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Multi-ethnic polygenic risk scores improve risk prediction in diverse populations
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/gepi.20509openalex-snapshot
Risk prediction using genome‐wide association studies
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A Better Coefficient of Determination for Genetic Profile Analysis
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Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction
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Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
inferredcites →https://doi.org/10.1016/j.ajhg.2014.09.007openalex-snapshot
Effective Genetic-Risk Prediction Using Mixed Models
inferredcites →https://doi.org/10.1016/j.ajhg.2014.12.006openalex-snapshot
Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
inferredcites →https://doi.org/10.1016/j.ajhg.2015.05.014openalex-snapshot
Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations
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A Fast Method that Uses Polygenic Scores to Estimate the Variance Explained by Genome-wide Marker Panels and the Proportion of Variants Affecting a Trait
inferredcites →https://doi.org/10.1016/j.ajhg.2015.09.001openalex-snapshot
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1016/j.ajhg.2015.10.002openalex-snapshot
Two-Variance-Component Model Improves Genetic Prediction in Family Datasets
inferredcites →https://doi.org/10.1016/j.ajhg.2015.12.022openalex-snapshot
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia
inferredcites →https://doi.org/10.1016/j.ajhg.2016.05.001openalex-snapshot
Transethnic Genetic-Correlation Estimates from Summary Statistics
inferredcites →https://doi.org/10.1016/j.ajhg.2016.09.014openalex-snapshot
Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Reconstructing Indian population history
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Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
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Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
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Evidence of widespread selection on standing variation in Europe at height-associated SNPs
inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
inferredcites →https://doi.org/10.1038/ng.2579openalex-snapshot
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
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Advantages and pitfalls in the application of mixed-model association methods
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3401openalex-snapshot
Population genetic differentiation of height and body mass index across Europe
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The contribution of rare variation to prostate cancer heritability
inferredcites →https://doi.org/10.1038/ng.921openalex-snapshot
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
inferredcites →https://doi.org/10.1038/nrg.2016.27openalex-snapshot
Developing and evaluating polygenic risk prediction models for stratified disease prevention
inferredcites →https://doi.org/10.1038/nrg2760openalex-snapshot
Genome-wide association studies in diverse populations
inferredcites →https://doi.org/10.1038/nrg2898openalex-snapshot
Predicting genetic predisposition in humans: the promise of whole-genome markers
inferredcites →https://doi.org/10.1038/nrg3457openalex-snapshot
Pitfalls of predicting complex traits from SNPs
inferredcites →https://doi.org/10.1101/gr.169375.113openalex-snapshot
MultiBLUP: improved SNP-based prediction for complex traits
inferredcites →https://doi.org/10.1101/gr.201996.115openalex-snapshot
Multikernel linear mixed models for complex phenotype prediction
inferredcites →https://doi.org/10.1371/journal.pgen.1002298openalex-snapshot
Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry
inferredcites →https://doi.org/10.1371/journal.pgen.1002621openalex-snapshot
Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases
inferredcites →https://doi.org/10.1371/journal.pgen.1003264openalex-snapshot
Polygenic Modeling with Bayesian Sparse Linear Mixed Models
inferredcites →https://doi.org/10.1371/journal.pgen.1003348openalex-snapshot
Power and Predictive Accuracy of Polygenic Risk Scores
inferredcites →https://doi.org/10.1371/journal.pgen.1003447openalex-snapshot
Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
inferredcites →https://doi.org/10.1371/journal.pgen.1004969openalex-snapshot
Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model
inferredcites →https://doi.org/10.1371/journal.pgen.1006288openalex-snapshot
Using Genetic Distance to Infer the Accuracy of Genomic Prediction
inferredcites →https://doi.org/10.1371/journal.pgen.1006493openalex-snapshot
Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/gepi.22382openalex-snapshot
Incorporating European GWAS findings improve polygenic risk prediction accuracy of breast cancer among East Asians
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Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations
inferred← citeshttps://doi.org/10.1007/s10519-019-09982-7openalex-snapshot
Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample
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Polygenic Risk for Aggression Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood and is Moderated by a Family-Centered Intervention
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Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods
inferred← citeshttps://doi.org/10.1007/s11914-021-00680-0openalex-snapshot
The Polygenic and Monogenic Basis of Paediatric Fractures
inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.04.002openalex-snapshot
Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups
inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.04.012openalex-snapshot
Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data
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Predicting Polygenic Risk of Psychiatric Disorders
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Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations
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Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
inferred← citeshttps://doi.org/10.1016/j.drugalcdep.2016.07.029openalex-snapshot
Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population
inferred← citeshttps://doi.org/10.1016/j.psychres.2018.03.016openalex-snapshot
Evaluating the genetic susceptibility to peer reported bullying behaviors
inferred← citeshttps://doi.org/10.1016/j.tig.2021.06.004openalex-snapshot
Genetic prediction of complex traits with polygenic scores: a statistical review
inferred← citeshttps://doi.org/10.1016/j.xhgg.2021.100029openalex-snapshot
Genetic discovery and risk characterization in type 2 diabetes across diverse populations
inferred← citeshttps://doi.org/10.1038/s41431-018-0230-3openalex-snapshot
A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure
inferred← citeshttps://doi.org/10.1038/s41467-018-05747-8openalex-snapshot
Deep-coverage whole genome sequences and blood lipids among 16,324 individuals
inferred← citeshttps://doi.org/10.1038/s41467-020-15464-wopenalex-snapshot
Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
inferred← citeshttps://doi.org/10.1038/s41467-020-17374-3openalex-snapshot
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
inferred← citeshttps://doi.org/10.1038/s41467-020-17719-yopenalex-snapshot
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
inferred← citeshttps://doi.org/10.1038/s41467-021-21286-1openalex-snapshot
Population-specific causal disease effect sizes in functionally important regions impacted by selection
inferred← citeshttps://doi.org/10.1038/s41569-020-00466-4openalex-snapshot
Genomics of hypertension: the road to precision medicine
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The influence of evolutionary history on human health and disease
inferred← citeshttps://doi.org/10.1038/s41576-024-00794-yopenalex-snapshot
Biobanking with genetics shapes precision medicine and global health
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Comparative genetic architectures of schizophrenia in East Asian and European populations
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Functionally informed fine-mapping and polygenic localization of complex trait heritability
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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
inferred← citeshttps://doi.org/10.1038/s41588-023-01501-zopenalex-snapshot
A new method for multiancestry polygenic prediction improves performance across diverse populations
inferred← citeshttps://doi.org/10.1038/s41588-026-02712-wopenalex-snapshot
Correlations between causal effect sizes of proximal SNPs vary with functional annotations and implicate stabilizing selection
inferred← citeshttps://doi.org/10.1038/s41596-020-0353-1openalex-snapshot
Tutorial: a guide to performing polygenic risk score analyses
inferred← citeshttps://doi.org/10.1053/j.gastro.2020.12.034openalex-snapshot
Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort
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Polygenic burden in focal and generalized epilepsies
inferred← citeshttps://doi.org/10.1093/jnci/djab050openalex-snapshot
Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry
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Polygenic risk scores based on European GWAS correlate to disease prevalence differences around the world
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Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity
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Importance of Genetic Studies of Cardiometabolic Disease in Diverse Populations
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Genetic architecture of cardiometabolic risks in people living with HIV
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Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus
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