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Exploiting enzyme promiscuity to shape plant specialized metabolism

https://doi.org/10.1093/jxb/erz025
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Underground metabolism
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Einfluss der Configuration auf die Wirkung der Enzyme
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Nicotinamide‐Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes
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Evolution by Gene Duplication
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(−)-Menthol biosynthesis and molecular genetics
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The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Δ4,5-steroid 5β-reductase activity in Arabidopsis thaliana L.
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Underground metabolism: network-level perspective and biotechnological potential
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Biological messiness vs. biological genius: Mechanistic aspects and roles of protein promiscuity
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Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family
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Vein Patterning 1-encoded progesterone 5β-reductase: Activity-guided improvement of catalytic efficiency
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PRISEs (progesterone 5β-reductase and/or iridoid synthase-like 1,4-enone reductases): Catalytic and substrate promiscuity allows for realization of multiple pathways in plant metabolism
inferredcites →https://doi.org/10.1016/j.phytochem.2018.10.012openalex-snapshot
A promiscuous beta-glucosidase is involved in benzoxazinoid deglycosylation in Lamium galeobdolon
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Phytochemical diversity: The sounds of silent metabolism
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Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism
inferredcites →https://doi.org/10.1016/j.tetlet.2017.04.041openalex-snapshot
Enzymatic glucosylation of unnatural naphthols by a promiscuous glycosyltransferase from Aloe arborescens
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An evolutionary biochemist's perspective on promiscuity
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Enzyme promiscuity: mechanism and applications
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Seeing double: gene duplication and diversification in plant secondary metabolism
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Moonlighting proteins
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Catalytic promiscuity and the evolution of new enzymatic activities
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The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness
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Identifying Latent Enzyme Activities: Substrate Ambiguity within Modern Bacterial Sugar Kinases
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The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
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Evolutionary Rate at the Molecular Level
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Rational modification of enzyme catalysis by engineering surface charge
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An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
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The Lego-ization of polyketide biosynthesis
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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
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Protein promiscuity and its implications for biotechnology
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Messy biology and the origins of evolutionary innovations
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The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
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The distribution of fitness effects of new mutations
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Evolution of a flipped pathway creates metabolic innovation in tomato trichomes through BAHD enzyme promiscuity
inferredcites →https://doi.org/10.1038/s41467-018-04878-2openalex-snapshot
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
inferredcites →https://doi.org/10.1039/np9860300217openalex-snapshot
Secondary metabolism ? fact and fiction
inferredcites →https://doi.org/10.1042/bcj20160289openalex-snapshot
Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase
inferredcites →https://doi.org/10.1055/s-0043-111240openalex-snapshot
The Foxgloves (Digitalis) Revisited
inferredcites →https://doi.org/10.1073/pnas.1406102111openalex-snapshot
Network-level architecture and the evolutionary potential of underground metabolism
inferredcites →https://doi.org/10.1073/pnas.1606241113openalex-snapshot
Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories
inferredcites →https://doi.org/10.1073/pnas.44.2.98openalex-snapshot
Application of a Theory of Enzyme Specificity to Protein Synthesis
inferredcites →https://doi.org/10.1074/jbc.273.4.2078openalex-snapshot
Sesquiterpene Synthases from Grand Fir (Abies grandis)
inferredcites →https://doi.org/10.1074/jbc.m111.274050openalex-snapshot
Origins of Specificity and Promiscuity in Metabolic Networks
inferredcites →https://doi.org/10.1074/jbc.m114.595363openalex-snapshot
Escherichia coli d-Malate Dehydrogenase, a Generalist Enzyme Active in the Leucine Biosynthesis Pathway
inferredcites →https://doi.org/10.1080/07391102.2015.1088797openalex-snapshot
Progesterone 5β-reductases/iridoid synthases (PRISE): gatekeeper role of highly conserved phenylalanines in substrate preference and trapping is supported by molecular dynamics simulations
inferredcites →https://doi.org/10.1093/jxb/erp002openalex-snapshot
A Darwinian view of metabolism: molecular properties determine fitness
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The function of the oxylipin 12-oxophytodienoic acid in cell signaling, stress acclimation, and development
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The Origin of Species by Means of Natural Selection
inferredcites →https://doi.org/10.1098/rstb.1991.0077openalex-snapshot
On the evolution of plant secondary chemical diversity
inferredcites →https://doi.org/10.1104/pp.83.3.557openalex-snapshot
Hevea Linamarase—A Nonspecific β-Glycosidase
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Diversity and variability of plant secondary metabolism: a mechanistic view
inferredcites →https://doi.org/10.1111/nph.13441openalex-snapshot
Lineage‐specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales
inferredcites →https://doi.org/10.1111/nph.14822openalex-snapshot
Relaxation of tyrosine pathway regulation underlies the evolution of betalain pigmentation in Caryophyllales
inferredcites →https://doi.org/10.1126/science.860134openalex-snapshot
Evolution and Tinkering
inferredcites →https://doi.org/10.1146/annurev-biochem-030409-143718openalex-snapshot
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
inferredcites →https://doi.org/10.1146/annurev-biochem-062917-012023openalex-snapshot
Metabolite–Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks
inferredcites →https://doi.org/10.1146/annurev.arplant.47.1.185openalex-snapshot
THE ORGANIZATION AND REGULATION OF PLANT GLYCOLYSIS
inferredcites →https://doi.org/10.1146/annurev.mi.30.100176.002205openalex-snapshot
ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION
inferredcites →https://doi.org/10.17877/de290r-6134openalex-snapshot
Lehrbuch der Botanik
inferredcites →https://doi.org/10.2976/1.2754665openalex-snapshot
The subtle benefits of being promiscuous: Adaptive evolution potentiated by enzyme promiscuity
inferredcites →https://doi.org/10.5860/choice.48-2085openalex-snapshot
Nature's chemicals: the natural products that shaped our world
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Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata
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Homospermidine synthase evolution and the origin(s) of pyrrolizidine alkaloids in Apocynaceae
inferred← citeshttps://doi.org/10.1002/bies.202000164openalex-snapshot
Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis
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Variational Factors and Regulation Processes of Secondary Metabolites
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Using interdisciplinary, phylogeny-guided approaches to understand the evolution of plant metabolism
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Enzyme Evolution in Secondary Metabolism
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Silent constraints: the hidden challenges faced in plant metabolic engineering
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Cascade chemo-enzymatic synthesis of disubstituted 1,2,3-triazole derivatives: Enhancing the activity by immobilized enzyme on g-C3N4
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Directed Evolution of Plant Processes: Towards a Green (r)Evolution?
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Restricting Promiscuity of Plant Flavonoid 3′-Hydroxylase and 4′- O -Methyltransferase Improves the Biosynthesis of (2 S )-Hesperetin in E. coli
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From Plants to Microbes: Harnessing Enzyme Promiscuity for Natural Product Synthesis
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Promiscuity of Cytochrome P450 Enzymes: Discovery Strategies, Mechanistic Insights, and Applications in Terpenoid Biosynthesis
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Horizontal Natural Product Transfer: Intriguing Insights into a Newly Discovered Phenomenon
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Discover the maze-like network for glabridin biosynthesis
inferred← citeshttps://doi.org/10.1039/c9np00048hopenalex-snapshot
Evolutionary dynamics of natural product biosynthesis in bacteria
inferred← citeshttps://doi.org/10.1039/d1nr07236fopenalex-snapshot
Chiral carbon dots – a functional domain for tyrosinase Cu active site modulation via remote target interaction
inferred← citeshttps://doi.org/10.1055/a-2074-9186openalex-snapshot
Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis
inferred← citeshttps://doi.org/10.1055/s-0041-1736952openalex-snapshot
Identifying structural features for changing substrate preferences in two Plantago PRISEs (progesterone 5β-reductase and /or iridoid synthase)
inferred← citeshttps://doi.org/10.1080/07352689.2019.1682791openalex-snapshot
The Hot and the Colorful: Understanding the Metabolism, Genetics and Evolution of Consumer Preferred Metabolic Traits in Pepper and Related Species
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Multiple routes of functional diversification of the plant BAHD acyltransferase family revealed by comparative biochemical and genomic analyses
inferred← citeshttps://doi.org/10.1101/2021.12.17.473194openalex-snapshot
Diversity and Divergence: Evolution of defense chemistry in the tropical tree genus Inga
inferred← citeshttps://doi.org/10.1101/2022.12.29.522212openalex-snapshot
The P450 Sterol Side Chain Cleaving Enzyme (P450 scc ) for Digoxin Biosynthesis in the Foxglove Plant Belongs to the CYP87A Family
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In defense of Apocynaceae: inference on evolution of pyrrolizidine alkaloids from evolution of an enzyme in their biosynthetic pathway, homospermidine synthase
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Discover the Maze-like Pathway for Glabridin Biosynthesis
inferred← citeshttps://doi.org/10.1111/nph.18064openalex-snapshot
2‐oxoglutarate‐dependent dioxygenases drive expansion of steroidal alkaloid structural diversity in the genus Solanum
inferred← citeshttps://doi.org/10.1111/nph.18554openalex-snapshot
Diversity and divergence: evolution of secondary metabolism in the tropical tree genus Inga
inferred← citeshttps://doi.org/10.1111/tpj.15704openalex-snapshot
Substrate promiscuity of acyltransferases contributes to the diversity of hydroxycinnamic acid derivatives in purple coneflower
inferred← citeshttps://doi.org/10.1111/tpj.70820openalex-snapshot
Open data phylometabolomics reveals turnover‐dominated chemical divergence and clade‐specific physicochemical regimes across angiosperms
inferred← citeshttps://doi.org/10.1126/sciadv.aeb6806openalex-snapshot
Unlocking translational control of specialized metabolism in plants through 5′UTR structure
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Computational approaches to discover novel enzymes for fragrance and flavour
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Knockout of Arabidopsis thaliana VEP1, Encoding a PRISE (Progesterone 5β-Reductase/Iridoid Synthase-Like Enzyme), Leads to Metabolic Changes in Response to Exogenous Methyl Vinyl Ketone (MVK)
inferred← citeshttps://doi.org/10.3390/molecules29235788openalex-snapshot
Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species
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Origin and Function of Structural Diversity in the Plant Specialized Metabolome
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A Diploid Panax Genome Reveals Ginsenoside Diversity Driven by UGT Family Diversification and Network Rewiring Rather than Gene Family Expansion
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