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Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration

https://doi.org/10.1096/fj.202100584rr
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.299.18.2164openalex-snapshot
Effect of Clopidogrel on Early Failure of Arteriovenous Fistulas for Hemodialysis
inferredcites →https://doi.org/10.1006/geno.1999.5831openalex-snapshot
Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes
inferredcites →https://doi.org/10.1007/s00109-016-1448-6openalex-snapshot
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2
inferredcites →https://doi.org/10.1007/s00395-014-0431-zopenalex-snapshot
Smooth muscle cells from the anastomosed artery are the major precursors for neointima formation in both artery and vein grafts
inferredcites →https://doi.org/10.1007/s11010-011-0846-xopenalex-snapshot
Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway
inferredcites →https://doi.org/10.1016/j.cytogfr.2004.03.004openalex-snapshot
PDGF and cardiovascular disease
inferredcites →https://doi.org/10.1016/j.febslet.2012.03.005openalex-snapshot
SnoN in regulation of embryonic development and tissue morphogenesis
inferredcites →https://doi.org/10.1016/j.jocn.2010.11.009openalex-snapshot
Mitotic arrest deficient protein MAD2B is overexpressed in human glioma, with depletion enhancing sensitivity to ionizing radiation
inferredcites →https://doi.org/10.1016/j.jvs.2016.01.053openalex-snapshot
Outcomes of vascular access for hemodialysis: A systematic review and meta-analysis
inferredcites →https://doi.org/10.1016/j.kint.2015.12.019openalex-snapshot
The molecular mechanisms of hemodialysis vascular access failure
inferredcites →https://doi.org/10.1016/j.mcn.2007.01.002openalex-snapshot
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
inferredcites →https://doi.org/10.1016/j.mod.2006.12.006openalex-snapshot
Drosophila SnoN modulates growth and patterning by antagonizing TGF-β signalling
inferredcites →https://doi.org/10.1016/j.neuron.2006.03.034openalex-snapshot
Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN
inferredcites →https://doi.org/10.1016/j.semcdb.2011.03.012openalex-snapshot
The emerging role of APC/CCdh1 in development
inferredcites →https://doi.org/10.1016/j.ydbio.2007.02.039openalex-snapshot
Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila
inferredcites →https://doi.org/10.1016/s0140-6736(02)07751-6openalex-snapshot
Viewpoint Overcoming restenosis with sirolimus: from alphabet soup to clinical reality
inferredcites →https://doi.org/10.1016/s0140-6736(14)60405-0openalex-snapshot
Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study): a multicentre, open-label, randomised superiority trial
inferredcites →https://doi.org/10.1016/s0140-6736(14)61601-9openalex-snapshot
Worldwide access to treatment for end-stage kidney disease: a systematic review
inferredcites →https://doi.org/10.1016/s0140-6736(19)31877-xopenalex-snapshot
Biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with ST-segment elevation myocardial infarction (BIOSTEMI): a single-blind, prospective, randomised superiority trial
inferredcites →https://doi.org/10.1016/s0749-4041(08)79037-7openalex-snapshot
Effect of Clopidogrel on Early Failure of Arteriovenous Fistulas for Hemodialysis: A Randomized Controlled Trial
inferredcites →https://doi.org/10.1016/s1097-2765(01)00382-3openalex-snapshot
The Anaphase-Promoting Complex Mediates TGF-β Signaling by Targeting SnoN for Destruction
inferredcites →https://doi.org/10.1038/cr.2008.324openalex-snapshot
Ski and SnoN, potent negative regulators of TGF-β signaling
inferredcites →https://doi.org/10.1038/ki.2015.73openalex-snapshot
Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima
inferredcites →https://doi.org/10.1038/labinvest.3700344openalex-snapshot
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues
inferredcites →https://doi.org/10.1038/nature02330openalex-snapshot
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
inferredcites →https://doi.org/10.1074/jbc.m500375200openalex-snapshot
MAGI1 Recruits Dll1 to Cadherin-based Adherens Junctions and Stabilizes It on the Cell Surface
inferredcites →https://doi.org/10.1083/jcb.201302060openalex-snapshot
Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset
inferredcites →https://doi.org/10.1093/cvr/cvx190openalex-snapshot
Semaphorin-3E attenuates neointimal formation via suppressing VSMCs migration and proliferation
inferredcites →https://doi.org/10.1093/nar/17.14.5489openalex-snapshot
Isolation of human cDNA clones ofskiand the ski-related gene,sno
inferredcites →https://doi.org/10.1096/fj.201800437ropenalex-snapshot
Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas
inferredcites →https://doi.org/10.1101/gad.898701openalex-snapshot
MAD2B is an inhibitor of the anaphase-promoting complex
inferredcites →https://doi.org/10.1101/gr.203201openalex-snapshot
Systematic Identification of Novel Protein Domain Families Associated with Nuclear Functions
inferredcites →https://doi.org/10.1111/cas.12390openalex-snapshot
Suppression of REV 7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells
inferredcites →https://doi.org/10.1152/ajpcell.00526.2003openalex-snapshot
Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. Focus on “The mTOR/p70 S6K1 pathway regulates vascular smooth muscle differentiation”
inferredcites →https://doi.org/10.1152/ajprenal.00409.2014openalex-snapshot
MAD2B contributes to podocyte injury of diabetic nephropathy via inducing cyclin B1 and Skp2 accumulation
inferredcites →https://doi.org/10.1152/ajprenal.00600.2015openalex-snapshot
MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis
inferredcites →https://doi.org/10.1152/physrev.00041.2003openalex-snapshot
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
inferredcites →https://doi.org/10.1158/0008-5472.can-05-3602openalex-snapshot
Inactivation of Human MAD2B in Nasopharyngeal Carcinoma Cells Leads to Chemosensitization to DNA-Damaging Agents
inferredcites →https://doi.org/10.1161/01.cir.103.24.2967openalex-snapshot
Role for p27 Kip1 in Vascular Smooth Muscle Cell Migration
inferredcites →https://doi.org/10.1161/jaha.116.004891openalex-snapshot
Dual Function for Mature Vascular Smooth Muscle Cells During Arteriovenous Fistula Remodeling
inferredcites →https://doi.org/10.1371/journal.pone.0056774openalex-snapshot
Tanshinone IIA Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via Akt/Skp2/p27-Associated Pathway
inferredcites →https://doi.org/10.2215/cjn.02030216openalex-snapshot
New Insights into Dialysis Vascular Access: Molecular Targets in Arteriovenous Fistula and Arteriovenous Graft Failure and Their Potential to Improve Vascular Access Outcomes
inferredcites →https://doi.org/10.2741/3802openalex-snapshot
Proliferation unleashed: The role of Skp2 in vascular smooth muscle cell proliferation
inferredcites →https://doi.org/10.3390/ijms17060844openalex-snapshot
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27Kip1 Signaling Pathway
inferredcites →https://doi.org/10.3727/096504017x15049209129277openalex-snapshot
Mitotic Arrest-Deficient Protein 2B Overexpressed in Lung Cancer Promotes Proliferation, EMT, and Metastasis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4485600openalex-extracted
CTSG Promotes AVF Maturation by Positively Regulating the MMP2/MMP9 Pathway
inferred← citeshttps://doi.org/10.1002/adbi.202400437openalex-snapshot
The Role of Luteolin in Inhibiting Prostaglandin‐Endoperoxide Synthase 2 to Relieve Neointimal Hyperplasia in Arteriovenous Fistula
inferred← citeshttps://doi.org/10.1016/j.bbadis.2026.168390openalex-snapshot
EGR2 promotes vascular smooth muscle cell differentiation and proliferation in outward remodeling during arteriovenous fistula maturation
inferred← citeshttps://doi.org/10.1016/j.jare.2025.03.032openalex-snapshot
Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration
inferred← citeshttps://doi.org/10.1080/0886022x.2024.2316269openalex-snapshot
Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway
inferred← citeshttps://doi.org/10.3389/fcell.2026.1859193openalex-snapshot
Targeting MAD2L2-dependent translesion synthesis impairs DNA damage tolerance and enhances cellular response to cisplatin
inferred← citeshttps://doi.org/10.3390/ijms25179519openalex-snapshot
The Pathological Mechanisms and Therapeutic Molecular Targets in Arteriovenous Fistula Dysfunction
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