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Population genomics of Cryptococcus neoformans var. grubii reveals new biogeographic relationships and finely maps hybridization

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1522-2683(19990101)20:8<1790::aid-elps1790>3.0.co;2-2openalex-snapshot
Molecular typing of global isolates ofCryptococcus neoformans var.neoformans by polymerase chain reaction fingerprinting and randomly amplified polymorphic DNA — a pilot study to standardize techniques on which to base a detailed epidemiological survey
inferredcites →https://doi.org/10.1007/s11046-008-9122-3openalex-snapshot
Cryptococcus neoformans Isolated from Passerine and Psittacine Bird Excreta in the State of Paraná, Brazil
inferredcites →https://doi.org/10.1016/j.cell.2008.07.046openalex-snapshot
Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1016/j.chom.2007.05.005openalex-snapshot
The Human Fungal Pathogen Cryptococcus Can Complete Its Sexual Cycle during a Pathogenic Association with Plants
inferredcites →https://doi.org/10.1016/j.fgb.2007.12.004openalex-snapshot
Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing
inferredcites →https://doi.org/10.1016/j.fgb.2015.02.009openalex-snapshot
Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex
inferredcites →https://doi.org/10.1016/j.idc.2015.10.006openalex-snapshot
Cryptococcosis
inferredcites →https://doi.org/10.1016/j.tim.2014.01.001openalex-snapshot
A neglected epidemic: fungal infections in HIV/AIDS
inferredcites →https://doi.org/10.1016/s0140-6736(04)16301-0openalex-snapshot
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
inferredcites →https://doi.org/10.1016/s1473-3099(17)30243-8openalex-snapshot
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis
inferredcites →https://doi.org/10.1038/nature03448openalex-snapshot
Sexual reproduction between partners of the same mating type in Cryptococcus neoformans
inferredcites →https://doi.org/10.1038/ncomms7757openalex-snapshot
Systematic functional profiling of transcription factor networks in Cryptococcus neoformans
inferredcites →https://doi.org/10.1046/j.1365-294x.2000.01021.xopenalex-snapshot
Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans
inferredcites →https://doi.org/10.1073/pnas.97.26.14455openalex-snapshot
Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct
inferredcites →https://doi.org/10.1074/jbc.m114.607705openalex-snapshot
Unraveling the Novel Structure and Biosynthetic Pathway of O-Linked Glycans in the Golgi Apparatus of the Human Pathogenic Yeast Cryptococcus neoformans
inferredcites →https://doi.org/10.1080/00275514.1976.12019972openalex-snapshot
A New Species ofFilobasidiella, The Sexual State ofCryptococcus NeoformansB and C Serotypes
inferredcites →https://doi.org/10.1080/13693780902953886openalex-snapshot
Consensus multi-locus sequence typing scheme forCryptococcus neoformansandCryptococcus gattii
inferredcites →https://doi.org/10.1080/714031049openalex-snapshot
Isolation of a Cryptococcus neoformans serotype A MATa strain from the Italian environment
inferredcites →https://doi.org/10.1086/507895openalex-snapshot
Symptomatic Relapse of HIV‐Associated Cryptococcal Meningitis after Initial Fluconazole Monotherapy: The Role of Fluconazole Resistance and Immune Reconstitution
inferredcites →https://doi.org/10.1086/518607openalex-snapshot
Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
inferredcites →https://doi.org/10.1086/588792openalex-snapshot
High‐Dose Amphotericin B with Flucytosine for the Treatment of Cryptococcal Meningitis in HIV‐Infected Patients: A Randomized Trial
inferredcites →https://doi.org/10.1093/bioinformatics/btp348openalex-snapshot
trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses
inferredcites →https://doi.org/10.1093/bioinformatics/btp352openalex-snapshot
The Sequence Alignment/Map format and SAMtools
inferredcites →https://doi.org/10.1093/bioinformatics/btr330openalex-snapshot
The variant call format and VCFtools
inferredcites →https://doi.org/10.1093/bioinformatics/btu033openalex-snapshot
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
inferredcites →https://doi.org/10.1093/cid/cir745openalex-snapshot
Comparison of the Early Fungicidal Activity of High-Dose Fluconazole, Voriconazole, and Flucytosine as Second-Line Drugs Given in Combination With Amphotericin B for the Treatment of HIV-Associated Cryptococcal Meningitis
inferredcites →https://doi.org/10.1093/genetics/155.2.945openalex-snapshot
Inference of Population Structure Using Multilocus Genotype Data
inferredcites →https://doi.org/10.1093/molbev/msl070openalex-snapshot
Recent Evolution of the Human Pathogen Cryptococcus neoformans by Intervarietal Transfer of a 14-Gene Fragment
inferredcites →https://doi.org/10.1093/molbev/msm088openalex-snapshot
PAML 4: Phylogenetic Analysis by Maximum Likelihood
inferredcites →https://doi.org/10.1093/molbev/mst055openalex-snapshot
Chromosome Painting In Silico in a Bacterial Species Reveals Fine Population Structure
inferredcites →https://doi.org/10.1093/molbev/msu136openalex-snapshot
PopGenome: An Efficient Swiss Army Knife for Population Genomic Analyses in R
inferredcites →https://doi.org/10.1093/nar/gkh340openalex-snapshot
MUSCLE: multiple sequence alignment with high accuracy and high throughput
inferredcites →https://doi.org/10.1097/qad.0b013e328322ffacopenalex-snapshot
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
inferredcites →https://doi.org/10.1097/qad.0b013e3283536a93openalex-snapshot
Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis
inferredcites →https://doi.org/10.1099/mic.0.2007/015594-0openalex-snapshot
Long-distance dispersal and recombination in environmental populations of Cryptococcus neoformans var. grubii from India
inferredcites →https://doi.org/10.1101/gad.1041402openalex-snapshot
Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1α
inferredcites →https://doi.org/10.1101/gr.081612.108openalex-snapshot
Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training
inferredcites →https://doi.org/10.1101/gr.107524.110openalex-snapshot
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
inferredcites →https://doi.org/10.1101/gr.1224503openalex-snapshot
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
inferredcites →https://doi.org/10.1101/gr.174623.114openalex-snapshot
Genetic and phenotypic intra-species variation in Candida albicans
inferredcites →https://doi.org/10.1101/gr.218727.116openalex-snapshot
Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1111/j.1365-2958.2010.07119.xopenalex-snapshot
KRE genes are required for β‐1,6‐glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans
inferredcites →https://doi.org/10.1111/j.1471-8286.2005.01155.xopenalex-snapshot
genalex 6: genetic analysis in Excel. Population genetic software for teaching and research
inferredcites →https://doi.org/10.1111/j.1474-7766.2004.00254.xopenalex-snapshot
Cryptococcal Meningitis
inferredcites →https://doi.org/10.1111/mec.13260openalex-snapshot
Comparative analyses of clinical and environmental populations of C ryptococcus neoformans in B otswana
inferredcites →https://doi.org/10.1111/mec.13891openalex-snapshot
Genomic epidemiology of Cryptococcus yeasts identifies adaptation to environmental niches underpinning infection across an African HIV / AIDS cohort
inferredcites →https://doi.org/10.1126/science.1103773openalex-snapshot
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1128/9781555816858openalex-snapshot
Cryptococcus
inferredcites →https://doi.org/10.1128/9781555818241openalex-snapshot
Cryptococcus neoformans
inferredcites →https://doi.org/10.1128/ec.00083-14openalex-snapshot
Literature-Based Gene Curation and Proposed Genetic Nomenclature for Cryptococcus
inferredcites →https://doi.org/10.1128/ec.00097-07openalex-snapshot
Cryptococcus neoformans Mates on Pigeon Guano: Implications for the Realized Ecological Niche and Globalization
inferredcites →https://doi.org/10.1128/ec.00097-08openalex-snapshot
Isolates of Cryptococcus neoformans from Infected Animals Reveal Genetic Exchange in Unisexual, α Mating Type Populations
inferredcites →https://doi.org/10.1128/ec.00193-13openalex-snapshot
Restricted Substrate Specificity for the Geranylgeranyltransferase-I Enzyme in Cryptococcus neoformans: Implications for Virulence
inferredcites →https://doi.org/10.1128/ec.2.6.1162-1168.2003openalex-snapshot
Evidence of Sexual Recombination among Cryptococcus neoformans Serotype A Isolates in Sub-Saharan Africa
inferredcites →https://doi.org/10.1128/iai.69.1.115-122.2001openalex-snapshot
Serotype AD Strains of Cryptococcus neoformans Are Diploid or Aneuploid and Are Heterozygous at the Mating-Type Locus
inferredcites →https://doi.org/10.1128/jcm.37.3.838-840.1999openalex-snapshot
Cryptococcus neoformans var. grubii : Separate Varietal Status for Cryptococcus neoformans Serotype A Isolates
inferredcites →https://doi.org/10.1128/jcm.42.3.1356-1359.2004openalex-snapshot
Cryptococcus neoformans Shows a Remarkable Genotypic Diversity in Brazil
inferredcites →https://doi.org/10.1128/jcm.43.2.556-564.2005openalex-snapshot
Comparative Analysis of Environmental and Clinical Populations ofCryptococcus neoformans
inferredcites →https://doi.org/10.1128/mbio.00166-17openalex-snapshot
Microevolution of Serial Clinical Isolates ofCryptococcus neoformansvar.grubiiandC. gattii
inferredcites →https://doi.org/10.1128/mbio.00311-15openalex-snapshot
Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation
inferredcites →https://doi.org/10.1128/mbio.00868-15openalex-snapshot
Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii
inferredcites →https://doi.org/10.1128/mbio.01340-15openalex-snapshot
Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation
inferredcites →https://doi.org/10.1128/mbio.01464-14openalex-snapshot
Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal
inferredcites →https://doi.org/10.1128/mmbr.64.4.746-785.2000openalex-snapshot
Signal Transduction Cascades Regulating Fungal Development and Virulence
inferredcites →https://doi.org/10.1128/msphere.00084-15openalex-snapshot
Relative Contributions of Prenylation and Postprenylation Processing in Cryptococcus neoformans Pathogenesis
inferredcites →https://doi.org/10.1139/gen-2014-0077openalex-snapshot
Evidence for genetic incompatibilities associated with post-zygotic reproductive isolation in the human fungal pathogenCryptococcus neoformans
inferredcites →https://doi.org/10.1155/2013/675213openalex-snapshot
Global Molecular Epidemiology ofCryptococcus neoformansandCryptococcus gattii: An Atlas of the Molecular Types
inferredcites →https://doi.org/10.1186/1471-2164-12-526openalex-snapshot
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients
inferredcites →https://doi.org/10.1186/gb-2008-9-1-r7openalex-snapshot
Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
inferredcites →https://doi.org/10.1186/gb-2008-9-2-r41openalex-snapshot
Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans
inferredcites →https://doi.org/10.1371/journal.pbio.1001653openalex-snapshot
Unisexual and Heterosexual Meiotic Reproduction Generate Aneuploidy and Phenotypic Diversity De Novo in the Yeast Cryptococcus neoformans
inferredcites →https://doi.org/10.1371/journal.pgen.0020190openalex-snapshot
Population Structure and Eigenanalysis
inferredcites →https://doi.org/10.1371/journal.pgen.0030186openalex-snapshot
αADα Hybrids of Cryptococcus neoformans: Evidence of Same-Sex Mating in Nature and Hybrid Fitness
inferredcites →https://doi.org/10.1371/journal.pgen.1002453openalex-snapshot
Inference of Population Structure using Dense Haplotype Data
inferredcites →https://doi.org/10.1371/journal.pgen.1004261openalex-snapshot
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
inferredcites →https://doi.org/10.1371/journal.pgen.1004849openalex-snapshot
Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in Cryptococcus neoformans
inferredcites →https://doi.org/10.1371/journal.pmed.0040021openalex-snapshot
Determinants of Disease Presentation and Outcome during Cryptococcosis: The CryptoA/D Study
inferredcites →https://doi.org/10.1371/journal.pntd.0003847openalex-snapshot
Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa
inferredcites →https://doi.org/10.1371/journal.pntd.0005223openalex-snapshot
MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst Cryptococcus neoformans var. grubii VNI Isolates from HIV Patients in Southeastern Brazil
inferredcites →https://doi.org/10.1371/journal.pone.0005862openalex-snapshot
Genetic Diversity of the Cryptococcus Species Complex Suggests that Cryptococcus gattii Deserves to Have Varieties
inferredcites →https://doi.org/10.1371/journal.pone.0019688openalex-snapshot
Evidence that the Human Pathogenic Fungus Cryptococcus neoformans var. grubii May Have Evolved in Africa
inferredcites →https://doi.org/10.1371/journal.pone.0071148openalex-snapshot
Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest
inferredcites →https://doi.org/10.1371/journal.pone.0072222openalex-snapshot
Geographically Structured Populations of Cryptococcus neoformans Variety grubii in Asia Correlate with HIV Status and Show a Clonal Population Structure
inferredcites →https://doi.org/10.1371/journal.ppat.0030114openalex-snapshot
Many Globally Isolated AD Hybrid Strains of Cryptococcus neoformans Originated in Africa
inferredcites →https://doi.org/10.1371/journal.ppat.1000283openalex-snapshot
Diploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating
inferredcites →https://doi.org/10.1371/journal.ppat.1000848openalex-snapshot
Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes
inferredcites →https://doi.org/10.1371/journal.ppat.1001343openalex-snapshot
Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin
inferredcites →https://doi.org/10.1371/journal.ppat.1002495openalex-snapshot
Population Genetic Analyses Reveal the African Origin and Strain Variation of Cryptococcus neoformans var. grubii
inferredcites →https://doi.org/10.1371/journal.ppat.1002765openalex-snapshot
The Link between Morphotype Transition and Virulence in Cryptococcus neoformans
inferredcites →https://doi.org/10.1534/g3.113.005660openalex-snapshot
Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence
inferredcites →https://doi.org/10.1534/g3.116.037499openalex-snapshot
A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection
inferredcites →https://doi.org/10.1534/genetics.105.046672openalex-snapshot
Multilocus Sequence Typing Reveals Three Genetic Subpopulations of Cryptococcus neoformans var. grubii (Serotype A), Including a Unique Population in Botswana
inferredcites →https://doi.org/10.2307/3758813openalex-snapshot
A New Species of Filobasidiella, the Sexual State of Cryptococcus neoformans B and C Serotypes
inferredcites →https://doi.org/10.2307/3758842openalex-snapshot
A New Genus, Filobasidiella, the Perfect State of Cryptococcus neoformans
inferredcites →https://doi.org/10.6084/m9.figshare.963153.v1openalex-snapshot
Aligning sequence reads, clone sequences and assembly con*gs with BWA-MEM

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/yea.3242openalex-snapshot
Hybridization and emergence of virulence in opportunistic human yeast pathogens
inferred← citeshttps://doi.org/10.1016/j.meegid.2018.10.011openalex-snapshot
Hybrids and hybridization in the Cryptococcus neoformans and Cryptococcus gattii species complexes
inferred← citeshttps://doi.org/10.1111/myc.13040openalex-snapshot
Patterns of allele distribution in a hybrid population of the Cryptococcus neoformans species complex
inferred← citeshttps://doi.org/10.3390/genes11010101openalex-snapshot
Hybridization Facilitates Adaptive Evolution in Two Major Fungal Pathogens
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