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A Biomaterial Screening Approach Reveals Microenvironmental Mechanisms of Drug Resistance

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Maleimide Cross‐Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross‐Linking for Cell Encapsulation and In Situ Delivery

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Three‐dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins

inferredcites →https://doi.org/10.1016/j.biomaterials.2010.07.064openalex-snapshot

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

inferredcites →https://doi.org/10.1016/j.biomaterials.2014.03.058openalex-snapshot

Sorafenib resistance and JNK signaling in carcinoma during extracellular matrix stiffening

inferredcites →https://doi.org/10.1016/j.biomaterials.2015.04.058openalex-snapshot

Regulation of metastatic ability and drug resistance in pulmonary adenocarcinoma by matrix rigidity via activating c-Met and EGFR

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Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

inferredcites →https://doi.org/10.1016/j.ccr.2005.08.010openalex-snapshot

Tensional homeostasis and the malignant phenotype

inferredcites →https://doi.org/10.1016/j.ccr.2010.11.023openalex-snapshot

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

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Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia

inferredcites →https://doi.org/10.1016/j.ccr.2011.12.024openalex-snapshot

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

inferredcites →https://doi.org/10.1016/j.cell.2009.10.027openalex-snapshot

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

inferredcites →https://doi.org/10.1016/j.cell.2012.02.053openalex-snapshot

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

inferredcites →https://doi.org/10.1016/j.cell.2012.03.031openalex-snapshot

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

inferredcites →https://doi.org/10.1016/j.celrep.2015.03.037openalex-snapshot

Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains

inferredcites →https://doi.org/10.1016/j.ctrv.2016.12.001openalex-snapshot

Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of MEK

inferredcites →https://doi.org/10.1016/j.jmbbm.2015.06.023openalex-snapshot

Mechanics of intact bone marrow

inferredcites →https://doi.org/10.1016/j.yexcr.2015.10.033openalex-snapshot

Mechanosensing via cell-matrix adhesions in 3D microenvironments

inferredcites →https://doi.org/10.1016/s1040-8428(00)00086-xopenalex-snapshot

Multicellular resistance: a paradigm for clinical resistance?

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Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells

inferredcites →https://doi.org/10.1021/acsbiomaterials.7b00069openalex-snapshot

Comparative Study of Multicellular Tumor Spheroid Formation Methods and Implications for Drug Screening

inferredcites →https://doi.org/10.1021/bm400418gopenalex-snapshot

PEG-Phosphorylcholine Hydrogels As Tunable and Versatile Platforms for Mechanobiology

inferredcites →https://doi.org/10.1021/mp500059qopenalex-snapshot

A 3D Biomimetic Model of Tissue Stiffness Interface for Cancer Drug Testing

inferredcites →https://doi.org/10.1038/415530aopenalex-snapshot

Gene expression profiling predicts clinical outcome of breast cancer

inferredcites →https://doi.org/10.1038/ncb2953openalex-snapshot

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

inferredcites →https://doi.org/10.1038/ncomms12624openalex-snapshot

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

inferredcites →https://doi.org/10.1038/ng1180openalex-snapshot

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

inferredcites →https://doi.org/10.1038/nm.3394openalex-snapshot

Microenvironmental regulation of tumor progression and metastasis

inferredcites →https://doi.org/10.1038/nmeth.3853openalex-snapshot

Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

inferredcites →https://doi.org/10.1038/nprot.2012.016openalex-snapshot

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

inferredcites →https://doi.org/10.1039/c6ib00229copenalex-snapshot

PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity

inferredcites →https://doi.org/10.1056/nejmoa044238openalex-snapshot

EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

inferredcites →https://doi.org/10.1073/pnas.1611338113openalex-snapshot

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

inferredcites →https://doi.org/10.1073/pnas.95.26.15665openalex-snapshot

A multidrug resistance transporter from human MCF-7 breast cancer cells

inferredcites →https://doi.org/10.1074/jbc.m112.349365openalex-snapshot

α2β1 Integrin Promotes Chemoresistance against Doxorubicin in Cancer Cells through Extracellular Signal-regulated Kinase (ERK)

inferredcites →https://doi.org/10.1093/jnci/djm135openalex-snapshot

Drug Resistance and the Solid Tumor Microenvironment

inferredcites →https://doi.org/10.1093/nar/gkw343openalex-snapshot

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update

inferredcites →https://doi.org/10.1126/scisignal.2004155openalex-snapshot

The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells

inferredcites →https://doi.org/10.1126/scitranslmed.aai8504openalex-snapshot

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

inferredcites →https://doi.org/10.1158/0008-5472.can-08-4490openalex-snapshot

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

inferredcites →https://doi.org/10.1158/0008-5472.can-09-4032openalex-snapshot

Disruption of Laminin-Integrin-CD151-Focal Adhesion Kinase Axis Sensitizes Breast Cancer Cells to ErbB2 Antagonists

inferredcites →https://doi.org/10.1158/0008-5472.can-16-0123openalex-snapshot

JNK Pathway Activation Modulates Acquired Resistance to EGFR/HER2–Targeted Therapies

inferredcites →https://doi.org/10.1158/0008-5472.can-16-2808openalex-snapshot

Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer

inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1978openalex-snapshot

A Phase I Study with Neratinib (HKI-272), an Irreversible Pan ErbB Receptor Tyrosine Kinase Inhibitor, in Patients with Solid Tumors

inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-3377openalex-snapshot

MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0933openalex-snapshot

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

inferredcites →https://doi.org/10.1186/bcr2936openalex-snapshot

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

inferredcites →https://doi.org/10.1186/bcr3650openalex-snapshot

RETRACTED ARTICLE: Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models

inferredcites →https://doi.org/10.1200/jco.2007.14.5375openalex-snapshot

Phase II Study of Sunitinib Malate, an Oral Multitargeted Tyrosine Kinase Inhibitor, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

inferredcites →https://doi.org/10.1200/jco.2008.21.4437openalex-snapshot

Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

inferredcites →https://doi.org/10.1200/jco.2009.27.9414openalex-snapshot

Neratinib, an Irreversible Pan-ErbB Receptor Tyrosine Kinase Inhibitor: Results of a Phase II Trial in Patients With Advanced Non–Small-Cell Lung Cancer

inferredcites →https://doi.org/10.1200/jco.2011.35.7376openalex-snapshot

First-Line Treatment of Advanced Breast Cancer With Sunitinib in Combination With Docetaxel Versus Docetaxel Alone: Results of a Prospective, Randomized Phase III Study

inferredcites →https://doi.org/10.1242/jcs.144378openalex-snapshot

Metastatic ovarian cancer cell malignancy is increased on soft matrices through a mechanosensitive Rho/ROCK pathway

inferredcites →https://doi.org/10.1242/jcs.188102openalex-snapshot

Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response

inferredcites →https://doi.org/10.1371/journal.pone.0019144openalex-snapshot

Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression

inferredcites →https://doi.org/10.1371/journal.pone.0019929openalex-snapshot

A Multiwell Platform for Studying Stiffness-Dependent Cell Biology

inferredcites →https://doi.org/10.1371/journal.pone.0101771openalex-snapshot

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

inferredcites →https://doi.org/10.1371/journal.pone.0108283openalex-snapshot

3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems

inferredcites →https://doi.org/10.15252/msb.20145877openalex-snapshot

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis

inferredcites →https://doi.org/10.15252/msb.20166796openalex-snapshot

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

inferredcites →https://doi.org/10.1530/erc-11-0155openalex-snapshot

Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro

inferredcites →https://doi.org/10.1615/critrevoncog.v17.i1.20openalex-snapshot

Intrinsic and Acquired Resistance to HER2-Targeted Therapies in HER2 Gene-Amplified Breast Cancer: Mechanisms and Clinical Implications

inferredcites →https://doi.org/10.4161/cc.9.9.11483openalex-snapshot

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

inferredcites →https://doi.org/10.7554/elife.01308openalex-snapshot

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1063/1.5019196openalex-snapshot

Anomalously diffusing and persistently migrating cells in 2D and 3D culture environments

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