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Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma
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miR‐191/DAB2 axis regulates the tumorigenicity of estrogen receptor‐positive breast cancer
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Influence of Insulin-Like Growth Factor Binding Protein (IGFBP)-1 and IGFBP-3 on Bone Health: Results from the European Male Ageing Study
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Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity
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Odontoceti phylogeny and divergence data resolved: evidence from nuclear genes and complete mitochondrial genomes of Neophocaena phocaenoides
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A Homozygous Nonsense Mutation in the Human Desmocollin-3 (DSC3) Gene Underlies Hereditary Hypotrichosis and Recurrent Skin Vesicles
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Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
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Insights into the Evolution of Longevity from the Bowhead Whale Genome
inferredcites →https://doi.org/10.1016/j.celrep.2018.07.042openalex-snapshot
A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage
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Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer
inferredcites →https://doi.org/10.1016/j.gde.2016.12.004openalex-snapshot
Evolution of cancer suppression as revealed by mammalian comparative genomics
inferredcites →https://doi.org/10.1016/j.isci.2020.101373openalex-snapshot
Comparative Oncology: New Insights into an Ancient Disease
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Stress, cell senescence and organismal ageing
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On the revolution of cetacean evolution
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Senescence: a new weapon for cancer therapy
inferredcites →https://doi.org/10.1016/j.tem.2017.07.004openalex-snapshot
Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species
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Peto's Paradox: evolution's prescription for cancer prevention
inferredcites →https://doi.org/10.1016/s0531-5565(00)00239-4openalex-snapshot
Age determination and validation studies of marine fishes: do deep-dwellers live longer?
inferredcites →https://doi.org/10.1016/s1470-2045(11)70154-1openalex-snapshot
Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer risk
inferredcites →https://doi.org/10.1038/bjc.2011.28openalex-snapshot
DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer
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Why haven't we made an efficacious vaccine for malaria?
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Endless paces of degeneration—applying comparative genomics to study evolution's moulding of longevity
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Role of stem-cell divisions in cancer risk
inferredcites →https://doi.org/10.1038/nrc1387openalex-snapshot
Insulin-like growth factors and neoplasia
inferredcites →https://doi.org/10.1038/nrg3728openalex-snapshot
Comparative genetics of longevity and cancer: insights from long-lived rodents
inferredcites →https://doi.org/10.1038/s41440-019-0249-zopenalex-snapshot
Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1)
inferredcites →https://doi.org/10.1038/s41568-018-0004-9openalex-snapshot
Mechanisms of cancer resistance in long-lived mammals
inferredcites →https://doi.org/10.1038/sj.bjc.6603006openalex-snapshot
Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours
inferredcites →https://doi.org/10.1086/692326openalex-snapshot
The Evolution of Energetic Scaling across the Vertebrate Tree of Life
inferredcites →https://doi.org/10.1093/bib/bbq072openalex-snapshot
PHAST and RPHAST: phylogenetic analysis with space/time models
inferredcites →https://doi.org/10.1093/bioinformatics/btq003openalex-snapshot
CD-HIT Suite: a web server for clustering and comparing biological sequences
inferredcites →https://doi.org/10.1093/bioinformatics/btx063openalex-snapshot
Phyx: phylogenetic tools for unix
inferredcites →https://doi.org/10.1093/bioinformatics/btx229openalex-snapshot
Orthologous Matrix (OMA) algorithm 2.0: more robust to asymmetric evolutionary rates and more scalable hierarchical orthologous group inference
inferredcites →https://doi.org/10.1093/bioinformatics/bty994openalex-snapshot
iHam and pyHam: visualizing and processing hierarchical orthologous groups
inferredcites →https://doi.org/10.1093/brain/awr252openalex-snapshot
Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease
inferredcites →https://doi.org/10.1093/emboj/cdf595openalex-snapshot
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
inferredcites →https://doi.org/10.1093/icb/icm062openalex-snapshot
Why don't all whales have cancer? A novel hypothesis resolving Peto's paradox
inferredcites →https://doi.org/10.1093/molbev/msi237openalex-snapshot
Evaluation of an Improved Branch-Site Likelihood Method for Detecting Positive Selection at the Molecular Level
inferredcites →https://doi.org/10.1093/molbev/msm088openalex-snapshot
PAML 4: Phylogenetic Analysis by Maximum Likelihood
inferredcites →https://doi.org/10.1093/molbev/mst010openalex-snapshot
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
inferredcites →https://doi.org/10.1093/molbev/mst100openalex-snapshot
Estimating Gene Gain and Loss Rates in the Presence of Error in Genome Assembly and Annotation Using CAFE 3
inferredcites →https://doi.org/10.1093/molbev/msw046openalex-snapshot
ETE 3: Reconstruction, Analysis, and Visualization of Phylogenomic Data
inferredcites →https://doi.org/10.1093/molbev/msx116openalex-snapshot
TimeTree: A Resource for Timelines, Timetrees, and Divergence Times
inferredcites →https://doi.org/10.1093/molbev/msz099openalex-snapshot
Return to the Sea, Get Huge, Beat Cancer: An Analysis of Cetacean Genomes Including an Assembly for the Humpback Whale (Megaptera novaeangliae)
inferredcites →https://doi.org/10.1093/nar/gkl842openalex-snapshot
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
inferredcites →https://doi.org/10.1093/nar/gkx1042openalex-snapshot
Human Ageing Genomic Resources: new and updated databases
inferredcites →https://doi.org/10.1093/nar/gkz401openalex-snapshot
WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs
inferredcites →https://doi.org/10.1098/rspb.1999.0664openalex-snapshot
Lineage selection and the evolution of multistage carcinogenesis
inferredcites →https://doi.org/10.1098/rspb.2016.1510openalex-snapshot
Size, longevity and cancer: age structure
inferredcites →https://doi.org/10.1098/rstb.2014.0177openalex-snapshot
Peto's paradox and the promise of comparative oncology
inferredcites →https://doi.org/10.1098/rstb.2014.0219openalex-snapshot
Cancer across the tree of life: cooperation and cheating in multicellularity
inferredcites →https://doi.org/10.1098/rstb.2015.0161openalex-snapshot
Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer
inferredcites →https://doi.org/10.1098/rstb.2015.0198openalex-snapshot
Quantitative implications of the approximate irrelevance of mammalian body size and lifespan to lifelong cancer risk
inferredcites →https://doi.org/10.1098/rstb.2016.0443openalex-snapshot
Evolution of telomere maintenance and tumour suppressor mechanisms across mammals
inferredcites →https://doi.org/10.1101/gr.243212.118openalex-snapshot
OMA standalone: orthology inference among public and custom genomes and transcriptomes
inferredcites →https://doi.org/10.1111/acel.13041openalex-snapshot
A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence
inferredcites →https://doi.org/10.1111/bjd.19342openalex-snapshot
Mutations in genes encoding desmosomal proteins: spectrum of cutaneous and extracutaneous abnormalities*
inferredcites →https://doi.org/10.1111/bjh.14887openalex-snapshot
Congenital neutropenia in the era of genomics: classification, diagnosis, and natural history
inferredcites →https://doi.org/10.1111/eva.12018openalex-snapshot
The real war on cancer: the evolutionary dynamics of cancer suppression
inferredcites →https://doi.org/10.1111/j.1474-9726.2010.00588.xopenalex-snapshot
Resistance to experimental tumorigenesis in cells of a long‐lived mammal, the naked mole‐rat ( Heterocephalus glaber )
inferredcites →https://doi.org/10.1111/j.2041-210x.2011.00169.xopenalex-snapshot
phytools: an R package for phylogenetic comparative biology (and other things)
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/sciadv.aao0926openalex-snapshot
Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
inferredcites →https://doi.org/10.1126/sciadv.aaw6671openalex-snapshot
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
inferredcites →https://doi.org/10.1126/science.1230835openalex-snapshot
Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3772openalex-snapshot
A Role for CXCR2 in Senescence, but What about in Cancer?
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1207openalex-snapshot
Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments
inferredcites →https://doi.org/10.1177/104063879700900427openalex-snapshot
Immunoblastic Malignant Lymphoma in Dolphins: Histologic, Ultrastructural, and Immunohistochemical Features
inferredcites →https://doi.org/10.1186/1471-2407-12-387openalex-snapshot
Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox
inferredcites →https://doi.org/10.1186/bcr1273openalex-snapshot
Epigenetic silencing of DSC3 is a common event in human breast cancer
inferredcites →https://doi.org/10.1186/s12862-019-1461-9openalex-snapshot
Insights into body size variation in cetaceans from the evolution of body-size-related genes
inferredcites →https://doi.org/10.1186/s12915-017-0401-7openalex-snapshot
Peto’s Paradox: how has evolution solved the problem of cancer prevention?
inferredcites →https://doi.org/10.1186/s13059-020-01990-9openalex-snapshot
A multidimensional systems biology analysis of cellular senescence in aging and disease
inferredcites →https://doi.org/10.1354/vp.43-6-865openalex-snapshot
Marine Mammal Neoplasia: A Review
inferredcites →https://doi.org/10.1371/journal.pcbi.1002375openalex-snapshot
Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
inferredcites →https://doi.org/10.1371/journal.pone.0065491openalex-snapshot
How to Make a Dolphin: Molecular Signature of Positive Selection in Cetacean Genome
inferredcites →https://doi.org/10.1517/14728222.2011.538682openalex-snapshot
Emerging strategies for EphA2 receptor targeting for cancer therapeutics
inferredcites →https://doi.org/10.18632/oncotarget.16701openalex-snapshot
Clinical verification of plasma messenger RNA as novel noninvasive biomarker identified through bioinformatics analysis for lung cancer
inferredcites →https://doi.org/10.32388/l9dk44openalex-snapshot
Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency
inferredcites →https://doi.org/10.32614/cran.package.caperopenalex-snapshot
caper: Comparative Analyses of Phylogenetics and Evolution in R
inferredcites →https://doi.org/10.32614/r.manualsopenalex-snapshot
R: A Language and Environment for Statistical Computing
inferredcites →https://doi.org/10.5061/dryad.c59zw3r6mopenalex-snapshot
Tumour suppressor genes fasta files for orthologous groups and hierarchical orthologous groups
inferredcites →https://doi.org/10.7554/elife.11994openalex-snapshot
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
inferredcites →https://doi.org/10.7554/elife.24307openalex-snapshot
Correction: TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
inferredcites →https://doi.org/10.7554/elife.31157openalex-snapshot
Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
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Arginines of the CGN codon family are Achilles’ heels of cancer genes
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Evolution of ion channels in cetaceans: a natural experiment in the tree of life
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TP53 Mutant Versus Wild-Type Zebrafish Larvae Under Starvation Stress: Larvae Can Live Up to 17 Days Post-Fertilization Without Food
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Additional file 6 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
inferred← citeshttps://doi.org/10.6084/m9.figshare.22600691openalex-snapshot
Additional file 7 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
inferred← citeshttps://doi.org/10.6084/m9.figshare.25546945openalex-snapshot
Additional file 1 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.25547091openalex-snapshot
Additional file 2 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701966openalex-snapshot
Additional file 3 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701969openalex-snapshot
Additional file 4 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701972openalex-snapshot
Additional file 5 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701975openalex-snapshot
Additional file 6 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701978openalex-snapshot
Additional file 7 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701984openalex-snapshot
Additional file 8 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.6084/m9.figshare.26701987openalex-snapshot
Additional file 9 of Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
inferred← citeshttps://doi.org/10.64898/2026.02.25.707932openalex-snapshot
Tracing the expansion of p53 retrogenes in elephant species: A foundation for functional insights
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