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Role of dihydrofolate reductase in tetrahydrobiopterin biosynthesis and lipid metabolism in the oleaginous fungus Mortierella alpina

https://doi.org/10.1099/mic.0.000345

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Prediction of protein subcellular localization

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Lipid status and fatty acid metabolism in phenylketonuria

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Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin

inferredcites →https://doi.org/10.1007/s00253-009-2076-7openalex-snapshot

Improved production of various polyunsaturated fatty acids through filamentous fungus Mortierella alpina breeding

inferredcites →https://doi.org/10.1016/0003-2697(67)90179-0openalex-snapshot

Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase

inferredcites →https://doi.org/10.1016/0378-1119(94)90049-3openalex-snapshot

Sequence of a dihydrofolate reductase-encoding gene from Candida albicans

inferredcites →https://doi.org/10.1016/b978-0-12-024909-1.50009-0openalex-snapshot

The Origin of Hydrogen in Fatty Acid Synthesis

inferredcites →https://doi.org/10.1016/j.chembiol.2008.07.013openalex-snapshot

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

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Cloning, expression, and characterization of Cryptococcus neoformans dihydrofolate reductase.

inferredcites →https://doi.org/10.1016/s0021-9258(18)61643-6openalex-snapshot

Biochemical characterization of recombinant human phenylalanine hydroxylase produced in Escherichia coli.

inferredcites →https://doi.org/10.1016/s0021-9258(19)85059-7openalex-snapshot

Characterization of Candida albicans Dihydrofolate Reductase

inferredcites →https://doi.org/10.1016/s0021-9258(20)80589-4openalex-snapshot

The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants.

inferredcites →https://doi.org/10.1016/s0022-2836(02)00916-6openalex-snapshot

The Effect of Salts on the Activity and Stability of Escherichia coli and Haloferax volcanii Dihydrofolate Reductases

inferredcites →https://doi.org/10.1016/s0166-6851(01)00402-9openalex-snapshot

Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax

inferredcites →https://doi.org/10.1016/s0378-1097(04)00038-2openalex-snapshot

Cloning, expression, and characterization ofMycobacterium tuberculosisdihydrofolate reductase

inferredcites →https://doi.org/10.1023/a:1015142001578openalex-snapshot

Lipid Status and Long‐Chain Polyunsaturated Fatty Acid Concentrations in Adults and Adolescents with Phenylketonuria on Phenylalanine‐Restricted Diet

inferredcites →https://doi.org/10.1038/nature13236openalex-snapshot

Quantitative flux analysis reveals folate-dependent NADPH production

inferredcites →https://doi.org/10.1038/nbt.1621openalex-snapshot

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

inferredcites →https://doi.org/10.1038/ncomms4128openalex-snapshot

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

inferredcites →https://doi.org/10.1038/nmeth.1226openalex-snapshot

Mapping and quantifying mammalian transcriptomes by RNA-Seq

inferredcites →https://doi.org/10.1038/srep11247openalex-snapshot

Identification of a critical determinant that enables efficient fatty acid synthesis in oleaginous fungi

inferredcites →https://doi.org/10.1042/bj1710267openalex-snapshot

Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase

inferredcites →https://doi.org/10.1073/pnas.1307130110openalex-snapshot

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

inferredcites →https://doi.org/10.1074/jbc.m109.041483openalex-snapshot

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling

inferredcites →https://doi.org/10.1093/glycob/cww032openalex-snapshot

Characterization of an fungal l-fucokinase involved inMortierella alpinaGDP-l-fucose salvage pathway

inferredcites →https://doi.org/10.1093/nar/15.24.10355openalex-snapshot

Molecular characterization of theSaccharomyces cerevisiaedihydrofolate reductase gene (DFRl)

inferredcites →https://doi.org/10.1099/13500872-145-8-1911openalex-snapshot

The role of malic enzyme in the regulation of lipid accumulation in filamentous fungi

inferredcites →https://doi.org/10.1099/mic.0.051847-0openalex-snapshot

Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina

inferredcites →https://doi.org/10.1099/mic.0.2006/002683-0openalex-snapshot

Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation

inferredcites →https://doi.org/10.1111/j.1432-1033.1992.tb17334.xopenalex-snapshot

Desaturation of polyunsaturated fatty acids in Mucor circinelloides and the involvement of a novel membrane‐bound malic enzyme

inferredcites →https://doi.org/10.1111/j.1747-0285.2011.01169.xopenalex-snapshot

Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl‐Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity

inferredcites →https://doi.org/10.1128/aem.00238-13openalex-snapshot

Role of the Phenylalanine-Hydroxylating System in Aromatic Substance Degradation and Lipid Metabolism in the Oleaginous Fungus Mortierella alpina

inferredcites →https://doi.org/10.1128/aem.69.12.7507-7513.2003openalex-snapshot

GTPCyclohydrolase I: Purification, Characterization, and Effects ofInhibition on Nitric Oxide Synthase in Nocardia Species

inferredcites →https://doi.org/10.1139/o59-099openalex-snapshot

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

inferredcites →https://doi.org/10.1146/annurev.bi.36.070167.001131openalex-snapshot

Pteridine Cofactors

inferredcites →https://doi.org/10.1146/annurev.biophys.33.110502.133613openalex-snapshot

Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase

inferredcites →https://doi.org/10.1146/annurev.mi.24.100170.000515openalex-snapshot

Microbiology of Unconjugated Pteridines

inferredcites →https://doi.org/10.1146/annurev.nu.13.070193.001401openalex-snapshot

New Tetrahydrobiopterin-Dependent Systems

inferredcites →https://doi.org/10.1146/annurev.nutr.13.1.261openalex-snapshot

New Tetrahydrobiopterin-Dependent Systems

inferredcites →https://doi.org/10.1371/journal.pone.0028319openalex-snapshot

Genome Characterization of the Oleaginous Fungus Mortierella alpina

inferredcites →https://doi.org/10.1515/pteridines.1998.9.2.103openalex-snapshot

Pteridines and Lipid Metabolism

inferredcites →https://doi.org/10.2174/1389200024605073openalex-snapshot

Tetrahydrobiopterin Biosynthesis, Utilization and Pharmacological Effects

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Ecological Adaptation of Phoxinus Minnows: Divergence in Phenotype, Genetics, and Evolution

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Nitric Oxide Synthases in Cyanobacteria: Diversity, Cellular Implications and Ecological Pertinence

inferred← citeshttps://doi.org/10.1007/s11274-020-02984-2openalex-snapshot

Research advances on arachidonic acid production by fermentation and genetic modification of Mortierella alpina

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107794openalex-snapshot

Lipid metabolism research in oleaginous fungus Mortierella alpina: Current progress and future prospects

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.11.124openalex-snapshot

Expression of BmDHFR is up-regulated to trigger an increase in the BH4/BH2 ratio when the de novo synthesis of BH4 is blocked in silkworm, Bombyx mori

inferred← citeshttps://doi.org/10.1099/mic.0.000897openalex-snapshot

The role of MTHFDL in mediating intracellular lipogenesis in oleaginous Mortierella alpina

inferred← citeshttps://doi.org/10.1099/mic.0.001062openalex-snapshot

The role of phenylalanine hydroxylase in lipogenesis in the oleaginous fungus Mortierella alpina

inferred← citeshttps://doi.org/10.1186/s13068-019-1552-2openalex-snapshot

Screening chemical modulators of benzoic acid derivatives to improve lipid accumulation in Schizochytrium limacinum SR21 with metabolomics analysis

inferred← citeshttps://doi.org/10.21203/rs.3.rs-908683/v1openalex-snapshot

Identification of New Inhibitors for Klebsiella Pneumoniae Trimethoprim-Resistant Dihydrofolate Reductase: An in Silico Drug Repurposing Study

inferred← citeshttps://doi.org/10.3389/fmicb.2020.00250openalex-snapshot

Tetrahydrobiopterin Plays a Functionally Significant Role in Lipogenesis in the Oleaginous Fungus Mortierella alpina

inferred← citeshttps://doi.org/10.3390/app14072856openalex-snapshot

Using Integrated Multi-Omics to Explore the Differences in the Three Developmental Stages of Thelephora ganbajun Zang

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Study on the Dynamics of Microflora during Natural Fermentation of Different Blueberry Wines

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