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Widely used commercial ELISA does not detect preHP-2, but recognizes properdin as a potential second member of the zonulin family

https://doi.org/10.1101/157578
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00011-015-0907-9openalex-snapshot
Urinary trypsin inhibitor attenuates LPS-induced endothelial barrier dysfunction by upregulation of vascular endothelial-cadherin expression
inferredcites →https://doi.org/10.1007/s12026-011-8239-5openalex-snapshot
Membrane attack by complement: the assembly and biology of terminal complement complexes
inferredcites →https://doi.org/10.1016/j.chom.2008.02.015openalex-snapshot
Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome
inferredcites →https://doi.org/10.1016/j.diabres.2014.08.017openalex-snapshot
Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients
inferredcites →https://doi.org/10.1016/j.nutres.2012.07.003openalex-snapshot
Potential mechanisms for the emerging link between obesity and increased intestinal permeability
inferredcites →https://doi.org/10.1038/ejhg.2009.107openalex-snapshot
Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
inferredcites →https://doi.org/10.1038/ejhg.2011.65openalex-snapshot
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity
inferredcites →https://doi.org/10.1038/mi.2015.141openalex-snapshot
Novel strategies for targeting innate immune responses to influenza
inferredcites →https://doi.org/10.1038/nprot.2006.468openalex-snapshot
In-gel digestion for mass spectrometric characterization of proteins and proteomes
inferredcites →https://doi.org/10.1073/pnas.0508723103openalex-snapshot
Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken
inferredcites →https://doi.org/10.1073/pnas.0906773106openalex-snapshot
Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
inferredcites →https://doi.org/10.1073/pnas.77.6.3388openalex-snapshot
Covalent structure of human haptoglobin: a serine protease homolog.
inferredcites →https://doi.org/10.1073/pnas.88.12.5242openalex-snapshot
Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions.
inferredcites →https://doi.org/10.1074/jbc.m605684200openalex-snapshot
A Unique Loop Extension in the Serine Protease Domain of Haptoglobin Is Essential for CD163 Recognition of the Haptoglobin-Hemoglobin Complex
inferredcites →https://doi.org/10.1080/00365520500235334openalex-snapshot
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
inferredcites →https://doi.org/10.1093/clinchem/42.10.1589openalex-snapshot
Biological and clinical significance of haptoglobin polymorphism in humans
inferredcites →https://doi.org/10.1093/clinchem/48.9.1377openalex-snapshot
Genotyping of the Common Haptoglobin Hp 1/2 Polymorphism Based on PCR
inferredcites →https://doi.org/10.1093/hmg/ddp423openalex-snapshot
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
inferredcites →https://doi.org/10.1111/dom.12157openalex-snapshot
Metagenome and metabolism: the tissue microbiota hypothesis
inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb05244.xopenalex-snapshot
Regulation of Intercellular Tight Junctions by Zonula Occludens Toxin and Its Eukaryotic Analogue Zonulin
inferredcites →https://doi.org/10.1136/bmjopen-2016-014596openalex-snapshot
Prospective observational study in two Dutch hospitals to assess the performance of inflammatory plasma markers to determine disease severity of viral respiratory tract infections in children
inferredcites →https://doi.org/10.1136/gut.2005.085373openalex-snapshot
Alterations in intestinal permeability
inferredcites →https://doi.org/10.1136/gut.2008.165886openalex-snapshot
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.395openalex-snapshot
BIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR
inferredcites →https://doi.org/10.1152/ajplung.00196.2012openalex-snapshot
Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system
inferredcites →https://doi.org/10.1152/physrev.00003.2008openalex-snapshot
Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer
inferredcites →https://doi.org/10.1155/2012/879151openalex-snapshot
Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?
inferredcites →https://doi.org/10.1155/2013/523652openalex-snapshot
The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging
inferredcites →https://doi.org/10.1155/2013/674106openalex-snapshot
Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects
inferredcites →https://doi.org/10.1172/jci118114openalex-snapshot
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
inferredcites →https://doi.org/10.1177/0148607111413772openalex-snapshot
Gut Microbiota, Intestinal Permeability, Obesity‐Induced Inflammation, and Liver Injury
inferredcites →https://doi.org/10.1186/s12876-014-0189-7openalex-snapshot
Intestinal permeability – a new target for disease prevention and therapy
inferredcites →https://doi.org/10.1210/jc.2013-4483openalex-snapshot
Bacterial DNA Translocation Holds Increased Insulin Resistance and Systemic Inflammatory Levels in Morbid Obese Patients
inferredcites →https://doi.org/10.1242/jcs.113.24.4435openalex-snapshot
Human zonulin, a potential modulator of intestinal tight junctions
inferredcites →https://doi.org/10.1248/bpb.26.753openalex-snapshot
Calprotectin (S100A8/S100A9), an Inflammatory Protein Complex from Neutrophils with a Broad Apoptosis-Inducing Activity
inferredcites →https://doi.org/10.1371/journal.pone.0037160openalex-snapshot
Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance
inferredcites →https://doi.org/10.1590/s1415-47572008000400002openalex-snapshot
Polymorphism of human haptoglobin and its clinical importance
inferredcites →https://doi.org/10.2337/db05-1367openalex-snapshot
2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice
inferredcites →https://doi.org/10.2337/db07-1403openalex-snapshot
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
inferredcites →https://doi.org/10.2337/dc13-2817openalex-snapshot
Gut Dysbiosis and Detection of “Live Gut Bacteria” in Blood of Japanese Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fimmu.2013.00093openalex-snapshot
Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”
inferredcites →https://doi.org/10.3945/ajcn.116.131110openalex-snapshot
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00702-020-02234-7openalex-snapshot
Examination of plasma zonulin levels in bipolar I disorder: a case–control study with follow-up
inferred← citeshttps://doi.org/10.17116/dokgastro20221101128openalex-snapshot
Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review)
inferred← citeshttps://doi.org/10.21508/1027-4065-2021-66-1-31-38openalex-snapshot
Biological role of zonulin: a biomarker of increased intestinal permeability syndrome
inferred← citeshttps://doi.org/10.51821/85.2.10100openalex-snapshot
Belgian consensus on irritable bowel syndrome
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