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Psychosocial Stress and Psychosis. A Review of the Neurobiological Mechanisms and the Evidence for Gene-Stress Interaction

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Influence of Child Abuse on Adult Depression

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Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia

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Emotional Reactivity to Daily Life Stress in Psychosis

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Hippocampal Volumes in Schizophrenic Twins

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Strategy for Investigating Interactions Between Measured Genes and Measured Environments

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Catechol O-methyltransferase Val158Met Genotype and Neural Mechanisms Related to Affective Arousal and Regulation

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Anxiety and Comorbid Measures Associated With PLXNA2

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Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

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American Journal of Psychiatry

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Evidence that the COMTVal158Met polymorphism moderates sensitivity to stress in psychosis: An experience‐sampling study

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The BDNF Val66Met × 5‐HTTLPR × child adversity interaction and depressive symptoms: An attempt at replication

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Do mood symptoms subdivide the schizophrenia phenotype? association of the GMP6A gene with a depression subgroup

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Genetic Transmission of Negative and Positive Symptoms in the Biological Relatives of Schizophrenics

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Provocative tests with psychostimulant drugs in schizophrenia

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The relationship between cognitive dysfunction and stress sensitivity in schizophrenia

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Genetic liability, illicit drug use, life stress and psychotic symptoms: preliminary findings from the Edinburgh study of people at high risk for schizophrenia

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Increased hunger and thirst during glucoprivation in humans

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Catechol-O-methyltransferase and catecholamines in anxiety and relaxation

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Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

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Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report

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Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide

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A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia

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Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness

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Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction

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Subtle Fluctuations in Psychotic Phenomena as Functional States of Abnormal Dopamine Reactivity in Individuals at Risk

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Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children

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Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression

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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

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Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis

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Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship?

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Serotonergic response to stress: A protective factor against abnormal dopaminergic reactivity in schizophrenia?

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Childhood trauma and emotional reactivity to daily life stress in adult frequent attenders of general practitioners

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The amphetamine-induced sensitized state as a model of schizophrenia

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Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women

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Evidence of basal pituitary–adrenal overactivity in first episode, drug naïve patients with schizophrenia

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Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release

inferredcites →https://doi.org/10.1016/j.schres.2004.04.006openalex-snapshot

Risk factors for transition to first episode psychosis among individuals with ‘at-risk mental states’

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Stressful life events in recent-onset schizophrenia: reduced frequencies and altered subjective appraisals

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Neurotrophins and schizophrenia

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Effects of acute metabolic stress on the dopaminergic and pituitary–adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls

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Child maltreatment and the developing HPA axis

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Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders

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Lack of Enhanced Response to Repeated d-Amphetamine Challenge in First-Episode Psychosis: Implications for a Sensitization Model of Psychosis in Humans

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The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia

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Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review

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The role of prenatal stress in the etiology of developmental behavioural disorders

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Effects of dopamine depletion in the medial prefrontal cortex on the stress-induced increase in extracellular dopamine in the nucleus accumbens core and shell

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Effects of Acute Metabolic Stress on Striatal Dopamine Release in Healthy Volunteers

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Do urbanicity and familial liability co-participate in causing psychosis?

inferredcites →https://doi.org/10.1017/s0033291702006785openalex-snapshot

Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress?

inferredcites →https://doi.org/10.1017/s0033291703001715openalex-snapshot

Abnormal response to metabolic stress in schizophrenia: marker of vulnerability or acquired sensitization?

inferredcites →https://doi.org/10.1017/s0033291704004179openalex-snapshot

Behavioural sensitization to daily life stress in psychosis

inferredcites →https://doi.org/10.1017/s0033291705006902openalex-snapshot

Evidence that the outcome of developmental expression of psychosis is worse for adolescents growing up in an urban environment

inferredcites →https://doi.org/10.1017/s0033291707001080openalex-snapshot

COMT Val158Met moderation of stress-induced psychosis

inferredcites →https://doi.org/10.1017/s1461145703004000openalex-snapshot

Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder

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Pathways to schizophrenia: the impact of environmental factors

inferredcites →https://doi.org/10.1017/s1461145706006882openalex-snapshot

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders

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The Effects of Stress on Central Dopaminergic Neurons: Possible Clinical Implications

inferredcites →https://doi.org/10.1037//0021-843x.100.4.607openalex-snapshot

Psychometric detection of schizotypy: Perceptual aberration and physical anhedonia in relatives of schizophrenics.

inferredcites →https://doi.org/10.1037//0021-843x.109.1.139openalex-snapshot

Life events can trigger depressive exacerbation in the early course of schizophrenia.

inferredcites →https://doi.org/10.1037//0021-843x.99.2.202openalex-snapshot

Anhedonia and perceptual aberration in first-episode psychotic patients and their relatives.

inferredcites →https://doi.org/10.1037/0033-2909.130.3.355openalex-snapshot

Acute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research.

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Schizophrenia: A neural diathesis-stress model.

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COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET

inferredcites →https://doi.org/10.1038/nature06858openalex-snapshot

Genetic variation in human NPY expression affects stress response and emotion

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Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT)

inferredcites →https://doi.org/10.1038/sj.mp.4001139openalex-snapshot

Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders

inferredcites →https://doi.org/10.1038/sj.mp.4001259openalex-snapshot

Glucocorticoid receptor mRNA in human frontal cortex

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Glucocorticoid receptor mRNA in human frontal cortex

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MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

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Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia

inferredcites →https://doi.org/10.1038/sj.npp.1300496openalex-snapshot

The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis

inferredcites →https://doi.org/10.1038/sj.npp.1300542openalex-snapshot

The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes

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Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

inferredcites →https://doi.org/10.1038/sj.npp.1300787openalex-snapshot

COMT Polymorphisms and Anxiety-Related Personality Traits

inferredcites →https://doi.org/10.1038/sj.npp.1300898openalex-snapshot

Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression

inferredcites →https://doi.org/10.1038/sj.npp.1301597openalex-snapshot

Stress-Induced Dopamine Release in Humans at Risk of Psychosis: a [11C]Raclopride PET Study

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Local Influence of Endogenous Norepinephrine on Extracellular Dopamine in Rat Medial Prefrontal Cortex

inferredcites →https://doi.org/10.1073/pnas.93.17.9235openalex-snapshot

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

inferredcites →https://doi.org/10.1073/pnas.94.6.2569openalex-snapshot

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

inferredcites →https://doi.org/10.1086/376549openalex-snapshot

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia

inferredcites →https://doi.org/10.1086/425589openalex-snapshot

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

inferredcites →https://doi.org/10.1093/ije/dym085openalex-snapshot

Discrimination and the incidence of psychotic disorders among ethnic minorities in The Netherlands

inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a009164openalex-snapshot

Biologic Synergism and Parallelism

inferredcites →https://doi.org/10.1093/schbul/sbl058openalex-snapshot

A New Look at the Neural Diathesis Stress Model of Schizophrenia: The Primacy of Social-Evaluative and Uncontrollable Situations

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Cumulative Traumas and Psychosis: an Analysis of the National Comorbidity Survey and the British Psychiatric Morbidity Survey

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Childhood Trauma and Psychotic Disorders: a Systematic, Critical Review of the Evidence

inferredcites →https://doi.org/10.1093/schbul/sbm163openalex-snapshot

Does the Concept of "Sensitization" Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?

inferredcites →https://doi.org/10.1093/schbul/sbn002openalex-snapshot

Life Events and High-Trait Reactivity Together Predict Psychotic Symptom Increases in Schizophrenia

inferredcites →https://doi.org/10.1093/schbul/sbn117openalex-snapshot

Gene-Environment Interactions in Schizophrenia: Review of Epidemiological Findings and Future Directions

inferredcites →https://doi.org/10.1097/00001756-200507130-00020openalex-snapshot

Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion

inferredcites →https://doi.org/10.1097/00041444-200303000-00006openalex-snapshot

Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism

inferredcites →https://doi.org/10.1097/00041444-200506000-00007openalex-snapshot

Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health

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Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

inferredcites →https://doi.org/10.1111/j.1600-0447.2005.00634.xopenalex-snapshot

Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications

inferredcites →https://doi.org/10.1126/science.1078546openalex-snapshot

COMT val 158 met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor

inferredcites →https://doi.org/10.1146/annurev.clinpsy.4.022007.141248openalex-snapshot

Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia.

inferredcites →https://doi.org/10.1146/annurev.neuro.24.1.1217openalex-snapshot

Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair

inferredcites →https://doi.org/10.1159/000052043openalex-snapshot

The Early Developmental Stages of Psychopathology Study (EDSP): A Methodological Update

inferredcites →https://doi.org/10.1159/000079107openalex-snapshot

Association Study of Catechol- O-Methyltransferase Gene and Dopamine D4 Receptor Gene Polymorphisms and Personality Traits in Healthy Young Chinese Females

inferredcites →https://doi.org/10.1176/ajp.148.11.1474openalex-snapshot

Dopamine in schizophrenia: a review and reconceptualization

inferredcites →https://doi.org/10.1176/ajp.155.6.761openalex-snapshot

Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort

inferredcites →https://doi.org/10.1176/ajp.155.7.979openalex-snapshot

Effect of Acute Metabolic Stress on Pituitary-Adrenal Axis Activation in Patients With Schizophrenia

inferredcites →https://doi.org/10.1176/appi.ajp.159.3.443openalex-snapshot

Are Cognitive Impairments Associated With Sensitivity to Stress in Schizophrenia? An Experience Sampling Study

inferredcites →https://doi.org/10.1176/appi.ajp.160.1.13openalex-snapshot

Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia

inferredcites →https://doi.org/10.1176/appi.ajp.160.3.477openalex-snapshot

Do Urbanicity and Familial Liability Coparticipate in Causing Psychosis?

inferredcites →https://doi.org/10.1176/appi.ajp.161.12.2312openalex-snapshot

Confirmation of Synergy Between Urbanicity and Familial Liability in the Causation of Psychosis

inferredcites →https://doi.org/10.1176/appi.ajp.162.1.12openalex-snapshot

Schizophrenia and Migration: A Meta-Analysis and Review

inferredcites →https://doi.org/10.1192/bjp.182.1.71openalex-snapshot

Discrimination and delusional ideation

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Genotype–environment interaction in schizophrenia-spectrum disorder

inferredcites →https://doi.org/10.1192/bjp.184.4.287openalex-snapshot

Does the urban environment cause psychosis?

inferredcites →https://doi.org/10.1192/bjp.185.3.196openalex-snapshot

Stimulant psychosis: systematic review

inferredcites →https://doi.org/10.1192/bjp.185.4.298openalex-snapshot

Prevalence and correlates of self-reported psychotic symptoms in the British population

inferredcites →https://doi.org/10.1192/bjp.187.2.101openalex-snapshot

Social defeat: Risk factor for schizophrenia?

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Brain volume in first-episode schizophrenia

inferredcites →https://doi.org/10.1192/bjp.191.51.s9openalex-snapshot

Hypothesis: social defeat is a risk factor for schizophrenia?

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Self-reported psychotic symptoms in the general population

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Chronic Stress‐Induced Effects of Corticosterone on Brain: Direct and Indirect

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Stress Sensitization in Schizophrenia

inferredcites →https://doi.org/10.1210/jc.78.2.249openalex-snapshot

Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls

inferredcites →https://doi.org/10.1210/jc.85.6.2215openalex-snapshot

Endocrine Consequences of Long-Term Intrathecal Administration of Opioids

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Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls.

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Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

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Catechol-O-Methyltransferaseval158metGenotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex

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Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [ 11 C]Raclopride

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Excitability of Dopamine Neurons: Modulation and Physiological Consequences

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Behavioural Events During Environmental Disasters

inferred← citeshttps://doi.org/10.1007/978-3-031-27349-0_7openalex-snapshot

Stress Assessment in Daily Life Using the Experience Sampling Method

inferred← citeshttps://doi.org/10.1007/978-3-319-08359-9_40openalex-snapshot

Trauma Exposure, Schizophrenia Symptoms, and the Stress Vulnerability Model

inferred← citeshttps://doi.org/10.1007/978-3-319-08613-2_40-1openalex-snapshot

Trauma Exposure, Schizophrenia Symptoms and the Stress Vulnerability Model

inferred← citeshttps://doi.org/10.1007/978-3-319-33774-6_6openalex-snapshot

Modeling OCD Endophenotypes in Zebrafish

inferred← citeshttps://doi.org/10.1007/978-3-319-44103-0_7openalex-snapshot

Stress Biomarkers as an Objective Window on Experience

inferred← citeshttps://doi.org/10.1007/978-3-319-95360-1_33openalex-snapshot

Schizophrenia: A Complex Mental Illness

inferred← citeshttps://doi.org/10.1007/978-90-368-2683-9_2openalex-snapshot

Wederkerige interacties tussen chronische stress en het neuro-endocriene en immuunsysteem

inferred← citeshttps://doi.org/10.1007/978-90-481-8553-5_12openalex-snapshot

Is a Neuroprotective Therapy Suitable for Schizophrenia Patients?

inferred← citeshttps://doi.org/10.1007/978-94-007-0831-0_3openalex-snapshot

Stress, Dissociation and Schizophrenia

inferred← citeshttps://doi.org/10.1007/978-94-007-0837-2_3openalex-snapshot

Toward a Multidimensional Continuum Model of Functional Psychoses for Research Purposes

inferred← citeshttps://doi.org/10.1007/s00115-024-01608-6openalex-snapshot

Management von Therapieresistenzen – therapieresistente Schizophrenie

inferred← citeshttps://doi.org/10.1007/s00127-011-0446-9openalex-snapshot

Modelling the emergence of hallucinations: early acquired vulnerabilities, proximal life stressors and maladaptive psychological processes

inferred← citeshttps://doi.org/10.1007/s00127-014-0894-0openalex-snapshot

Childhood maltreatment, adult attachment and psychotic symptomatology: a study in patients, siblings and controls

inferred← citeshttps://doi.org/10.1007/s00127-019-01711-zopenalex-snapshot

Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms

inferred← citeshttps://doi.org/10.1007/s00213-015-3894-1openalex-snapshot

Hypofunction of prefrontal cortex NMDA receptors does not change stress-induced release of dopamine and noradrenaline in amygdala but disrupts aversive memory

inferred← citeshttps://doi.org/10.1007/s00213-019-05442-6openalex-snapshot

Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

inferred← citeshttps://doi.org/10.1007/s00406-011-0258-7openalex-snapshot

How much stress is needed to increase vulnerability to psychosis? A community assessment of psychic experiences (CAPE) evaluation 10 months after an earthquake in L’Aquila (Italy)

inferred← citeshttps://doi.org/10.1007/s00406-016-0720-7openalex-snapshot

The emerging role of the FKBP5 gene polymorphisms in vulnerability–stress model of schizophrenia: further evidence from a Serbian population

inferred← citeshttps://doi.org/10.1007/s00702-009-0319-5openalex-snapshot

The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia

inferred← citeshttps://doi.org/10.1007/s00702-011-0754-yopenalex-snapshot

Early life stress exacerbates cognitive dysfunction induced by d-amphetamine: amelioration by valproic acid

inferred← citeshttps://doi.org/10.1007/s00702-013-1049-2openalex-snapshot

Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats

inferred← citeshttps://doi.org/10.1007/s00787-025-02905-4openalex-snapshot

The prevalence and influencing factors of psychotic-like experiences in children and adolescents: a meta-analysis and systematic review

inferred← citeshttps://doi.org/10.1007/s10055-023-00857-1openalex-snapshot

Physiological responses to the virtual reality-based Trier social stress test in patients with psychosis

inferred← citeshttps://doi.org/10.1007/s10548-020-00806-0openalex-snapshot

EEG Microstates and Psychosocial Stress During an Exchange Year

inferred← citeshttps://doi.org/10.1007/s10578-018-0792-xopenalex-snapshot

Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study

inferred← citeshttps://doi.org/10.1007/s10903-012-9676-5openalex-snapshot

Perceived Discrimination and Psychological Distress Among Asian Americans: Does Education Matter?

inferred← citeshttps://doi.org/10.1007/s10903-018-0715-8openalex-snapshot

Perceived Racial Discrimination and Pain Intensity/Disability Among Economically Disadvantaged Latinos in a Federally Qualified Health Center: The Role of Anxiety Sensitivity

inferred← citeshttps://doi.org/10.1007/s11064-015-1586-1openalex-snapshot

Intermittent Hypoxia-Induced Parvalbumin-Immunoreactive Interneurons Loss and Neurobehavioral Impairment is Mediated by NADPH-Oxidase-2

inferred← citeshttps://doi.org/10.1007/s11920-010-0107-9openalex-snapshot

Borderline Personality Disorder and Psychosis: A Review

inferred← citeshttps://doi.org/10.1007/s11920-012-0260-4openalex-snapshot

From Classical Psychodynamics to Evidence Synthesis: The Motif of Repression and a Contemporary Understanding of a Key Mediatory Mechanism in Psychosis

inferred← citeshttps://doi.org/10.1007/s12017-009-8066-1openalex-snapshot

microRNAs in CNS Disorders

inferred← citeshttps://doi.org/10.1007/s12035-015-9656-6openalex-snapshot

Environmental Enrichment Prevent the Juvenile Hypoxia-Induced Developmental Loss of Parvalbumin-Immunoreactive Cells in the Prefrontal Cortex and Neurobehavioral Alterations Through Inhibition of NADPH Oxidase-2-Derived Oxidative Stress

inferred← citeshttps://doi.org/10.1007/s12640-010-9163-5openalex-snapshot

Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders

inferred← citeshttps://doi.org/10.1007/s12671-021-01611-xopenalex-snapshot

Evidence Map of Mindfulness for Stages of Psychosis: State of the Literature and Implications for Future Research

inferred← citeshttps://doi.org/10.1007/s40211-012-0031-9openalex-snapshot

Trauma und Psychose – Teil 2

inferred← citeshttps://doi.org/10.1007/s40806-024-00384-5openalex-snapshot

Towards a Unified Account of Aberrant Salience in Psychosis: Proximate and Evolutionary Mechanisms

inferred← citeshttps://doi.org/10.1007/s44192-025-00223-4openalex-snapshot

Mediating effect of risk propensity between impulsivity and psychotic experiences among Lebanese young adults

inferred← citeshttps://doi.org/10.1016/b978-0-12-387002-5.16001-9openalex-snapshot

References

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Chapitre 12 – Schizophrénie et autres troubles psychotiques

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Vulnerability, Stress, and Support in the Disease Trajectory from Prodrome to Diagnosed Schizophrenia: Diathesis–Stress–Support Model

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Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene × environment interaction

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Dopamine in the nucleus accumbens modulates the memory of social defeat in Syrian hamsters (Mesocricetus auratus)

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Developmental loss of parvalbumin-positive cells in the prefrontal cortex and psychiatric anxiety after intermittent hypoxia exposures in neonatal rats might be mediated by NADPH oxidase-2

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Salivary cortisol in Schizophrenia: a selective review and meta-analysis of controlled studies of the past decade

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Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

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Weaving a Net of Neurobiological Mechanisms in Schizophrenia and Unraveling the Underlying Pathophysiology

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Prepubertal Environmental Enrichment Prevents Dopamine Dysregulation and Hippocampal Hyperactivity in MAM Schizophrenia Model Rats

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Interactive effects of early life stress and CACNA1C genotype on cortisol awakening response

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Abnormal immune system development and function in schizophrenia helps reconcile diverse findings and suggests new treatment and prevention strategies

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Stress-based animal models of depression: Do we actually know what we are doing?

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Induced pluripotent stem cells for 2D and 3D modelling the biological basis of schizophrenia and screening possible therapeutics

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Mental health disorders as cooccuring and predictive factors of psychotic disorders in sexually abused children

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Childhood sexual abuse increases risk of auditory hallucinations in psychotic disorders

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Sex differences in the effect of childhood trauma on the clinical expression of early psychosis

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Proteomic analysis of oxidized proteins in the brain and liver of the Nile tilapia (Oreochromis niloticus) exposed to a water-accommodated fraction of Maya crude oil

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Urban social stress – Risk factor for mental disorders. The case of schizophrenia

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Influence of the serotonin transporter gene polymorphism, cannabis and childhood sexual abuse on phenotype of bipolar disorder: A preliminary study

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Childhood adversity and psychosis: Examining whether the association is due to genetic confounding using a monozygotic twin differences approach

inferred← citeshttps://doi.org/10.1016/j.eurpsy.2014.03.001openalex-snapshot

TheBDNF-Val66Met polymorphism modulates parental rearing effects on adult psychiatric symptoms: A community twin-based study

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Childhood abuse in the etiological continuum underlying psychosis from first-episode psychosis to psychotic experiences

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Coping as a mediator of stress and psychotic-like experiences

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Is sensitivity to daily stress predictive of onset or persistence of psychopathology?

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Association between adverse childhood experiences and intrinsic capacity impairment among middle-aged and older adults in China: A nationwide cross-sectional survey from CHARLS

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Perceived Stress and Internalized Stigma Among Patients with Mental Disorders in Al Ahsa Governorate – Saudi Arabia

inferred← citeshttps://doi.org/10.1016/j.jaac.2013.02.008openalex-snapshot

Practice Parameter for the Assessment and Treatment of Children and Adolescents With Schizophrenia

inferred← citeshttps://doi.org/10.1016/j.jaac.2020.07.003openalex-snapshot

Environmental Risk Factors and Psychotic-like Experiences in Children Aged 9–10

inferred← citeshttps://doi.org/10.1016/j.jadr.2026.101104openalex-snapshot

Correlates of the embittered mind: Radical, psychotic, and conspiracy ideations

inferred← citeshttps://doi.org/10.1016/j.jbtep.2012.07.010openalex-snapshot

The impact of social stress on self-esteem and paranoid ideation

inferred← citeshttps://doi.org/10.1016/j.jenvp.2024.102293openalex-snapshot

Urbanicity and psychotic experiences: Social adversities, isolation and exposure to natural environments predict psychosis

inferred← citeshttps://doi.org/10.1016/j.joms.2010.06.178openalex-snapshot

Schizophrenia: Current Therapy and Review

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Preterm Birth and Adolescent Social Functioning–Alterations in Emotion-Processing Brain Areas

inferred← citeshttps://doi.org/10.1016/j.jpsychires.2013.02.002openalex-snapshot

Gene–environment interaction on cognition: A twin study of childhood maltreatment and COMT variability

inferred← citeshttps://doi.org/10.1016/j.jpsychires.2014.01.017openalex-snapshot

Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders

inferred← citeshttps://doi.org/10.1016/j.jpsychires.2015.05.005openalex-snapshot

Childhood maltreatment, 9/11 exposure, and latent dimensions of psychopathology: A test of stress sensitization

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Do common genotypes of FK506 binding protein 5 (FKBP5) moderate the effects of childhood maltreatment on cognition in schizophrenia and healthy controls?

inferred← citeshttps://doi.org/10.1016/j.jpsychires.2016.08.014openalex-snapshot

Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples

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Development and validation of the Questionnaire of Stressful Life Events (QSLE)

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BDNF in antipsychotic naive first episode psychosis: Effects of risperidone and the immune-inflammatory response system

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Role of childhood trauma in interoception and alexithymia in schizophrenia

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Voyage et troubles psychotiques : clinique et recommandations pratiques

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A unifying hypothesis of schizophrenia: Abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction

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Etiopathogenic perspectives on chronic psycho traumatic and chronic psychotic symptoms: The hypothesis of a hyperdopaminergic endophenotype of PTSD

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Childhood attachment and schizophrenia: The “attachment-developmental-cognitive” (ADC) hypothesis

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Genes and environments in schizophrenia: The different pieces of a manifold puzzle

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The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

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Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2022.104894openalex-snapshot

Schizophrenia: The new etiological synthesis

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Validity of mental and physical stress models

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The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms

inferred← citeshttps://doi.org/10.1016/j.neulet.2012.03.024openalex-snapshot

The response of neuregulin 1 mutant mice to acute restraint stress

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2011.04.025openalex-snapshot

Mouse models of genetic effects on cognition: Relevance to schizophrenia

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Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy

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Corticosterone modulates dopamine and serotonin1A receptor mediated regulation of prepulse inhibition and startle in male rats

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Stress and neurodevelopmental processes in the emergence of psychosis

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Epigenetics and the regulation of stress vulnerability and resilience

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Prefrontal cortical glutathione-dependent defense and proinflammatory mediators in chronically isolated rats: Modulation by fluoxetine or clozapine

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Psychometric schizotypy predicts psychotic-like, paranoid, and negative symptoms in real life

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Mindfulness training and false perception in individuals with high unusual experiences

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Isolated delusional syndrome in Parkinson’s Disease

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Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli

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Ability of palatable food consumption to buffer against the short- and long-term behavioral consequences of social defeat exposure during juvenility in rats

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Genetic markers of stress, resilience and success at an elite military selection course

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Sex difference in stress susceptibility and resilience in a restraint stress-induced depression mouse model: A proteomic investigation of the hippocampal dentate gyrus

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2009.10.015openalex-snapshot

Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia

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A theoretical framework informing research about the role of stress in the pathophysiology of bipolar disorder

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ErbB signaling antagonist ameliorates behavioral deficit induced by phencyclidine (PCP) in mice, without affecting metabolic syndrome markers

inferred← citeshttps://doi.org/10.1016/j.pscychresns.2018.09.002openalex-snapshot

Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders

inferred← citeshttps://doi.org/10.1016/j.psychres.2010.03.011openalex-snapshot

Considering a frame of reference for physical activity research related to the cardiometabolic risk profile in schizophrenia

inferred← citeshttps://doi.org/10.1016/j.psychres.2010.12.002openalex-snapshot

Investigation of shared genetic effects for psychotic and obsessive symptoms in young adult twins

inferred← citeshttps://doi.org/10.1016/j.psychres.2011.03.019openalex-snapshot

The association between trauma and delusional-like experiences

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Early maladaptive schemas predict positive symptomatology in schizophrenia: A cross-sectional study

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Childhood trauma and dissociation in first-episode psychosis, chronic schizophrenia and community controls

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Measuring trauma and stressful events in childhood and adolescence among patients with first-episode psychosis: Initial factor structure, reliability, and validity of the Trauma Experiences Checklist

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Associations between the Five-Factor Model personality traits and psychotic experiences in patients with psychotic disorders, their siblings and controls

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Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis

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A systematic review of the benefits of physical therapy within a multidisciplinary care approach for people with schizophrenia: An update

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Fetal exposure to maternal stress and risk for schizophrenia spectrum disorders among offspring: Differential influences of fetal sex

inferred← citeshttps://doi.org/10.1016/j.psychres.2016.05.006openalex-snapshot

Perceived ethnic discrimination and persecutory paranoia in individuals at ultra-high risk for psychosis

inferred← citeshttps://doi.org/10.1016/j.psychres.2017.06.042openalex-snapshot

Recent life events and psychosis: The role of childhood adversities

inferred← citeshttps://doi.org/10.1016/j.psychres.2017.09.055openalex-snapshot

Adversity and persecutory ideation: A moderated mediational model

inferred← citeshttps://doi.org/10.1016/j.psychres.2017.11.009openalex-snapshot

Self-disturbances, cognitive biases and insecure attachment as mechanisms of the relationship between traumatic life events and psychotic-like experiences in non-clinical adults – A path analysis

inferred← citeshttps://doi.org/10.1016/j.psychres.2017.12.012openalex-snapshot

Stress reactivity links childhood trauma exposure to an admixture of depressive, anxiety, and psychosis symptoms

inferred← citeshttps://doi.org/10.1016/j.psychres.2018.07.039openalex-snapshot

Exploring anxiety in schizophrenia: New light on a hidden figure

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Reductions in reported persecutory ideation and psychotic-like experiences during exposure therapy for posttraumatic stress disorder

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The role of attachment anxiety in the relationship between childhood trauma and schizophrenia-spectrum psychosis

inferred← citeshttps://doi.org/10.1016/j.psychres.2020.113372openalex-snapshot

Urban upbringing and psychotic experiences in the United States: A racial and geographic comparison

inferred← citeshttps://doi.org/10.1016/j.psychres.2021.114017openalex-snapshot

Recent stressful life events and stress sensitivity in children and adolescents at clinical risk for psychosis

inferred← citeshttps://doi.org/10.1016/j.psychres.2022.114872openalex-snapshot

The impact of childhood trauma and daily life experiences on emotional and psychotic symptom intensity in psychosis: An experience sampling study

inferred← citeshttps://doi.org/10.1016/j.psychres.2022.114900openalex-snapshot

Loneliness and psychosocial predictors of psychosis-proneness during COVID-19: Preliminary findings from Croatia

inferred← citeshttps://doi.org/10.1016/j.psychres.2024.116219openalex-snapshot

Prenatal immune activation in rats and adult exposure to inescapable shocks reveal sex-dependent effects on fear conditioning that might be relevant for schizophrenia

inferred← citeshttps://doi.org/10.1016/j.psychres.2024.116220openalex-snapshot

Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2011.09.018openalex-snapshot

Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2015.06.009openalex-snapshot

Cumulative stress pathophysiology in schizophrenia as indexed by allostatic load

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2015.09.010openalex-snapshot

Disrupted glucocorticoid—Immune interactions during stress response in schizophrenia

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2016.03.010openalex-snapshot

Perceived stress and hair cortisol: Differences in bipolar disorder and schizophrenia

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2017.03.027openalex-snapshot

Modulation of HPA axis response to social stress in schizophrenia by childhood trauma

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2017.08.024openalex-snapshot

Interaction between FKBP5 gene and childhood trauma on psychosis, depression and anxiety symptoms in a non-clinical sample

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2019.01.010openalex-snapshot

The Trier Social Stress Test in first episode psychosis patients: Impact of perceived stress, protective factors and childhood trauma

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2019.104513openalex-snapshot

Increased interleukin 18 activity in adolescents with early-onset psychosis is associated with cortisol and depressive symptoms

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2020.104684openalex-snapshot

The relevance of chronic stress for the acute stress reaction in people at elevated risk for psychosis

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2021.105205openalex-snapshot

The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2021.105601openalex-snapshot

Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system

inferred← citeshttps://doi.org/10.1016/j.schres.2010.05.020openalex-snapshot

Evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment

inferred← citeshttps://doi.org/10.1016/j.schres.2010.12.010openalex-snapshot

Psychotic symptoms in young adults exposed to childhood trauma—A 20year follow-up study

inferred← citeshttps://doi.org/10.1016/j.schres.2011.03.019openalex-snapshot

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: Implication for antioxidative psychotropic actions via microglia

inferred← citeshttps://doi.org/10.1016/j.schres.2011.11.035openalex-snapshot

HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia

inferred← citeshttps://doi.org/10.1016/j.schres.2013.02.019openalex-snapshot

Attenuated cortisol response to acute psychosocial stress in individuals at ultra-high risk for psychosis

inferred← citeshttps://doi.org/10.1016/j.schres.2013.09.010openalex-snapshot

Molecular genetic gene–environment studies using candidate genes in schizophrenia: A systematic review

inferred← citeshttps://doi.org/10.1016/j.schres.2014.04.006openalex-snapshot

Neuropeptide Y, social function and long-term outcome in schizophrenia

inferred← citeshttps://doi.org/10.1016/j.schres.2014.04.036openalex-snapshot

Perceived discrimination and psychotic experiences across multiple ethnic groups in the United States

inferred← citeshttps://doi.org/10.1016/j.schres.2014.09.017openalex-snapshot

Stress exposure and sensitivity in the clinical high-risk syndrome: Initial findings from the North American Prodrome Longitudinal Study (NAPLS)

inferred← citeshttps://doi.org/10.1016/j.schres.2015.07.020openalex-snapshot

Parental socioeconomic status and prognosis in individuals with ultra-high risk for psychosis: A 2-year follow-up study

inferred← citeshttps://doi.org/10.1016/j.schres.2016.04.048openalex-snapshot

Reliability and Validity of the List of Mental Health Items (LISMEN)

inferred← citeshttps://doi.org/10.1016/j.schres.2016.10.008openalex-snapshot

Experimentally induced psychosocial stress in schizophrenia spectrum disorders: A systematic review

inferred← citeshttps://doi.org/10.1016/j.schres.2017.01.058openalex-snapshot

Modelling gene-environment interaction in first episodes of psychosis

inferred← citeshttps://doi.org/10.1016/j.schres.2017.02.010openalex-snapshot

Sex differences in prolactin levels in emerging psychosis: Indication for enhanced stress reactivity in women

inferred← citeshttps://doi.org/10.1016/j.schres.2017.10.009openalex-snapshot

Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors

inferred← citeshttps://doi.org/10.1016/j.schres.2018.02.022openalex-snapshot

Psychotic experiences among police officers working in high-stress situations

inferred← citeshttps://doi.org/10.1016/j.schres.2018.04.010openalex-snapshot

Interaction between childhood adversity and functional polymorphisms in the dopamine pathway on first-episode psychosis

inferred← citeshttps://doi.org/10.1016/j.schres.2018.05.043openalex-snapshot

Psychotic experiences as indicators of risk for cardiovascular disease

inferred← citeshttps://doi.org/10.1016/j.schres.2019.03.011openalex-snapshot

Recovery from daily-life stressors in early and chronic psychosis

inferred← citeshttps://doi.org/10.1016/j.schres.2019.07.003openalex-snapshot

HPA axis in psychotic major depression and schizophrenia spectrum disorders: Cortisol, clinical symptomatology, and cognition

inferred← citeshttps://doi.org/10.1016/j.schres.2019.08.012openalex-snapshot

Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis

inferred← citeshttps://doi.org/10.1016/j.schres.2020.11.033openalex-snapshot

Perceived skin tone discrimination and psychotic experiences among Black Americans: Findings from the National Survey of American Life

inferred← citeshttps://doi.org/10.1016/j.schres.2021.06.005openalex-snapshot

Childhood adversity and psychotic disorders: Epidemiological evidence, theoretical models and clinical considerations

inferred← citeshttps://doi.org/10.1016/j.schres.2022.05.022openalex-snapshot

Impact of childhood trauma on antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial

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