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A New Big-Data Paradigm for Target Identification and Drug Discovery

https://doi.org/10.1101/134973
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Microtubules as a target for anticancer drugs
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Drug-induced adverse events prediction with the LINCS L1000 data
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Tubulin/Microtubules: Still a Promising Target for New Chemotherapeutic Agents
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KEGG: Kyoto Encyclopedia of Genes and Genomes
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TarFisDock: a web server for identifying drug targets with docking approach
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DrugBank: a knowledgebase for drugs, drug actions and drug targets
inferredcites →https://doi.org/10.1093/nar/gkt1068openalex-snapshot
DrugBank 4.0: shedding new light on drug metabolism
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Network-Based Drug-Target Interaction Prediction with Probabilistic Soft Logic
inferredcites →https://doi.org/10.1126/science.1132939openalex-snapshot
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
inferredcites →https://doi.org/10.1126/science.1158140openalex-snapshot
Drug Target Identification Using Side-Effect Similarity
inferredcites →https://doi.org/10.1126/scitranslmed.3004828openalex-snapshot
Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects
inferredcites →https://doi.org/10.1136/bmj.1.6118.954openalex-snapshot
Effect of new dopamine-blocking agent (oxiperomide) on drug-induced dyskinesias in Parkinson's disease and spontaneous dyskinesias.
inferredcites →https://doi.org/10.1136/jnnp.43.3.264openalex-snapshot
Oxiperomide in tardive dyskinesia.
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-3252openalex-snapshot
Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0791openalex-snapshot
Targeting Microtubules by Natural Agents for Cancer Therapy
inferredcites →https://doi.org/10.1172/jci29999openalex-snapshot
Drug discovery in jeopardy
inferredcites →https://doi.org/10.1177/1087057108327329openalex-snapshot
Characterizing Cannabinoid CB2 Receptor Ligands Using DiscoveRx PathHunter™ β-Arrestin Assay
inferredcites →https://doi.org/10.1182/blood.v124.21.3122.3122openalex-snapshot
ONC201 Induces p53-Independent Apoptosis and Cell Cycle Arrest in Hematological Malignancies and Leukemic Stem/Progenitor Cells By Inducing ER Stress and mTOR Inhibition
inferredcites →https://doi.org/10.1186/s12920-015-0158-1openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pcbi.1003315openalex-snapshot
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Advances in computational methods to predict the biological activity of compounds
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The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity
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Eribulin disrupts EB1-microtubule plus-tip complex formation
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Eribulin Mesylate in Pretreated Breast Cancer Patients: A Multicenter Retrospective Observational Study

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Formatting biological big data for modern machine learning in drug discovery
inferred← citeshttps://doi.org/10.1007/978-3-030-16391-4_11openalex-snapshot
Artificial Intelligence and Personalized Medicine
inferred← citeshttps://doi.org/10.1016/j.neo.2017.10.002openalex-snapshot
Role of Dopamine Receptors in the Anticancer Activity of ONC201
inferred← citeshttps://doi.org/10.1016/j.tips.2019.06.001openalex-snapshot
The Missing Pieces of Artificial Intelligence in Medicine
inferred← citeshttps://doi.org/10.1038/s41467-019-12928-6openalex-snapshot
A Bayesian machine learning approach for drug target identification using diverse data types
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Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2
inferred← citeshttps://doi.org/10.1101/576017openalex-snapshot
Multi-task learning predicts drug combination synergy in cells and in the clinic
inferred← citeshttps://doi.org/10.1101/838334openalex-snapshot
Imatinib overrides taxane resistance by selective inhibition of novel CLIP1 variant obstructing the microtubule pore
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Landscape of Big Medical Data: A Pragmatic Survey on Prioritized Tasks
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Integrated stress response and immune cell infiltration in an ibrutinib‐refractory mantle cell lymphoma patient following ONC 201 treatment
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-18-2572openalex-snapshot
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-17-0614openalex-snapshot
ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer
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A machine learning and network framework to discover new indications for small molecules
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ONC201: a new treatment option being tested clinically for recurrent glioblastoma
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Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective
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Artificial Intelligence and Its Role In The Development Of Personalized Medicine And Drug Control
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Modernizing the Methods and Analytics Curricula for Health Science Doctoral Programs
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