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Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Vitamin C supplementation on hepatic oxidative stress induced by cigarette smoke
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Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease
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Genetics of urogenital abnormalities in ACI inbred rats
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Biotransformation of Acrolein in Rat: Excretion of Mercapturic Acids after Inhalation and Intraperitoneal Injection
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Respiratory System and Mesothelium
inferredcites →https://doi.org/10.1007/bf00217067openalex-snapshot
Sex differences in nicotine's effects on consummatory behavior and body weight in rats
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Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains
inferredcites →https://doi.org/10.1007/s00109-007-0253-7openalex-snapshot
Dysfunction of dysferlin-deficient hearts
inferredcites →https://doi.org/10.1007/s00204-018-2215-yopenalex-snapshot
Levels of selected analytes in the emissions of “heat not burn” tobacco products that are relevant to assess human health risks
inferredcites →https://doi.org/10.1007/s10875-010-9459-5openalex-snapshot
Nicotine Stimulated Dendritic Cells Could Achieve Anti-Tumor Effects in Mouse Lung and Liver Cancer
inferredcites →https://doi.org/10.1007/s11739-019-02045-zopenalex-snapshot
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products
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Histologic changes in the respiratory tract induced by inhalation of xenobiotics: Physiologic adaptation or toxicity?
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Nicotinic receptor agonist-induced salivation and its cellular mechanism in parotid acini of rats
inferredcites →https://doi.org/10.1016/j.biocel.2010.08.022openalex-snapshot
Mechanisms involved in lung cancer development in COPD
inferredcites →https://doi.org/10.1016/j.ccr.2009.12.008openalex-snapshot
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
inferredcites →https://doi.org/10.1016/j.fct.2014.02.034openalex-snapshot
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes
inferredcites →https://doi.org/10.1016/j.fct.2015.03.009openalex-snapshot
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
inferredcites →https://doi.org/10.1016/j.fct.2017.09.001openalex-snapshot
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints
inferredcites →https://doi.org/10.1016/j.fct.2019.02.008openalex-snapshot
A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.01.003openalex-snapshot
Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE−/− mouse: Implications for a “multihit” hypothesis of fatty liver disease
inferredcites →https://doi.org/10.1016/j.imlet.2004.06.003openalex-snapshot
Nicotinic environment affects the differentiation and functional maturation of monocytes derived dendritic cells (DCs)
inferredcites →https://doi.org/10.1016/j.jaerosci.2017.12.011openalex-snapshot
Innovative methodology based on the thermo-denuder principle for the detection of combustion-related solid particles or high boiling point droplets: Application to 3R4F cigarette and the Tobacco Heating System THS 2.2
inferredcites →https://doi.org/10.1016/j.lfs.2012.10.004openalex-snapshot
The non-neuronal cholinergic system: Basic science, therapeutic implications and new perspectives
inferredcites →https://doi.org/10.1016/j.lungcan.2011.05.001openalex-snapshot
Neuroglobin and myoglobin in non-small cell lung cancer: Expression, regulation and prognosis
inferredcites →https://doi.org/10.1016/j.molmed.2013.07.001openalex-snapshot
Muscular dystrophies share pathogenetic mechanisms with muscle sarcomas
inferredcites →https://doi.org/10.1016/j.reprotox.2010.12.006openalex-snapshot
Effect of in vitro exposure to benzo[a]pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation
inferredcites →https://doi.org/10.1016/j.tiv.2016.11.009openalex-snapshot
A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures
inferredcites →https://doi.org/10.1016/j.tox.2010.05.005openalex-snapshot
Murine lung tumor response after exposure to cigarette mainstream smoke or its particulate and gas/vapor phase fractions
inferredcites →https://doi.org/10.1016/j.tox.2013.01.005openalex-snapshot
Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse
inferredcites →https://doi.org/10.1016/j.tox.2013.09.013openalex-snapshot
Cigarette smoke induces molecular responses in respiratory tissues of ApoE−/− mice that are progressively deactivated upon cessation
inferredcites →https://doi.org/10.1016/j.yrtph.2016.07.006openalex-snapshot
Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program
inferredcites →https://doi.org/10.1016/j.yrtph.2016.10.001openalex-snapshot
Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol
inferredcites →https://doi.org/10.1016/j.yrtph.2016.10.015openalex-snapshot
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke
inferredcites →https://doi.org/10.1016/j.yrtph.2016.10.016openalex-snapshot
Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol
inferredcites →https://doi.org/10.1016/j.yrtph.2016.11.004openalex-snapshot
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke
inferredcites →https://doi.org/10.1016/j.yrtph.2017.08.017openalex-snapshot
Assessment of novel tobacco heating product THP1.0. Part 7: Comparative in vitro toxicological evaluation
inferredcites →https://doi.org/10.1016/s0022-5347(17)42033-7openalex-snapshot
Congenital Progressive Hydronephrosis in Mice: A New Recessive Mutation
inferredcites →https://doi.org/10.1016/s0278-6915(01)00089-8openalex-snapshot
Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity
inferredcites →https://doi.org/10.1016/s0304-3835(00)00590-5openalex-snapshot
Chemoprevention of lung tumorigenesis induced by a mixture of benzo( a )pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate
inferredcites →https://doi.org/10.1016/s0304-3835(98)00072-xopenalex-snapshot
Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis
inferredcites →https://doi.org/10.1016/s1470-2045(04)01597-9openalex-snapshot
Stress, depression, the immune system, and cancer
inferredcites →https://doi.org/10.1021/acs.chemrestox.5b00321openalex-snapshot
In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette
inferredcites →https://doi.org/10.1021/acs.chemrestox.6b00174openalex-snapshot
Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures
inferredcites →https://doi.org/10.1021/acs.chemrestox.9b00085openalex-snapshot
Comparison of Free Radical Levels in the Aerosol from Conventional Cigarettes, Electronic Cigarettes, and Heat-Not-Burn Tobacco Products
inferredcites →https://doi.org/10.1038/nm.2084openalex-snapshot
Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth
inferredcites →https://doi.org/10.1038/nri803openalex-snapshot
Effects of cigarette smoke on the immune system
inferredcites →https://doi.org/10.1039/c002643copenalex-snapshot
Sorption, desorption, and surface oxidative fate of nicotine
inferredcites →https://doi.org/10.1039/c7tx00152eopenalex-snapshot
Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach
inferredcites →https://doi.org/10.1046/j.1365-2818.1999.00457.xopenalex-snapshot
The efficiency of systematic sampling in stereology — reconsidered
inferredcites →https://doi.org/10.1073/pnas.0508270103openalex-snapshot
Hypoxia-inducible myoglobin expression in nonmuscle tissues
inferredcites →https://doi.org/10.1080/08958370490258372openalex-snapshot
Lung Tumor Response in Strain a Mice Exposed to Tobacco Smoke: Some Dose-Effect Relationships
inferredcites →https://doi.org/10.1080/08958370590922544openalex-snapshot
Mechanisms Involved in A/J Mouse Lung Tumorigenesis Induced by Inhalation of an Environmental Tobacco Smoke Surrogate
inferredcites →https://doi.org/10.1089/neu.2013.2888openalex-snapshot
Determination of Urine 3-HPMA, a Stable Acrolein Metabolite in a Rat Model of Spinal Cord Injury
inferredcites →https://doi.org/10.1093/carcin/13.8.1491openalex-snapshot
Protection against benzo[α]pyrene- and N-nitrosodiethylamineinduced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice
inferredcites →https://doi.org/10.1093/hmg/ddh212openalex-snapshot
Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency
inferredcites →https://doi.org/10.1093/humrep/dep023openalex-snapshot
Cigarette smoke causes follicle loss in mice ovaries at concentrations representative of human exposure
inferredcites →https://doi.org/10.1093/nar/gkr1061openalex-snapshot
Mouse Phenome Database (MPD)
inferredcites →https://doi.org/10.1093/nar/gkx1082openalex-snapshot
Mouse Phenome Database: an integrative database and analysis suite for curated empirical phenotype data from laboratory mice
inferredcites →https://doi.org/10.1093/toxsci/68.2.322openalex-snapshot
A Mouse Lung Tumor Model of Tobacco Smoke Carcinogenesis
inferredcites →https://doi.org/10.1093/toxsci/kfaa132openalex-snapshot
Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
inferredcites →https://doi.org/10.1093/toxsci/kfh175openalex-snapshot
Lung Tumorigenicity in A/J and rasH2 Transgenic Mice Following Mainstream Tobacco Smoke Inhalation
inferredcites →https://doi.org/10.1093/toxsci/kfs312openalex-snapshot
Lung Inflammatory Effects, Tumorigenesis, and Emphysema Development in a Long-Term Inhalation Study with Cigarette Mainstream Smoke in Mice
inferredcites →https://doi.org/10.1093/toxsci/kfv243openalex-snapshot
An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe−/−Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
inferredcites →https://doi.org/10.1096/fj.07-9574lsfopenalex-snapshot
Dose translation from animal to human studies revisited
inferredcites →https://doi.org/10.1111/j.1476-5381.1984.tb16463.xopenalex-snapshot
Some effects of nicotine on food and water intake in undeprived rats
inferredcites →https://doi.org/10.1111/j.1600-065x.2012.01099.xopenalex-snapshot
NF‐κB and the link between inflammation and cancer
inferredcites →https://doi.org/10.1111/j.1600-0668.2011.00737.xopenalex-snapshot
Influence of relative humidity and gaseous ammonia on the nicotine sorption to indoor materials
inferredcites →https://doi.org/10.1124/jpet.109.162610openalex-snapshot
Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model
inferredcites →https://doi.org/10.1152/ajplung.00429.2012openalex-snapshot
Quantitative microscopy of the lung: a problem-based approach. Part 1: basic principles of lung stereology
inferredcites →https://doi.org/10.1158/0008-5472.can-03-3376openalex-snapshot
Classification of Proliferative Pulmonary Lesions of the Mouse
inferredcites →https://doi.org/10.1159/000324601openalex-snapshot
Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights
inferredcites →https://doi.org/10.1164/rccm.200809-1522stopenalex-snapshot
An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure
inferredcites →https://doi.org/10.1172/jci30848openalex-snapshot
Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury
inferredcites →https://doi.org/10.1177/0192623309353423openalex-snapshot
Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract
inferredcites →https://doi.org/10.1177/0192623312466452openalex-snapshot
Interpreting Stress Responses during Routine Toxicity Studies
inferredcites →https://doi.org/10.1177/019262339802600301openalex-snapshot
A Review of Chronic Inhalation Studies with Mainstream Cigarett Smoke in Rats and Mice
inferredcites →https://doi.org/10.1177/0300985811430696openalex-snapshot
Pathobiology of Aging Mice and GEM
inferredcites →https://doi.org/10.1177/0300985815612556openalex-snapshot
Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study
inferredcites →https://doi.org/10.1177/0960327116681653openalex-snapshot
Investigation of solid particles in the mainstream aerosol of the Tobacco Heating System THS2.2 and mainstream smoke of a 3R4F reference cigarette
inferredcites →https://doi.org/10.1186/1757-2215-5-25openalex-snapshot
Cigarette smoke impairs granulosa cell proliferation and oocyte growth after exposure cessation in young Swiss mice: an experimental study
inferredcites →https://doi.org/10.1201/9781420078848openalex-snapshot
The Chemical Components of Tobacco and Tobacco Smoke
inferredcites →https://doi.org/10.1201/b13973openalex-snapshot
The Chemical Components of Tobacco and Tobacco Smoke
inferredcites →https://doi.org/10.1210/en.2012-1750openalex-snapshot
Additive Effects of Nicotine and High-Fat Diet on Hepatic Steatosis in Male Mice
inferredcites →https://doi.org/10.1242/jeb.00243openalex-snapshot
Myoglobin function reassessed
inferredcites →https://doi.org/10.1258/002367777780936512openalex-snapshot
Abnormal urogenital organs occurring spontaneously in inbred ACI and Kyoto-notched rats
inferredcites →https://doi.org/10.1258/ebm.2012.012103openalex-snapshot
Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice
inferredcites →https://doi.org/10.1371/journal.pone.0023498openalex-snapshot
Rhabdomyosarcomas in Aging A/J Mice
inferredcites →https://doi.org/10.1371/journal.pone.0087999openalex-snapshot
Serotonin and Corticosterone Rhythms in Mice Exposed to Cigarette Smoke and in Patients with COPD: Implication for COPD-Associated Neuropathogenesis
inferredcites →https://doi.org/10.1513/annalsats.201808-537mgopenalex-snapshot
Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer
inferredcites →https://doi.org/10.21037/tlcr.2018.06.04openalex-snapshot
Autochthonous murine models for the study of smoker and never-smoker associated lung cancers
inferredcites →https://doi.org/10.2353/ajpath.2009.080930openalex-snapshot
Dysferlin Deficiency and the Development of Cardiomyopathy in a Mouse Model of Limb-Girdle Muscular Dystrophy 2B
inferredcites →https://doi.org/10.2353/ajpath.2009.081124openalex-snapshot
Expression and Functional Regulation of Myoglobin in Epithelial Cancers
inferredcites →https://doi.org/10.2478/cttr-2013-0912openalex-snapshot
Mainstream Smoke Chemistry and in Vitro and In Vivo Toxicity of the Reference Cigarettes 3R4F and 2R4F
inferredcites →https://doi.org/10.2478/intox-2014-0010openalex-snapshot
Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model
inferredcites →https://doi.org/10.3109/08958378.2014.935535openalex-snapshot
Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract
inferredcites →https://doi.org/10.3109/08958378.2015.1046000openalex-snapshot
Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology
inferredcites →https://doi.org/10.4314/njps.v24i1.46374openalex-snapshot
Effect Of Nicotine Administration On Weight And Histology Of Some Vital Visceral Organs In Female Albino Rats
inferredcites →https://doi.org/10.7150/thno.14915openalex-snapshot
CD163-Macrophages Are Involved in Rhabdomyolysis-Induced Kidney Injury and May Be Detected by MRI with Targeted Gold-Coated Iron Oxide Nanoparticles

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Comparative review of chemical composition and toxicological evaluation of heated tobacco products compared to regular combustible cigarettes
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inferred← citeshttps://doi.org/10.1002/jat.4338openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/tox.24405openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.toxrep.2024.101878openalex-snapshot
Inhalation exposure to dihydroxyacetone promotes lung injury and pulmonary fibrosis in A/J mice
inferred← citeshttps://doi.org/10.1093/jat/bkaf031openalex-snapshot
Preparation and stability characterization of flavor ingredients in E-liquids for preclinical assessment of electronic nicotine delivering system products: a case study of 38 flavor ingredients in a single mixture
inferred← citeshttps://doi.org/10.1093/ntr/ntaf189openalex-snapshot
RETRACTED: Critical Appraisal of Animal Studies Assessing Risk of Heated Tobacco Products—A Systematic Review
inferred← citeshttps://doi.org/10.1186/s40001-023-01374-2openalex-snapshot
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inferred← citeshttps://doi.org/10.12688/f1000research.74718.1openalex-snapshot
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inferred← citeshttps://doi.org/10.1293/tox.2024-0069openalex-snapshot
Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes
inferred← citeshttps://doi.org/10.18332/tid/188867openalex-snapshot
A scoping review of the toxicity and health impact of IQOS
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1609234/v1openalex-snapshot
Beneficial Impact of Switching from Cigarette Smoking to Tobacco Heating System Use on Biomarkers of Potential Harm in a Randomized Trial
inferred← citeshttps://doi.org/10.33590/emjcardiol/10124537openalex-snapshot
Heated Tobacco Products and Cardiovascular Disease: A Narrative Review of Peer-Reviewed Publications
inferred← citeshttps://doi.org/10.3389/ftox.2021.634035openalex-snapshot
Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data
inferred← citeshttps://doi.org/10.3389/ftox.2022.747508openalex-snapshot
Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products
inferred← citeshttps://doi.org/10.3389/ftox.2022.878976openalex-snapshot
Toxicological Assessment of Flavor Ingredients in E-Vapor Products
inferred← citeshttps://doi.org/10.3390/antiox15010008openalex-snapshot
Heated Tobacco Products: Emerging Health Outcomes and Insights into Oxidative Stress and Pro-Inflammatory-Driving Mechanisms
inferred← citeshttps://doi.org/10.5937/medrec2002095copenalex-snapshot
Are heated tobacco products (HTPs) a public health opportunity?
inferred← citeshttps://doi.org/10.7759/cureus.111861openalex-snapshot
A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health
inferred← citeshttps://doi.org/10.7759/cureus.61223openalex-snapshot
The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature
inferred← citeshttps://doi.org/10.7759/cureus.65773openalex-snapshot
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