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Deep Learning and Association Rule Mining for Predicting Drug Response in Cancer. A Personalised Medicine Approach

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Comparison of Chemotherapy Response with P-Glycoprotein, Multidrug Resistance-Related Protein-1, and Lung Resistance-Related Protein Expression in Untreated Small Cell Lung Cancer
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An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitro
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Drug Resistance in Glioblastoma: A Mini Review
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Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding
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Comparison of the predicted and observed secondary structure of T4 phage lysozyme
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Multilayer feedforward networks are universal approximators
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Cytotoxicity and estrogenicity of Invisalign appliances
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HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBα
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Suppression of invasion and metastasis in aggressive salivary cancer cells through targeted inhibition of ID1 gene expression
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Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
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A Landscape of Pharmacogenomic Interactions in Cancer
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The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells
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Pathophysiologically relevant in vitro tumor models for drug screening
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SAMSN1 Is a Tumor Suppressor Gene in Multiple Myeloma
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Deep learning in neural networks: An overview
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HDAC2 deficiency sensitizes colon cancer cells to TNFα-induced apoptosis through inhibition of NF-κB activity
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Random forests for genomic data analysis
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Basic principles of ROC analysis
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Suppression of tumor growth by growth hormone-releasing hormone antagonist JV-1-36 does not involve the inhibition of autocrine production of insulin-like growth factor II in H-69 small cell lung carcinoma
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Actin organization associated with the expression of multidrug resistant phenotype in osteosarcoma cells and the effect of actin depolymerization on drug resistance
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Selecting the right objective measure for association analysis
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Small cell lung cancer: new clinical recommendations and current status of biomarker assessment
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An Ichthyosaurus (Reptilia, Ichthyosauria) with gastric contents from Charmouth, England:first report of the genus from the Pliensbachian
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Deep Learning for Drug-Induced Liver Injury
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Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
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Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment
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Cell lines battle cancer
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PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes
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The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition
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Receptor tyrosine kinases in cancer escape from BRAF inhibitors
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Enabling personalized cancer medicine through analysis of gene-expression patterns
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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
inferredcites →https://doi.org/10.1038/nature11003openalex-snapshot
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
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Systematic identification of genomic markers of drug sensitivity in cancer cells
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Deep learning
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A community effort to assess and improve drug sensitivity prediction algorithms
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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
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The NCI60 human tumour cell line anticancer drug screen
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Machine learning applications in genetics and genomics
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The PTEN–PI3K pathway: of feedbacks and cross-talks
inferredcites →https://doi.org/10.1038/onc.2015.511openalex-snapshot
Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells
inferredcites →https://doi.org/10.1038/onc.2016.293openalex-snapshot
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells
inferredcites →https://doi.org/10.1038/sj.leu.2403836openalex-snapshot
Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia
inferredcites →https://doi.org/10.1038/sj.onc.1210494openalex-snapshot
Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice
inferredcites →https://doi.org/10.1056/nejmoa1406037openalex-snapshot
Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma
inferredcites →https://doi.org/10.1073/pnas.0605309103openalex-snapshot
Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel
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Mutation and Cancer: Statistical Study of Retinoblastoma
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Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase
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ROCR: visualizing classifier performance in R
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Pvclust: an R package for assessing the uncertainty in hierarchical clustering
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Drug susceptibility prediction against a panel of drugs using kernelized Bayesian multitask learning
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The value of prior knowledge in machine learning of complex network systems
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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes
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DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90
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COSMIC: exploring the world's knowledge of somatic mutations in human cancer
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Immunohistochemistry in the Diagnosis of Mucinous Neoplasms Involving the Ovary
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Pairwise input neural network for target-ligand interaction prediction
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Representation Learning: A Review and New Perspectives
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D³ Data-Driven Documents
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Targeting PI 3‐kinase ( PI 3 K ), AKT and m TOR axis in lymphoma
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Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb®, GW572016) in an expanded panel of human normal and tumour cell lines
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Regularization and Variable Selection Via the Elastic Net
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THE DISTRIBUTION OF THE FLORA IN THE ALPINE ZONE. 1
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An Oncogene-Induced DNA Damage Model for Cancer Development
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Regulation of mTORC1 Complex Assembly and Signaling by GRp58/ERp57
inferredcites →https://doi.org/10.1145/170036.170072openalex-snapshot
Mining association rules between sets of items in large databases
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Histone Deacetylase Inhibitors Suppress the Inducibility of Nuclear Factor-κB by Tumor Necrosis Factor-α Receptor-1 Down-regulation
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Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
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Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality
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The Use of Olaparib (AZD2281) Potentiates SN-38 Cytotoxicity in Colon Cancer Cells by Indirect Inhibition of Rad51-Mediated Repair of DNA Double-Strand Breaks
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Histone Deacetylase 6 Represents a Novel Drug Target in the Oncogenic Hedgehog Signaling Pathway
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Abstract 5315: Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer.
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In Human Leukemia Cells Ephrin-B–Induced Invasive Activity Is Supported by Lck and Is Associated with Reassembling of Lipid Raft Signaling Complexes
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Synergistic Effect of Olaparib with Combination of Cisplatin on PTEN -Deficient Lung Cancer Cells
inferredcites →https://doi.org/10.1158/1557-3265.pdx16-a27openalex-snapshot
Abstract A27: Addiction to the NF-κB–triggered IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells
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EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
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Systematic synergy modeling: understanding drug synergy from a systems biology perspective
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Outlook on PI3K/AKT/mTOR inhibition in acute leukemia
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ThePOF1Bcandidate gene for premature ovarian failure regulates epithelial polarity
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Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma
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P-Glycoprotein-Evading Anti-tumor Activity of a Novel Tubulin and HSP90 Dual Inhibitor in a Non-small-cell Lung Cancer Model
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Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties
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Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia
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SAMSN1 Is Highly Expressed and Associated with a Poor Survival in Glioblastoma Multiforme
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Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
inferredcites →https://doi.org/10.1371/journal.pone.0136746openalex-snapshot
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia
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Antagonistic analogs of growth hormone-releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study
inferredcites →https://doi.org/10.18632/oncotarget.5746openalex-snapshot
Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics
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vegan: Community Ecology Package
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Prognostic relevance of SAMSN1 expression in gastric cancer
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Natural chalcones as dual inhibitors of HDACs and NF-κB

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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