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High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

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Outcome and prognostic markers in severe drug‐induced liver disease†

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Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

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Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

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Entacapone‐Induced Hepatotoxicity and Hepatic Dysfunction

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Influence of tacrolimus on bile acid and lipid composition in continuously drained bile using a rat model

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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

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Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

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Mechanisms and in vitro models of drug-induced cholestasis

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Cholyl-lysylfluorescein: synthesis, biliary excretion in vivo and during single-pass perfusion of isolated perfused rat liver

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Fluorescence-based assays for the assessment of drug interaction with the human transporters OATP1B1 and OATP1B3

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The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks

inferredcites →https://doi.org/10.1016/j.cbi.2016.03.019openalex-snapshot

Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse

inferredcites →https://doi.org/10.1016/j.cld.2007.11.010openalex-snapshot

Mechanisms of Cholestasis

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Appropriate risk criteria for OATP inhibition at the drug discovery stage based on the clinical relevancy between OATP inhibitors and drug-induced adverse effect

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A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity

inferredcites →https://doi.org/10.1016/j.ejpb.2005.06.001openalex-snapshot

Development of a fluorescence-based assay for screening of modulators of human Organic Anion Transporter 1B3 (OATP1B3)

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Growth and differentiation of colony-forming human hepatocytes in vitro

inferredcites →https://doi.org/10.1016/j.taap.2013.10.032openalex-snapshot

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

inferredcites →https://doi.org/10.1016/j.tiv.2009.08.009openalex-snapshot

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

inferredcites →https://doi.org/10.1016/j.tiv.2016.03.008openalex-snapshot

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

inferredcites →https://doi.org/10.1016/j.tiv.2016.05.016openalex-snapshot

Inhibition of bile canalicular network formation in rat sandwich cultured hepatocytes by drugs associated with risk of severe liver injury

inferredcites →https://doi.org/10.1016/j.tiv.2018.01.019openalex-snapshot

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

inferredcites →https://doi.org/10.1016/j.toxrep.2016.01.009openalex-snapshot

ABC gene-ranking for prediction of drug-induced cholestasis in rats

inferredcites →https://doi.org/10.1016/j.xphs.2017.04.050openalex-snapshot

Metabolic Activation of Cholestatic Drug-Induced Bile Acid-Dependent Toxicity in Human Sandwich-Cultured Hepatocytes

inferredcites →https://doi.org/10.1016/s0002-9440(10)63352-4openalex-snapshot

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

inferredcites →https://doi.org/10.1021/acs.chemrestox.7b00048openalex-snapshot

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals

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Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

inferredcites →https://doi.org/10.1038/srep35434openalex-snapshot

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

inferredcites →https://doi.org/10.1042/bj2750501openalex-snapshot

Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis

inferredcites →https://doi.org/10.1053/j.gastro.2006.11.023openalex-snapshot

Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes

inferredcites →https://doi.org/10.1053/j.gastro.2011.07.042openalex-snapshot

Complementary Functions of the Flippase ATP8B1 and the Floppase ABCB4 in Maintaining Canalicular Membrane Integrity

inferredcites →https://doi.org/10.1073/pnas.95.1.282openalex-snapshot

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

inferredcites →https://doi.org/10.1089/aivt.2015.0014openalex-snapshot

High-Content Imaging in Human and Rat Hepatocytes Using the Fluorescent Dyes CLF and CMFDA Is Not Specific Enough to Assess BSEP/Bsep and/or MRP2/Mrp2 Inhibition by Cholestatic Drugs

inferredcites →https://doi.org/10.1093/toxsci/kft176openalex-snapshot

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

inferredcites →https://doi.org/10.1093/toxsci/kft197openalex-snapshot

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

inferredcites →https://doi.org/10.1093/toxsci/kfv159openalex-snapshot

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

inferredcites →https://doi.org/10.1093/toxsci/kfx060openalex-snapshot

In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties

inferredcites →https://doi.org/10.1093/toxsci/kfx284openalex-snapshot

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

inferredcites →https://doi.org/10.1093/toxsci/kfy058openalex-snapshot

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

inferredcites →https://doi.org/10.1097/01.fpc.0000236337.41799.b3openalex-snapshot

MRP2 haplotypes confer differential susceptibility to toxic liver injury

inferredcites →https://doi.org/10.1111/j.1572-0241.2007.01515.xopenalex-snapshot

Hepatotoxicity of 6-Mercaptopurine (6-MP) and Azathioprine (AZA) in Adult IBD Patients

inferredcites →https://doi.org/10.1124/dmd.108.024778openalex-snapshot

Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

inferredcites →https://doi.org/10.1124/dmd.111.040758openalex-snapshot

In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

inferredcites →https://doi.org/10.1124/dmd.113.054304openalex-snapshot

Risk Factors for Development of Cholestatic Drug-Induced Liver Injury: Inhibition of Hepatic Basolateral Bile Acid Transporters Multidrug Resistance-Associated Proteins 3 and 4

inferredcites →https://doi.org/10.1124/dmd.118.082719openalex-snapshot

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inferredcites →https://doi.org/10.1124/jpet.107.135483openalex-snapshot

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

inferredcites →https://doi.org/10.1124/jpet.110.166991openalex-snapshot

Hepatic Transport Mechanisms of Cholyl-l-Lysyl-Fluorescein

inferredcites →https://doi.org/10.1186/s12916-016-0553-2openalex-snapshot

Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

inferredcites →https://doi.org/10.1242/jcs.068098openalex-snapshot

Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1

inferredcites →https://doi.org/10.1248/bpb.26.1052openalex-snapshot

Effects of Dimethyl Sulfoxide on the Gene Induction of Cytochrome P450 Isoforms, UGT-Dependent Glucuronosyl Transferase Isoforms, and ABCB1 in Primary Culture of Human Hepatocytes

inferredcites →https://doi.org/10.1248/bpb.30.739openalex-snapshot

Involvement of Bile Salt Export Pump in Flutamide-Induced Cholestatic Hepatitis

inferredcites →https://doi.org/10.1373/clinchem.2005.050831openalex-snapshot

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Erythrocyte Thiopurine Nucleotides and Effect of Thiopurine Methyltransferase Gene Variants on These Metabolites in Patients Receiving Azathioprine/6-Mercaptopurine Therapy

inferredcites →https://doi.org/10.14814/phy2.12944openalex-snapshot

Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)

inferredcites →https://doi.org/10.1517/17425255.2013.741589openalex-snapshot

Species differences in drug transporters and implications for translating preclinical findings to humans

inferredcites →https://doi.org/10.2131/jts.42.427openalex-snapshot

Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics

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In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

inferredcites →https://doi.org/10.2337/db07-1515openalex-snapshot

Interaction of Oral Antidiabetic Drugs With Hepatic Uptake Transporters

inferredcites →https://doi.org/10.3748/wjg.v16.i1.1openalex-snapshot

Hepatocyte cryopreservation: is it time to change the strategy?

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Identification of a compound heterozygous mutation of ABCC2 in a patient with hyperbilirubinemia

inferredcites →https://doi.org/10.4161/sgtp.18087openalex-snapshot

Cellular mechanism of bile acid-accelerated hepatocyte polarity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Mechanism‐Based Experimental Models for the Evaluation of BSEP Inhibition and DILI

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Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies

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Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives

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