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Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ajpath.2011.01.044openalex-snapshot

Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

inferredcites →https://doi.org/10.1016/j.ajpath.2016.09.016openalex-snapshot

Sirtuin 1 Activation Reduces Transforming Growth Factor-β1–Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease

inferredcites →https://doi.org/10.1016/j.bbapap.2009.10.022openalex-snapshot

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

inferredcites →https://doi.org/10.1016/j.cardiores.2004.04.030openalex-snapshot

TGF-?1 and angiotensin networking in cardiac remodeling

inferredcites →https://doi.org/10.1016/j.cardiores.2007.06.022openalex-snapshot

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

inferredcites →https://doi.org/10.1016/j.cell.2006.11.013openalex-snapshot

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

inferredcites →https://doi.org/10.1016/j.cmet.2008.08.017openalex-snapshot

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

inferredcites →https://doi.org/10.1016/j.cmet.2011.10.001openalex-snapshot

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

inferredcites →https://doi.org/10.1016/j.jacc.2005.09.050openalex-snapshot

The Pathogenesis of Myocardial Fibrosis in the Setting of Diabetic Cardiomyopathy

inferredcites →https://doi.org/10.1016/j.tem.2016.04.015openalex-snapshot

Role of Sirtuins in Regulating Pathophysiology of the Heart

inferredcites →https://doi.org/10.1016/s0021-9258(18)68561-8openalex-snapshot

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

inferredcites →https://doi.org/10.1016/s0092-8674(01)00524-4openalex-snapshot

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

inferredcites →https://doi.org/10.1016/s0092-8674(01)00527-xopenalex-snapshot

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

inferredcites →https://doi.org/10.1016/s0735-1097(01)01792-2openalex-snapshot

Heart failure in pressure overload hypertrophy

inferredcites →https://doi.org/10.1038/35001622openalex-snapshot

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

inferredcites →https://doi.org/10.1038/nature06261openalex-snapshot

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

inferredcites →https://doi.org/10.1038/sj.emboj.7601332openalex-snapshot

Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

inferredcites →https://doi.org/10.1038/sj.onc.1209826openalex-snapshot

Smad3 is acetylated by p300/CBP to regulate its transactivation activity

inferredcites →https://doi.org/10.1042/bj20070140openalex-snapshot

Sirtuins in mammals: insights into their biological function

inferredcites →https://doi.org/10.1053/j.jvca.2013.04.020openalex-snapshot

Perioperative Applications of Deformation (Myocardial Strain) Imaging With Speckle-Tracking Echocardiography

inferredcites →https://doi.org/10.1056/nejm199411103311907openalex-snapshot

Transforming Growth Factor β in Tissue Fibrosis

inferredcites →https://doi.org/10.1056/nejmra1100831openalex-snapshot

Sirtuins, Aging, and Medicine

inferredcites →https://doi.org/10.1073/pnas.1114026108openalex-snapshot

Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia

inferredcites →https://doi.org/10.1074/jbc.m109.088682openalex-snapshot

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

inferredcites →https://doi.org/10.1074/jbc.m110.133892openalex-snapshot

SIRT1 Activation by Small Molecules

inferredcites →https://doi.org/10.1074/jbc.m607868200openalex-snapshot

The DNA Binding Activities of Smad2 and Smad3 Are Regulated by Coactivator-mediated Acetylation

inferredcites →https://doi.org/10.1093/cvr/cvs259openalex-snapshot

α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy

inferredcites →https://doi.org/10.1093/eurheartj/ehv290openalex-snapshot

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

inferredcites →https://doi.org/10.1096/fj.03-1273revopenalex-snapshot

TGF‐β signaling and the fibrotic response

inferredcites →https://doi.org/10.1096/fj.11-193979openalex-snapshot

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

inferredcites →https://doi.org/10.1097/hjh.0b013e3283462674openalex-snapshot

The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

inferredcites →https://doi.org/10.1101/gad.14.9.1021openalex-snapshot

Sir2 links chromatin silencing, metabolism, and aging

inferredcites →https://doi.org/10.1126/science.1175371openalex-snapshot

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

inferredcites →https://doi.org/10.1152/ajpheart.00418.2009openalex-snapshot

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

inferredcites →https://doi.org/10.1152/ajpheart.01167.2006openalex-snapshot

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

inferredcites →https://doi.org/10.1152/ajpheart.01339.2007openalex-snapshot

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression

inferredcites →https://doi.org/10.1152/ajplung.00151.2001openalex-snapshot

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

inferredcites →https://doi.org/10.1161/01.cir.0000051865.66123.b7openalex-snapshot

Progression From Compensated Hypertrophy to Failure in the Pressure-Overloaded Human Heart

inferredcites →https://doi.org/10.1161/01.hyp.0000215579.81408.8eopenalex-snapshot

Development of Heart Failure in Chronic Hypertensive Dahl Rats

inferredcites →https://doi.org/10.1161/01.res.0000049100.22673.f6openalex-snapshot

DNA Microarray Profiling to Identify Angiotensin-Responsive Genes in Vascular Smooth Muscle Cells

inferredcites →https://doi.org/10.1161/01.res.0000267723.65696.4aopenalex-snapshot

Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

inferredcites →https://doi.org/10.1161/circheartfailure.108.765750openalex-snapshot

Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

inferredcites →https://doi.org/10.1161/circresaha.109.209338openalex-snapshot

Protein Acetylation in the Cardiorenal Axis

inferredcites →https://doi.org/10.1161/circresaha.113.300536openalex-snapshot

Regulation of Akt Signaling by Sirtuins

inferredcites →https://doi.org/10.1161/circulationaha.107.704197openalex-snapshot

Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling

inferredcites →https://doi.org/10.1161/circulationaha.108.787440openalex-snapshot

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

inferredcites →https://doi.org/10.1161/circulationaha.110.942268openalex-snapshot

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

inferredcites →https://doi.org/10.1161/circulationaha.110.958033openalex-snapshot

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

inferredcites →https://doi.org/10.1161/circulationaha.113.001879openalex-snapshot

Pathological Ventricular Remodeling

inferredcites →https://doi.org/10.1161/hypertensionaha.109.128645openalex-snapshot

The (Pro)Renin Receptor

inferredcites →https://doi.org/10.1172/jci118107openalex-snapshot

Fibrosis linked to TGF-beta in yet another disease.

inferredcites →https://doi.org/10.1172/jci33099openalex-snapshot

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

inferredcites →https://doi.org/10.1172/jci94753openalex-snapshot

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

inferredcites →https://doi.org/10.1186/1475-2840-13-89openalex-snapshot

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

inferredcites →https://doi.org/10.1186/1475-2840-9-5openalex-snapshot

Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat

inferredcites →https://doi.org/10.1186/1478-811x-9-11openalex-snapshot

Mammalian Sirt1: insights on its biological functions

inferredcites →https://doi.org/10.1371/journal.pone.0009543openalex-snapshot

Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism

inferredcites →https://doi.org/10.1503/cmaj.111958openalex-snapshot

Trends in the incidence and outcomes of heart failure in Ontario, Canada: 1997 to 2007

inferredcites →https://doi.org/10.2353/ajpath.2010.090392openalex-snapshot

Evidence for Calreticulin Attenuation of Cardiac Hypertrophy Induced by Pressure Overload and Soluble Agonists

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4077250openalex-extracted

Adiponectin Ameliorates Hypertrophic Scar by Inhibiting YAP Transcription Through SIRT1-Mediated Deacetylation of C/EBPβ and Histone H3

inferred← citeshttps://doi.org/10.1002/ame2.12496openalex-snapshot

Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

inferred← citeshttps://doi.org/10.1002/ejhf.1732openalex-snapshot

Autophagy Stimulation and Intracellular Sodium Reduction as Mediators of the Cardioprotective Effect of Sodium–Glucose Cotransporter 2 Inhibitors

inferred← citeshttps://doi.org/10.1002/hep.31418openalex-snapshot

Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells

inferred← citeshttps://doi.org/10.1002/jbt.23164openalex-snapshot

Downregulation of miR‐34c‐5p alleviates chronic intermittent hypoxia‐induced myocardial damage by targeting sirtuin 1

inferred← citeshttps://doi.org/10.1002/smll.202207600openalex-snapshot

Implantable Triboelectric Nanogenerators for Self‐Powered Cardiovascular Healthcare

inferred← citeshttps://doi.org/10.1007/978-3-031-90598-8_7openalex-snapshot

Cardiovascular Toxicity of Catecholamines

inferred← citeshttps://doi.org/10.1007/978-981-13-8946-7_21openalex-snapshot

New Technologies in Drug Development Provide New Hope in Targeting of Dysregulated Redox Signalling in Cardiovascular Disease

inferred← citeshttps://doi.org/10.1007/s00109-019-01743-7openalex-snapshot

Role of sirtuin-1 in diabetic nephropathy

inferred← citeshttps://doi.org/10.1007/s10557-021-07190-2openalex-snapshot

Empagliflozin Disrupts a Tnfrsf12a-Mediated Feed Forward Loop That Promotes Left Ventricular Hypertrophy

inferred← citeshttps://doi.org/10.1007/s11033-021-06768-1openalex-snapshot

Cardiac fibrosis and curcumin: a novel perspective on this natural medicine

inferred← citeshttps://doi.org/10.1007/s12012-025-10052-0openalex-snapshot

Sirtuins as Endogenous Regulators of Cardiac Fibrosis: A Current Perspective

inferred← citeshttps://doi.org/10.1007/s12035-023-03378-9openalex-snapshot

Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14–3-3ζ

inferred← citeshttps://doi.org/10.1007/s13273-025-00592-5openalex-snapshot

Myricetin alleviates myocardial infarction-induced cardiac fibrosis in mice by upregulating SIRT1 to inhibit TGF-β1/Smad2/3 signaling

inferred← citeshttps://doi.org/10.1016/b978-0-12-814118-2.00018-5openalex-snapshot

Scope to develop sirtuins modulators as a therapy to attenuate cardiac complications

inferred← citeshttps://doi.org/10.1016/b978-0-12-814118-2.00021-5openalex-snapshot

Role of sirtuins in cardiovascular diseases

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102467openalex-snapshot

Insights into the post-translational modifications in heart failure

inferred← citeshttps://doi.org/10.1016/j.biopha.2019.109227openalex-snapshot

SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114936openalex-snapshot

Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cells

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118882openalex-snapshot

Aging hearts, fibrotic fears: The sirtuin connection

inferred← citeshttps://doi.org/10.1016/j.carpath.2024.107673openalex-snapshot

Current concepts in the epigenetic regulation of cardiac fibrosis

inferred← citeshttps://doi.org/10.1016/j.cophys.2022.100556openalex-snapshot

Transcriptional regulation of cardiac fibroblast phenotypic plasticity

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.117969openalex-snapshot

Activation of Sirt1 by acetate alleviates silicofibrosis: Contribution of the gut microbiota

inferred← citeshttps://doi.org/10.1016/j.gene.2025.149418openalex-snapshot

New insights into Smad3 in cardiac fibrosis

inferred← citeshttps://doi.org/10.1016/j.isci.2022.105236openalex-snapshot

Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3

inferred← citeshttps://doi.org/10.1016/j.jacep.2025.09.043openalex-snapshot

The Complex Interplay Between Aging, Cardiac Remodeling, and Atrial Fibrillation

inferred← citeshttps://doi.org/10.1016/j.jchf.2021.05.019openalex-snapshot

Differential Pathophysiological Mechanisms in Heart Failure With a Reduced or Preserved Ejection Fraction in Diabetes

inferred← citeshttps://doi.org/10.1016/j.jgr.2025.01.001openalex-snapshot

Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119186openalex-snapshot

Epigenetics-based therapeutics for myocardial fibrosis

inferred← citeshttps://doi.org/10.1016/j.omtn.2021.10.013openalex-snapshot

Diverging targets mediate the pathological role of miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.107983openalex-snapshot

Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105910openalex-snapshot

Epigenetic regulation in fibrosis progress

inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106815openalex-snapshot

Review: Acetylation mechanisms and targeted therapies in cardiac fibrosis

inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107936openalex-snapshot

Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions

inferred← citeshttps://doi.org/10.1016/j.yexcr.2026.115003openalex-snapshot

Sirt1 deficiency promotes dynamic fibroblast-to-myofibroblast transition in ligamentum flavum hypertrophy via the Smad2/3 pathway

inferred← citeshttps://doi.org/10.1016/j.yjmcc.2021.06.003openalex-snapshot

Epigenetic alterations of TGFβ and its main canonical signaling mediators in the context of cardiac fibrosis

inferred← citeshttps://doi.org/10.1038/s41392-022-00972-6openalex-snapshot

Signaling cascades in the failing heart and emerging therapeutic strategies

inferred← citeshttps://doi.org/10.1038/s41401-026-01859-wopenalex-snapshot

S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity

inferred← citeshttps://doi.org/10.1038/s41419-022-04724-wopenalex-snapshot

Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway

inferred← citeshttps://doi.org/10.1038/s41598-023-36145-wopenalex-snapshot

Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress

inferred← citeshttps://doi.org/10.1038/s41598-024-58239-9openalex-snapshot

LncRNA GAS5 restrains ISO-induced cardiac fibrosis by modulating mir-217 regulation of SIRT1

inferred← citeshttps://doi.org/10.1063/5.0054967openalex-snapshot

A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosis

inferred← citeshttps://doi.org/10.1093/cvr/cvaa297openalex-snapshot

Caloric restriction mimetics for the treatment of cardiovascular diseases

inferred← citeshttps://doi.org/10.1093/cvr/cvag066openalex-snapshot

Suppressor of variegation 3–9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2

inferred← citeshttps://doi.org/10.1093/cvr/cvy297openalex-snapshot

Sirtuin 1/soluble guanylyl cyclase: a nitric oxide-independent pathway to rescue ageing-induced vascular dysfunction

inferred← citeshttps://doi.org/10.1093/cvr/cvy307openalex-snapshot

Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure

inferred← citeshttps://doi.org/10.1093/eurheartj/ehaa360openalex-snapshot

Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure

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Research progress of sirtuins in renal and cardiovascular diseases

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Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells

inferred← citeshttps://doi.org/10.1111/wrr.12943openalex-snapshot

Fibrosis: Sirtuins at the checkpoints of myofibroblast differentiation and profibrotic activity

inferred← citeshttps://doi.org/10.1136/openhrt-2021-001663openalex-snapshot

A nutraceutical strategy for downregulating TGFβ signalling: prospects for prevention of fibrotic disorders, including post-COVID-19 pulmonary fibrosis

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Curcumin Management of Myocardial Fibrosis and its Mechanisms of Action: A Review

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The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway

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Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis

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Progress in the Treatment of Pathological Cardiac Remodeling with Sodium-Glucose Cotransporter 2 Inhibitors

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The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function

inferred← citeshttps://doi.org/10.14336/ad.2021.1204openalex-snapshot

SIRT6 in Vascular Diseases, from Bench to Bedside

inferred← citeshttps://doi.org/10.14814/phy2.14044openalex-snapshot

Impaired SIRT 1 activity leads to diminution in glomerular endowment without accelerating age‐associated GFR decline

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Clinical Evidence and Proposed Mechanisms of Sodium–Glucose Cotransporter 2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Class Effect?

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Downregulation of SIRT1 and GADD45G genes and left atrial fibrosis induced by right ventricular dependent pacing in a complete atrioventricular block pig model

inferred← citeshttps://doi.org/10.18632/aging.102454openalex-snapshot

Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1

inferred← citeshttps://doi.org/10.18699/vjgb-24-26openalex-snapshot

Role of sirtuins in epigenetic regulation and aging control

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2912391/v1openalex-snapshot

LncRNA GAS5 restrains ISO-induced cardiac fibrosis by targeting miR-217 through regulating SIRT1

inferred← citeshttps://doi.org/10.2147/ott.s195234openalex-snapshot

SIRT1 inhibits hepatocellular carcinoma metastasis by promoting M1 macrophage polarization via NF-κB pathway

inferred← citeshttps://doi.org/10.2174/1389450124666230907115831openalex-snapshot

Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy

inferred← citeshttps://doi.org/10.22489/cinc.2022.426openalex-snapshot

Impact of Mechanically-Induced Fibrosis on Atrial Electromechanical Function

inferred← citeshttps://doi.org/10.2337/db18-0410openalex-snapshot

The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca2+ Flux and Phosphoinositide 3-Kinase γ

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Key profibrotic and pro-inflammatory pathways in the pathogenesis of diabetic kidney disease

inferred← citeshttps://doi.org/10.3389/fcell.2021.697614openalex-snapshot

A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b Induced Mesenchymal Transition of Intestinal Epithelial Cells

inferred← citeshttps://doi.org/10.3389/fcell.2025.1702207openalex-snapshot

Atrial myocyte senescence as a driver of atrial fibrillation: mechanisms and therapeutic implications

inferred← citeshttps://doi.org/10.3389/fcvm.2022.845878openalex-snapshot

The Scientific Rationale for the Introduction of Renalase in the Concept of Cardiac Fibrosis

inferred← citeshttps://doi.org/10.3389/fendo.2019.00601openalex-snapshot

Novel Insight Into the Epigenetic and Post-transcriptional Control of Cardiac Gene Expression by Thyroid Hormone

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Novel Therapeutic Targets in Liver Fibrosis

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Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

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Sirtuin 1 and Hormonal Regulations in Aging

inferred← citeshttps://doi.org/10.3390/biom16060793openalex-snapshot

Sirtuins in Medicine: Multifaceted Roles in Physiological Processes and Cardiovascular Diseases

inferred← citeshttps://doi.org/10.3390/biomedicines10081834openalex-snapshot

Cardiac Acetylation in Metabolic Diseases

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Emerging Epigenetic Therapies for the Treatment of Cardiac Fibrosis

inferred← citeshttps://doi.org/10.3390/cells11152272openalex-snapshot

Canadian Contributions in Fibroblast Biology

inferred← citeshttps://doi.org/10.3390/cimb46120827openalex-snapshot

SIRT1 Activation Suppresses Corneal Endothelial–Mesenchymal Transition via the TGF-β/Smad2/3 Pathway

inferred← citeshttps://doi.org/10.3390/ijms20205005openalex-snapshot

Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload

inferred← citeshttps://doi.org/10.3390/ijms22073321openalex-snapshot

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

inferred← citeshttps://doi.org/10.3390/ijms22094701openalex-snapshot

Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells

inferred← citeshttps://doi.org/10.3390/ijms25116004openalex-snapshot

Fibroblast Diversity and Epigenetic Regulation in Cardiac Fibrosis

inferred← citeshttps://doi.org/10.3390/ijms27083425openalex-snapshot

ML216 Alleviates Age-Related Cardiac Fibrosis by Suppressing TGF-β1 Signaling Pathway

inferred← citeshttps://doi.org/10.3390/ijms27114877openalex-snapshot

Bioinformatics Identification and Molecular Docking Validation of Post-Translational Modification-Related Hub Genes as Diagnostic Biomarkers and Therapeutic Targets in Myocardial Fibrosis

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The Role of Sirtuin 1 in Palmitic Acid-Induced Endoplasmic Reticulum Stress in Cardiac Myoblasts

inferred← citeshttps://doi.org/10.3390/molecules30183740openalex-snapshot

Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review

inferred← citeshttps://doi.org/10.3390/ph16101449openalex-snapshot

Searching for Effective Treatments in HFpEF: Implications for Modeling the Disease in Rodents

inferred← citeshttps://doi.org/10.34133/research.1418openalex-snapshot

Therapeutic Potential of the Deubiquitinase BRCC3 in Attenuating Ischemic Myocardial Injury and Ventricular Remodeling

inferred← citeshttps://doi.org/10.3892/ijmm.2020.4647openalex-snapshot

Inhibition of miRNA‑135a‑5p ameliorates TGF‑β1‑induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy

inferred← citeshttps://doi.org/10.5483/bmbrep.2024-0122openalex-snapshot

Contribution of histone deacetylases (HDACs) to the regulation of histone and non-histone proteins: implications for fibrotic diseases

inferred← citeshttps://doi.org/10.6515/acs.202403_40(2).20230925bopenalex-snapshot

Sirt1 Inhibits Atrial Fibrosis by Downregulating the Expression of the Transforming Growth Factor-β1/Smad Pathway.

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