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Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Fibrinogen and Risk of Cardiovascular Disease

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Fibrinogen and risk of cardiovascular disease. The Framingham Study

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Toward Customized Extracellular Niche Engineering: Progress in Cell‐Entrapment Technologies

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Long‐term expansion of human induced pluripotent stem cells in a microcarrier‐based dynamic system

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Subtype-specific cardiomyocytes for precision medicine: Where are we now?

inferredcites →https://doi.org/10.1007/7651_2020_300openalex-snapshot

Generation of Quiescent Cardiac Fibroblasts Derived from Human Induced Pluripotent Stem Cells

inferredcites →https://doi.org/10.1007/978-3-319-49674-0_13openalex-snapshot

Fibrin Formation, Structure and Properties

inferredcites →https://doi.org/10.1007/s12015-014-9533-0openalex-snapshot

Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

inferredcites →https://doi.org/10.1007/s12265-013-9510-zopenalex-snapshot

Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells

inferredcites →https://doi.org/10.1016/0735-1097(94)90612-2openalex-snapshot

The neonatal heart has a relatively high content of total collagen and type I collagen, a condition that may explain the less compliant state

inferredcites →https://doi.org/10.1016/j.actbio.2016.11.058openalex-snapshot

Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation

inferredcites →https://doi.org/10.1016/j.actbio.2019.05.016openalex-snapshot

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

inferredcites →https://doi.org/10.1016/j.biomaterials.2016.09.024openalex-snapshot

Dynamic culture yields engineered myocardium with near-adult functional output

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Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

inferredcites →https://doi.org/10.1016/j.cell.2018.11.042openalex-snapshot

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

inferredcites →https://doi.org/10.1016/j.cell.2021.04.034openalex-snapshot

Cardioids reveal self-organizing principles of human cardiogenesis

inferredcites →https://doi.org/10.1016/j.celrep.2018.08.079openalex-snapshot

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

inferredcites →https://doi.org/10.1016/j.celrep.2020.107925openalex-snapshot

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

inferredcites →https://doi.org/10.1016/j.jacbts.2017.12.007openalex-snapshot

Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model

inferredcites →https://doi.org/10.1016/j.jacc.2016.01.083openalex-snapshot

Translation of Human-Induced Pluripotent Stem Cells

inferredcites →https://doi.org/10.1016/j.jacc.2017.11.009openalex-snapshot

The Future Role of the United States in Global Health

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2017.07.003openalex-snapshot

Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research

inferredcites →https://doi.org/10.1016/j.scr.2014.06.002openalex-snapshot

An intermittent rocking platform for integrated expansion and differentiation of human pluripotent stem cells to cardiomyocytes in suspended microcarrier cultures

inferredcites →https://doi.org/10.1016/j.scr.2015.08.002openalex-snapshot

Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells

inferredcites →https://doi.org/10.1016/j.scr.2018.07.020openalex-snapshot

Meticulous optimization of cardiomyocyte yields in a 3-stage continuous integrated agitation bioprocess

inferredcites →https://doi.org/10.1016/j.stem.2008.09.001openalex-snapshot

The Systematic Production of Cells for Cell Therapies

inferredcites →https://doi.org/10.1016/j.stem.2010.12.008openalex-snapshot

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

inferredcites →https://doi.org/10.1016/j.stem.2017.07.003openalex-snapshot

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

inferredcites →https://doi.org/10.1016/j.stem.2019.02.015openalex-snapshot

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

inferredcites →https://doi.org/10.1016/j.stem.2020.05.004openalex-snapshot

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

inferredcites →https://doi.org/10.1016/j.stem.2020.06.001openalex-snapshot

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

inferredcites →https://doi.org/10.1016/j.stem.2020.10.013openalex-snapshot

Capturing Cardiogenesis in Gastruloids

inferredcites →https://doi.org/10.1016/j.stemcr.2014.09.017openalex-snapshot

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture

inferredcites →https://doi.org/10.1016/j.stemcr.2017.08.025openalex-snapshot

Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes

inferredcites →https://doi.org/10.1016/j.stemcr.2018.01.039openalex-snapshot

Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes

inferredcites →https://doi.org/10.1016/j.stemcr.2019.06.004openalex-snapshot

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture

inferredcites →https://doi.org/10.1016/j.stemcr.2019.08.013openalex-snapshot

Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

inferredcites →https://doi.org/10.1016/j.stemcr.2019.09.001openalex-snapshot

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture

inferredcites →https://doi.org/10.1016/j.taap.2019.114711openalex-snapshot

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

inferredcites →https://doi.org/10.1016/j.ydbio.2008.12.028openalex-snapshot

Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5

inferredcites →https://doi.org/10.1016/j.ydbio.2013.06.010openalex-snapshot

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis

inferredcites →https://doi.org/10.1016/j.yjmcc.2013.12.024openalex-snapshot

Fibroblast–myocyte electrotonic coupling: Does it occur in native cardiac tissue?

inferredcites →https://doi.org/10.1016/j.yjmcc.2014.04.005openalex-snapshot

Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells

inferredcites →https://doi.org/10.1016/j.yjmcc.2014.05.009openalex-snapshot

Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

inferredcites →https://doi.org/10.1016/j.yjmcc.2018.03.016openalex-snapshot

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

inferredcites →https://doi.org/10.1016/j.yjmcc.2019.10.001openalex-snapshot

Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment

inferredcites →https://doi.org/10.1021/acsbiomaterials.8b01112openalex-snapshot

Optimizing Blended Collagen-Fibrin Hydrogels for Cardiac Tissue Engineering with Human iPSC-derived Cardiomyocytes

inferredcites →https://doi.org/10.1023/a:1006860104840openalex-snapshot

Maturation of fatty acid and carbohydrate metabolism in the newborn heart

inferredcites →https://doi.org/10.1038/cdd.2014.181openalex-snapshot

Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

inferredcites →https://doi.org/10.1038/cr.2010.163openalex-snapshot

Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals

inferredcites →https://doi.org/10.1038/nature05934openalex-snapshot

Generation of germline-competent induced pluripotent stem cells

inferredcites →https://doi.org/10.1038/nature06894openalex-snapshot

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

inferredcites →https://doi.org/10.1038/nature22978openalex-snapshot

The extracellular matrix protein agrin promotes heart regeneration in mice

inferredcites →https://doi.org/10.1038/nbt.3745openalex-snapshot

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

inferredcites →https://doi.org/10.1038/ncb3205openalex-snapshot

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

inferredcites →https://doi.org/10.1038/nm.4087openalex-snapshot

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

inferredcites →https://doi.org/10.1038/nmat4782openalex-snapshot

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

inferredcites →https://doi.org/10.1038/nmeth.1740openalex-snapshot

NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes

inferredcites →https://doi.org/10.1038/nmeth.2999openalex-snapshot

Chemically defined generation of human cardiomyocytes

inferredcites →https://doi.org/10.1038/nmeth.3448openalex-snapshot

Chemically defined, albumin-free human cardiomyocyte generation

inferredcites →https://doi.org/10.1038/nprot.2012.150openalex-snapshot

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

inferredcites →https://doi.org/10.1038/nprot.2016.153openalex-snapshot

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

inferredcites →https://doi.org/10.1038/nrd.2015.34openalex-snapshot

Evolution of strategies to improve preclinical cardiac safety testing

inferredcites →https://doi.org/10.1038/nrd4309openalex-snapshot

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

inferredcites →https://doi.org/10.1038/s41467-017-01946-xopenalex-snapshot

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

inferredcites →https://doi.org/10.1038/s41467-018-05067-xopenalex-snapshot

Human pluripotent reprogramming with CRISPR activators

inferredcites →https://doi.org/10.1038/s41467-019-09831-5openalex-snapshot

Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

inferredcites →https://doi.org/10.1038/s41467-019-13868-xopenalex-snapshot

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

inferredcites →https://doi.org/10.1038/s41467-020-18031-5openalex-snapshot

In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

inferredcites →https://doi.org/10.1038/s41551-017-0141-6openalex-snapshot

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods

inferredcites →https://doi.org/10.1038/s41551-020-0539-4openalex-snapshot

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

inferredcites →https://doi.org/10.1038/s41571-019-0313-2openalex-snapshot

New drug approvals in oncology

inferredcites →https://doi.org/10.1038/s41586-018-0016-3openalex-snapshot

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

inferredcites →https://doi.org/10.1038/s41598-017-08713-4openalex-snapshot

Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells

inferredcites →https://doi.org/10.1038/srep24637openalex-snapshot

Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays

inferredcites →https://doi.org/10.1038/srep29933openalex-snapshot

The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages

inferredcites →https://doi.org/10.1039/c5lc01356aopenalex-snapshot

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

inferredcites →https://doi.org/10.1039/c7lc00210fopenalex-snapshot

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

inferredcites →https://doi.org/10.1039/c8bm01348aopenalex-snapshot

Native cardiac environment and its impact on engineering cardiac tissue

inferredcites →https://doi.org/10.1073/pnas.1200250109openalex-snapshot

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

inferredcites →https://doi.org/10.1073/pnas.1508073112openalex-snapshot

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

inferredcites →https://doi.org/10.1073/pnas.1707316114openalex-snapshot

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

inferredcites →https://doi.org/10.1073/pnas.2008245117openalex-snapshot

Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose

inferredcites →https://doi.org/10.1074/jbc.m116.767384openalex-snapshot

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes

inferredcites →https://doi.org/10.1074/jbc.m512671200openalex-snapshot

Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways

inferredcites →https://doi.org/10.1089/ten.tec.2019.0228openalex-snapshot

Early Vascular Cells Improve Microvascularization Within 3D Cardiac Spheroids

inferredcites →https://doi.org/10.1093/cvr/cvq033openalex-snapshot

The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

inferredcites →https://doi.org/10.1093/cvr/cvu021openalex-snapshot

Signalling between microvascular endothelium and cardiomyocytes through neuregulin

inferredcites →https://doi.org/10.1093/cvr/cvw159openalex-snapshot

Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy

inferredcites →https://doi.org/10.1093/eurheartj/ehy249openalex-snapshot

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

inferredcites →https://doi.org/10.1093/hmg/ddt182openalex-snapshot

Glucocorticoid receptor is required for foetal heart maturation

inferredcites →https://doi.org/10.1093/toxsci/kfw200openalex-snapshot

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

inferredcites →https://doi.org/10.1093/toxsci/kfy110openalex-snapshot

Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

inferredcites →https://doi.org/10.1096/fj.13-228007openalex-snapshot

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

inferredcites →https://doi.org/10.1111/aor.12801openalex-snapshot

Danshen‐Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human‐Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Model

inferredcites →https://doi.org/10.1124/pr.116.013003openalex-snapshot

Patient and Disease–Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics

inferredcites →https://doi.org/10.1126/scitranslmed.aaf2584openalex-snapshot

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

inferredcites →https://doi.org/10.1126/scitranslmed.aax9276openalex-snapshot

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

inferredcites →https://doi.org/10.1146/annurev-genet-112414-054911openalex-snapshot

Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine

inferredcites →https://doi.org/10.1152/ajpheart.00799.2013openalex-snapshot

Matrix elasticity regulates the optimal cardiac myocyte shape for contractility

inferredcites →https://doi.org/10.1161/01.cir.0000068356.38592.68openalex-snapshot

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes

inferredcites →https://doi.org/10.1161/01.cir.90.2.713openalex-snapshot

Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium.

inferredcites →https://doi.org/10.1161/01.res.56.3.377openalex-snapshot

Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts.

inferredcites →https://doi.org/10.1161/cir.0000000000000757openalex-snapshot

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

inferredcites →https://doi.org/10.1161/circresaha.109.211458openalex-snapshot

Development of a Drug Screening Platform Based on Engineered Heart Tissue

inferredcites →https://doi.org/10.1161/circresaha.112.273144openalex-snapshot

Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells

inferredcites →https://doi.org/10.1161/circresaha.115.307778openalex-snapshot

Revisiting Cardiac Cellular Composition

inferredcites →https://doi.org/10.1161/circresaha.117.305365openalex-snapshot

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

inferredcites →https://doi.org/10.1161/circresaha.117.310782openalex-snapshot

Emerging Role of Precision Medicine in Cardiovascular Disease

inferredcites →https://doi.org/10.1161/circresaha.117.311920openalex-snapshot

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes

inferredcites →https://doi.org/10.1161/circresaha.118.313249openalex-snapshot

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA

inferredcites →https://doi.org/10.1161/circresaha.118.313973openalex-snapshot

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes

inferredcites →https://doi.org/10.1161/circresaha.119.314970openalex-snapshot

Emerging Concepts in Precision Medicine and Cardiovascular Diseases in Racial and Ethnic Minority Populations

inferredcites →https://doi.org/10.1161/circresaha.119.315862openalex-snapshot

Cardiomyocyte Maturation

inferredcites →https://doi.org/10.1161/circresaha.120.318049openalex-snapshot

Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells

inferredcites →https://doi.org/10.1161/circulationaha.114.014998openalex-snapshot

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue

inferredcites →https://doi.org/10.1161/circulationaha.116.024145openalex-snapshot

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

inferredcites →https://doi.org/10.1161/circulationaha.117.032273openalex-snapshot

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells

inferredcites →https://doi.org/10.1161/circulationaha.118.034624openalex-snapshot

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay

inferredcites →https://doi.org/10.1161/circulationaha.118.037357openalex-snapshot

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

inferredcites →https://doi.org/10.1186/s13287-020-01618-6openalex-snapshot

Selection of human induced pluripotent stem cells lines optimization of cardiomyocytes differentiation in an integrated suspension microcarrier bioreactor

inferredcites →https://doi.org/10.1186/s41232-018-0084-7openalex-snapshot

Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft

inferredcites →https://doi.org/10.1186/scrt162openalex-snapshot

Topological and electrical control of cardiac differentiation and assembly

inferredcites →https://doi.org/10.1203/pdr.0b013e318199093copenalex-snapshot

Force Frequency Relationship of the Human Ventricle Increases During Early Postnatal Development

inferredcites →https://doi.org/10.1242/dev.123810openalex-snapshot

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells

inferredcites →https://doi.org/10.1242/dev.143438openalex-snapshot

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells

inferredcites →https://doi.org/10.1253/circj.cj-12-0987openalex-snapshot

Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture

inferredcites →https://doi.org/10.1371/journal.pbio.1001666openalex-snapshot

Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism

inferredcites →https://doi.org/10.1371/journal.pone.0151264openalex-snapshot

Defined Essential 8™ Medium and Vitronectin Efficiently Support Scalable Xeno-Free Expansion of Human Induced Pluripotent Stem Cells in Stirred Microcarrier Culture Systems

inferredcites →https://doi.org/10.15252/emmm.201404757openalex-snapshot

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

inferredcites →https://doi.org/10.1530/jme-13-0204openalex-snapshot

Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming

inferredcites →https://doi.org/10.3389/fmolb.2020.00014openalex-snapshot

3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids

inferredcites →https://doi.org/10.3389/fphar.2021.607364openalex-snapshot

Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies

inferredcites →https://doi.org/10.3389/fphys.2020.00384openalex-snapshot

Beyond Family: Modeling Non-hereditary Heart Diseases With Human Pluripotent Stem Cell-Derived Cardiomyocytes

inferredcites →https://doi.org/10.3390/cells8091095openalex-snapshot

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes

inferredcites →https://doi.org/10.3791/61879openalex-snapshot

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells

inferredcites →https://doi.org/10.4137/bmi.s20050openalex-snapshot

Differentiation of Cardiomyocytes from Human Pluripotent Stem Cells Using Monolayer Culture

inferredcites →https://doi.org/10.5966/sctm.2014-0275openalex-snapshot

A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells

inferredcites →https://doi.org/10.7150/thno.32058openalex-snapshot

Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations

inferredcites →https://doi.org/10.7554/elife.19406openalex-snapshot

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

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3D‐Printed Myocardium‐Specific Structure Enhances Maturation and Therapeutic Efficacy of Engineered Heart Tissue in Myocardial Infarction

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The origin, progress, and application of cell‐based cardiac regeneration therapy

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Human-Induced Pluripotent Stem Cell-Based Differentiation of Cardiomyocyte Subtypes for Drug Discovery and Cell Therapy

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Success and Challenges with Models for Cardiac Translational Research

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Bioinspired and Biomimetic Materials/Architecture in Cardiovascular Regeneration

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Sex Chromosome Effects on Cardiovascular Health and Disease

inferred← citeshttps://doi.org/10.1007/s10103-026-04821-8openalex-snapshot

Enhancing human-induced pluripotent stem cell proliferation and cardiac differentiation through 810-nm photobiomodulation

inferred← citeshttps://doi.org/10.1007/s10439-026-03985-2openalex-snapshot

Microgroove and Cyclic Stretch-Based Stem Cell Gym Enhance Maturation of Human iPSC-Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.1007/s12012-024-09850-9openalex-snapshot

Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: “What Are the Tools Needed for the Job?” and “Do We Have Them?”

inferred← citeshttps://doi.org/10.1007/s12015-024-10721-7openalex-snapshot

Delivery of Stem Cells and BMP-2 With Functionalized Self-Assembling Peptide Enhances Regeneration of Infarcted Myocardium

inferred← citeshttps://doi.org/10.1007/s12015-025-10871-2openalex-snapshot

Circular CRISPR Edits Human Pluripotent Stem Cells for Disease Modeling

inferred← citeshttps://doi.org/10.1016/b978-0-443-13344-2.00004-3openalex-snapshot

Considerations in the development of pluripotent stem cell–based therapies

inferred← citeshttps://doi.org/10.1016/j.arr.2026.103336openalex-snapshot

Mechanisms and therapeutic strategies for VEGFR inhibitor-induced cardiotoxicity and hepatotoxicity in cancer therapy

inferred← citeshttps://doi.org/10.1016/j.bioactmat.2024.08.043openalex-snapshot

Hydrogel microsphere stem cell encapsulation enhances cardiomyocyte differentiation and functionality in scalable suspension system

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115377openalex-snapshot

Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts

inferred← citeshttps://doi.org/10.1016/j.crtox.2026.100288openalex-snapshot

The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes

inferred← citeshttps://doi.org/10.1016/j.isci.2025.113003openalex-snapshot

Integrative approaches in cardiac tissue engineering: Bridging cellular complexity to create accurate physiological models

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113224openalex-snapshot

Ginkgolide A enhances cardiomyocyte differentiation from pluripotent stem cells by targeting cytochrome c to attenuate intrinsic apoptosis

inferred← citeshttps://doi.org/10.1016/j.jmccpl.2024.100122openalex-snapshot

Modeling immune checkpoint inhibitor associated myocarditis in vitro and its therapeutic implications

inferred← citeshttps://doi.org/10.1016/j.mex.2024.102548openalex-snapshot

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

inferred← citeshttps://doi.org/10.1016/j.semcdb.2021.05.018openalex-snapshot

The role of metabolism in directed differentiation versus trans-differentiation of cardiomyocytes

inferred← citeshttps://doi.org/10.1016/j.semcdb.2025.103656openalex-snapshot

In vitro modeling of cell types in cardiogenesis and congenital heart disease

inferred← citeshttps://doi.org/10.1016/j.stemcr.2024.08.005openalex-snapshot

Rod-shaped micropatterning enhances the electrophysiological maturation of cardiomyocytes derived from human induced pluripotent stem cells

inferred← citeshttps://doi.org/10.1016/j.xgen.2023.100445openalex-snapshot

Harnessing human genetics and stem cells for precision cardiovascular medicine

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2025.02.009openalex-snapshot

Integrin stimulation by collagen I at the progenitor stage accelerates maturation of human iPSC-derived cardiomyocytes

inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.08.013openalex-snapshot

Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis

inferred← citeshttps://doi.org/10.1038/s41401-025-01543-5openalex-snapshot

A simple and efficient method for purification of human pluripotent stem cell-derived cardiomyocytes via activating p53

inferred← citeshttps://doi.org/10.1038/s41420-024-01907-6openalex-snapshot

PLEKHM2 deficiency induces impaired mitochondrial clearance and elevated ROS levels in human iPSC-derived cardiomyocytes

inferred← citeshttps://doi.org/10.1038/s41591-026-04605-1openalex-snapshot

Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial

inferred← citeshttps://doi.org/10.1038/s41598-023-31144-3openalex-snapshot

Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2

inferred← citeshttps://doi.org/10.1038/s44161-025-00761-8openalex-snapshot

Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy

inferred← citeshttps://doi.org/10.1088/1758-5090/ac975dopenalex-snapshot

Heart-on-a-chip using human iPSC-derived cardiomyocytes with an integrated vascular endothelial layer based on a culture patch as a potential platform for drug evaluation

inferred← citeshttps://doi.org/10.1089/cell.2024.0073openalex-snapshot

Reprogramming of Expanded Cord Blood-Derived CD34 + Cells from Umbilical Cord-Mesenchymal Stromal Cell Co-Culture to Generate Human-Induced Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1089/ten.teb.2023.0080openalex-snapshot

Induced Pluripotent Stem Cell-Derived Cardiomyocytes: From Regulatory Status to Clinical Translation

inferred← citeshttps://doi.org/10.1089/wound.2021.0049openalex-snapshot

Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine

inferred← citeshttps://doi.org/10.1093/cvr/cvaf023openalex-snapshot

Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists…

inferred← citeshttps://doi.org/10.1093/cvr/cvaf110openalex-snapshot

From lipids and inflammation to artificial intelligence-driven therapeutics: the 93rd European atherosclerosis society (EAS) congress 2025 in focus

inferred← citeshttps://doi.org/10.1093/stcltm/szag060openalex-snapshot

Weekend-free and robotics-compatible protocols for high-throughput human-induced pluripotent stem cell maintenance, amplification, and differentiation

inferred← citeshttps://doi.org/10.1093/stmcls/sxac022openalex-snapshot

Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.1101/2023.05.15.540892openalex-snapshot

Monitoring and maturation of cardiomyocyte differentiated from human induced pluripotent stem cells using a multi-functional tissue engineering platform

inferred← citeshttps://doi.org/10.1101/2024.04.05.588306openalex-snapshot

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

inferred← citeshttps://doi.org/10.1101/2025.10.17.683184openalex-snapshot

A Novel Method to Characterize Functional Human Embryonic Stem Cells Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.1101/2025.10.29.684362openalex-snapshot

Enhanced iPSC Cardiomyocyte Maturation via Combined 3D-Culture and Metabolic Cues

inferred← citeshttps://doi.org/10.1111/cts.70325openalex-snapshot

Cardiotoxicity Assessment of EGFR Tyrosine Kinase Inhibitors Using Human iPS Cell‐Derived Cardiomyocytes and FDA Adverse Events Reporting System

inferred← citeshttps://doi.org/10.1113/jp282562openalex-snapshot

Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

inferred← citeshttps://doi.org/10.1124/molpharm.124.000958openalex-snapshot

Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-022724-095035openalex-snapshot

Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish

inferred← citeshttps://doi.org/10.1161/circresaha.121.319843openalex-snapshot

Leveraging Spaceflight to Advance Cardiovascular Research on Earth

inferred← citeshttps://doi.org/10.1161/circresaha.122.320305openalex-snapshot

Cellular and Engineered Organoids for Cardiovascular Models

inferred← citeshttps://doi.org/10.1186/s12872-022-02543-7openalex-snapshot

An evidence appraisal of heart organoids in a dish and commensurability to human heart development in vivo

inferred← citeshttps://doi.org/10.1186/s13287-023-03312-9openalex-snapshot

Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes

inferred← citeshttps://doi.org/10.14797/mdcvj.1295openalex-snapshot

Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights

inferred← citeshttps://doi.org/10.14814/phy2.70845openalex-snapshot

Models of the human heart for biomedical research: Opportunities and challenges

inferred← citeshttps://doi.org/10.20935/acadmolbiogen8336openalex-snapshot

Molecular mechanisms and RNA biomarkers in cardiomyopathy diagnosis

inferred← citeshttps://doi.org/10.2147/ijn.s402855openalex-snapshot

4D Thermo-Responsive Smart hiPSC-CM Cardiac Construct for Myocardial Cell Therapy

inferred← citeshttps://doi.org/10.2298/mpns2302029ropenalex-snapshot

Evaluation of knowledge on induced pluripotent stem cells among the general population and medical professionals

inferred← citeshttps://doi.org/10.31083/rcm28251openalex-snapshot

Induced Pluripotent Stem Cells in Congenital Long QT Syndrome: Research Progress and Clinical Applications

inferred← citeshttps://doi.org/10.3389/fbioe.2025.1687840openalex-snapshot

Human induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug discovery

inferred← citeshttps://doi.org/10.3389/fcvm.2022.981982openalex-snapshot

Cardiac regeneration: Options for repairing the injured heart

inferred← citeshttps://doi.org/10.3389/fcvm.2024.1435874openalex-snapshot

Mapping the landscape of PSC-CM research through bibliometric analysis

inferred← citeshttps://doi.org/10.3389/fmmed.2023.1222986openalex-snapshot

How can we use stem cell-derived cardiomyocytes to understand the involvement of energetic metabolism in alterations of cardiac function?

inferred← citeshttps://doi.org/10.3390/cells10123483openalex-snapshot

Human Induced Pluripotent Stem Cell as a Disease Modeling and Drug Development Platform—A Cardiac Perspective

inferred← citeshttps://doi.org/10.3390/cells12172168openalex-snapshot

Optical Mapping of Cardiomyocytes in Monolayer Derived from Induced Pluripotent Stem Cells

inferred← citeshttps://doi.org/10.3390/cells13221913openalex-snapshot

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

inferred← citeshttps://doi.org/10.3390/gels10090568openalex-snapshot

Brown Adipose Stem Cell-Loaded Resilin Elastic Hydrogel Rebuilds Cardiac Function after Myocardial Infarction via Collagen I/III Reorganisation

inferred← citeshttps://doi.org/10.3390/gels11080593openalex-snapshot

Cardiac Tissue Bioprinting: Integrating Structure and Functions Through Biomimetic Design, Bioinks, and Stimulation

inferred← citeshttps://doi.org/10.3390/genes14101864openalex-snapshot

Understanding Arrhythmogenic Cardiomyopathy: Advances through the Use of Human Pluripotent Stem Cell Models

inferred← citeshttps://doi.org/10.3390/ijms23084460openalex-snapshot

The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes

inferred← citeshttps://doi.org/10.3390/ijms25147971openalex-snapshot

Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.34133/bmr.0030openalex-snapshot

Highly Durable, Stretchable Multielectrode Array for Electro-mechanical Co-stimulation of Cells

inferred← citeshttps://doi.org/10.34133/research.1165openalex-snapshot

3D Cardiac Constructs in Drug Discovery: Current Advances and Future Challenges

inferred← citeshttps://doi.org/10.3791/64265openalex-snapshot

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

inferred← citeshttps://doi.org/10.53846/goediss-9728openalex-snapshot

Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy

inferred← citeshttps://doi.org/10.57238/jbb.2025.7432.1140openalex-snapshot

Development of 3D Bioprinted Vascularized Cardiac Tissues Using Patient-Derived Stem Cells: A Preclinical Study

inferred← citeshttps://doi.org/10.6084/m9.figshare.22639558openalex-snapshot

Additional file 1 of Overexpression of KCNJ2 enhances maturation of human-induced pluripotent stem cell-derived cardiomyocytes

inferred← citeshttps://doi.org/10.64898/2026.06.02.729411openalex-snapshot

Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance

inferred← citeshttps://doi.org/10.7759/cureus.66821openalex-snapshot

Comparison of Knowledge About Induced Pluripotent Stem Cells in Relation to Gender Among Healthcare Professionals and in the General Population

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