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Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/path.4777openalex-snapshot
Dysregulated Wnt signalling and recurrent mutations of the tumour suppressor RNF43 in early gastric carcinogenesis
inferredcites →https://doi.org/10.1002/path.5098openalex-snapshot
Impact of loss‐of‐function mutations at the RNF43 locus on colorectal cancer development and progression
inferredcites →https://doi.org/10.1007/s00018-011-0735-1openalex-snapshot
Vimentin in cancer and its potential as a molecular target for cancer therapy
inferredcites →https://doi.org/10.1016/j.ccell.2017.11.018openalex-snapshot
Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
inferredcites →https://doi.org/10.1016/j.ccr.2008.10.011openalex-snapshot
Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice
inferredcites →https://doi.org/10.1038/nature11308openalex-snapshot
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
inferredcites →https://doi.org/10.1038/nature13480openalex-snapshot
Comprehensive molecular characterization of gastric adenocarcinoma
inferredcites →https://doi.org/10.1038/nbt.3080openalex-snapshot
A comprehensive transcriptional portrait of human cancer cell lines
inferredcites →https://doi.org/10.1038/nbt.3966openalex-snapshot
Analysis of somatic microsatellite indels identifies driver events in human tumors
inferredcites →https://doi.org/10.1038/ng.2983openalex-snapshot
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
inferredcites →https://doi.org/10.1038/ng.3127openalex-snapshot
RNF43 is frequently mutated in colorectal and endometrial cancers
inferredcites →https://doi.org/10.1053/j.gastro.2014.09.042openalex-snapshot
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
inferredcites →https://doi.org/10.1073/pnas.1118046108openalex-snapshot
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
inferredcites →https://doi.org/10.1073/pnas.1307218110openalex-snapshot
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
inferredcites →https://doi.org/10.1097/pas.0000000000000664openalex-snapshot
RNF43 Is an Early and Specific Mutated Gene in the Serrated Pathway, With Increased Frequency in Traditional Serrated Adenoma and Its Associated Malignancy
inferredcites →https://doi.org/10.1097/pas.0000000000000877openalex-snapshot
WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps
inferredcites →https://doi.org/10.1126/science.274.5285.259openalex-snapshot
Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein
inferredcites →https://doi.org/10.1126/scisignal.aac6757openalex-snapshot
The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane
inferredcites →https://doi.org/10.1136/gutjnl-2016-311849openalex-snapshot
RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation
inferredcites →https://doi.org/10.1155/2016/3710836openalex-snapshot
Three‐Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche
inferredcites →https://doi.org/10.1158/0008-5472.can-14-0013openalex-snapshot
Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
inferredcites →https://doi.org/10.1159/000430154openalex-snapshot
RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
inferredcites →https://doi.org/10.1172/jci34944openalex-snapshot
STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
inferredcites →https://doi.org/10.1186/s13287-017-0548-8openalex-snapshot
Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-β/catenin signaling pathway
inferredcites →https://doi.org/10.1371/journal.pone.0086582openalex-snapshot
Identification of Two Wnt-Responsive Elements in the Intron of RING Finger Protein 43 (RNF43) Gene
inferredcites →https://doi.org/10.18632/oncotarget.12130openalex-snapshot
RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis
inferredcites →https://doi.org/10.2217/fon-2016-0430openalex-snapshot
Identification of Novel Genes by Whole-Exome Sequencing Can Improve Gastric Cancer Precision Oncology
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/bies.202000297openalex-snapshot
Post‐translational Wnt receptor regulation: Is the fog slowly clearing?
inferred← citeshttps://doi.org/10.1002/cam4.5229openalex-snapshot
Combining expression of RNF43 and infiltration level of CD163 + tumor associated macrophage predicts prognosis of clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1002/ctm2.70594openalex-snapshot
Liquid biopsy biomarkers for early detection of gastrointestinal cancers: Current landscape and emerging technologies
inferred← citeshttps://doi.org/10.1007/s00109-020-02015-5openalex-snapshot
Roles of E3 ubiquitin ligases in gastric cancer carcinogenesis and their effects on cisplatin resistance
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189217openalex-snapshot
RNF43 and ZNRF3: Versatile regulators at the membrane and their role in cancer
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111272openalex-snapshot
Pervasive Conditional Selection of Driver Mutations and Modular Epistasis Networks in Cancer
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2020.11.005openalex-snapshot
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111206openalex-snapshot
Adrenal cortex development and related disorders leading to adrenal insufficiency
inferred← citeshttps://doi.org/10.1038/s12276-022-00854-5openalex-snapshot
Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and disease
inferred← citeshttps://doi.org/10.1038/s41388-020-1232-5openalex-snapshot
Commonly observed RNF43 mutations retain functionality in attenuating Wnt/β-catenin signaling and unlikely confer Wnt-dependency onto colorectal cancers
inferred← citeshttps://doi.org/10.1038/s41467-020-18257-3openalex-snapshot
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
inferred← citeshttps://doi.org/10.1038/s41568-020-00307-zopenalex-snapshot
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
inferred← citeshttps://doi.org/10.1038/s41580-024-00823-yopenalex-snapshot
Mechanistic insights into Wnt–β-catenin pathway activation and signal transduction
inferred← citeshttps://doi.org/10.1038/s41598-019-51349-9openalex-snapshot
Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines
inferred← citeshttps://doi.org/10.1038/s41598-023-30294-8openalex-snapshot
The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent
inferred← citeshttps://doi.org/10.1093/carcin/bgz108openalex-snapshot
Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing
inferred← citeshttps://doi.org/10.1101/2020.09.28.317701openalex-snapshot
Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasis
inferred← citeshttps://doi.org/10.1101/2023.01.23.525135openalex-snapshot
Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial Transcriptomics
inferred← citeshttps://doi.org/10.1101/2024.01.30.577936openalex-snapshot
RNF43 is a gatekeeper for colitis-associated cancer
inferred← citeshttps://doi.org/10.1111/sji.13268openalex-snapshot
PD‐L1 expression downregulation by RNF43 in gastric carcinoma enhances antitumour activity of T cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0283894openalex-snapshot
Issues with RNF43 antibodies to reliably detect intracellular location
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2978508/v1openalex-snapshot
Systematic profiling of alternative splicing of ZNF family in Colorectal cancer
inferred← citeshttps://doi.org/10.32604/or.2022.03458openalex-snapshot
RNF43 is a novel tumor-suppressor and prognostic indicator in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.3389/fgene.2021.608742openalex-snapshot
Genomic Profiling Reveals the Molecular Landscape of Gastrointestinal Tract Cancers in Chinese Patients
inferred← citeshttps://doi.org/10.3389/fonc.2023.1140452openalex-snapshot
UPS: Opportunities and challenges for gastric cancer treatment
inferred← citeshttps://doi.org/10.3390/biom10030476openalex-snapshot
Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine
inferred← citeshttps://doi.org/10.3390/cancers11030372openalex-snapshot
Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology
inferred← citeshttps://doi.org/10.3390/cancers16030652openalex-snapshot
Role of Post-Translational Modifications in Colorectal Cancer Metastasis
inferred← citeshttps://doi.org/10.3390/ijms23084147openalex-snapshot
JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis
inferred← citeshttps://doi.org/10.3390/ph17070949openalex-snapshot
Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?
inferred← citeshttps://doi.org/10.3892/ol.2021.13107openalex-snapshot
RNF43 overexpression attenuates the Wnt/β‑catenin signalling pathway to suppress tumour progression in cholangiocarcinoma
inferred← citeshttps://doi.org/10.7554/elife.65759openalex-snapshot
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
inferred← citeshttps://doi.org/10.7554/elife.95639openalex-snapshot
Loss of ZNRF3/RNF43 unleashes EGFR in cancer
inferred← citeshttps://doi.org/10.7554/elife.95639.1openalex-snapshot
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
inferred← citeshttps://doi.org/10.7554/elife.95639.2openalex-snapshot
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
inferred← citeshttps://doi.org/10.7554/elife.95639.3openalex-snapshot
Loss of ZNRF3/RNF43 unleashes EGFR in cancer
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