLC Adjuvant in Preclinical Models of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1016/j.medidd.2020.100023openalex-snapshot
Delivery of nucleic acid therapeutics for cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2021.01.001openalex-snapshot
Bacille Calmette-Guérin attenuates vascular amyloid pathology and maximizes synaptic preservation in APP/PS1 mice following active amyloid-β immunotherapy
inferred← citeshttps://doi.org/10.1016/j.omtn.2022.07.020openalex-snapshot
Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer
inferred← citeshttps://doi.org/10.1016/j.omto.2019.03.007openalex-snapshot
Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.12.002openalex-snapshot
Immune mechanisms mediating abscopal effects in radioimmunotherapy
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108387openalex-snapshot
Immunotherapy for hepatocellular carcinoma: Recent advances and future targets
inferred← citeshttps://doi.org/10.1016/j.retram.2026.103606openalex-snapshot
Clinical translation of mRNA-based cancer vaccines for solid tumors
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.09.041openalex-snapshot
Designing nucleic acid-based therapeutics for cancer treatment: Updates on the state of the art
inferred← citeshttps://doi.org/10.1021/acsnanomed.5c00063openalex-snapshot
Intratumoral Manipulation of the Immune Microenvironment of Solid Tumors
inferred← citeshttps://doi.org/10.1038/nrd.2018.132openalex-snapshot
An RNA toolbox for cancer immunotherapy
inferred← citeshttps://doi.org/10.1038/s41392-022-01102-yopenalex-snapshot
Radiotherapy combined with immunotherapy: the dawn of cancer treatment
inferred← citeshttps://doi.org/10.1038/s41392-023-01462-zopenalex-snapshot
Radiation-induced tumor immune microenvironments and potential targets for combination therapy
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Ex vivo pulsed dendritic cell vaccination against cancer
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Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1
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Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer
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Poly (ortho esters) (POEs) as cutting-edge biodegradable polymers for targeted cancer treatment and overcoming multidrug resistance
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Prostate cancer cells enhance interleukin‐15‐mediated expansion of NK cells
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Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
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Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors
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Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity
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Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control
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Effects of Injectable Solutions on the Quality of Monocyte‐Derived Dendritic Cells for Immunotherapy
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Data from RIG-I–Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy
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Data from RIG-I–Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy
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RIG-I–Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy
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In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma
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Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer
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Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma
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Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
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Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma
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A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis
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Immunotherapeutic effects of intratumoral nanoplexed poly I:C
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90K predicts the prognosis of glioma patients and enhances tumor lysate-pulsed DC vaccine for immunotherapy of GBM in vitro
inferred← citeshttps://doi.org/10.21037/atm-23-1882openalex-snapshot
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Harnessing the abscopal effect for gastrointestinal malignancies in the era of immunotherapy
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Systematical assessment of cancer stemness traits via one-class logistic regression (OCLR) algorithm and associations with tumor immune infiltrates in prostate cancer based on seven cohorts
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Research Progress and Existing Problems for Abscopal Effect
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Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities
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COMPARITIVE STUDY OF DENDRITIC CELL VACCINE PREPARATION WITH PRESENCE AND ABSENCE OF MALPIGHIA EMARGINATA FRUIT EXTRACT USING TUMOR RNA TRANSFECTION METHOD: A PROMISING APPROACH FOR PROSTATE CANCER
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Research Progress of Chinese and Western Medicine in the Treatment of CRC
inferred← citeshttps://doi.org/10.32948/auo.2019.09.04openalex-snapshot
Immunotherapy Landscape in Prostate Cancer: Successes, Failures and Promises
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1298264openalex-snapshot
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2021.686809openalex-snapshot
Immune Microenvironment and Response in Prostate Cancer Using Large Population Cohorts
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PD-1-siRNA Delivered by Attenuated Salmonella Enhances the Antitumor Effect of Chloroquine in Colon Cancer
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Vessel state and immune infiltration of the angiogenesis subgroup and construction of a prediction model in osteosarcoma
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1199173openalex-snapshot
T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems
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Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1711815openalex-snapshot
Current update on toll-like receptors and prostate cancer: a decade of progress and emerging insights
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Monitoring T Cells Responses Mounted by Therapeutic Cancer Vaccines
inferred← citeshttps://doi.org/10.3389/fonc.2021.737425openalex-snapshot
Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2021.744679openalex-snapshot
Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.909066openalex-snapshot
Identification of Metabolism-Related Gene-Based Subgroup in Prostate Cancer
inferred← citeshttps://doi.org/10.3390/biomedicines12030699openalex-snapshot
Development of Cell Technologies Based on Dendritic Cells for Immunotherapy of Oncological Diseases
inferred← citeshttps://doi.org/10.3390/cancers11040521openalex-snapshot
Dendritic Cells and Cancer: From Biology to Therapeutic Intervention
inferred← citeshttps://doi.org/10.3390/cancers11040537openalex-snapshot
A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials
inferred← citeshttps://doi.org/10.3390/cancers12071987openalex-snapshot
Tumor-Associated Macrophage Status in Cancer Treatment
inferred← citeshttps://doi.org/10.3390/cancers13061468openalex-snapshot
Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy
inferred← citeshttps://doi.org/10.3390/cancers16050981openalex-snapshot
Dendritic Cells in Cancer Immunology and Immunotherapy
inferred← citeshttps://doi.org/10.3390/cells11050835openalex-snapshot
Combined TLR-3/TLR-8 Signaling in the Presence of α-Type-1 Cytokines Represents a Novel and Potent Dendritic Cell Type-1, Anti-Cancer Maturation Protocol
inferred← citeshttps://doi.org/10.3390/cells11182793openalex-snapshot
Boosting the Immune Response—Combining Local and Immune Therapy for Prostate Cancer Treatment
inferred← citeshttps://doi.org/10.3390/cells11233826openalex-snapshot
Dying of Stress: Chemotherapy, Radiotherapy, and Small-Molecule Inhibitors in Immunogenic Cell Death and Immunogenic Modulation
inferred← citeshttps://doi.org/10.3390/cells12071023openalex-snapshot
Isolated Peptide from Spider Venom Modulates Dendritic Cells In Vitro: A Possible Application in Oncoimmunotherapy for Glioblastoma
inferred← citeshttps://doi.org/10.3390/cells9092061openalex-snapshot
Nucleic Acid-Based Approaches for Tumor Therapy
inferred← citeshttps://doi.org/10.3390/ijms19082391openalex-snapshot
In Vivo Irradiation of Mice Induces Activation of Dendritic Cells
inferred← citeshttps://doi.org/10.3390/ijms222011061openalex-snapshot
The Abscopal Effect: A Review of Pre-Clinical and Clinical Advances
inferred← citeshttps://doi.org/10.3390/ijms27114968openalex-snapshot
Poly(I:C) Lipoamino Bundle LNPs Induce Tumor Cytotoxicity and Immune Activation with Enhanced Efficacy by Survivin Silencing
inferred← citeshttps://doi.org/10.3390/jcm10215124openalex-snapshot
Abscopal Effects in Metastatic Cancer: Is a Predictive Approach Possible to Improve Individual Outcomes?
inferred← citeshttps://doi.org/10.3390/pharmaceutics14061228openalex-snapshot
The Role of Toll-like Receptor Agonists and Their Nanomedicines for Tumor Immunotherapy
inferred← citeshttps://doi.org/10.3390/pharmaceutics15061743openalex-snapshot
Smart Nanocarriers for the Targeted Delivery of Therapeutic Nucleic Acid for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3390/vaccines13030237openalex-snapshot
Recent Advances in the Development and Efficacy of Anti-Cancer Vaccines—A Narrative Review
inferred← citeshttps://doi.org/10.3390/vaccines8030529openalex-snapshot
The Role of the Tumor Microenvironment in Developing Successful Therapeutic and Secondary Prophylactic Breast Cancer Vaccines
inferred← citeshttps://doi.org/10.3727/096504019x15498329881440openalex-snapshot
The Role of Toll-Like Receptors in Oncotherapy
inferred← citeshttps://doi.org/10.3857/roj.2021.00115openalex-snapshot
Abscopal effect in the radio and immunotherapy
inferred← citeshttps://doi.org/10.4254/wjh.v14.i10.1862openalex-snapshot
Immunotherapy for hepatocellular carcinoma: A promising therapeutic option for advanced disease
inferred← citeshttps://doi.org/10.48095/ccko20236openalex-snapshot
Radiation induced lymphopenia – a possible critical factor in current oncological treatment
inferred← citeshttps://doi.org/10.5306/wjco.v13.i6.448openalex-snapshot
Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances
inferred← citeshttps://doi.org/10.6084/m9.figshare.13076442openalex-snapshot
Additional file 2 of Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26315606openalex-snapshot
Additional file 1 of Integration of photomagnetic bimodal imaging to monitor an autogenous exosome loaded platform: unveiling strong targeted retention effects for guiding the photothermal and magnetothermal therapy in a mouse prostate cancer model
inferred← citeshttps://doi.org/10.64898/2026.06.23.733291openalex-snapshot
Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy
inferred← citeshttps://doi.org/10.70675/7e1fa4d8z5408z419bz9394z19ae17697026openalex-snapshot
Local Anti-CTLA4 Cancer Immunotherapy From Bench to Bedside
inferred← citeshttps://doi.org/10.7759/cureus.29620openalex-snapshot
A Review of the Abscopal Effect in the Era of Immunotherapy
inferred← citeshttps://doi.org/10.7759/cureus.7054openalex-snapshot
Radiation Therapy as a Modality to Create Abscopal Effects: Current and Future Practices
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