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A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bip.360221211openalex-snapshot
Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
inferredcites →https://doi.org/10.1002/pro.3187openalex-snapshot
A mechanistic study of helicases with magnetic traps
inferredcites →https://doi.org/10.1007/978-1-60327-475-3_7openalex-snapshot
Quantitative Analysis of Protein-RNA Interactions by Gel Mobility Shift
inferredcites →https://doi.org/10.1016/b978-0-12-396546-2.00012-7openalex-snapshot
Biochemical Characterization of the RNA Helicase UPF1 Involved in Nonsense-Mediated mRNA Decay
inferredcites →https://doi.org/10.1016/j.cell.2006.01.054openalex-snapshot
Structural Basis for RNA Unwinding by the DEAD-Box Protein Drosophila Vasa
inferredcites →https://doi.org/10.1016/j.cell.2006.08.006openalex-snapshot
The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on mRNA
inferredcites →https://doi.org/10.1016/j.cell.2010.11.043openalex-snapshot
Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay
inferredcites →https://doi.org/10.1016/j.febslet.2007.05.027openalex-snapshot
mRNA quality control: An ancient machinery recognizes and degrades mRNAs with nonsense codons
inferredcites →https://doi.org/10.1016/j.molcel.2007.07.014openalex-snapshot
The Long Unwinding Road of RNA Helicases
inferredcites →https://doi.org/10.1016/j.molcel.2011.02.010openalex-snapshot
Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2
inferredcites →https://doi.org/10.1016/j.molcel.2015.06.036openalex-snapshot
Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity
inferredcites →https://doi.org/10.1016/j.sbi.2010.03.011openalex-snapshot
SF1 and SF2 helicases: family matters
inferredcites →https://doi.org/10.1016/j.tibs.2010.07.008openalex-snapshot
RNA helicases at work: binding and rearranging
inferredcites →https://doi.org/10.1016/s0962-8924(03)00106-5openalex-snapshot
The interplay of nuclear mRNP assembly, mRNA surveillance and export
inferredcites →https://doi.org/10.1017/s1355838200000546openalex-snapshot
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
inferredcites →https://doi.org/10.1038/emboj.2008.144openalex-snapshot
DNA binding to RecD: role of the 1B domain in SF1B helicase activity
inferredcites →https://doi.org/10.1038/emboj.2009.175openalex-snapshot
Unusual bipartite mode of interaction between the nonsense‐mediated decay factors, UPF1 and UPF2
inferredcites →https://doi.org/10.1038/nchembio.236openalex-snapshot
Coupling DNA unwinding activity with primer synthesis in the bacteriophage T4 primosome
inferredcites →https://doi.org/10.1038/ncomms8581openalex-snapshot
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities
inferredcites →https://doi.org/10.1038/nrm3154openalex-snapshot
From unwinding to clamping — the DEAD box RNA helicase family
inferredcites →https://doi.org/10.1038/nsmb.1561openalex-snapshot
The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner
inferredcites →https://doi.org/10.1038/nsmb1246openalex-snapshot
Structural basis for DNA duplex separation by a superfamily-2 helicase
inferredcites →https://doi.org/10.1038/nsmb1330openalex-snapshot
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
inferredcites →https://doi.org/10.1038/sj.emboj.7601464openalex-snapshot
Structural and functional insights into the human Upf1 helicase core
inferredcites →https://doi.org/10.1073/pnas.95.17.10009openalex-snapshot
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsensecontaining mRNAs in mammalian cells
inferredcites →https://doi.org/10.1083/jcb.201311103openalex-snapshot
Protecting the proteome: Eukaryotic cotranslational quality control pathways
inferredcites →https://doi.org/10.1093/nar/gkm216openalex-snapshot
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
inferredcites →https://doi.org/10.1093/nar/gks1320openalex-snapshot
Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains
inferredcites →https://doi.org/10.1093/nar/gku645openalex-snapshot
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot
Phaser crystallographic software
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1111/febs.13198openalex-snapshot
The conformational plasticity of eukaryotic RNA ‐dependent ATP ases
inferredcites →https://doi.org/10.1126/science.1111443openalex-snapshot
From Birth to Death: The Complex Lives of Eukaryotic mRNAs
inferredcites →https://doi.org/10.1126/science.1131981openalex-snapshot
Structure of the Exon Junction Core Complex with a Trapped DEAD-Box ATPase Bound to RNA
inferredcites →https://doi.org/10.1146/annurev.biophys.37.032807.125908openalex-snapshot
Translocation and Unwinding Mechanisms of RNA and DNA Helicases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.3897/imafungus.16.151785zenodo-depositor-declared
Annotation and functional prediction of RNA helicases in Ustilago maydis
inferred← citeshttps://doi.org/10.1002/wrna.1548openalex-snapshot
Nonsense‐mediated mRNA decay: The challenge of telling right from wrong in a complex transcriptome
inferred← citeshttps://doi.org/10.1002/wrna.1684openalex-snapshot
Assembly of multicomponent machines in RNA metabolism: A common theme in mRNA decay pathways
inferred← citeshttps://doi.org/10.1007/s12033-024-01062-4openalex-snapshot
Messenger RNA Surveillance: Current Understanding, Regulatory Mechanisms, and Future Implications
inferred← citeshttps://doi.org/10.1016/j.abb.2024.109989openalex-snapshot
Advances in molecular function of UPF1 in Cancer
inferred← citeshttps://doi.org/10.1016/j.chom.2022.09.017openalex-snapshot
An expanded arsenal of immune systems that protect bacteria from phages
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110418openalex-snapshot
Functional investigation of the RNA helicase MOV10 with respect to its interplay with factors involved in nonsense-mediated mRNA decay
inferred← citeshttps://doi.org/10.1016/j.jmb.2026.169752openalex-snapshot
Standing on the Shoulders of Giant Ribosomes: UPF1-dependent Surveillance of Translation Dynamics to Proteostasis
inferred← citeshttps://doi.org/10.1016/j.jmb.2026.169913openalex-snapshot
UPF1 at Work: Structural and Mechanistic Insights Into a Master Regulator of Nonsense-Mediated mRNA Decay
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.05.013openalex-snapshot
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay
inferred← citeshttps://doi.org/10.1016/j.molcel.2023.10.026openalex-snapshot
Structural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless
inferred← citeshttps://doi.org/10.1016/j.tibs.2018.02.001openalex-snapshot
Unravelling the Mechanisms of RNA Helicase Regulation
inferred← citeshttps://doi.org/10.1016/j.tibs.2022.06.003openalex-snapshot
The broader sense of nonsense
inferred← citeshttps://doi.org/10.1016/j.ymeth.2018.12.005openalex-snapshot
Defining nonsense-mediated mRNA decay intermediates in human cells
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c00247openalex-snapshot
Synergistic Binding of ATP and Nucleic Acids Necessitates UPF1’s ATPase Functional Cycle
inferred← citeshttps://doi.org/10.1038/s41418-024-01433-zopenalex-snapshot
Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma
inferred← citeshttps://doi.org/10.1038/s41467-019-13080-xopenalex-snapshot
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
inferred← citeshttps://doi.org/10.1038/s41598-025-05711-9openalex-snapshot
The prognostic significance of the NMD core factor UPF1 in low-grade glioma
inferred← citeshttps://doi.org/10.1042/bcj20210556openalex-snapshot
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
inferred← citeshttps://doi.org/10.1074/jbc.ra120.013824openalex-snapshot
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay
inferred← citeshttps://doi.org/10.1093/nar/gkac1026openalex-snapshot
UPF1 mutants with intact ATPase but deficient helicase activities promote efficient nonsense-mediated mRNA decay
inferred← citeshttps://doi.org/10.1093/nar/gkae136openalex-snapshot
UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency
inferred← citeshttps://doi.org/10.1093/nar/gkae323openalex-snapshot
UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2
inferred← citeshttps://doi.org/10.1101/2021.01.27.428318openalex-snapshot
An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decay
inferred← citeshttps://doi.org/10.1101/2021.08.02.454737openalex-snapshot
Dissecting the import and export pathways of the human RNA helicase UPF1
inferred← citeshttps://doi.org/10.1186/s12863-023-01173-yopenalex-snapshot
SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.1242/dmm.044891openalex-snapshot
A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
inferred← citeshttps://doi.org/10.1261/rna.080476.125openalex-snapshot
UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities
inferred← citeshttps://doi.org/10.1261/rna.081099.126openalex-snapshot
The moonlighting functions of SEC13 in nonsense-mediated mRNA decay and the regulation of ER stress
inferred← citeshttps://doi.org/10.1515/hsz-2020-0338openalex-snapshot
Regulation of DEAH-box RNA helicases by G-patch proteins
inferred← citeshttps://doi.org/10.1515/hsz-2023-0154openalex-snapshot
Molecular simulations of DEAH-box helicases reveal control of domain flexibility by ligands: RNA, ATP, ADP, and G-patch proteins
inferred← citeshttps://doi.org/10.15252/embj.2021108898openalex-snapshot
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay
inferred← citeshttps://doi.org/10.15252/embj.2023114378openalex-snapshot
Translation‐coupled mRNA quality control mechanisms
inferred← citeshttps://doi.org/10.3389/fcell.2026.1750689openalex-snapshot
G-patch proteins: important regulators of pre-mRNA splicing and ribosome biogenesis
inferred← citeshttps://doi.org/10.3390/biom10070999openalex-snapshot
UPF1-Mediated RNA Decay—Danse Macabre in a Cloud
inferred← citeshttps://doi.org/10.3390/biomedicines10010141openalex-snapshot
Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism
inferred← citeshttps://doi.org/10.3390/biomedicines11030722openalex-snapshot
Nonsense-Mediated mRNA Decay Factor Functions in Human Health and Disease
inferred← citeshttps://doi.org/10.3390/cells12030419openalex-snapshot
UPF1—From mRNA Degradation to Human Disorders
inferred← citeshttps://doi.org/10.3390/ijms222312744openalex-snapshot
Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the ‘Regulatory Loop’
inferred← citeshttps://doi.org/10.3390/ijms232112800openalex-snapshot
Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe
inferred← citeshttps://doi.org/10.3390/jof11060404openalex-snapshot
Up-Frameshift Factors from Phytopathogenic Fungi Play a Crucial Role in Nonsense-Mediated mRNA Decay
inferred← citeshttps://doi.org/10.53846/goediss-9579openalex-snapshot
Functional and Structural Characterization of the DEAH-box Helicase Prp43
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642371openalex-snapshot
Additional file 1 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642374openalex-snapshot
Additional file 2 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642377openalex-snapshot
Additional file 3 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642380openalex-snapshot
Additional file 4 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642383openalex-snapshot
Additional file 5 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642386openalex-snapshot
Additional file 6 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26642389openalex-snapshot
Additional file 7 of SARS-CoV-2 helicase might interfere with cellular nonsense-mediated RNA decay: insights from a bioinformatics study
inferred← citeshttps://doi.org/10.70675/2b685cc9zbdcbz4ab4zb8ddz38ae334d002dopenalex-snapshot
In vitro biochemical study of Nonsense-mediated mRNA Decay complexes in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.70675/61bd4108zec99z4471z8a6ez2454d54bdfa3openalex-snapshot
Composition et dynamique des complexes protéiques impliqués dans le "nonsense-mediated mRNA decay" chez la levure Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.70675/d05116ccz5de4z4d60z98ebz918144463fdbopenalex-snapshot
The Role of Convergent Transcription in Regulating Alternative Splicing : Targeted Epigenetic Modification via Repurposed CRISPR/Cas9 System and Its Impact on Alternative Splicing Modulation
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