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Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2014.2704openalex-snapshot

Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

inferredcites →https://doi.org/10.1001/jamaneurol.2016.1948openalex-snapshot

Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings

inferredcites →https://doi.org/10.1002/aja.1002030302openalex-snapshot

Stages of embryonic development of the zebrafish

inferredcites →https://doi.org/10.1002/cm.20133openalex-snapshot

Imaging macrophage chemotaxis in vivo: Studies of microtubule function in zebrafish wound inflammation

inferredcites →https://doi.org/10.1002/cne.21057openalex-snapshot

Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio)

inferredcites →https://doi.org/10.1002/dneu.20918openalex-snapshot

Adult neurogenesis and brain regeneration in zebrafish

inferredcites →https://doi.org/10.1002/glia.21260openalex-snapshot

Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish

inferredcites →https://doi.org/10.1002/humu.21277openalex-snapshot

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

inferredcites →https://doi.org/10.1002/humu.22075openalex-snapshot

Deep sequencing of theLRRK2gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe

inferredcites →https://doi.org/10.1002/humu.22117openalex-snapshot

Locus‐specific mutation databases for neurodegenerative brain diseases

inferredcites →https://doi.org/10.1002/humu.22981openalex-snapshot

HGVS Recommendations for the Description of Sequence Variants: 2016 Update

inferredcites →https://doi.org/10.1002/jemt.20829openalex-snapshot

3D reconstruction of histological sections: Application to mammary gland tissue

inferredcites →https://doi.org/10.1002/jnr.23754openalex-snapshot

LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation

inferredcites →https://doi.org/10.1007/978-1-61779-210-6_19openalex-snapshot

Mutant Generation in Vertebrate Model Organisms by TILLING

inferredcites →https://doi.org/10.1007/s00418-009-0619-8openalex-snapshot

Complementary developmental expression of the two tyrosine hydroxylase transcripts in zebrafish

inferredcites →https://doi.org/10.1007/s00418-014-1240-zopenalex-snapshot

The tyrosine hydroxylase 2 (TH2) system in zebrafish brain and stress activation of hypothalamic cells

inferredcites →https://doi.org/10.1007/s10048-006-0041-5openalex-snapshot

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson’s disease risk in Taiwan

inferredcites →https://doi.org/10.1016/j.bbrc.2012.11.113openalex-snapshot

Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson’s disease caused by LRRK2 I2020T mutation

inferredcites →https://doi.org/10.1016/j.brainres.2012.12.024openalex-snapshot

Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice

inferredcites →https://doi.org/10.1016/j.devcel.2004.06.005openalex-snapshot

A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish

inferredcites →https://doi.org/10.1016/j.devcel.2014.11.018openalex-snapshot

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

inferredcites →https://doi.org/10.1016/j.expneurol.2012.12.008openalex-snapshot

Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease

inferredcites →https://doi.org/10.1016/j.ijdevneu.2010.04.002openalex-snapshot

Expression of leucine‐rich‐repeat‐kinase 2 (LRRK2) during embryonic development

inferredcites →https://doi.org/10.1016/j.nbd.2010.07.010openalex-snapshot

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

inferredcites →https://doi.org/10.1016/j.nbd.2010.12.008openalex-snapshot

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

inferredcites →https://doi.org/10.1016/j.nbd.2014.07.013openalex-snapshot

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

inferredcites →https://doi.org/10.1016/j.nbd.2015.02.019openalex-snapshot

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

inferredcites →https://doi.org/10.1016/j.nbd.2015.02.031openalex-snapshot

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

inferredcites →https://doi.org/10.1016/j.neuron.2009.11.006openalex-snapshot

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

inferredcites →https://doi.org/10.1016/j.neuron.2012.08.022openalex-snapshot

LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

inferredcites →https://doi.org/10.1016/j.neuroscience.2007.10.062openalex-snapshot

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease

inferredcites →https://doi.org/10.1016/j.parkreldis.2014.09.033openalex-snapshot

Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease

inferredcites →https://doi.org/10.1016/j.ydbio.2006.03.040openalex-snapshot

Neural stem cells and neurogenesis in the adult zebrafish brain: Origin, proliferation dynamics, migration and cell fate

inferredcites →https://doi.org/10.1016/j.yexcr.2007.07.007openalex-snapshot

The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity

inferredcites →https://doi.org/10.1016/s0022-2836(05)80360-2openalex-snapshot

Basic Local Alignment Search Tool

inferredcites →https://doi.org/10.1016/s0925-4773(03)00135-7openalex-snapshot

Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling

inferredcites →https://doi.org/10.1038/cdd.2012.42openalex-snapshot

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

inferredcites →https://doi.org/10.1038/msb.2011.75openalex-snapshot

Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega

inferredcites →https://doi.org/10.1038/nature14580openalex-snapshot

Genetic compensation induced by deleterious mutations but not gene knockdowns

inferredcites →https://doi.org/10.1038/ncomms9255openalex-snapshot

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

inferredcites →https://doi.org/10.1038/nm.2199openalex-snapshot

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot

Fiji: an open-source platform for biological-image analysis

inferredcites →https://doi.org/10.1038/nn.2349openalex-snapshot

Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

inferredcites →https://doi.org/10.1038/nprot.2015.085openalex-snapshot

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

inferredcites →https://doi.org/10.1042/bj20070209openalex-snapshot

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

inferredcites →https://doi.org/10.1042/bj20100483openalex-snapshot

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

inferredcites →https://doi.org/10.1042/bj20120637openalex-snapshot

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

inferredcites →https://doi.org/10.1073/pnas.0507360102openalex-snapshot

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

inferredcites →https://doi.org/10.1073/pnas.0900470106openalex-snapshot

Olfactory neural circuitry for attraction to amino acids revealed by transposon-mediated gene trap approach in zebrafish

inferredcites →https://doi.org/10.1073/pnas.0906334106openalex-snapshot

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

inferredcites →https://doi.org/10.1073/pnas.1004676107openalex-snapshot

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

inferredcites →https://doi.org/10.1073/pnas.1308335110openalex-snapshot

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

inferredcites →https://doi.org/10.1074/jbc.m115.697466openalex-snapshot

A Novel Developmental Role for Dopaminergic SigNAling to Specify Hypothalamic Neurotransmitter Identity

inferredcites →https://doi.org/10.1093/bioinformatics/btt276openalex-snapshot

TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization

inferredcites →https://doi.org/10.1093/hmg/ddi439openalex-snapshot

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

inferredcites →https://doi.org/10.1093/hmg/ddr348openalex-snapshot

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

inferredcites →https://doi.org/10.1093/oso/9780199638086.003.0002openalex-snapshot

Keeping and raising zebrafish

inferredcites →https://doi.org/10.1097/wnr.0b013e32801254b6openalex-snapshot

Leucine-Rich Repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population

inferredcites →https://doi.org/10.1101/gad.8.11.1311openalex-snapshot

Xenopus embryos regulate the nuclear localization of XMyoD.

inferredcites →https://doi.org/10.1111/j.1471-4159.2008.05793.xopenalex-snapshot

MPTP and MPP+ target specific aminergic cell populations in larval zebrafish

inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb06900.xopenalex-snapshot

The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

inferredcites →https://doi.org/10.1126/science.1228773openalex-snapshot

Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain

inferredcites →https://doi.org/10.1155/2016/7917128openalex-snapshot

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity

inferredcites →https://doi.org/10.1159/000210960openalex-snapshot

Mouse Skin Inflammation Induced by Multiple Topical Applications of 12-O-Tetradecanoylphorbol-13-Acetate

inferredcites →https://doi.org/10.1186/1742-2094-11-52openalex-snapshot

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

inferredcites →https://doi.org/10.1186/1750-1326-4-25openalex-snapshot

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

inferredcites →https://doi.org/10.1186/1750-1326-7-15openalex-snapshot

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

inferredcites →https://doi.org/10.1186/1750-1326-7-25openalex-snapshot

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

inferredcites →https://doi.org/10.1186/2047-9158-4-1openalex-snapshot

Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

inferredcites →https://doi.org/10.1242/dev.052696openalex-snapshot

In vivo evidence for transdifferentiation of peripheral neurons

inferredcites →https://doi.org/10.1242/dev.072587openalex-snapshot

Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors

inferredcites →https://doi.org/10.1242/dev.125.13.2381openalex-snapshot

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisy

inferredcites →https://doi.org/10.1242/dev.129155openalex-snapshot

Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish

inferredcites →https://doi.org/10.1242/dev.144907openalex-snapshot

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

inferredcites →https://doi.org/10.1242/jcs.158196openalex-snapshot

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

inferredcites →https://doi.org/10.1371/journal.pgen.1000914openalex-snapshot

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

inferredcites →https://doi.org/10.1371/journal.pone.0004640openalex-snapshot

Temporally-Controlled Site-Specific Recombination in Zebrafish

inferredcites →https://doi.org/10.1371/journal.pone.0018568openalex-snapshot

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

inferredcites →https://doi.org/10.1371/journal.pone.0020630openalex-snapshot

Disruption of LRRK2 Does Not Cause Specific Loss of Dopaminergic Neurons in Zebrafish

inferredcites →https://doi.org/10.1371/journal.pone.0063778openalex-snapshot

Expression Analysis of Lrrk1, Lrrk2 and Lrrk2 Splice Variants in Mice

inferredcites →https://doi.org/10.1371/journal.pone.0080705openalex-snapshot

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

inferredcites →https://doi.org/10.1371/journal.pone.0118947openalex-snapshot

No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

inferredcites →https://doi.org/10.1523/jneurosci.21-11-03740.2001openalex-snapshot

Protective Autoimmunity Is a Physiological Response to CNS Trauma

inferredcites →https://doi.org/10.1523/jneurosci.5092-10.2011openalex-snapshot

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

inferredcites →https://doi.org/10.1523/jneurosci.5601-11.2012openalex-snapshot

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

inferredcites →https://doi.org/10.2147/cpaa.s102191openalex-snapshot

LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives

inferredcites →https://doi.org/10.2147/nedt.2007.3.1.145openalex-snapshot

Prodromal non-motor symptoms of Parkinson's disease

inferredcites →https://doi.org/10.3109/01677063.2011.627072openalex-snapshot

Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular Functions

inferredcites →https://doi.org/10.3233/jpd-130230openalex-snapshot

The Role of Oxidative Stress in Parkinson's Disease

inferredcites →https://doi.org/10.3389/fncel.2013.00082openalex-snapshot

LRRK2: an éminence grise of Wnt-mediated neurogenesis?

inferredcites →https://doi.org/10.5607/en.2011.20.1.1openalex-snapshot

MAO-inhibitors in Parkinson's Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41598-021-84278-7openalex-snapshot

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

inferred← citeshttps://doi.org/10.3389/fnmol.2022.940484openalex-snapshot

Zebrafish as a model organism for neurodegenerative disease

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