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Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection

https://doi.org/10.1093/infdis/jiz100
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1038/ni.3152openalex-snapshot
HIV reservoirs as obstacles and opportunities for an HIV cure
inferredcites →https://doi.org/10.1038/s41591-018-0026-6openalex-snapshot
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
inferredcites →https://doi.org/10.1073/pnas.1302634110openalex-snapshot
Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo
inferredcites →https://doi.org/10.1073/pnas.96.26.15109openalex-snapshot
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
inferredcites →https://doi.org/10.1093/infdis/jiw648openalex-snapshot
Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies
inferredcites →https://doi.org/10.1097/coh.0000000000000123openalex-snapshot
Posttreatment controllers
inferredcites →https://doi.org/10.1097/coh.0000000000000316openalex-snapshot
Lessons from acute HIV infection
inferredcites →https://doi.org/10.1097/coh.0000000000000484openalex-snapshot
Lessons learned from HIV antiretroviral treatment interruption trials
inferredcites →https://doi.org/10.1097/qad.0000000000001909openalex-snapshot
Analytical antiretroviral therapy interruption does not irreversibly change preinterruption levels of cellular HIV
inferredcites →https://doi.org/10.1126/science.278.5341.1291openalex-snapshot
Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia
inferredcites →https://doi.org/10.1126/science.278.5341.1295openalex-snapshot
Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy
inferredcites →https://doi.org/10.1126/scitranslmed.aan8848openalex-snapshot
A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection
inferredcites →https://doi.org/10.1128/jvi.00285-18openalex-snapshot
Effect of Short-Term Antiretroviral Therapy Interruption on Levels of Integrated HIV DNA
inferredcites →https://doi.org/10.1172/jci120194openalex-snapshot
HIV-1 latent reservoir size and diversity are stable following brief treatment interruption
inferredcites →https://doi.org/10.1371/journal.ppat.1006792openalex-snapshot
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4586461openalex-extracted
The Impact of Analytical Treatment Interruptions and Trial Interventions on Time to Viral Re-Suppression in People Living with HIV Restarting ART in Cure-Related Clinical Studies: A Systematic Review and Meta-Analysis
inferred← citeshttps://doi.org/10.1002/jia2.26349openalex-snapshot
The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis
inferred← citeshttps://doi.org/10.1007/s11904-022-00605-1openalex-snapshot
HIV Compartmentalization in the CNS and Its Impact in Treatment Outcomes and Cure Strategies
inferred← citeshttps://doi.org/10.1016/j.jve.2025.100604openalex-snapshot
The impact of magnitude and duration of plasma viremia during analytical treatment interruptions on CD4+ T cell recovery after ART resumption
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00570openalex-snapshot
LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis
inferred← citeshttps://doi.org/10.1038/s41591-023-02547-6openalex-snapshot
Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial
inferred← citeshttps://doi.org/10.1038/s41598-020-79002-wopenalex-snapshot
Prolonged administration of maraviroc reactivates latent HIV in vivo but it does not prevent antiretroviral-free viral rebound
inferred← citeshttps://doi.org/10.1073/pnas.1919408117openalex-snapshot
Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window
inferred← citeshttps://doi.org/10.1093/infdis/jiaa634openalex-snapshot
Nonstructured Treatment Interruptions Are Associated With Higher Human Immunodeficiency Virus Reservoir Size Measured by Intact Proviral DNA Assay in People Who Inject Drugs
inferred← citeshttps://doi.org/10.1097/coh.0000000000000973openalex-snapshot
The role of analytical treatment interruptions in shaping HIV-specific immunity and HIV cure
inferred← citeshttps://doi.org/10.1101/2023.11.14.23298452openalex-snapshot
In-depth profiling of the immuno-virological landscape after a decade of sustained HIV-1 suppression following ART resumption
inferred← citeshttps://doi.org/10.1126/sciadv.ads1911openalex-snapshot
Synthesis and preclinical evaluation of tigilanol tiglate analogs as latency-reversing agents for the eradication of HIV
inferred← citeshttps://doi.org/10.1172/jci.insight.173864openalex-snapshot
Predictors of HIV rebound differ by timing of antiretroviral therapy initiation
inferred← citeshttps://doi.org/10.1186/s13063-022-06151-wopenalex-snapshot
The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study protocol for a two-stage…
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00823openalex-snapshot
HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)
inferred← citeshttps://doi.org/10.6084/m9.figshare.19522755openalex-snapshot
Additional file 1 of The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study…
inferred← citeshttps://doi.org/10.6084/m9.figshare.19522758openalex-snapshot
Additional file 2 of The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study…
inferred← citeshttps://doi.org/10.6084/m9.figshare.19522761openalex-snapshot
Additional file 3 of The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study…
inferred← citeshttps://doi.org/10.6084/m9.figshare.19522764openalex-snapshot
Additional file 4 of The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study…
inferred← citeshttps://doi.org/10.64898/2026.06.02.729658openalex-snapshot
Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Reduced Neuroaxonal Integrity
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