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Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/pro.5560020401openalex-snapshot

Peptidylglycine α‐amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains

inferredcites →https://doi.org/10.1007/s00018-007-7254-0openalex-snapshot

The endocrine role for chromogranin A: A prohormone for peptides with regulatory properties

inferredcites →https://doi.org/10.1007/s00125-003-1304-4openalex-snapshot

Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?

inferredcites →https://doi.org/10.1007/s00125-010-2012-5openalex-snapshot

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

inferredcites →https://doi.org/10.1007/s00441-017-2580-5openalex-snapshot

Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion

inferredcites →https://doi.org/10.1016/0141-0229(94)90014-0openalex-snapshot

C-Terminal amidated peptides: Production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity

inferredcites →https://doi.org/10.1016/j.ab.2003.09.012openalex-snapshot

An enzyme-coupled assay for glyoxylic acid

inferredcites →https://doi.org/10.1016/j.bbamem.2011.06.012openalex-snapshot

Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment

inferredcites →https://doi.org/10.1016/j.bbrc.2015.05.072openalex-snapshot

Physiological characterization of the human EndoC-βH1 β-cell line

inferredcites →https://doi.org/10.1016/j.celrep.2014.11.010openalex-snapshot

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells

inferredcites →https://doi.org/10.1016/j.cmet.2014.12.020openalex-snapshot

Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?

inferredcites →https://doi.org/10.1016/s0021-9258(18)77318-3openalex-snapshot

Ca2(+)-induced conformational change and aggregation of chromogranin A.

inferredcites →https://doi.org/10.1016/s0021-9258(19)50625-1openalex-snapshot

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM).

inferredcites →https://doi.org/10.1016/s0092-8674(01)00459-7openalex-snapshot

Chromogranin A, an “On/Off” Switch Controlling Dense-Core Secretory Granule Biogenesis

inferredcites →https://doi.org/10.1016/s0167-0115(98)00044-5openalex-snapshot

Amidated and non-amidated glucagon-like peptide-1 (GLP-1): non-pancreatic effects (cephalic phase acid secretion) and stability in plasma in humans

inferredcites →https://doi.org/10.1016/s0896-6273(00)80147-6openalex-snapshot

Protein Kinase C Enhances Exocytosis from Chromaffin Cells by Increasing the Size of the Readily Releasable Pool of Secretory Granules

inferredcites →https://doi.org/10.1021/bi00085a012openalex-snapshot

Dimerization and tetramerization properties of the C-terminal region of chromogranin A: A thermodynamic analysis

inferredcites →https://doi.org/10.1021/bi00471a006openalex-snapshot

Novel substrates and inhibitors of peptidylglycine .alpha.-amidating monooxygenase

inferredcites →https://doi.org/10.1021/bi016013mopenalex-snapshot

Structural Consequences of Carboxyamidation of Dermaseptin S3

inferredcites →https://doi.org/10.1021/bi0360915openalex-snapshot

How C-Terminal Carboxyamidation Alters the Biological Activity of Peptides from the Venom of the Eumenine Solitary Wasp

inferredcites →https://doi.org/10.1021/bi700704ropenalex-snapshot

Biogenesis of the Secretory Granule: Chromogranin A Coiled-Coil Structure Results in Unusual Physical Properties and Suggests a Mechanism for Granule Core Condensation

inferredcites →https://doi.org/10.1038/nature18642openalex-snapshot

The genetic architecture of type 2 diabetes

inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

inferredcites →https://doi.org/10.1038/ng.2507openalex-snapshot

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

inferredcites →https://doi.org/10.1038/ng.2882openalex-snapshot

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

inferredcites →https://doi.org/10.1074/jbc.271.1.48openalex-snapshot

Secretory Granule Content Proteins and the Luminal Domains of Granule Membrane Proteins Aggregate in Vitro at Mildly Acidic pH

inferredcites →https://doi.org/10.1074/jbc.271.29.17526openalex-snapshot

Identification of Routing Determinants in the Cytosolic Domain of a Secretory Granule-associated Integral Membrane Protein

inferredcites →https://doi.org/10.1074/jbc.274.5.2929openalex-snapshot

Kalirin, a Multifunctional PAM COOH-terminal Domain Interactor Protein, Affects Cytoskeletal Organization and ACTH Secretion from AtT-20 Cells

inferredcites →https://doi.org/10.1074/jbc.m115.667246openalex-snapshot

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

inferredcites →https://doi.org/10.1074/jbc.m513886200openalex-snapshot

Role for an Essential Tyrosine in Peptide Amidation

inferredcites →https://doi.org/10.1091/mbc.e05-08-0755openalex-snapshot

Protease Nexin-1 Promotes Secretory Granule Biogenesis by Preventing Granule Protein Degradation

inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a022605openalex-snapshot

A Spectrophotometric Method for the Determination of Glycolate Urine and Plasma with Glycolate Oxidase

inferredcites →https://doi.org/10.1101/gr.150706.112openalex-snapshot

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

inferredcites →https://doi.org/10.1111/j.1464-5491.1994.tb00273.xopenalex-snapshot

Understanding Oral Glucose Tolerance: Comparison of Glucose or Insulin Measurements During the Oral Glucose Tolerance Test with Specific Measurements of Insulin Resistance and Insulin Secretion

inferredcites →https://doi.org/10.1111/j.1471-4159.1993.tb03261.xopenalex-snapshot

Neurosecretory Vesicles Contain Soluble and Membrane‐Associated Monofunctional and Bifunctional Peptidylglycine α‐Amidating Monooxygenase Proteins

inferredcites →https://doi.org/10.1126/science.1262110openalex-snapshot

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

inferredcites →https://doi.org/10.1128/mcb.19.8.5811openalex-snapshot

Multiple Roles of Ligand in Transforming the Dioxin Receptor to an Active Basic Helix-Loop-Helix/PAS Transcription Factor Complex with the Nuclear Protein Arnt

inferredcites →https://doi.org/10.1172/jci58447openalex-snapshot

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

inferredcites →https://doi.org/10.1177/002215540205001013openalex-snapshot

Immunocytochemical Finding of the Amidating Enzymes in Mouse Pancreatic A-, B-, and D-cells

inferredcites →https://doi.org/10.1186/1471-2164-15-620openalex-snapshot

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

inferredcites →https://doi.org/10.1210/en.141.8.3020openalex-snapshot

Cell Type-Specific Metabolism of Peptidylglycine -Amidating Monooxygenase in Anterior Pituitary

inferredcites →https://doi.org/10.1210/en.2015-1562openalex-snapshot

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

inferredcites →https://doi.org/10.1210/endo.141.8.7620openalex-snapshot

Cell Type-Specific Metabolism of Peptidylglycineα -Amidating Monooxygenase in Anterior Pituitary*

inferredcites →https://doi.org/10.1210/er.2010-0027openalex-snapshot

The Extended Granin Family: Structure, Function, and Biomedical Implications

inferredcites →https://doi.org/10.1210/me.2010-0124openalex-snapshot

Serpinin: A Novel Chromogranin A-Derived, Secreted Peptide Up-Regulates Protease Nexin-1 Expression and Granule Biogenesis in Endocrine Cells

inferredcites →https://doi.org/10.1210/me.6.12.2185openalex-snapshot

Expression of a peptide processing enzyme in cultured cells: truncation mutants reveal a routing domain

inferredcites →https://doi.org/10.1242/jcs.110.6.695openalex-snapshot

Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells

inferredcites →https://doi.org/10.1371/journal.pgen.1005694openalex-snapshot

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

inferredcites →https://doi.org/10.1371/journal.pone.0120879openalex-snapshot

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line

inferredcites →https://doi.org/10.2337/db13-0949openalex-snapshot

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

inferredcites →https://doi.org/10.2337/db15-0039openalex-snapshot

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

inferredcites →https://doi.org/10.2337/diabetes.51.2007.s434openalex-snapshot

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

inferredcites →https://doi.org/10.3389/fendo.2017.00020openalex-snapshot

Chromogranin A Regulation of Obesity and Peripheral Insulin Sensitivity

inferredcites →https://doi.org/10.3727/096368912x636975openalex-snapshot

Collagenase does Not Persist in Human Islets following Isolation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1101/371450openalex-snapshot

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

inferred← citeshttps://doi.org/10.1111/dom.13401openalex-snapshot

Islet prohormone processing in health and disease

inferred← citeshttps://doi.org/10.14341/omet12778openalex-snapshot

Beta-cell autophagy under the scope of hypoglycemic drugs; possible mechanism as a novel therapeutic target

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