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mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

https://doi.org/10.1096/fj.15-278606
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470151808.sc02f01s12openalex-snapshot
In Situ Hybridization to Identify Gut Stem Cells
inferredcites →https://doi.org/10.1002/9780470151808.sc02f01s34openalex-snapshot
In Situ Hybridization to Identify Gut Stem Cells
inferredcites →https://doi.org/10.1002/9781118399668openalex-snapshot
Morson and Dawson's Gastrointestinal Pathology
inferredcites →https://doi.org/10.1002/gene.20042openalex-snapshot
Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium
inferredcites →https://doi.org/10.1002/stem.1655openalex-snapshot
Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location‐Specific Function
inferredcites →https://doi.org/10.1002/wdev.48openalex-snapshot
Control of adult stem cells in vivo by a dynamic physiological environment: diet‐dependent systemic factors in Drosophila and beyond
inferredcites →https://doi.org/10.1007/s10555-014-9495-3openalex-snapshot
Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation
inferredcites →https://doi.org/10.1016/j.canlet.2012.01.005openalex-snapshot
mTOR inhibitors in cancer therapy
inferredcites →https://doi.org/10.1016/j.cell.2008.07.021openalex-snapshot
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1016/j.cell.2011.08.048openalex-snapshot
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
inferredcites →https://doi.org/10.1016/j.cell.2012.03.017openalex-snapshot
mTOR Signaling in Growth Control and Disease
inferredcites →https://doi.org/10.1016/j.cmet.2008.10.002openalex-snapshot
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
inferredcites →https://doi.org/10.1016/j.coph.2013.09.014openalex-snapshot
Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery
inferredcites →https://doi.org/10.1016/j.devcel.2006.08.013openalex-snapshot
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
inferredcites →https://doi.org/10.1016/j.devcel.2010.07.015openalex-snapshot
Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling
inferredcites →https://doi.org/10.1016/j.jss.2012.03.037openalex-snapshot
Intestinal crypts reproducibly expand in culture
inferredcites →https://doi.org/10.1016/j.molmed.2007.04.002openalex-snapshot
mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer
inferredcites →https://doi.org/10.1016/j.physbeh.2014.03.026openalex-snapshot
Nutrient-induced intestinal adaption and its effect in obesity
inferredcites →https://doi.org/10.1016/j.regpep.2014.01.002openalex-snapshot
The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat
inferredcites →https://doi.org/10.1016/j.stem.2012.06.009openalex-snapshot
mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis
inferredcites →https://doi.org/10.1016/j.stem.2013.11.008openalex-snapshot
Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration
inferredcites →https://doi.org/10.1016/j.stem.2014.12.006openalex-snapshot
Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts
inferredcites →https://doi.org/10.1016/j.stemcr.2014.05.018openalex-snapshot
Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus
inferredcites →https://doi.org/10.1016/j.tcb.2012.02.006openalex-snapshot
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
inferredcites →https://doi.org/10.1016/j.yexcr.2011.09.006openalex-snapshot
Intestinal development and differentiation
inferredcites →https://doi.org/10.1016/s0344-0338(98)80063-0openalex-snapshot
The Role of Enterocytes in Gut Dysfunction
inferredcites →https://doi.org/10.1016/s0960-9822(06)00122-9openalex-snapshot
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
inferredcites →https://doi.org/10.1038/nature06196openalex-snapshot
Identification of stem cells in small intestine and colon by marker gene Lgr5
inferredcites →https://doi.org/10.1038/nature09584openalex-snapshot
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
inferredcites →https://doi.org/10.1038/nature09637openalex-snapshot
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
inferredcites →https://doi.org/10.1038/nature10337openalex-snapshot
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
inferredcites →https://doi.org/10.1038/nature11163openalex-snapshot
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
inferredcites →https://doi.org/10.1038/nature13896openalex-snapshot
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth
inferredcites →https://doi.org/10.1038/nature14484openalex-snapshot
Cloning and variation of ground state intestinal stem cells
inferredcites →https://doi.org/10.1053/gast.2002.32975openalex-snapshot
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
inferredcites →https://doi.org/10.1053/j.gastro.2007.05.020openalex-snapshot
SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium
inferredcites →https://doi.org/10.1053/j.gastro.2012.07.106openalex-snapshot
Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant
inferredcites →https://doi.org/10.1053/j.gastro.2012.08.031openalex-snapshot
Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells
inferredcites →https://doi.org/10.1053/j.gastro.2014.05.007openalex-snapshot
Stem Cells Marked by the R-Spondin Receptor LGR5
inferredcites →https://doi.org/10.1073/pnas.0800041105openalex-snapshot
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc Δ716 mice
inferredcites →https://doi.org/10.1073/pnas.1118857109openalex-snapshot
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
inferredcites →https://doi.org/10.1073/pnas.1201652109openalex-snapshot
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)
inferredcites →https://doi.org/10.1074/jbc.272.38.23729openalex-snapshot
Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice
inferredcites →https://doi.org/10.1083/jcb.200903131openalex-snapshot
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
inferredcites →https://doi.org/10.1101/gad.1353905openalex-snapshot
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
inferredcites →https://doi.org/10.1126/science.1218370openalex-snapshot
Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells
inferredcites →https://doi.org/10.1126/science.1234852openalex-snapshot
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
inferredcites →https://doi.org/10.1128/mcb.00124-06openalex-snapshot
Gata4 Is Essential for the Maintenance of Jejunal-Ileal Identities in the Adult Mouse Small Intestine
inferredcites →https://doi.org/10.1128/mcb.23.21.7525-7530.2003openalex-snapshot
Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice
inferredcites →https://doi.org/10.1128/mcb.24.21.9508-9516.2004openalex-snapshot
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
inferredcites →https://doi.org/10.1136/gut.40.1.5openalex-snapshot
Regional expression of intestinal genes for nutrient absorption.
inferredcites →https://doi.org/10.1210/en.2004-0051openalex-snapshot
Minireview: Development and Differentiation of Gut Endocrine Cells
inferredcites →https://doi.org/10.1242/dev.050351openalex-snapshot
Specific roles of Target of rapamycin in the control of stem cells and their progeny in theDrosophilaovary
inferredcites →https://doi.org/10.1242/dev.058230openalex-snapshot
An emerging role for TOR signaling in mammalian tissue and stem cell physiology
inferredcites →https://doi.org/10.1242/dev.070763openalex-snapshot
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
inferredcites →https://doi.org/10.1242/dev.104018openalex-snapshot
Specification of regional intestinal stem cell identity during Drosophila metamorphosis
inferredcites →https://doi.org/10.1242/jcs.02724openalex-snapshot
Protein kinase B/Akt at a glance
inferredcites →https://doi.org/10.1371/journal.pgen.1002619openalex-snapshot
SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians
inferredcites →https://doi.org/10.18632/oncotarget.1548openalex-snapshot
mTOR pathway in colorectal cancer: an update
inferredcites →https://doi.org/10.2337/db11-0765openalex-snapshot
l -Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway
inferredcites →https://doi.org/10.3324/haematol.2012.080424openalex-snapshot
Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
inferredcites →https://doi.org/10.3945/an.111.000976openalex-snapshot
Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4465495openalex-extracted
inferred← citeshttps://doi.org/10.1002/cphy.c170038openalex-snapshot
Proton Coupled Oligopeptide Transporter 1 (PepT1) Function, Regulation, and Influence on the Intestinal Homeostasis
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2018.tb00027.xopenalex-snapshot
Proton Coupled Oligopeptide Transporter 1 (PepT1) Function, Regulation, and Influence on the Intestinal Homeostasis
inferred← citeshttps://doi.org/10.1002/jcp.28542openalex-snapshot
mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation
inferred← citeshttps://doi.org/10.1002/mnfr.202300704openalex-snapshot
L‐Glutamine Substantially Improves 5‐Fluorouracil‐Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice
inferred← citeshttps://doi.org/10.1002/stem.3036openalex-snapshot
Inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response
inferred← citeshttps://doi.org/10.1007/978-3-319-90578-5_23openalex-snapshot
Anti-Fibrotic Therapies from Other Organs: What the Gut Can Learn from the Liver, Skin, Lung and Heart
inferred← citeshttps://doi.org/10.1007/s00018-019-03085-6openalex-snapshot
Role of mTORC1 in intestinal epithelial repair and tumorigenesis
inferred← citeshttps://doi.org/10.1007/s12015-020-10073-yopenalex-snapshot
Signaling Network Centered on mTORC1 Dominates Mammalian Intestinal Stem Cell Ageing
inferred← citeshttps://doi.org/10.1007/s40778-017-0103-7openalex-snapshot
The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury
inferred← citeshttps://doi.org/10.1016/j.ajpath.2025.12.011openalex-snapshot
Colitogenic Environment Suppresses Notch/Mechanistic Target of Rapamycin–Mediated Epithelial Proliferation to Promote Goblet Cell Differentiation in the Colon
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2020.736281openalex-snapshot
Growth and metabolic responses of grouper juveniles (Epinephelus coioides) fed diets containing varying levels of leucine
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.110009openalex-snapshot
CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113975openalex-snapshot
SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
inferred← citeshttps://doi.org/10.1016/j.chom.2019.03.012openalex-snapshot
Nutrient Sensing by the Intestinal Epithelium Orchestrates Mucosal Antimicrobial Defense via Translational Control of Hes1
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.11.006openalex-snapshot
mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.110523openalex-snapshot
The effects of chronic cadmium exposure on the gut of Bufo gargarizans larvae at metamorphic climax: Histopathological impairments, microbiota changes and intestinal remodeling disruption
inferred← citeshttps://doi.org/10.1016/j.fsi.2020.09.014openalex-snapshot
New insights into the immune regulation and tissue repair of Litopenaeus vannamei during temperature fluctuation using TMT-based proteomics
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.109060openalex-snapshot
Comprehensive study on the effect of dietary leucine supplementation on intestinal physiology, TOR signaling and microbiota in juvenile turbot (Scophthalmus maximus L.)
inferred← citeshttps://doi.org/10.1016/j.isci.2019.10.011openalex-snapshot
Diet, Microbiota, and Colorectal Cancer
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109912openalex-snapshot
Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2016.10.006openalex-snapshot
Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2020.02.007openalex-snapshot
A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2020.05.013openalex-snapshot
Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2022.109087openalex-snapshot
Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells
inferred← citeshttps://doi.org/10.1016/j.jpba.2026.117685openalex-snapshot
Unravelling metabolites conferring intestinal protection in asymptomatic first-degree relatives of patients with celiac disease
inferred← citeshttps://doi.org/10.1016/j.mce.2025.112607openalex-snapshot
Enteroendocrine cell differentiation: Implications for human disease
inferred← citeshttps://doi.org/10.1016/j.mcpro.2021.100107openalex-snapshot
Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101546openalex-snapshot
Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity
inferred← citeshttps://doi.org/10.1016/j.psj.2023.102773openalex-snapshot
The effects of arginine and branched-chain amino acid supplementation to reduced-protein diet on intestinal health, cecal short-chain fatty acid profiles, and immune response in broiler chickens challenged with Eimeria spp.
inferred← citeshttps://doi.org/10.1016/j.stem.2024.05.009openalex-snapshot
Activation of fetal-like molecular programs during regeneration in the intestine and beyond
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.01.026openalex-snapshot
Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells
inferred← citeshttps://doi.org/10.1017/s0954422421000172openalex-snapshot
Modulation of intestinal stem cell homeostasis by nutrients: a novel therapeutic option for intestinal diseases
inferred← citeshttps://doi.org/10.1017/s1751731117003342openalex-snapshot
Leucine alters immunoglobulin a secretion and inflammatory cytokine expression induced by lipopolysaccharide via the nuclear factor-κB pathway in intestine of chicken embryos
inferred← citeshttps://doi.org/10.1038/ncb3385openalex-snapshot
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
inferred← citeshttps://doi.org/10.1038/s41385-021-00399-2openalex-snapshot
Emc3 maintains intestinal homeostasis by preserving secretory lineages
inferred← citeshttps://doi.org/10.1038/s41392-025-02476-5openalex-snapshot
Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury
inferred← citeshttps://doi.org/10.1038/s41467-018-05450-8openalex-snapshot
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
inferred← citeshttps://doi.org/10.1038/s41467-019-13911-xopenalex-snapshot
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
inferred← citeshttps://doi.org/10.1038/s41467-021-24792-4openalex-snapshot
The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
inferred← citeshttps://doi.org/10.1038/s41467-025-65180-6openalex-snapshot
The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration
inferred← citeshttps://doi.org/10.1038/s41575-018-0021-xopenalex-snapshot
Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis
inferred← citeshttps://doi.org/10.1038/s41598-017-06070-wopenalex-snapshot
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine
inferred← citeshttps://doi.org/10.1038/s41598-025-09278-3openalex-snapshot
Comparative effects of dietary sodium butyrate and tributyrin on broiler chickens’ performance, gene expression, intestinal histomorphometry, blood indices, and litter
inferred← citeshttps://doi.org/10.1038/s42003-020-01347-9openalex-snapshot
Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b
inferred← citeshttps://doi.org/10.1039/c9ra07742aopenalex-snapshot
Uridine inhibits the stemness of intestinal stem cells in 3D intestinal organoids and mice
inferred← citeshttps://doi.org/10.1053/j.gastro.2023.09.012openalex-snapshot
CXADR-Like Membrane Protein Regulates Colonic Epithelial Cell Proliferation and Prevents Tumor Growth
inferred← citeshttps://doi.org/10.1073/pnas.1621400114openalex-snapshot
Creatine maintains intestinal homeostasis and protects against colitis
inferred← citeshttps://doi.org/10.1073/pnas.1809575115openalex-snapshot
Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism
inferred← citeshttps://doi.org/10.1073/pnas.2426742122openalex-snapshot
Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1080/15548627.2021.1909406openalex-snapshot
How autophagy controls the intestinal epithelial barrier
inferred← citeshttps://doi.org/10.1080/1828051x.2021.2016509openalex-snapshot
Effects of probiotic feed additives (biosol and Zemos) on growth and related genes in broiler chickens
inferred← citeshttps://doi.org/10.1080/21541248.2021.1882832openalex-snapshot
Investigating increased hematopoietic stem cell fitness in a novel mouse model
inferred← citeshttps://doi.org/10.1089/ars.2020.8240openalex-snapshot
Microbiome Profile and Molecular Pathways Alterations in Gastrointestinal Tract by Hydrogen Sulfide-Releasing Nonsteroidal Anti-Inflammatory Drug (ATB-352): Insight into Possible Safer Polypharmacy
inferred← citeshttps://doi.org/10.1093/intimm/dxaa015openalex-snapshot
Metabolic and immunologic control of intestinal cell function by mTOR
inferred← citeshttps://doi.org/10.1096/fj.202301833rropenalex-snapshot
mTORC2‐AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells
inferred← citeshttps://doi.org/10.1097/mog.0000000000000540openalex-snapshot
The cyclical hit model
inferred← citeshttps://doi.org/10.1101/2022.12.22.521159openalex-snapshot
Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche
inferred← citeshttps://doi.org/10.1101/2023.01.24.524966openalex-snapshot
Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response
inferred← citeshttps://doi.org/10.1101/2023.05.13.540666openalex-snapshot
Paneth and Paneth-like cells undergoing necroptosis fuel intestinal epithelial cell proliferation following IFN-γ stimulation
inferred← citeshttps://doi.org/10.1101/2023.10.13.562288openalex-snapshot
Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps
inferred← citeshttps://doi.org/10.1101/2025.06.18.25329871openalex-snapshot
Tracing Early Molecular Drivers of Gastrinoma in MEN1: A Systematic Review for Precision Surveillance and Improved Patient Outcomes
inferred← citeshttps://doi.org/10.1101/364133openalex-snapshot
Gfi1-expressing Paneth cells revert to stem cells following intestinal injury
inferred← citeshttps://doi.org/10.1111/boc.70076openalex-snapshot
AP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids
inferred← citeshttps://doi.org/10.1111/cas.14702openalex-snapshot
Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis
inferred← citeshttps://doi.org/10.1111/jam.14464openalex-snapshot
Dietary leucine supplementation improves intestinal health of mice through intestinal SIgA secretion
inferred← citeshttps://doi.org/10.1111/jgh.15656openalex-snapshot
Recombinant soluble thrombomodulin accelerates epithelial stem cell proliferation in mouse intestinal organoids and promotes the mucosal healing in colitis
inferred← citeshttps://doi.org/10.1128/cmr.00178-24openalex-snapshot
Immunosuppressant imprecision: multidirectional effects on metabolism and microbiome
inferred← citeshttps://doi.org/10.1152/ajpgi.00126.2023openalex-snapshot
Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine
inferred← citeshttps://doi.org/10.1152/ajpgi.00403.2017openalex-snapshot
RNA regulons are essential in intestinal homeostasis
inferred← citeshttps://doi.org/10.1155/2019/1862531openalex-snapshot
Manipulation of Intestinal Antiviral Innate Immunity and Immune Evasion Strategies of Porcine Epidemic Diarrhea Virus
inferred← citeshttps://doi.org/10.1172/jci133264openalex-snapshot
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer
inferred← citeshttps://doi.org/10.1186/s12864-021-07951-1openalex-snapshot
Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide
inferred← citeshttps://doi.org/10.1186/s12929-025-01119-9openalex-snapshot
EGF receptor in organ development, tissue homeostasis and regeneration
inferred← citeshttps://doi.org/10.1186/s13287-020-01857-7openalex-snapshot
Plasticity of Paneth cells and their ability to regulate intestinal stem cells
inferred← citeshttps://doi.org/10.1186/s40104-019-0334-9openalex-snapshot
Influence of starch sources and dietary protein levels on intestinal functionality and intestinal mucosal amino acids catabolism in broiler chickens
inferred← citeshttps://doi.org/10.1186/s40104-024-01041-4openalex-snapshot
Effects of methionine supplementation in a reduced protein diet on growth performance, oxidative status, intestinal health, oocyst shedding, and methionine and folate metabolism in broilers under Eimeria challenge
inferred← citeshttps://doi.org/10.1186/s40659-023-00444-3openalex-snapshot
Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus
inferred← citeshttps://doi.org/10.1242/dev.137992openalex-snapshot
A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis
inferred← citeshttps://doi.org/10.1247/csf.20018openalex-snapshot
p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine
inferred← citeshttps://doi.org/10.1371/journal.pbio.2002417openalex-snapshot
The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile
inferred← citeshttps://doi.org/10.15252/embr.202050047openalex-snapshot
Ageing, metabolism and the intestine
inferred← citeshttps://doi.org/10.1667/rr14830.1openalex-snapshot
Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury
inferred← citeshttps://doi.org/10.21203/rs.3.rs-108513/v1openalex-snapshot
Hyperbaric oxygen treatment increases intestinal stem cell proliferation through mTORc1 signaling in Mus musculus
inferred← citeshttps://doi.org/10.26508/lsa.202403090openalex-snapshot
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer
inferred← citeshttps://doi.org/10.31435/ijitss.1(49).2026.4898openalex-snapshot
CREATINE SUPPLEMENTATION IN INFLAMMATORY BOWEL DISEASE: LITERATURE REVIEW
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1889686openalex-snapshot
Unraveling the pleiotropic roles of the mTOR-glycolytic axis in ulcerative colitis: from immunometabolic dysregulation to mucosal barrier remodeling
inferred← citeshttps://doi.org/10.3389/fnut.2024.1423576openalex-snapshot
Maternal docosahexaenoic acid supplementation during lactation improves exercise performance, enhances intestinal glucose absorption and modulates gut microbiota in weaning offspring mice
inferred← citeshttps://doi.org/10.3389/fvets.2020.572142openalex-snapshot
Effect of Probiotics and Multi-Component Feed Additives on Microbiota, Gut Barrier and Immune Responses in Broiler Chickens During Subclinical Necrotic Enteritis
inferred← citeshttps://doi.org/10.3390/ani13182949openalex-snapshot
The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review
inferred← citeshttps://doi.org/10.3390/cells11071130openalex-snapshot
ROCK ‘n TOR: An Outlook on Keratinocyte Stem Cell Expansion in Regenerative Medicine via Protein Kinase Inhibition
inferred← citeshttps://doi.org/10.3390/cells12162078openalex-snapshot
Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development
inferred← citeshttps://doi.org/10.3390/ijms21238890openalex-snapshot
Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface
inferred← citeshttps://doi.org/10.3390/ijms232012470openalex-snapshot
mTOR as a Potential Target for the Treatment of Microbial Infections, Inflammatory Bowel Diseases, and Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/ijms252111526openalex-snapshot
Comparative Analysis of Commercial and Home-Made Media on RSPO1/S6R Axis in Organoids with Different Wnt Backgrounds: A Methodological Guide for the Selection of Intestinal Patient-Derived Organoids Culture Media
inferred← citeshttps://doi.org/10.3390/ijms252312679openalex-snapshot
Network-Based Bioinformatics Highlights Broad Importance of Human Milk Hyaluronan
inferred← citeshttps://doi.org/10.3390/microorganisms13040762openalex-snapshot
The Mechanistic Target of Rapamycin Mediates Clostridium perfringens-Induced Chicken Necrotic Enteritis Attenuated by Secondary Bile Acid Deoxycholic Acid
inferred← citeshttps://doi.org/10.3390/nu13062030openalex-snapshot
Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice
inferred← citeshttps://doi.org/10.3892/etm.2021.10270openalex-snapshot
miR‑125b‑5p inhibits cell proliferation by targeting ASCT2 and regulating the PI3K/AKT/mTOR pathway in an LPS‑induced intestinal mucosa cell injury model
inferred← citeshttps://doi.org/10.3892/mmr.2018.8971openalex-snapshot
Helicobacter�pylori infection impairs gastric epithelial barrier function via microRNA‑100‑mediated mTOR signaling inhibition
inferred← citeshttps://doi.org/10.3945/an.116.013276openalex-snapshot
Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting
inferred← citeshttps://doi.org/10.4049/jimmunol.1701148openalex-snapshot
miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus–Infected Rhesus Macaques
inferred← citeshttps://doi.org/10.4252/wjsc.v15.i5.354openalex-snapshot
Modulation of stem cell fate in intestinal homeostasis, injury and repair
inferred← citeshttps://doi.org/10.6084/m9.figshare.26603866openalex-snapshot
Additional file 1 of Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus
inferred← citeshttps://doi.org/10.6084/m9.figshare.26603869openalex-snapshot
Additional file 2 of Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus
inferred← citeshttps://doi.org/10.70675/705c7be2z0d56z4f71z877bz8333490d3004openalex-snapshot
Bénéfices thérapeutiques des cellules Muse dans le modèle murin de syndrome gastro-intestinal aigu (SGIA) radio-induit
inferred← citeshttps://doi.org/10.70675/baa79427z3972z46a0zbf49zb12b1554e87fopenalex-snapshot
La fonction suppresseur de tumeur de la protéine adaptatrice SLAP dans le cancer colorectal implique la régulation de la signalisation mTORC2
inferred← citeshttps://doi.org/10.7150/ijbs.94297openalex-snapshot
Amino acid transporter SLC7A5 regulates cell proliferation and secretary cell differentiation and distribution in the mouse intestine
inferred← citeshttps://doi.org/10.7554/elife.60478openalex-snapshot
IFN-γ mediates Paneth cell death via suppression of mTOR
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