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When GWAS meets the Connectivity Map: drug repositioning for seven psychiatric disorders

https://doi.org/10.1101/096503
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Outgoing claims: the papers this work cites, builds on, or argues with.

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The Genotype-Tissue Expression (GTEx) project
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
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Loxapine Add-on for Adolescents and Adults with Autism Spectrum Disorders and Irritability
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limma powers differential expression analyses for RNA-sequencing and microarray studies
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Effects of Reserpine and Amphetamine on the Development of Hyperactivity in Maternally Deprived Rat Pups
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Double-Blind, Placebo-Controlled Trial of Risperidone Plus Amantadine in Children With Autism
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Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals
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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
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Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
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The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders
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Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia
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Metyrapone in treatment-resistant depression
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GWAS and drug targets
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Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes
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Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety
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Targeting of NMDA Receptors in the Treatment of Major Depression
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder
inferred← citeshttps://doi.org/10.1016/j.meegid.2020.104610openalex-snapshot
A connectivity map-based drug repurposing study and integrative analysis of transcriptomic profiling of SARS-CoV-2 infection
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Exploring novel therapeutic opportunities for hypertension: a paradigm-shifting approach via integrative multiomic analysis, pioneering the path to precision medicine
inferred← citeshttps://doi.org/10.1101/132563openalex-snapshot
Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug Classes
inferred← citeshttps://doi.org/10.1101/326017openalex-snapshot
Metanalysis of genome-wide association studies for panic disorder suggest pathways and mechanisms of pathogenesis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4686166/v1openalex-snapshot
Repositioning randomly selected Drugs as Antidepressants by computational and Invivo methods
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Hacking Aging: A Strategy to Use Big Data From Medical Studies to Extend Human Life
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