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CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway

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1 of the 51 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1046/j.1365-313x.2003.01676.x (notice 2015-11-13).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbdv.201100256openalex-snapshot

Natural Friedelanes

inferredcites →https://doi.org/10.1002/pca.626openalex-snapshot

Quantitative determination of cytotoxicFriedo‐nor‐oleanane derivatives from five morphological types of Maytenus ilicifolia (celastraceae) by reverse‐phase high‐performance liquid chromatography

inferredcites →https://doi.org/10.1002/yea.1502openalex-snapshot

A suite of Gateway® cloning vectors for high‐throughput genetic analysis in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1007/978-94-024-1552-0_29openalex-snapshot

Maytenus ilicifolia Mart. ex Reissek

inferredcites →https://doi.org/10.1007/s00299-018-2296-3openalex-snapshot

Engineering terpenoid production through transient expression in Nicotiana benthamiana

inferredcites →https://doi.org/10.1007/s11240-014-0459-7openalex-snapshot

Cell cultures of Maytenus ilicifolia Mart. are richer sources of quinone-methide triterpenoids than plant roots in natura

inferredcites →https://doi.org/10.1016/0031-9422(81)85151-5openalex-snapshot

Isolation and characterization of natural products from plant tissue cultures of Maytenus buchananii

inferredcites →https://doi.org/10.1016/0031-9422(91)80096-jopenalex-snapshot

Triterpenes fromMaytenus ilicifolia

inferredcites →https://doi.org/10.1016/0031-9422(95)00116-oopenalex-snapshot

Triterpenes from Tripterigium wilfordii

inferredcites →https://doi.org/10.1016/j.bbagen.2006.07.018openalex-snapshot

Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

inferredcites →https://doi.org/10.1016/j.cell.2015.05.011openalex-snapshot

Treatment of Obesity with Celastrol

inferredcites →https://doi.org/10.1016/j.phrs.2017.11.027openalex-snapshot

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

inferredcites →https://doi.org/10.1016/j.plantsci.2016.05.015openalex-snapshot

Saponin determination, expression analysis and functional characterization of saponin biosynthetic genes in Chenopodium quinoa leaves

inferredcites →https://doi.org/10.1016/j.sajb.2005.12.011openalex-snapshot

Antibacterial activity of maytenonic acid isolated from the root-bark of Maytenus senegalensis

inferredcites →https://doi.org/10.1016/j.ymben.2017.02.007openalex-snapshot

An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

inferredcites →https://doi.org/10.1016/j.ymben.2017.06.012openalex-snapshot

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

inferredcites →https://doi.org/10.1016/s0031-9422(00)00007-8openalex-snapshot

Triterpenoids from Tripterygium wilfordii

inferredcites →https://doi.org/10.1016/s0031-9422(00)00285-5openalex-snapshot

Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris

inferredcites →https://doi.org/10.1016/s0031-9422(97)00048-4openalex-snapshot

Terpenoids from Tripterygium wilfordii

inferredcites →https://doi.org/10.1016/s0040-4020(01)82592-8openalex-snapshot

Triterpenes of calophyllum inophyllum linn

inferredcites →https://doi.org/10.1016/s0076-6879(02)50957-5openalex-snapshot

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

inferredcites →https://doi.org/10.1016/s1360-1385(02)02251-3openalex-snapshot

GATEWAY™ vectors for Agrobacterium-mediated plant transformation

inferredcites →https://doi.org/10.1021/cr200021mopenalex-snapshot

Biosynthesis of Cholesterol and Other Sterols

inferredcites →https://doi.org/10.1021/jo00169a030openalex-snapshot

Crystal structure of orthosphenic acid

inferredcites →https://doi.org/10.1038/nature12685openalex-snapshot

The protein quality control system manages plant defence compound synthesis

inferredcites →https://doi.org/10.1038/nbt.1883openalex-snapshot

Full-length transcriptome assembly from RNA-Seq data without a reference genome

inferredcites →https://doi.org/10.1038/ncomms14153openalex-snapshot

The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

inferredcites →https://doi.org/10.1038/s41467-017-01813-9openalex-snapshot

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

inferredcites →https://doi.org/10.1038/srep22627openalex-snapshot

Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging

inferredcites →https://doi.org/10.1038/srep36858openalex-snapshot

Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene

inferredcites →https://doi.org/10.1039/p19790000349openalex-snapshot

Salaspermic acid, a new triterpene acid from Salacia macrosperma Wight

inferredcites →https://doi.org/10.1046/j.1365-313x.2003.01676.xopenalex-snapshot

Retracted: An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy stunt virus

inferredcites →https://doi.org/10.1073/pnas.1323369111openalex-snapshot

Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum

inferredcites →https://doi.org/10.1073/pnas.1700367114openalex-snapshot

Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids

inferredcites →https://doi.org/10.1093/bioinformatics/btu170openalex-snapshot

Trimmomatic: a flexible trimmer for Illumina sequence data

inferredcites →https://doi.org/10.1093/nar/gkt135openalex-snapshot

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

inferredcites →https://doi.org/10.1093/nar/gkx925openalex-snapshot

The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis

inferredcites →https://doi.org/10.1093/pcp/pcv062openalex-snapshot

P450s and UGTs: Key Players in the Structural Diversity of Triterpenoid Saponins

inferredcites →https://doi.org/10.1105/tpc.110.082685openalex-snapshot

Triterpene Functional Genomics in Licorice for Identification of CYP72A154 Involved in the Biosynthesis of Glycyrrhizin

inferredcites →https://doi.org/10.1105/tpc.111.087312openalex-snapshot

Medicago truncatula CYP716A12 Is a Multifunctional Oxidase Involved in the Biosynthesis of Hemolytic Saponins

inferredcites →https://doi.org/10.1105/tpc.114.134486openalex-snapshot

OSC2 and CYP716A14v2 Catalyze the Biosynthesis of Triterpenoids for the Cuticle of Aerial Organs of Artemisia annua

inferredcites →https://doi.org/10.1111/j.1467-7652.2009.00434.xopenalex-snapshot

pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants

inferredcites →https://doi.org/10.1111/nph.12325openalex-snapshot

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro

inferredcites →https://doi.org/10.1111/nph.15809openalex-snapshot

Friedelane‐type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast

inferredcites →https://doi.org/10.1128/aem.68.5.2095-2100.2002openalex-snapshot

Auxotrophic Yeast Strains in Fundamental and Applied Research

inferredcites →https://doi.org/10.1146/annurev-arplant-050312-120229openalex-snapshot

Triterpene Biosynthesis in Plants

inferredcites →https://doi.org/10.1186/s13059-015-0846-3openalex-snapshot

Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency

inferredcites →https://doi.org/10.1371/journal.pone.0165954openalex-snapshot

Cloning and Functional Characterization of Cycloartenol Synthase from the Red Seaweed Laurencia dendroidea

inferredcites →https://doi.org/10.1600/036364417x696456openalex-snapshot

Systematics of New World Maytenus (Celastraceae) and a New Delimitation of the Genus

inferredcites →https://doi.org/10.2174/138161211796391029openalex-snapshot

A Review of the Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus

inferredcites →https://doi.org/10.3390/molecules23030700openalex-snapshot

Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112868zenodo-depositor-declared

Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol

inferred← citeshttps://doi.org/10.1002/med.21751openalex-snapshot

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol

inferred← citeshttps://doi.org/10.1007/s00299-021-02748-8openalex-snapshot

De novo transcriptome analysis and identification of candidate genes associated with triterpenoid biosynthesis in Trichosanthes cucumerina L.

inferred← citeshttps://doi.org/10.1007/s11101-025-10191-wopenalex-snapshot

Scratching the surface: The diversity and roles of triterpenoids in plant cuticular waxes

inferred← citeshttps://doi.org/10.1007/s11240-021-02214-zopenalex-snapshot

Modulation of quinonemethide triterpenes biosynthesis in Monteverdia floribunda (Reissek) biral root cultures by exogenous inhibitors

inferred← citeshttps://doi.org/10.1007/s43450-024-00520-zopenalex-snapshot

Pristimerin: Natural Occurrence, Biosynthesis, Pharmacology, and Pharmacokinetics

inferred← citeshttps://doi.org/10.1016/j.indcrop.2022.115506openalex-snapshot

Agrobacterium tumefaciens mediated genetic transformation of Tripterygium wilfordii and its application to enhance the accumulation of triptolide

inferred← citeshttps://doi.org/10.1016/j.molp.2021.06.028openalex-snapshot

Plant cytochrome P450 plasticity and evolution

inferred← citeshttps://doi.org/10.1016/j.pbi.2024.102615openalex-snapshot

Celastrol: A century-long journey from the isolation to the biotechnological production and the development of an antiobesity drug

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105572openalex-snapshot

Celastrol in metabolic diseases: Progress and application prospects

inferred← citeshttps://doi.org/10.1016/j.synres.2020.100068openalex-snapshot

Synergistic anti-cancer effect of pristimerin and docetaxel on human colorectal HCT-116 cells

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00674openalex-snapshot

Characterization of the Cytochrome P450 CYP716C52 in Celastrol Biosynthesis and Its Applications in Engineered Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1038/s41467-022-35500-1openalex-snapshot

Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast

inferred← citeshttps://doi.org/10.1039/d2np00063fopenalex-snapshot

Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis

inferred← citeshttps://doi.org/10.1080/07352689.2026.2713963openalex-snapshot

Harnessing the potential of oxygenases in plant specialized metabolism

inferred← citeshttps://doi.org/10.1080/07388551.2021.2003292openalex-snapshot

Cytochrome P450s in plant terpenoid biosynthesis: discovery, characterization and metabolic engineering

inferred← citeshttps://doi.org/10.1080/14786419.2024.2421902openalex-snapshot

Thymic epithelial cell responses to the friedelin triterpene in vitro

inferred← citeshttps://doi.org/10.1105/tpc.19.00609openalex-snapshot

A Seed-Specific Regulator of Triterpene Saponin Biosynthesis in Medicago truncatula

inferred← citeshttps://doi.org/10.1111/nph.18272openalex-snapshot

The tomato cytochrome P450 CYP712G1 catalyses the double oxidation of orobanchol en route to the rhizosphere signalling strigolactone, solanacol

inferred← citeshttps://doi.org/10.1111/tpj.15575openalex-snapshot

Probing the functions of friedelane‐type triterpene cyclases from four celastrol‐producing plants

inferred← citeshttps://doi.org/10.17504/protocols.io.bspfndjnopenalex-snapshot

Protocols for "The genome analysis of Tripterygium wilfordii reveals TwCYP712K1 and TwCYP712K2 responsible for oxidation of friedelin in celastrol biosynthesis pathway" v1

inferred← citeshttps://doi.org/10.33448/rsd-v12i1.39393openalex-snapshot

Ações farmacológicas e aplicações clínicas da Maytenus ilicifolia (Espinheira Santa)

inferred← citeshttps://doi.org/10.3389/fntpr.2023.1252092openalex-snapshot

Twenty-five years of natural products research in NuBBE

inferred← citeshttps://doi.org/10.3390/molecules26226806openalex-snapshot

The Methionine 549 and Leucine 552 Residues of Friedelin Synthase from Maytenus ilicifolia Are Important for Substrate Binding Specificity

inferred← citeshttps://doi.org/10.3762/bjoc.18.135openalex-snapshot

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants

inferred← citeshttps://doi.org/10.46471/gigabyte.14openalex-snapshot

The genome of Tripterygium wilfordii and characterization of the celastrol biosynthesis pathway

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