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Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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HEAT SHOCK RESPONSE AND AGEING: MECHANISMS AND APPLICATIONS
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Models of the biological age of the rat. I. A factor model of age parameters
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Assessment of biological age by principal component analysis
inferredcites →https://doi.org/10.1016/0531-5565(88)90048-4openalex-snapshot
Key questions in developing biomarkers of aging
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Development of models for predicting biological age (BA) with physical, biochemical, and hormonal parameters
inferredcites →https://doi.org/10.1016/j.cell.2005.02.001openalex-snapshot
Mitochondria, Oxidants, and Aging
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A comparative analysis of measurement approaches for physiological dysregulation in an older population
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The essential mechanisms of aging: Irreparable damage accumulation of biochemical side-reactions
inferredcites →https://doi.org/10.1016/j.exger.2006.09.006openalex-snapshot
Recent results: Biomarkers of aging
inferredcites →https://doi.org/10.1016/j.exger.2009.07.008openalex-snapshot
Biomarkers of aging and disease: Introduction and definitions
inferredcites →https://doi.org/10.1016/j.mad.2005.10.004openalex-snapshot
A new approach to the concept and computation of biological age
inferredcites →https://doi.org/10.1016/j.mad.2008.09.020openalex-snapshot
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey
inferredcites →https://doi.org/10.1016/j.mad.2009.12.001openalex-snapshot
An empirical comparative study on biological age estimation algorithms with an application of Work Ability Index (WAI)
inferredcites →https://doi.org/10.1016/j.mad.2011.08.001openalex-snapshot
Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study
inferredcites →https://doi.org/10.1016/s0065-2423(08)00405-8openalex-snapshot
Chapter 5 Biomarkers Related To Aging In Human Populations
inferredcites →https://doi.org/10.1016/s0092-8674(01)00306-3openalex-snapshot
A Conserved Regulatory System for Aging
inferredcites →https://doi.org/10.1016/s0140-6736(69)90950-7openalex-snapshot
TEST-BATTERY TO MEASURE AGEING-RATE IN MAN
inferredcites →https://doi.org/10.1016/s0197-4580(02)00027-1openalex-snapshot
Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
inferredcites →https://doi.org/10.1016/s0531-5565(00)00084-xopenalex-snapshot
Caloric restriction and aging: an update
inferredcites →https://doi.org/10.1016/s0531-5565(97)00114-9openalex-snapshot
Alex Comfort and the Measure of Aging
inferredcites →https://doi.org/10.1023/a:1026594602252openalex-snapshot
On the use of regression analysis for the estimation of human biological age
inferredcites →https://doi.org/10.1038/35041682openalex-snapshot
Why do we age?
inferredcites →https://doi.org/10.1093/gerona/59.6.b560openalex-snapshot
Aging: The Reality: Biomarkers of Aging: From Primitive Organisms to Humans
inferredcites →https://doi.org/10.1093/gerona/60.5.574openalex-snapshot
Disentangling the Genetic Determinants of Human Aging: Biological Age as an Alternative to the Use of Survival Measures
inferredcites →https://doi.org/10.1093/gerona/62.10.1096openalex-snapshot
A Method for Identifying Biomarkers of Aging and Constructing an Index of Biological Age in Humans
inferredcites →https://doi.org/10.1093/gerona/63.10.1053openalex-snapshot
Cumulative Deficits and Physiological Indices as Predictors of Mortality and Long Life
inferredcites →https://doi.org/10.1159/000075557openalex-snapshot
Biological Age and 12-Year Cognitive Change in Older Adults: Findings from the Victoria Longitudinal Study
inferredcites →https://doi.org/10.1172/jci200422475openalex-snapshot
Ink4a/Arf expression is a biomarker of aging
inferredcites →https://doi.org/10.1172/jci22475openalex-snapshot
Ink4a/Arf expression is a biomarker of aging
inferredcites →https://doi.org/10.1186/1471-2318-2-1openalex-snapshot
Frailty, fitness and late-life mortality in relation to chronological and biological age
inferredcites →https://doi.org/10.1196/annals.1395.001openalex-snapshot
Biological Aging Is No Longer an Unsolved Problem
inferredcites →https://doi.org/10.3109/14639238209010720openalex-snapshot
Evaluation of biological age and physical age by multiple regression analysis
inferredcites →https://doi.org/10.59566/ijbs.2008.4089openalex-snapshot
Free Radicals, Antioxidants in Disease and Health

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Association of lifestyle with mortality and the mediating role of aging among older adults in China
inferred← citeshttps://doi.org/10.1016/j.archger.2022.104905openalex-snapshot
Biological age models based on a healthy Han Chinese population
inferred← citeshttps://doi.org/10.1016/j.archger.2023.105175openalex-snapshot
The biological age model for evaluating the degree of aging in centenarians
inferred← citeshttps://doi.org/10.1016/j.archger.2024.105477openalex-snapshot
Association between biological aging and the risk of mortality in individuals with non-alcoholic fatty liver disease: A prospective cohort study
inferred← citeshttps://doi.org/10.1016/j.archger.2026.106404openalex-snapshot
Biological age acceleration and multidomain functional impairment: Mortality associations and incremental value in NHANES and CHARLS
inferred← citeshttps://doi.org/10.1016/j.arcmed.2024.103033openalex-snapshot
Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology
inferred← citeshttps://doi.org/10.1016/j.arr.2015.07.006openalex-snapshot
Pharmacotherapy in the ageing patient: The impact of age per se (A review)
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101136openalex-snapshot
Social hallmarks of aging: Suggestions for geroscience research
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101164openalex-snapshot
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101314openalex-snapshot
DNA methylation-based age clocks: From age prediction to age reversion
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101609openalex-snapshot
What can we learn from physical capacity about biological age? A systematic review
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102390openalex-snapshot
Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102942openalex-snapshot
The association between early life circumstances and multi-system biological aging: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.artd.2024.101356openalex-snapshot
Age-Based Heuristics Bias Treatment of Displaced Femoral Neck Fractures in the Elderly
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.017openalex-snapshot
Phenome and genome based studies into human ageing and longevity: An overview
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.165612openalex-snapshot
Current nutritional and pharmacological anti-aging interventions
inferred← citeshttps://doi.org/10.1016/j.biopsych.2024.10.008openalex-snapshot
Sex-Differential Markers of Psychiatric Risk and Treatment Response Based on Premature Aging of Functional Brain Network Dynamics and Peripheral Physiology
inferred← citeshttps://doi.org/10.1016/j.bone.2024.117255openalex-snapshot
Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective
inferred← citeshttps://doi.org/10.1016/j.bpsgos.2024.100341openalex-snapshot
Childhood Maltreatment and Biological Aging in Middle Adulthood: The Role of Psychiatric Symptoms
inferred← citeshttps://doi.org/10.1016/j.bspc.2026.109812openalex-snapshot
The application of convolutional neural networks for brain age prediction: A systematic review
inferred← citeshttps://doi.org/10.1016/j.cdnut.2026.109462openalex-snapshot
Clinical Protocol for the Dietary Approaches to Longevity and Health (DiAL Health) Pilot Trial
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110459openalex-snapshot
Distinct biological ages of organs and systems identified from a multi-omics study
inferred← citeshttps://doi.org/10.1016/j.cels.2019.02.005openalex-snapshot
Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks
inferred← citeshttps://doi.org/10.1016/j.clbc.2026.07.013openalex-snapshot
Phenotypic Age Acceleration Predicts Survival Outcomes in HR+/HER2-Negative Metastatic Breast Cancer Treated With CDK4/6 Inhibitors: A Real-World Cohort Study
inferred← citeshttps://doi.org/10.1016/j.clineuro.2023.107714openalex-snapshot
DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients
inferred← citeshttps://doi.org/10.1016/j.cllc.2025.10.009openalex-snapshot
Biological Aging and Survival Outcomes in Patients With Advanced Non–Small Cell Lung Cancer Receiving Systemic Therapy
inferred← citeshttps://doi.org/10.1016/j.clnu.2023.11.007openalex-snapshot
Association of dietary inflammatory potential, dietary oxidative balance score and biological aging
inferred← citeshttps://doi.org/10.1016/j.cmpb.2025.109176openalex-snapshot
Novel machine learning framework for multidimensional biological age estimation reveals heterogeneous aging of organ systems
inferred← citeshttps://doi.org/10.1016/j.copsyc.2018.11.015openalex-snapshot
Networks of problems: social, psychological, and genetic influences on health
inferred← citeshttps://doi.org/10.1016/j.diabres.2025.112375openalex-snapshot
PhenoAgeAccel is associated with all-cause and cardiovascular mortality in patients with diabetes and prediabetes: A cohort study
inferred← citeshttps://doi.org/10.1016/j.diabres.2025.112449openalex-snapshot
Synergistic association of estimated glucose disposal rate and neutrophil-to-albumin ratio with accelerated biological aging
inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2025.112825openalex-snapshot
Time from waking to first cigarette, accelerated biological aging, and risk of premature mortality
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.03.046openalex-snapshot
Biological Age Predictors
inferred← citeshttps://doi.org/10.1016/j.ebiom.2022.104404openalex-snapshot
Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104458openalex-snapshot
Modeling biological age using blood biomarkers and physical measurements in Chinese adults
inferred← citeshttps://doi.org/10.1016/j.ebiom.2024.105494openalex-snapshot
Accelerated biological aging increases the risk of short- and long-term stroke prognosis in patients with ischemic stroke or TIA
inferred← citeshttps://doi.org/10.1016/j.eclinm.2025.103178openalex-snapshot
Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populations
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.116438openalex-snapshot
Associations of phthalates with accelerated aging and the mitigating role of physical activity
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117582openalex-snapshot
Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118455openalex-snapshot
Biological ageing mediates the associations between urinary metals and metabolic dysfunction-associated steatotic liver disease
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118819openalex-snapshot
The association between per- and polyfluoroalkyl substances and biological aging among middle and older age adults: The moderating effect of caffeine
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.119907openalex-snapshot
Association of the essential metal mixture with biological aging in Chinese older adults: Investigating superoxide dismutase as a potential mediator
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120733openalex-snapshot
Long-term ambient benzene exposure, acceleration of biological aging, and risk of incident psychiatric disorders: A cohort study in the UK Biobank
inferred← citeshttps://doi.org/10.1016/j.ejogrb.2025.114595openalex-snapshot
Associations between biological aging and the risk of endometriosis: Evidence from a large population-based prospective cohort study
inferred← citeshttps://doi.org/10.1016/j.ejso.2019.11.003openalex-snapshot
Should we invest in biological age predictors to treat colorectal cancer in older adults?
inferred← citeshttps://doi.org/10.1016/j.ejvs.2020.11.013openalex-snapshot
Editor's Choice – The GermanVasc Score: A Pragmatic Risk Score Predicts Five Year Amputation Free Survival in Patients with Peripheral Arterial Occlusive Disease
inferred← citeshttps://doi.org/10.1016/j.enceco.2026.08.009openalex-snapshot
Differential associations of PM2.5 constituents on different stages of CKD: The role of lifestyle, genetic risk, and biological age acceleration
inferred← citeshttps://doi.org/10.1016/j.envint.2019.105071openalex-snapshot
Air pollution, particulate matter composition and methylation-based biologic age
inferred← citeshttps://doi.org/10.1016/j.envint.2024.108447openalex-snapshot
The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target
inferred← citeshttps://doi.org/10.1016/j.envint.2024.109019openalex-snapshot
Ambient fine particulate matter and its constituents may exacerbate the acceleration of aging in adults
inferred← citeshttps://doi.org/10.1016/j.envint.2026.110125openalex-snapshot
Exposure to polycyclic aromatic hydrocarbons and aging acceleration: Unraveling the underlying mechanisms and the role of AKT1 via integrative methods
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126047openalex-snapshot
Complex metal interaction networks and the mediating role of biological aging in dyslipidemia
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126474openalex-snapshot
Associations of non-essential metal mixture with biological aging and the mediating role of inflammation in Chinese older adults
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126603openalex-snapshot
Biological age acceleration mediates effects of household air pollution from solid fuels on dementia risk: A prospective cohort study in China
inferred← citeshttps://doi.org/10.1016/j.envres.2023.115714openalex-snapshot
The variable associations between PFASs and biological aging by sex and reproductive stage in NHANES 1999–2018
inferred← citeshttps://doi.org/10.1016/j.envres.2024.119426openalex-snapshot
Sexual dimorphism association of combined exposure to volatile organic compounds (VOC) with kidney damage
inferred← citeshttps://doi.org/10.1016/j.envres.2025.122709openalex-snapshot
Accelerated biological aging among chemical plant workers
inferred← citeshttps://doi.org/10.1016/j.exger.2017.07.011openalex-snapshot
The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations
inferred← citeshttps://doi.org/10.1016/j.exger.2017.09.017openalex-snapshot
Towards a biological geriatric assessment
inferred← citeshttps://doi.org/10.1016/j.exger.2019.110715openalex-snapshot
If my muscle could talk: Myokines as a biomarker of frailty
inferred← citeshttps://doi.org/10.1016/j.exger.2022.111926openalex-snapshot
Intrinsic capacity and 10-year mortality: Findings from a cohort of older people
inferred← citeshttps://doi.org/10.1016/j.exger.2025.112933openalex-snapshot
Difference between estimated GFR based on cystatin C versus creatinine and incident dementia, cognitive functions and biological aging: A cohort study of the UK Biobank
inferred← citeshttps://doi.org/10.1016/j.exger.2026.113168openalex-snapshot
Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging
inferred← citeshttps://doi.org/10.1016/j.exger.2026.113183openalex-snapshot
Remnant cholesterol, serum uric acid, and biological aging: insights from two nationally representative cohorts
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.03.012openalex-snapshot
The biological age linked to oxidative stress modifies breast cancer aggressiveness
inferred← citeshttps://doi.org/10.1016/j.heha.2026.100193openalex-snapshot
Epigenetic age acceleration mediates the association between phthalate exposure and higher mortality risk in U.S. older adults
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e19158openalex-snapshot
Accelerometer-measured physical activity patterns are associated with phenotypic age: Isotemporal substitution effects
inferred← citeshttps://doi.org/10.1016/j.hrthm.2024.12.009openalex-snapshot
Is aging a modifiable risk factor for atrial fibrillation?
inferred← citeshttps://doi.org/10.1016/j.hrtlng.2026.102824openalex-snapshot
The association of accelerated biological aging with heart diseases in adults aged 40–69 years: a population-based cohort study
inferred← citeshttps://doi.org/10.1016/j.ijcard.2017.12.068openalex-snapshot
Factors of importance to 30-day survival after in-hospital cardiac arrest in Sweden – A population-based register study of more than 18,000 cases
inferred← citeshttps://doi.org/10.1016/j.ijcha.2023.101172openalex-snapshot
Cardiovascular events and artificial intelligence-predicted age using 12-lead electrocardiograms
inferred← citeshttps://doi.org/10.1016/j.ijcha.2025.101838openalex-snapshot
Accelerated biological aging and incident degenerative valvular heart disease: Findings from 408,783 UK Biobank participants
inferred← citeshttps://doi.org/10.1016/j.ijcrp.2026.200664openalex-snapshot
Accelerated biological aging, genetic susceptibility, and the risk of peripheral arterial disease: Evidence from the UK Biobank cohort study
inferred← citeshttps://doi.org/10.1016/j.ins.2021.12.015openalex-snapshot
Risk score-embedded deep learning for biological age estimation: Development and validation
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108375openalex-snapshot
Sulfur mustard and biological ageing: A multisystem biological health score approach as an extension of the allostatic load in Sardasht chemical veterans
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114478openalex-snapshot
Association between biological aging and coronary heart disease: A secondary analysis of two observational studies
inferred← citeshttps://doi.org/10.1016/j.jacadv.2022.100012openalex-snapshot
Born to Age: When Adult Congenital Heart Disease Converges With Geroscience
inferred← citeshttps://doi.org/10.1016/j.jacadv.2025.101659openalex-snapshot
Aerobic Exercise Training, Biological Age, and Mortality in Chronic Heart Failure With Reduced Ejection Fraction
inferred← citeshttps://doi.org/10.1016/j.jacasi.2025.11.019openalex-snapshot
Biological Age Acceleration and All-Cause Mortality in Moderate to Severe Aortic Valve Stenosis
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