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Activin Signaling Regulates Autophagy and Cardiac Aging through mTORC2

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/embr.201338310openalex-snapshot

Genome‐wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development

inferredcites →https://doi.org/10.1016/j.arr.2015.02.003openalex-snapshot

Quality control systems in cardiac aging

inferredcites →https://doi.org/10.1016/j.bbrc.2007.04.086openalex-snapshot

Discrete functions of rictor and raptor in cell growth regulation in Drosophila

inferredcites →https://doi.org/10.1016/j.bbrc.2016.10.050openalex-snapshot

Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells

inferredcites →https://doi.org/10.1016/j.cell.2010.09.013openalex-snapshot

TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

inferredcites →https://doi.org/10.1016/j.cell.2010.10.007openalex-snapshot

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

inferredcites →https://doi.org/10.1016/j.cell.2011.07.030openalex-snapshot

Autophagy and Aging

inferredcites →https://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot

mTOR Signaling in Growth, Metabolism, and Disease

inferredcites →https://doi.org/10.1016/j.celrep.2014.05.001openalex-snapshot

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

inferredcites →https://doi.org/10.1016/j.celrep.2014.08.064openalex-snapshot

Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

inferredcites →https://doi.org/10.1016/j.celrep.2015.03.010openalex-snapshot

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

inferredcites →https://doi.org/10.1016/j.cmet.2006.05.013openalex-snapshot

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity

inferredcites →https://doi.org/10.1016/j.cmet.2007.11.001openalex-snapshot

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

inferredcites →https://doi.org/10.1016/j.cmet.2010.09.014openalex-snapshot

High-Fat-Diet-Induced Obesity and Heart Dysfunction Are Regulated by the TOR Pathway in Drosophila

inferredcites →https://doi.org/10.1016/j.cub.2007.08.058openalex-snapshot

The C. elegans TGF-β Dauer Pathway Regulates Longevity via Insulin Signaling

inferredcites →https://doi.org/10.1016/j.cyto.2014.06.017openalex-snapshot

Regulation and actions of activin A and follistatin in myocardial ischaemia–reperfusion injury

inferredcites →https://doi.org/10.1016/j.cytogfr.2006.01.001openalex-snapshot

Roles of activin in tissue repair, fibrosis, and inflammatory disease

inferredcites →https://doi.org/10.1016/j.devcel.2004.07.009openalex-snapshot

Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

inferredcites →https://doi.org/10.1016/j.devcel.2010.03.008openalex-snapshot

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

inferredcites →https://doi.org/10.1016/j.devcel.2010.05.005openalex-snapshot

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

inferredcites →https://doi.org/10.1016/j.devcel.2015.03.013openalex-snapshot

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

inferredcites →https://doi.org/10.1016/j.ijcard.2013.04.012openalex-snapshot

The expression and role of activin A and follistatin in heart failure rats after myocardial infarction

inferredcites →https://doi.org/10.1016/j.molcel.2010.09.023openalex-snapshot

Autophagy and the Integrated Stress Response

inferredcites →https://doi.org/10.1016/j.tibs.2016.04.001openalex-snapshot

TORC2 Structure and Function

inferredcites →https://doi.org/10.1016/j.yjmcc.2017.02.002openalex-snapshot

Haplodeficiency of activin receptor-like kinase 4 alleviates myocardial infarction-induced cardiac fibrosis and preserves cardiac function

inferredcites →https://doi.org/10.1016/j.ymeth.2014.03.031openalex-snapshot

Methods to assess Drosophila heart development, function and aging

inferredcites →https://doi.org/10.1016/s0531-5565(01)00117-6openalex-snapshot

Activin A serum levels and aging of the pituitary-gonadal axis: a cross-sectional study in middle-aged and elderly healthy subjects

inferredcites →https://doi.org/10.1016/s0925-4773(01)00361-6openalex-snapshot

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

inferredcites →https://doi.org/10.1038/cr.2013.159openalex-snapshot

A current perspective of autophagosome biogenesis

inferredcites →https://doi.org/10.1038/ki.2013.559openalex-snapshot

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

inferredcites →https://doi.org/10.1038/nature02549openalex-snapshot

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

inferredcites →https://doi.org/10.1038/nature11861openalex-snapshot

mTOR is a key modulator of ageing and age-related disease

inferredcites →https://doi.org/10.1038/nature12143openalex-snapshot

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

inferredcites →https://doi.org/10.1038/ncb3407openalex-snapshot

Protein kinase C controls lysosome biogenesis independently of mTORC1

inferredcites →https://doi.org/10.1038/ncomms8007openalex-snapshot

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

inferredcites →https://doi.org/10.1038/nrd3810openalex-snapshot

Targeting the TGFβ signalling pathway in disease

inferredcites →https://doi.org/10.1038/srep25252openalex-snapshot

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

inferredcites →https://doi.org/10.1073/pnas.1319116111openalex-snapshot

Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogaster

inferredcites →https://doi.org/10.1080/15548627.2015.1063766openalex-snapshot

Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis

inferredcites →https://doi.org/10.1080/15548627.2015.1100356openalex-snapshot

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

inferredcites →https://doi.org/10.1080/15548627.2016.1221565openalex-snapshot

Brain trauma and autophagy: What flies and mice can teach us about conserved responses

inferredcites →https://doi.org/10.1083/jcb.200711108openalex-snapshot

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

inferredcites →https://doi.org/10.1089/ars.2011.4179openalex-snapshot

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

inferredcites →https://doi.org/10.1093/ajh/hpx185openalex-snapshot

The Association Between Serum Activin A Levels and Hypertension in the Elderly: A Cross-Sectional Analysis From I-Lan Longitudinal Aging Study

inferredcites →https://doi.org/10.1093/cvr/cvp384openalex-snapshot

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

inferredcites →https://doi.org/10.1093/cvr/cvv252openalex-snapshot

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy

inferredcites →https://doi.org/10.1097/hjh.0000000000001020openalex-snapshot

Partial inhibition of activin receptor-like kinase 4 attenuates pressure overload-induced cardiac fibrosis and improves cardiac function

inferredcites →https://doi.org/10.1101/cshperspect.a022152openalex-snapshot

TGF-β Family Signaling in Drosophila

inferredcites →https://doi.org/10.1101/cshperspect.a031963openalex-snapshot

Erratum: TGF-β Family Signaling in Drosophila

inferredcites →https://doi.org/10.1101/gad.13.1.98openalex-snapshot

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

inferredcites →https://doi.org/10.1101/gad.1775409openalex-snapshot

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

inferredcites →https://doi.org/10.1101/gad.203406.112openalex-snapshot

Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance

inferredcites →https://doi.org/10.1101/gad.901101openalex-snapshot

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

inferredcites →https://doi.org/10.1111/acel.12256openalex-snapshot

Depletion of Rictor, an essential protein component of m TORC 2, decreases male lifespan

inferredcites →https://doi.org/10.1111/acel.12425openalex-snapshot

Sex‐ and tissue‐specific changes in mTOR signaling with age in C57 BL /6J mice

inferredcites →https://doi.org/10.1111/j.1474-9726.2009.00504.xopenalex-snapshot

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila

inferredcites →https://doi.org/10.1126/science.1106148openalex-snapshot

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

inferredcites →https://doi.org/10.1126/science.1115535openalex-snapshot

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

inferredcites →https://doi.org/10.1126/science.1182228openalex-snapshot

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

inferredcites →https://doi.org/10.1146/annurev-genet-102808-114910openalex-snapshot

Regulation Mechanisms and Signaling Pathways of Autophagy

inferredcites →https://doi.org/10.1152/ajpheart.01048.2009openalex-snapshot

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

inferredcites →https://doi.org/10.1161/01.cir.0000048893.62841.f7openalex-snapshot

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

inferredcites →https://doi.org/10.1161/01.cir.0000057979.36322.88openalex-snapshot

Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice

inferredcites →https://doi.org/10.1161/01.cir.0000120704.97934.41openalex-snapshot

Elevated Levels of Activin A in Heart Failure

inferredcites →https://doi.org/10.1161/circresaha.111.246876openalex-snapshot

The Intersection Between Aging and Cardiovascular Disease

inferredcites →https://doi.org/10.1161/circresaha.111.248260openalex-snapshot

Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

inferredcites →https://doi.org/10.1161/circulationaha.108.822403openalex-snapshot

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

inferredcites →https://doi.org/10.1161/circulationaha.109.872200openalex-snapshot

Activin A and Follistatin-Like 3 Determine the Susceptibility of Heart to Ischemic Injury

inferredcites →https://doi.org/10.1172/jci75051openalex-snapshot

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

inferredcites →https://doi.org/10.1186/1478-811x-7-15openalex-snapshot

Activin signaling as an emerging target for therapeutic interventions

inferredcites →https://doi.org/10.1242/dev.01899openalex-snapshot

Handis a direct target of Tinman and GATA factors duringDrosophilacardiogenesis and hematopoiesis

inferredcites →https://doi.org/10.1242/dev.02711openalex-snapshot

The metalloprotease Tolloid-related and its TGF-β-like substrate Dawdle regulateDrosophilamotoneuron axon guidance

inferredcites →https://doi.org/10.1242/jcs.168724openalex-snapshot

TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules

inferredcites →https://doi.org/10.1371/journal.pgen.1001377openalex-snapshot

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

inferredcites →https://doi.org/10.1371/journal.pgen.1003081openalex-snapshot

dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila

inferredcites →https://doi.org/10.1371/journal.pgen.1003941openalex-snapshot

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

inferredcites →https://doi.org/10.1371/journal.pone.0044214openalex-snapshot

Advantages and Limitations of Different p62-Based Assays for Estimating Autophagic Activity in Drosophila

inferredcites →https://doi.org/10.1371/journal.pone.0164239openalex-snapshot

Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles

inferredcites →https://doi.org/10.1681/asn.2012080769openalex-snapshot

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

inferredcites →https://doi.org/10.2144/000113078openalex-snapshot

A New Method for Detection and Quantification of Heartbeat Parameters in Drosophila, Zebrafish, and Embryonic Mouse Hearts

inferredcites →https://doi.org/10.3390/ijms18020374openalex-snapshot

Effects of the Activin A–Follistatin System on Myocardial Cell Apoptosis through the Endoplasmic Reticulum Stress Pathway in Heart Failure

inferredcites →https://doi.org/10.3791/1435openalex-snapshot

Semi-automated Optical Heartbeat Analysis of Small Hearts

inferredcites →https://doi.org/10.4161/15548627.2014.981789openalex-snapshot

ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

inferredcites →https://doi.org/10.4161/auto.22971openalex-snapshot

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity

inferredcites →https://doi.org/10.4161/auto.4776openalex-snapshot

Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of β-Amyloid Peptide inC. elegans

inferredcites →https://doi.org/10.4161/auto.5.1.7279openalex-snapshot

Erratum to: Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide inC. elegans. Autophagy 2007; 3:569-80

inferredcites →https://doi.org/10.4161/auto.6.5.11947openalex-snapshot

Inhibition of autophagy in the heart induces age-related cardiomyopathy

inferredcites →https://doi.org/10.4161/cc.10.14.16586openalex-snapshot

mTOR complex 2 signaling and functions

inferredcites →https://doi.org/10.7554/elife.18459openalex-snapshot

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.jgg.2019.03.011openalex-snapshot

Organelle aging: Lessons from model organisms

inferred← citeshttps://doi.org/10.1161/circresaha.118.312208openalex-snapshot

Autophagy in Cardiovascular Aging

inferred← citeshttps://doi.org/10.31274/td-20240329-363openalex-snapshot

Genetic analysis of spermatogenesis and aging in Drosophila

inferred← citeshttps://doi.org/10.4330/wjc.v16.i3.109openalex-snapshot

Mechanistic insights into fasting-induced autophagy in the aging heart

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