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CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.jaci.2015.01.020openalex-snapshotSevere atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population
inferredcites →https://doi.org/10.1016/j.jaci.2015.08.007openalex-snapshotHematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function
inferredcites →https://doi.org/10.1016/s0140-6736(15)60125-8openalex-snapshotComparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials
inferredcites →https://doi.org/10.1038/ni.1731openalex-snapshotThe transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
inferredcites →https://doi.org/10.1038/ni.1741openalex-snapshotInterleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
inferredcites →https://doi.org/10.1038/ni.1767openalex-snapshotProduction of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
inferredcites →https://doi.org/10.1038/ni.1840openalex-snapshotSignaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
inferredcites →https://doi.org/10.1038/ni.1867openalex-snapshotThe transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
inferredcites →https://doi.org/10.1038/ni.2025openalex-snapshotBorder patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
inferredcites →https://doi.org/10.1038/ni.2842openalex-snapshotEarly specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses
inferredcites →https://doi.org/10.1038/ni.2886openalex-snapshotThe epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
inferredcites →https://doi.org/10.1038/ni.2937openalex-snapshotEpigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility
inferredcites →https://doi.org/10.1038/ni1375openalex-snapshotInterleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
inferredcites →https://doi.org/10.1038/ni1424openalex-snapshotTranscription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
inferredcites →https://doi.org/10.1038/nm.2684openalex-snapshotIL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
inferredcites →https://doi.org/10.1038/nm804openalex-snapshotInterleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
inferredcites →https://doi.org/10.1067/mai.2003.1557openalex-snapshotAirway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression
inferredcites →https://doi.org/10.1084/jem.194.4.519openalex-snapshotRequirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
inferredcites →https://doi.org/10.1084/jem.20120914openalex-snapshotNeuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
inferredcites →https://doi.org/10.4049/jimmunol.0903426openalex-snapshotPolycomb Group Gene Product Ring1B Regulates Th2-Driven Airway Inflammation through the Inhibition of Bim-Mediated Apoptosis of Effector Th2 Cells in the Lung
inferredcites →https://doi.org/10.4049/jimmunol.155.3.1151openalex-snapshotImmunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/advs.202102853openalex-snapshotTherapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting
inferred← citeshttps://doi.org/10.1002/advs.202509351openalex-snapshotNonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2 + PIRB + Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis
inferred← citeshttps://doi.org/10.1002/cam4.4239openalex-snapshotPreexisting immune‐mediated inflammatory disease is associated with improved survival and increased toxicity in melanoma patients who receive immune checkpoint inhibitors
inferred← citeshttps://doi.org/10.1002/clt2.12048openalex-snapshotBiomarkers for predicting response to long‐term high dose aspirin therapy in aspirin‐exacerbated respiratory disease
inferred← citeshttps://doi.org/10.1002/eji.201948098openalex-snapshotThe intestinal expansion of TCRγδ + and disappearance of IL4 + T cells suggest their involvement in the evolution from potential to overt celiac disease
inferred← citeshttps://doi.org/10.1002/fsn3.954openalex-snapshotEffect of silkworm peptide on inducting M1 type polarization and Th1 activation via TLR2‐induced MyD88‐dependent pathway
inferred← citeshttps://doi.org/10.1002/jor.24980openalex-snapshotVaccine of RANKL mutant conjugated with KLH effectively stabilizing bone metabolism and preventing trabecular microstructural degeneration in osteoporotic rats
inferred← citeshttps://doi.org/10.1002/kjm2.12587openalex-snapshotLong non‐coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA ‐135b‐5p/ GATA ‐3 axis in children with allergic rhinitis
inferred← citeshttps://doi.org/10.1002/path.4848openalex-snapshotProinflammatory effect of high‐mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development
inferred← citeshttps://doi.org/10.1002/rmb2.12488openalex-snapshotUnderstanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review
inferred← citeshttps://doi.org/10.1007/s00394-019-02114-1openalex-snapshotBerberis lycium fruit extract attenuates oxi-inflammatory stress and promotes mucosal healing by mitigating NF-κB/c-Jun/MAPKs signalling and augmenting splenic Treg proliferation in a murine model of dextran sulphate sodium-induced ulcerative colitis
inferred← citeshttps://doi.org/10.1007/s10753-018-0913-5openalex-snapshotAdvanced Glycated End Products Alter Neutrophil Effect on Regulation of CD4+ T Cell Differentiation Through Induction of Myeloperoxidase and Neutrophil Elastase Activities
inferred← citeshttps://doi.org/10.1007/s11033-024-09688-yopenalex-snapshotHuman umbilical cord mesenchymal stem cells promoted tumor cell growth associated with increased interleukin-18 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s11845-021-02858-yopenalex-snapshotThe relationship of blood CDC42 level with Th1 cells, Th17 cells, inflammation markers, disease risk/activity, and treatment efficacy of rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2023.119540openalex-snapshotTreponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113574openalex-snapshotPaeonia lactiflora Pallas extract alleviates antibiotics and DNCB-induced atopic dermatitis symptoms by suppressing inflammation and changing the gut microbiota composition in mice
inferred← citeshttps://doi.org/10.1016/j.fct.2019.110793openalex-snapshotEvaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2)
inferred← citeshttps://doi.org/10.1016/j.hsr.2024.100201openalex-snapshotDeciphering the intricacies of immune system dysfunction and its impact on diabetes mellitus: Revisiting the communication strategies to manage diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.imlet.2020.07.001openalex-snapshotIntermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection: Crosstalk among calorie restriction, autophagy and immune response
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106505openalex-snapshotVenom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117399openalex-snapshotMechanism of Qizhen decoction-mediated maturation of DC cells to activate the IL-12/JAK2/STAT4 pathway to sensitise PD-1 inhibitors in the treatment of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122287openalex-snapshotTargeting HIF-1α alleviates the inflammatory responses and rebuilds the CD4+ T cell subsets balance in the experimental autoimmune myasthenia gravis inflammation model via regulating cellular and humoral immunity
inferred← citeshttps://doi.org/10.1016/j.matbio.2022.09.001openalex-snapshotHuman intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells – A novel mechanism for maintenance of intestinal inflammation
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2018.07.001openalex-snapshotPrenatal exposure to environmental insults and enhanced risk of developing Schizophrenia and Autism Spectrum Disorder: focus on biological pathways and epigenetic mechanisms
inferred← citeshttps://doi.org/10.1016/j.tice.2025.103193openalex-snapshotActivation of TLR4/NF-κB/TNF-α pathway in inflammation and apoptosis during stable and progressive phases of canine transmissible venereal tumors
inferred← citeshttps://doi.org/10.1021/acsami.3c06399openalex-snapshotTumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response
inferred← citeshttps://doi.org/10.1021/acsnano.5c09136openalex-snapshotAn Antigen-Free Nanovaccine-Enabled Holo-Immunotherapy for Establishing Robust Memory Immune Tolerance in Autoimmune Diseases
inferred← citeshttps://doi.org/10.1039/d0nr09153gopenalex-snapshotGold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures
inferred← citeshttps://doi.org/10.1080/01616412.2017.1382800openalex-snapshotCombination treatment of docosahexaenoic acid (DHA) and all-trans-retinoic acid (ATRA) inhibit IL-17 and RORγt gene expression in PBMCs of patients with relapsing-remitting multiple sclerosis
inferred← citeshttps://doi.org/10.1080/10717544.2018.1450909openalex-snapshotNasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI®induces enhanced serological, cellular and protective immune responses
inferred← citeshttps://doi.org/10.1080/13880209.2021.1992451openalex-snapshotPolyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization
inferred← citeshttps://doi.org/10.1080/21645515.2019.1698900openalex-snapshotTryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model
inferred← citeshttps://doi.org/10.1093/eep/dvx013openalex-snapshotTrichloroethylene-induced alterations in DNA methylation were enriched in polycomb protein binding sites in effector/memory CD4+ T cells
inferred← citeshttps://doi.org/10.1093/hmg/ddy284openalex-snapshotSP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition
inferred← citeshttps://doi.org/10.1093/jamia/ocab270openalex-snapshotEmbedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis
inferred← citeshttps://doi.org/10.1093/jrr/rrae011openalex-snapshotA recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice
inferred← citeshttps://doi.org/10.1093/nar/gkac258openalex-snapshotThe TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes
inferred← citeshttps://doi.org/10.1093/pcmedi/pbac018openalex-snapshotCD4+ T cell metabolism, gut microbiota, and autoimmune diseases: implication in precision medicine of autoimmune diseases
inferred← citeshttps://doi.org/10.1093/toxsci/kfy066openalex-snapshotDevelopmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice
inferred← citeshttps://doi.org/10.1097/md.0000000000032019openalex-snapshotObservation on the efficacy of sublingual immunotherapy with dust mite allergen for perennial allergic rhinitis and the mechanism of action on ILCs with ILC1s and ILC2s and ILC3s
inferred← citeshttps://doi.org/10.1101/723783openalex-snapshotMammalian musculoskeletal regeneration is associated with reduced inflammatory cytokines and an influx of T cells
inferred← citeshttps://doi.org/10.1111/cas.15186openalex-snapshotAlteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1111/cas.15360openalex-snapshotTumor‐derived immunoglobulin like transcript 5 induces suppressive immunocyte infiltration in colorectal cancer
inferred← citeshttps://doi.org/10.1111/imm.12846openalex-snapshotNeurotransmitter signalling via NMDA receptors leads to decreased T helper type 1‐like and enhanced T helper type 2‐like immune balance in humans
inferred← citeshttps://doi.org/10.1111/imm.13203openalex-snapshotInterleukin‐33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response
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