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In silico identification of metabolic enzyme drug targets in Burkholderia pseudomallei

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THE KINETICS OF TRYPSIN DIGESTION
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Melioidosis
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The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),
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Lipoamide Channel-Binding Sulfonamides Selectively Inhibit Mycobacterial Lipoamide Dehydrogenase
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Species Differences in Alternative Substrate Utilization by the Antibacterial Target Undecaprenyl Pyrophosphate Synthase
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Murgocil is a Highly Bioactive Staphylococcal-Specific Inhibitor of the Peptidoglycan Glycosyltransferase Enzyme MurG
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Chemistry and Biology of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic Activity
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Identification of Active-Site Inhibitors of MurG Using a Generalizable, High-Throughput Glycosyltransferase Screen
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Deoxyuridine Triphosphate Nucleotidohydrolase as a Potential Antiparasitic Drug Target
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Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase
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NMR Metabolomic Analysis of Caco-2 Cell Differentiation
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Glutathione activates virulence gene expression of an intracellular pathogen
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Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
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A protocol for generating a high-quality genome-scale metabolic reconstruction
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Identification and Characterization of the First Class of Potent Bacterial Acetyl-CoA Carboxylase Inhibitors with Antibacterial Activity
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A Novel Inhibitor That Suspends the Induced Fit Mechanism of UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA)
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Genome-scale Reconstruction of Metabolic Network in Bacillus subtilis Based on High-throughput Phenotyping and Gene Essentiality Data
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Metabolic adaptation of human pathogenic and related nonpathogenic bacteria to extra- and intracellular habitats
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The Burkholderia pseudomallei Enoyl-Acyl Carrier Protein Reductase FabI1 Is Essential for In Vivo Growth and Is the Target of a Novel Chemotherapeutic with Efficacy
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Adaptation and Antibiotic Tolerance of Anaerobic Burkholderia pseudomallei
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Structure, Activity, and Inhibition of the Carboxyltransferase β-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis
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Role of iron in regulation of virulence genes
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CdpA Is a Burkholderia pseudomallei Cyclic di-GMP Phosphodiesterase Involved in Autoaggregation, Flagellum Synthesis, Motility, Biofilm Formation, Cell Invasion, and Cytotoxicity
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The Type 2 Secretion Pseudopilin, gspJ , Is Required for Multihost Pathogenicity of Burkholderia cenocepacia AU1054
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CsrA and Cra Influence Shigella flexneri Pathogenesis
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Burkholderia pseudomalleiIsocitrate Lyase Is a Persistence Factor in Pulmonary Melioidosis: Implications for the Development of Isocitrate Lyase Inhibitors as Novel Antimicrobials
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Genome-Wide Expression Analysis of Burkholderia pseudomallei Infection ina Hamster Model of Acute Melioidosis
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Development of Signature-Tagged Mutagenesis in Burkholderia pseudomallei To Identify Genes Important in Survival and Pathogenesis
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Identification ofBurkholderia pseudomalleiGenes Required for the Intracellular Life Cycle and In Vivo Virulence
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A Burkholderia pseudomallei Δ purM Mutant Is Avirulent in Immunocompetent and Immunodeficient Animals: Candidate Strain for Exclusion from Select-Agent Lists
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Enteropathogenic and Enterohemorrhagic Escherichia coli Virulence Gene Regulation
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The Burkholderia pseudomallei Δ asd Mutant Exhibits Attenuated Intracellular Infectivity and Imparts Protection against Acute Inhalation Melioidosis in Mice
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Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa
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A Mutant of Burkholderia pseudomallei , Auxotrophic in the Branched Chain Amino Acid Biosynthetic Pathway, Is Attenuated and Protective in a Murine Model of Melioidosis
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Isocitrate Lyase (AceA) Is Required for Salmonella Persistence but Not for Acute Lethal Infection in Mice
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Intracellular Gene Expression Profile of Listeria monocytogenes
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The ε Subunit of DNA Polymerase III Is Involved in the Nalidixic Acid-Induced SOS Response in Escherichia coli
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Global Map of Growth-Regulated Gene Expression in Burkholderia pseudomallei , the Causative Agent of Melioidosis
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Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify Novel Antimicrobial Drug Targets
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Genetic Analysis of the Leucine Region in Escherichia coli B/r: Gene-Enzyme Assignments
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The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene
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Genomic Diversity of Burkholderia pseudomallei Clinical Isolates: Subtractive Hybridization Reveals a Burkholderia mallei -Specific Prophage in B. pseudomallei 1026b
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Experimental Identification and Quantification of Glucose Metabolism in Seven Bacterial Species
inferredcites →https://doi.org/10.1128/jb.188.2.556-568.2006openalex-snapshot
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inferredcites →https://doi.org/10.1128/jb.62.3.293-300.1951openalex-snapshot
STUDIES ON LYSOGENESIS I
inferredcites →https://doi.org/10.1128/jb.73.5.649-654.1957openalex-snapshot
GLUCOSE CATABOLISM IN MALLEOMYCES PSEUDOMALLEI
inferredcites →https://doi.org/10.1128/jb.84.4.869-870.1962openalex-snapshot
MINOR ELEMENT COMPOSITION OF YEAST EXTRACT
inferredcites →https://doi.org/10.1128/mbio.00280-12openalex-snapshot
Virulence Meets Metabolism: Cra and KdpE Gene Regulation in Enterohemorrhagic Escherichia coli
inferredcites →https://doi.org/10.1128/mbio.00846-16openalex-snapshot
The Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers
inferredcites →https://doi.org/10.1128/mbio.00926-13openalex-snapshot
Genome-Wide Saturation Mutagenesis of Burkholderia pseudomallei K96243 Predicts Essential Genes and Novel Targets for Antimicrobial Development
inferredcites →https://doi.org/10.1128/microbe.7.506.1openalex-snapshot
Amoebae and Mammals Deliver Protein-Rich Atkins Diet Meals to Legionella Cells
inferredcites →https://doi.org/10.1142/s0219720007002564openalex-snapshot
METABOLIC PATHWAY ANALYSIS OFS. PNEUMONIAE: ANIN SILICOAPPROACH TOWARDS DRUG-DESIGN
inferredcites →https://doi.org/10.1146/annurev.biochem.71.110601.135414openalex-snapshot
Lipopolysaccharide Endotoxins
inferredcites →https://doi.org/10.1155/2008/841312openalex-snapshot
Structure‐Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases
inferredcites →https://doi.org/10.1183/09031936.03.00006203openalex-snapshot
Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions
inferredcites →https://doi.org/10.1186/1471-2164-13-328openalex-snapshot
Burkholderia pseudomallei transcriptional adaptation in macrophages
inferredcites →https://doi.org/10.1186/1471-2164-15-958openalex-snapshot
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inferredcites →https://doi.org/10.1186/1471-2164-9-75openalex-snapshot
The RAST Server: Rapid Annotations using Subsystems Technology
inferredcites →https://doi.org/10.1186/1475-2875-13-149openalex-snapshot
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inferredcites →https://doi.org/10.1186/1742-4682-8-5openalex-snapshot
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inferredcites →https://doi.org/10.1186/1752-0509-4-118openalex-snapshot
Systems approach to investigating host-pathogen interactions in infections with the biothreat agent Francisella. Constraints-based model of Francisella tularensis
inferredcites →https://doi.org/10.1186/1752-0509-5-83openalex-snapshot
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inferredcites →https://doi.org/10.1189/jlb.0206079openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pbio.0030176openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pcbi.0020072openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pgen.1003795openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pntd.0001488openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pntd.0001849openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0021523openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0043080openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0063369openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0064240openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0075245openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0085195openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0103598openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0115951openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pone.0121216openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.ppat.1000178openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.ppat.1001078openalex-snapshot
Host Imprints on Bacterial Genomes—Rapid, Divergent Evolution in Individual Patients
inferredcites →https://doi.org/10.1371/journal.ppat.1003505openalex-snapshot
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inferredcites →https://doi.org/10.1378/chest.68.2.261openalex-snapshot
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inferredcites →https://doi.org/10.2217/fmb.12.116openalex-snapshot
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inferredcites →https://doi.org/10.3233/isb-00138openalex-snapshot
A Novel Genomics Approach for the Identification of Drug Targets in Pathogens, with Special Reference to Pseudomonas Aeruginosa
inferredcites →https://doi.org/10.3389/fcimb.2013.00024openalex-snapshot
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inferredcites →https://doi.org/10.3389/fcimb.2013.00112openalex-snapshot
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inferredcites →https://doi.org/10.3389/fcimb.2014.00111openalex-snapshot
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inferredcites →https://doi.org/10.3389/fmicb.2010.00140openalex-snapshot
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inferredcites →https://doi.org/10.4049/jimmunol.81.5.433openalex-snapshot
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inferredcites →https://doi.org/10.4056/sigs.1794338openalex-snapshot
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inferredcites →https://doi.org/10.6026/97320630008664openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41598-020-64914-4openalex-snapshot
In vitro passage alters virulence, immune activation and proteomic profiles of Burkholderia pseudomallei
inferred← citeshttps://doi.org/10.2174/1389450121666200129103618openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/metabo11040240openalex-snapshot
Integrated Metabolomics and Transcriptomics Using an Optimised Dual Extraction Process to Study Human Brain Cancer Cells and Tissues
inferred← citeshttps://doi.org/10.7275/24145939.0openalex-snapshot
Metabolic Modeling of Cystic Fibrosis Airway Microbiota from Patient Samples
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